medicalcondition:breast cancer

Alcohol Is Killing More People Per Year Than The Opioid Crisis, And Most Deaths Are Young Women
▻https://www.newsweek.com/alcohol-killing-more-people-year-opioid-crisis-and-most-deaths-are-young-1

https://s.newsweek.com/sites/www.newsweek.com/files/styles/full/public/2018/11/17/gettyimages-1060372978.jpg

lcohol is killing more adults in the U.S. than the opioid epidemic according to the Institute for Health Metrics and Evaluation at the University of Washington. The opioid epidemic kills an average of 72,000 people per year, while alcohol kills 88,000. In those 88,000 deaths are 2.5 million years of potential life lost, according to the Center for Disease Control and Prevention.

The surge of alcohol related deaths is new. In ten years, the number of deaths by alcohol have increased 35 percent according the new report shared by USA Today on Friday. The statistics are based on findings from 2007 to 2017.

Most affected by the rising alcohol epidemic are young women. Among women, deaths rose 67 percent, while for men, the percentage rose only 27 percent.

Women are more susceptible to alcohol-related risks because they typically weigh less than men, and can feel the effects of alcohol faster, according to the National Institute on Alcohol and Abuse and Alcoholism. The complications that most affect women who drink excessively are Liver Damage, Heart Disease, Breast Cancer and complications with pregnancy.

#Addiction #Opioides #Alcool

China embraces a revolution in genetic testing, seeking answers on destiny and identity
▻https://www.statnews.com/2018/09/27/china-embraces-consumer-genetic-testing

BEIJING — It was from the news of American actress Angelina Jolie’s double mastectomy that Yang Yang learned it would be possible to have her DNA sequenced. A white-collar worker from Chongqing, a major city in southwest China, Yang admired her idol’s decision in 2013 to take her future into her own hands after a genetic test revealed a high risk of breast cancer. Five years later, Yang has discovered that genetic testing services are not only available to Hollywood stars, but also to the (...)

#23Mofang #biométrie #génétique

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Overwatch “Pink Mercy” sales raise $12.7 million for breast cancer research
▻https://www.gamesindustry.biz/articles/2018-07-09-overwatch-pink-mercy-sales-raise-USD12-7-million-for-breas

Additional $130,000 raised through Overwatch Twitch #Charity streams

It Was Supposed to Be an Unbiased Study of Drinking. They Wanted to Call It ‘Cheers.’ - The New York Times
▻https://www.nytimes.com/2018/06/18/health/nih-alcohol-study.html

https://static01.nyt.com/images/2018/06/19/science/19SCI-ALCOHOL1/19SCI-ALCOHOL1-facebookJumbo-v2.jpg

The director of the nation’s top health research agency pulled the plug on a study of alcohol’s health effects without hesitation on Friday, saying a Harvard scientist and some of his agency’s own staff had crossed “so many lines” in pursuit of alcohol industry funding that “people were frankly shocked.”

A 165-page internal investigation prepared for Dr. Francis Collins, director of the National Institutes of Health, concluded that Kenneth J. Mukamal, the lead investigator of the trial, was in close, frequent contact with beer and liquor executives while designing the study.

Buried in that document are disturbing examples of the coziness between the scientists and their industry patrons. Dr. Mukamal was eager to allay their concerns, respond to their questions and suggestions, and secure the industry’s buy-in.

Dr. Mukamal has repeatedly denied communicating with the alcohol industry while planning the trial, telling The Times last year that he had, “literally no contact with the alcohol industry.”

The study was intended to test the hypothesis that one drink a day is better for one’s heart than none, among other benefits of moderate drinking. But its design was such that it would not pick up harms, such as an increase in cancers or heart failure associated with alcohol, the investigation found.
Scientists who designed the trial were aware it was not large enough to detect a rise in breast cancer, and acknowledged to grant reviewers in 2016 that the study was focused on benefits and “not powered to identify negative health effects.”

“Clearly, there was a sense that this trial was being set up in a way that would maximize the chances of showing a positive effect of alcohol,” Dr. Collins said last week as he accepted his advisers’ recommendation to terminate the trial.

“Understandably, the alcoholic beverage industry would like to see that.”

If the study failed to find health benefits in moderate drinking but provided no evidence of harm, the results still would be a boon for the beverage makers. The findings would counter a 2014 World Health Organization edict that no level of alcohol consumption is safe because it raises the risk of cancer.

#Santé_publique #Alcool #Conflit_intérêt

What consumer DNA data can and can’t tell you about disease risk | Science News
▻https://www.sciencenews.org/article/health-dna-genetic-testing-disease

False alarm
A clinical lab checked worrisome results that people received from consumer DNA testing companies. Of the variants flagged as harmful, 40 percent were false positives. All but one of the bad calls were in cancer risk genes: BRCA1, BRCA2, TP53, CHEK2, MLH1 and ATM.

https://www.sciencenews.org/sites/default/files/2018/05/060918_genetics_lara-diamond_inline_pie.png

Risks explained
Customers of 23andMe who want to unlock information on their breast cancer risk must click through several screens of information before learning the result. This screen explains that risk goes beyond the three variants reported.

https://www.sciencenews.org/sites/default/files/2018/05/060918_genetics_lara-diamond_23andme_rev.jpg

Consumption of ultra-processed foods and #cancer risk: results from NutriNet-Santé prospective cohort | The BMJ
▻https://www.bmj.com/content/360/bmj.k322

Firstly, ultra-processed foods often have a higher content of total fat, saturated fat, and added sugar and salt, along with a lower fibre and vitamin density.101112131415161719 Beyond nutritional composition, neoformed #contaminants, some of which have carcinogenic properties (such as #acrylamide, heterocyclic amines, and polycyclic aromatic hydrocarbons), are present in heat treated processed food products as a result of the Maillard reaction.20 Secondly, the packaging of ultra-processed foods may contain some materials in contact with food for which carcinogenic and endocrine disruptor properties have been postulated, such as #bisphenol A.21 Finally, ultra-processed foods contain authorised,22 but controversial, food additives such as sodium #nitrite in processed meat or #titanium_dioxide (#TiO2, white food pigment), for which carcinogenicity has been suggested in animal or cellular models.2324

In this large prospective study, a 10% increase in the proportion of ultra-processed foods in the diet was associated with a significant increase of greater than 10% in risks of overall and breast cancer. Further studies are needed to better understand the relative effect of the various dimensions of processing (nutritional composition, food additives, contact materials, and neoformed contaminants) in these associations.

#agro_industrie #aliments_transformés #additifs #santé #cancer

Via 60 millions de consommateurs

Do Mammograms Save Lives ? - YouTube
▻https://www.youtube.com/watch?v=GTnC1P4XOF0

(Le sous-titrage existe en français)

For every life saved by mammography, as many as 2 to 10 women are overdiagnosed, meaning turned into breast cancer patients unnecessarily, along with all the attendant harms of chemo, radiation, or surgery without the benefits.

Sources et transcription : ▻https://nutritionfacts.org/video/do-mammograms-save-lives

#mammographies #cancer #mastectomie #surdiagnostic

À rapprocher de ►https://seenthis.net/messages/637162 et ►https://seenthis.net/messages/634803

Dominique Morisseau’s Skeleton Crew in #Detroit: A drama about the working class - World Socialist Web Site
▻https://www.wsws.org/en/articles/2017/11/03/skel-n03.html

https://www.wsws.org/asset/a34f6864-5476-434b-a822-06e80b440736/image.jpg

Audience members realize soon enough that Faye—who also suffers from breast cancer but eternally and defiantly puffs on a cigarette in front of the prominent “No Smoking” sign—is sleeping in the breakroom, because the cold weather has made spending nights in her car impossible. She has worked at the plant for 29 years (“Been on the line longer than you been born”) and serves as the UAW union representative.

#art #théâtre

The SCAR Project - Images
►http://www.thescarproject.org/gallery

http://www.thescarproject.org/gallery_image/1372181397_SCAR-8.jpg

Breast Cancer Is Not a Pink Ribbon

#mastectomie
#cancer_du_sein
#admiration

Does Having Kids Make Mothers Age Faster? - Issue 49: The Absurd
http://54.197.248.184/issue/49/the-absurd/does-having-kids-make-mothers-age-faster

http://static.nautil.us/12535_ee88b3cea2051be97bcddf2e0d9a28f6.png

There’s an old wives’ tale that having a child ages a woman. And why wouldn’t it? When a woman becomes pregnant, her body undergoes a massive transformation. She gains weight and her metabolic rate spikes. Her pulse quickens. Her uterus expands and presses on surrounding organs and blood vessels. Her estrogen and progesterone levels surge, reaching astronomical levels. The volume of gray matter in her brain shrinks. While all these changes are necessary or advantageous for childbirth, many of them can cause problems later in life. Sex hormones improve reproductive odds but can cause an increased risk of breast cancer. A greater amount of mitosis, or cell division, means greater cellular damage. The high metabolism required for pregnancy and lactation increases oxidative stress, believed (...)

Does Having Kids Make Mothers Age Faster? - Issue 49: The Absurd
▻http://nautil.us/issue/49/the-absurd/does-having-kids-make-mothers-age-faster

http://static.nautil.us/12535_ee88b3cea2051be97bcddf2e0d9a28f6.png

There’s an old wives’ tale that having a child ages a woman. And why wouldn’t it? When a woman becomes pregnant, her body undergoes a massive transformation. She gains weight and her metabolic rate spikes. Her pulse quickens. Her uterus expands and presses on surrounding organs and blood vessels. Her estrogen and progesterone levels surge, reaching astronomical levels. The volume of gray matter in her brain shrinks. While all these changes are necessary or advantageous for childbirth, many of them can cause problems later in life. Sex hormones improve reproductive odds but can cause an increased risk of breast cancer. A greater amount of mitosis, or cell division, means greater cellular damage. The high metabolism required for pregnancy and lactation increases oxidative stress, believed (...)

Why Are Black Women More Likely to Die from Breast Cancer? - Facts So Romantic
▻http://nautil.us/blog/why-are-black-women-more-likely-to-die-from-breast-cancer

http://static.nautil.us/11973_f9b625bde54bf6a9c3d40501c0d21f93.jpg

Because of “historic injustices in medical research and genetics,” according to a 2013 paper, blacks may be reluctant to seek out tests, for “fears that genetic risk information may be used by an insurer or employer to discriminate against them.”Photograph by Peathegee Inc / GettyHere’s a curious fact: Black American women are 37 percent more likely to die from breast cancer than white women, according to a 2015 report by the American Cancer Society, yet they receive early-stage diagnoses much less frequently. Why might that be? Biology’s role isn’t clear. The breast cancer death-rate in the U.S. is on the decline—from 1989 to 2012, it decreased by 36 percent, likely because, researchers suspect, treatments have improved and detection happens earlier. But that progress hasn’t benefitted (...)

Cancer du sein : Quand les craintes des patientes augmentent les mauvais effets des traitements
▻http://www.20minutes.fr/sante/1912171-20160823-cancer-sein-quand-craintes-patientes-augmentent-mauvais-e

Douleurs articulaires, gain de poids et bouffées de chaleur… L’importance des effets secondaires de certains traitements du cancer du sein, notamment l’hormonothérapie dépendrait étroitement des craintes des patientes, celles redoutant le pire souffrant des effets les plus importants.

PLOS Neglected Tropical Diseases: Diseases Neglected by the Media in Espírito Santo, Brazil in 2011–2012
▻http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004662

Abstract

Background
The aims of the present study were to identify and analyse the Diseases Neglected by the Media (DNMs) via a comparison between the most important health issues to the population of Espírito Santo, Brazil, from the epidemiological perspective (health value) and their effective coverage by the print media, and to analyse the DNMs considering the perspective of key journalists involved in the dissemination of health topics in the state media.

Methodology
Morbidity and mortality data were collected from official documents and from Health Information Systems. In parallel, the diseases reported in the two major newspapers of Espírito Santo in 2011–2012 were identified from 10,771 news articles. Concomitantly, eight interviews were conducted with reporters from the two newspapers to understand the journalists’ reasons for the coverage or neglect of certain health/disease topics.

Principal Findings
Quantitatively, the DNMs identified diseases associated with poverty, including tuberculosis, leprosy, schistosomiasis, leishmaniasis, and trachoma. Apart from these, diseases with outbreaks in the period evaluated, including whooping cough and meningitis, some cancers, respiratory diseases, ischaemic heart disease, and stroke, were also seldom addressed by the media. In contrast, dengue fever, acquired immune deficiency syndrome (AIDS), diabetes, breast cancer, prostate cancer, tracheal cancer, and bronchial and lung cancers were broadly covered in the period analysed, corroborating the tradition of media disclosure of these diseases. Qualitatively, the DNMs included rare diseases, such as amyotrophic lateral sclerosis (ALS), leishmaniasis, Down syndrome, and verminoses. The reasons for the neglect of these topics by the media included the political and economic interests of the newspapers, their editorial line, and the organizational routine of the newsrooms.

Conclusions
Media visibility acts as a strategy for legitimising priorities and contextualizing various realities. Therefore, we propose that the health problems identified should enter the public agenda and begin to be recognized as legitimate demands.

Winning the Cancer War: Start With the Deepest Intelligence - Facts So Romantic
▻http://nautil.us/blog/winning-the-cancer-war-start-with-the-deepest-intelligence

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This is the first in a three-part series, “Winning the Cancer War,” by Patrick Soon-Shiong, MD, FRCS(C), FACS In 2003, government agencies proclaimed we solved cancer because we solved the human genome. We thought we could halt cancer in its tracks by targeting mutations in our DNA and stopping those “cancer drivers.” This spurred the great genomics buildout over the last ten years. Hundreds of academic medical centers and companies began developing their own gene panels—everything from 40 DNA gene panel to 500 gene panels, from breast cancer panels to lung cancer panels, and everything in between—all in a tremendous race to treat cancer with targeted drugs. Large pharma and biotechs joined the bandwagon. They invested billions of dollars and utilized insights from limited gene panels as (...)

A Single Cell Shines New Light on How #Cancers Develop - The New York Times
▻http://www.nytimes.com/2016/01/29/health/how-skin-cancer-develops-melanoma-zebra-fish.html?smid=tw-nythealth&smtyp=c

“More and more data suggest that just having mutations is not sufficient to cause cancer,” said Dr. Kornelia Polyak, a breast cancer researcher at the Dana Farber Cancer institute, who was not associated with the new study. “You need the right context.”

That was where Dr. Zon and his colleagues began 10 years ago. They were investigating melanoma by creating it in zebra fish, tiny transparent creatures that allow researchers to see cells and organs without cutting the fish open. The researchers put human BRAF and P53 genes in every melanocyte, the pigmented skin cells, of the fish. If genes were all that was needed for cancer, the fish would explode with melanoma. But the researchers found only one to three melanomas per fish.

“That told us there has to be an additional event,” Dr. Zon said.

By luck, they found it. The pigmented skin cells that became cancerous had turned on a gene, crestin, that is normally activated only in cells that are part of the neural crest, a group of cells pinched off early in embryonic life from a region adjacent to the brain. These primitive cells, depending on where they are in the embryo, can turn into pigmented skin cells or a variety of other types of cells, like those that make up bones and teeth, the covering of the brain or those that sheath and insulate nerve cells. Once cells develop into their mature tissue type — pigmented skin cell, bone or tooth, for example — the crestin gene shuts down. Those pigmented skin cells in the fish that had an active crestin gene had reverted back to that primitive state when they were malleable, their fates still wide open.

Feeling like a Grinch ? At least it won’t shorten your life | Fox News
▻http://www.foxnews.com/health/2015/12/10/feeling-like-grinch-at-least-it-wont-shorten-your-life.html

Previous studies have linked happiness to longevity but researchers now say there’s no such scientific connection. So while being sick makes you unhappy, just being grouchy isn’t enough to make you ill or shorten your life.

The results are based on questionnaires from more than 715,000 British women aged 50 to 69 who were enrolled in a national breast cancer screening program in the late 1990s.

The women were asked things like how often they felt happy and how healthy they were. Nearly 40 percent of the women said they were happy most of the time while 17 percent said they were unhappy. After a decade of tracking the women, 4 percent had died.

Scientists found the death rate among unhappy women was the same as those who were happy. The research was published online Wednesday in the medical journal Lancet.

Doubt Is Raised Over Value of Surgery for Breast Lesion at Earliest Stage - The New York Times
▻http://www.nytimes.com/2015/08/21/health/breast-cancer-ductal-carcinoma-in-situ-study.html?_r=0

A majority of the 100,000 patients in the database the researchers used, from a national cancer registry, had lumpectomies, and nearly all the rest had mastectomies, the new study found. Their chance of dying of breast cancer in the two decades after treatment was 3.3 percent, no matter which procedure they had, about the same as an average woman’s chance of dying of breast #cancer, said Dr. Laura J. Esserman, a breast cancer surgeon and researcher at the University of California, San Francisco, who wrote an editorial accompanying the study.

#santé #chirurgie #cancer_du_sein

Early-Stage Breast Condition May Not Require Cancer Treatment - The New York Times
▻http://www.nytimes.com/2015/08/21/health/breast-cancer-ductal-carcinoma-in-situ-study.html

As many as 60,000 American women each year are told they have a very early stage of breast cancer — Stage 0, as it is commonly known — a possible precursor to what could be a deadly tumor. And almost every one of the women has either a lumpectomy or a mastectomy, and often a double mastectomy, removing a healthy breast as well.

Yet it now appears that treatment may make no difference in their outcomes. Patients with this condition had close to the same likelihood of dying of breast cancer as women in the general population, and the few who died did so despite treatment, not for lack of it, researchers reported Thursday in JAMA Oncology.

Their conclusions were based on the most extensive collection of data ever analyzed on the condition, known as ductal carcinoma in situ, or D.C.I.S.: 100,000 women followed for 20 years.

#cancer #femmes #mastectomie #recherche #santé #médecine via @isskein

Genetic variant helps protect Latinas from breast cancer
▻http://www.sfgate.com/bayarea/article/Genetic-variant-helps-protect-Latinas-from-breast-5835931.php

Women of Latin American descent, particularly those with indigenous ancestry, may carry a genetic variant that protects them from breast cancer.
Previous epidemiological studies have shown that Latinas seem to be less susceptible to developing breast cancer than women of other ethnicities. Now an international group of scientists, led by UCSF researchers, have identified the spot on the DNA sequence responsible for that protective effect.

(...)

UCSF’s Ziv said there are nongenetic factors that play a role in lowering breast cancer risk in Latinas, such as having children earlier in life than other women, and they are less inclined to take hormone-replacement therapy. But he said the indigenous genetic variant is still significant after adjusting for those factors.
Hh
In addition, women who carry the variant have breast tissue that appears less dense on mammograms. Breast density is associated with a higher risk of breast cancer, and dense tissue makes tumors more difficult to detect on mammograms. Researchers don’t yet understand how the variant affects density.

#cancer

Pinkwashing : Make Your Drilling Rig Less Carcinogenic, Paint It Pink !
▻http://www.filmsforaction.org/watch/pinkwashing-make-your-drilling-rig-less-carcinogenic-paint-it-pink

Sometimes you just can’t make this shit up. Fossil fuel frackers Baker Hughes have teamed up with breast cancer charity Susan G. Komen to “end breast cancer forever”. How? By painting 1,000 of...

Mammograms may cut breast cancer deaths by 28% - Health - Boston.com
▻http://www.boston.com/health/2014/06/18/mammograms-may-cut-breast-cancer-deaths/CQknrazRocdSxyLaUTehTN/story.html

In the new observational study, researchers tracked all Norwegian women aged 50 to 79 between 1986 and 2009, just as a national screening program was getting underway. Scientists used a model to estimate breast cancer death rates in women invited to get a mammogram as part of the government-funded program and in those who weren’t included yet. They said about 76 percent of women offered a mammogram actually got it.

The researchers estimated about 368 women need to be given a chance to have a mammogram to prevent one death from breast cancer and that screening reduces breast cancer deaths by about 28 percent — similar to what many other studies about mammography have concluded.

The research was published online Tuesday in the British journal, BMJ and was paid for by the Norwegian Research Council.

Bénéfices du dépistage systématique de la mammographie ?
Un marronnier. Cette fois-ci, il faut inviter 368 femmes (entre 50 et 79 ans) à se faire dépister, ou, vu le taux de non réponse dépister effectivement 280 femmes pour éviter un décès.

Dans l’article du Boston, l’un des auteurs évoque le risque de surdiagnostic et la baisse d’intérêt du dépistage étant donné les progrès des traitements…

‘‘Mammograms do provide some benefit, but the problem is the screening is so sensitive it captures tumors without malignant potential,’’ said Lars Vatten of the Norwegian University of Science and Technology, one of the study’s authors.

Vatten said improved treatments for breast cancer were also lowering death rates in developed countries, making mammograms less important since even cancers caught later are sometimes still treatable.

He said the benefits of getting a mammogram justified ongoing national screening programs but that women should be given more information about the potential harms, like having unnecessary treatment including surgery and chemotherapy.

Ce que ne fait pas du tout l’article original ▻http://www.bmj.com/content/348/bmj.g3701 , qui se focalise donc exclusivement sur les avantages.

Changing diet to fight breast cancer - Medical News Today
▻http://www.medicalnewstoday.com/releases/277335.php

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Changing diet to fight breast cancer - Medical News Today - ►http://www.medicalnewstoday.com/release...

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Calorie restriction, a kind of dieting in which food intake is decreased by a certain percentage, has been touted as way to help people live longer. New research suggests that there may be other benefits, including improving outcomes for women in breast cancer. According to a study published in Breast Cancer Research and Treatment, the triple negative subtype of breast cancer - one of the most aggressive forms - is less likely to spread, or metastasize, to new sites in the body when mice were fed a restricted diet. - (...)

Breast #cancer drug Kadcyla is too expensive for the NHS – not to pay for it is the correct decision | Deborah Orr | The Guardian
▻http://www.theguardian.com/commentisfree/2014/apr/25/kadcyla-cancer-drug-too-expensive-nhs

How do you put a price on life? How would you know where to start? In the case of the independent NHS watchdog, the National Institute for Health and Care Excellence (Nice), there is a points system, which calculates QALYs, or quality-adjusted life years. If a new drug costs more than £30,000 per QALY, then it’s deemed too expensive for use by the NHS. So it’s a bit rich for Roche, developers of the new breast cancer drug Kadcyla, to be acting all shocked that Nice says it’s too expensive for use by the NHS. At the moment, treatment with Kadcyla costs more than £180,000 per QALY. Which is clearly quite steep.

#santé #NICE

Faces of Breast #Cancer - Well - NYTimes.com
▻http://www.nytimes.com/projects/your-breast-cancer-stories/?story=1397

http://int.nyt.com/data/ugc/breast-cancer-stories/images/1397-500.jpg

#santé #photographie #design_web