medicalcondition:dementia

  • New Lessons About #Education Levels and Dementia Risk
    https://www.medscape.com/viewarticle/909043

    Contrary to the popular belief that higher education guards against dementia, new research suggests it has little, to no, protective effect.

    In a unique study that included annual cognitive assessments in older adults and neuropathologic autopsy results, investigators found that while there was a link between higher education levels and better cognitive function before old age, it did not reduce dementia risk or slow the rate of cognitive decline.

    Le niveau d’étude ne protègerait pas du risque de démence - A la une - Destination Santé
    https://destinationsante.com/le-niveau-detude-ne-protegerait-pas-du-risque-de-demence.html

    Différents travaux ont déjà montré qu’un niveau d’#études élevé créait une « réserve cognitive » éloignant ainsi le risque de #démence. Un récent travail américain s’inscrit en faux. Les auteurs affirment que l’éducation ne joue aucun rôle dans la survenue ou la rapidité d’évolution de la maladie.

    http://n.neurology.org/content/early/2019/02/06/WNL.0000000000007036

  • How is Technology Transforming #healthcare at Home
    https://hackernoon.com/how-is-technology-transforming-healthcare-at-home-1ce827b355b9?source=rs

    The potential for Transforming Healthcare at Home is growing tremendouslyhttps://medium.com/media/24aafa5d9039edf21952f173b4f78fad/hrefThe world today;Is experiencing a dramatic change in age demographics. Considering America as a prime example, it is estimated — In the year 2019, the group of people of age older than 65 will outnumber the group of those younger than five. As life expectancy increases, the number of people living with different chronic conditions and functional impairments, for instance, dementia, diabetes and the inability to manage household chores with growing age are further increasing.People belonging to the “old age” group are more likely to suffer from chronic diseases and require more care and attention. In such times, the need of the hour is to discover and (...)

    #telehealth #home-healthcare #remote-patient-monitoring #healthcare-technology

  • Neurocapitalism | openDemocracy
    https://www.opendemocracy.net/ewa-hess-hennric-jokeit/neurocapitalism

    There is good reason to assert the existence, or at least the emergence, of a new type of capitalism: neurocapitalism. After all, the capitalist economy, as the foundation of modern liberal societies, has shown itself to be not only exceptionally adaptable and crisis-resistant, but also, in every phase of its dominance, capable of producing the scientific and technological wherewithal to analyse and mitigate the self-generated “malfunctioning” to which its constituent subjects are prone. In doing so – and this too is one of capitalism’s algorithms – it involves them in the inexorably effective cycle of supply and demand.

    Just as globalisation is a consequence of optimising the means of production and paths of communication (as Karl Marx and Friedrich Engels predicted), so the brain, as the command centre of the modern human being, finally appears to be within reach of the humanities, a field closely associated with capitalism. It may seem uncanny just how closely the narrow path to scientific supremacy over the brain runs to the broad highway along which capitalism has been speeding for over 150 years. The relationship remains dynamic, yet what links capitalism with neuroscience is not so much strict regulation as a complex syndrome of systemic flaws.

    At this point, if not before, the unequal duo of capitalism and neuroscience was joined by a third partner. From now on, the blossoming pharmaceutical industry was to function as a kind of transmission belt connecting the two wheels and making them turn faster. In the first half of the twentieth century, mental disorders were treated mainly with sedative barbiturates, electric shock therapy and psychosurgery. But by the 1930s, neuro-psychopharmacology was already winning the day, as Freud had predicted it would.

    Is it a paradox, or one of those things that are so obvious they remain unobserved, that the success of Freud’s psychoanalysis and that of modern neuroscience are based on similar premises? Psychoanalysis was successful because it wove together medically relevant disciplines like psychiatry and psychology with art, culture, education, economics and politics, allowing it to penetrate important areas of social life. At the beginning of the twenty-first century, the neurosciences seem to be in a position to take on a comparable role in the future.

    The ten top-selling psychotropic substances in the USA include anti-depressants, neuroleptics (antipsychotics), stimulants and drugs for treating dementia. In 2007 one hundred million prescriptions were issued for these drugs with sales worth more than sixteen billion dollars. These figures illustrate how, in an environment that is regulated but difficult to control, supply and subjectively perceived need can create a market turning over billions of dollars. What is more, it is a market that is likely to expand into those areas in which a performance-driven society confronts the post-postmodern self with its own shortcomings: in others words in schools and further education, at work, in relationships, and in old age. Among the best-selling neuro-psychotropic drugs are those that modulate the way people experience emotions and those that improve their capacity to pay attention and to concentrate, in most cases regardless of whether there is a clinically definable impairment of these functions.

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    Neurocapitalism
    Ewa Hess and Hennric Jokeit 3 March 2010
    Despite the immense costs for healthcare systems, the fear of depression, dementia and attention deficit disorder legitimises the boom in neuro-psychotropic drugs. In a performance-driven society that confronts the self with its own shortcomings, neuroscience serves an expanding market

    Today, the phenomenology of the mind is stepping indignantly aside for a host of hyphenated disciplines such as neuro-anthropology, neuro-pedagogy, neuro-theology, neuro-aesthetics and neuro-economics. Their self-assurance reveals the neurosciences’ usurpatory tendency to become not only the humanities of science, but the leading science of the twenty-first century. The legitimacy, impetus and promise of this claim derive from the maxim that all human behaviour is determined by the laws governing neuronal activity and the way it is organised in the brain.

    Whether or not one accepts the universal validity of this maxim, it is fair to assume that a science that aggressively seeks to establish hermeneutic supremacy will change everyday capitalist reality via its discoveries and products. Or, to put it more cautiously, that its triumph is legitimated, if not enabled, by a significant shift in the capitalist world order.

    There is good reason to assert the existence, or at least the emergence, of a new type of capitalism: neurocapitalism. After all, the capitalist economy, as the foundation of modern liberal societies, has shown itself to be not only exceptionally adaptable and crisis-resistant, but also, in every phase of its dominance, capable of producing the scientific and technological wherewithal to analyse and mitigate the self-generated “malfunctioning” to which its constituent subjects are prone. In doing so – and this too is one of capitalism’s algorithms – it involves them in the inexorably effective cycle of supply and demand.

    Just as globalisation is a consequence of optimising the means of production and paths of communication (as Karl Marx and Friedrich Engels predicted), so the brain, as the command centre of the modern human being, finally appears to be within reach of the humanities, a field closely associated with capitalism. It may seem uncanny just how closely the narrow path to scientific supremacy over the brain runs to the broad highway along which capitalism has been speeding for over 150 years. The relationship remains dynamic, yet what links capitalism with neuroscience is not so much strict regulation as a complex syndrome of systemic flaws.

    Repressive late nineteenth-century capitalism, with its exploitative moral dictates, proscriptions and social injustices, was a breeding ground for the neurosis diagnosed by scientists in the early twentieth century as a spiritual epidemic. This mysterious scourge of the bourgeoisie, a class which according to Marx, “through the rapid improvement of all instruments of production [...] draws all, even the most barbarian nations, into civilisation”, expressed the silent rebellion of the abused creature in human beings. It was, in other words, the expression of resistance – as defiant as it was futile – of people’s inner “barbarian nation” to forceful modernisation and civilisation.

    To introduce here the inventor of psychoanalysis and neurosis researcher Sigmund Freud as the first neurocapitalist practitioner and thinker might be thought to be overstepping the mark. Yet people tend to forget that Freud was a neuro-anatomist and neurologist by training, and saw himself primarily as a neuroscientist. What distinguished him from his colleagues was that he was more aware of the limitations of the methods available for studying the brain at the end of the nineteenth century. Having identified neurosis as an acquired pathology of the nervous system for which there was no known treatment or way to localise, he decided instead to take an indirect route. The means he invented in order both to research and to cure this mysterious illness was psychoanalysis. Fellow researchers like Oskar Vogt, who continued to search for the key to psychopathology and genius in the anatomy of the brain, were doomed to fail. From then on, psychology served the requirements of everyday life in a constantly changing capitalist reality. As a method based on communication, psychoanalysis penetrated all spheres of social interaction, from the intimate and private to the economic and cultural. In doing so, it created new markets: a repair market for mental illness and a coaching market for those seeking to optimise capitalist production and reproduction.

    Delayed by the Second World War, the repressive capitalism of the nineteenth century was eventually replaced by libertarian, affluent capitalism. Conformity, discipline and feelings of guilt – the symptoms of failure to cope with a system of moral dictates and proscriptions – gave way to the new imperative of self-realisation. The psychic ideal of the successful individual was characterised by dynamically renewable readiness for self-expansion, which for the subject meant having a capacity for self-motivation that could be activated at any time and that was immune to frustration. Failure now meant not being able to exhaust the full potential of one’s options. This development brought a diametric change in the character of mental illness. Neurosis, a disorder born of guilt, powerlessness and lack of discipline, lost its significance. Attention shifted to the self’s failure to realise itself. Depression, the syndrome described by Alain Ehrenberg in The Weariness of the Self: Diagnosing the History of Depression in the Contemporary Age, began its triumphal march.

    Depression, however, was also the first widespread mental illness for which modern neuroscience promptly found a remedy. Depression and anxiety were located in the gaps between the synapses, which is precisely where they were treated. Where previously there had only been reflexive psychotherapy, an interface had now been identified where suffering induced by the self and the world could now be alleviated directly and pre-reflexively.

    At this point, if not before, the unequal duo of capitalism and neuroscience was joined by a third partner. From now on, the blossoming pharmaceutical industry was to function as a kind of transmission belt connecting the two wheels and making them turn faster. In the first half of the twentieth century, mental disorders were treated mainly with sedative barbiturates, electric shock therapy and psychosurgery. But by the 1930s, neuro-psychopharmacology was already winning the day, as Freud had predicted it would.

    Is it a paradox, or one of those things that are so obvious they remain unobserved, that the success of Freud’s psychoanalysis and that of modern neuroscience are based on similar premises? Psychoanalysis was successful because it wove together medically relevant disciplines like psychiatry and psychology with art, culture, education, economics and politics, allowing it to penetrate important areas of social life. At the beginning of the twenty-first century, the neurosciences seem to be in a position to take on a comparable role in the future.

    What cannot be overlooked is that the methodological anchoring of the neurosciences in pure science, combined with the ethical legitimacy ascribed to them as a branch of medicine, gives them a privileged position similar to that enjoyed by psychoanalysis in the early twentieth century. Unlike the latter, however, the neurosciences are extremely well funded by the state and even more so by private investment from the pharmaceutical industry. Their prominent status can be explained both by the number and significance of the problems they are attempting to solve, as well as the broad public recognition of these problems, and by the respectable profits to be made should they succeed. In other words, they are driven by economic and epistemic forces that emanate from the capitalism of today, and that will shape the capitalism of tomorrow – whatever that might look like.
    II

    In Germany, the USA and many western European countries, it is neither painkillers nor cardiovascular drugs that now put the greatest strain on health budgets, but rather neuro-psychotropic drugs. The huge market for this group of drugs will grow rapidly as life expectancy continues to rise, since age is the biggest risk factor for neurological and psychiatric illness. All over the world, whole armies of neuroscientists are engaged in research in universities, in projects often funded by the pharmaceuticals industry, and to an even greater extent in the industry’s own facilities, to find more effective and more profitable drugs to bring onto the market. The engine driving the huge advances being made in the neurosciences is capital, while the market seems both to unleash and to constrain the potential of this development.

    Depression, anxiety or attention deficit disorders are now regarded by researchers and clinical practitioners alike as products of neuro-chemical dysregulation in interconnected systems of neurotransmitters. They are therefore treated with substances that intervene either directly or indirectly in the regulation of neurotransmitters. Given that the body’s neuro-chemical systems are highly sensitive and inter-reactive, the art of successful treatment resides in a process of fine-tuning. New and more expensive drugs are able to do this increasingly effectively and selectively, thus reducing undesirable side effects. Despite the immense costs for healthcare systems, the high incidence of mental disorders and the fear of anxiety, depression and dementia make the development of ever better neuro-psychotropic drugs desirable and legitimate.

    However, the development and approval of drugs designed to alleviate the symptoms of mental disorders also open the gates to substances that can be used to deliberately alter non-pathological brain functions or mental states. The rigid ethical conventions in the USA and the European Union – today the most profitable markets for neuro-psychotropic drugs – mean that drug development, whether funded by the state or by the pharmaceuticals industry, is strictly geared towards the prevention and treatment of illness. Few pharmaceutical companies are therefore willing to make public their interest in studying and developing substances designed to increase the cognitive performance or psychological wellbeing of healthy people. The reason is simple: there is no legal market for these so-called “neuro-enhancers”. Taking such drugs to perform better in examinations, for example, is a punishable offence in the USA. Yet sales figures for certain neuro-psychotropic drugs are considerably higher than the incidence of the illnesses for which they are indicated would lead one to expect. This apparent paradox applies above all to neuropsychotropic drugs that have neuro-enhancement properties. The most likely explanation is that neuro-enhancers are currently undergoing millions of self-trials, including in universities – albeit probably not in their laboratories.

    The ten top-selling psychotropic substances in the USA include anti-depressants, neuroleptics (antipsychotics), stimulants and drugs for treating dementia. In 2007 one hundred million prescriptions were issued for these drugs with sales worth more than sixteen billion dollars. These figures illustrate how, in an environment that is regulated but difficult to control, supply and subjectively perceived need can create a market turning over billions of dollars. What is more, it is a market that is likely to expand into those areas in which a performance-driven society confronts the post-postmodern self with its own shortcomings: in others words in schools and further education, at work, in relationships, and in old age. Among the best-selling neuro-psychotropic drugs are those that modulate the way people experience emotions and those that improve their capacity to pay attention and to concentrate, in most cases regardless of whether there is a clinically definable impairment of these functions.

    Attempts to offset naturally occurring, non-pathological deviations from the norm are referred to as “compensatory” or “moderate enhancement” – in the same way that glasses are worn to correct the eyes’ decreasing ability to focus. The term describes a gradual improvement in function to a degree that is still physiologically natural. By contrast, “progressive” or “radical enhancement” denotes a qualitative improvement in function that exceeds natural boundaries. To return to the optical metaphor, we could say that the difference between these forms of performance enhancement is like that between wearing spectacles and night-vision glasses.

    In all ages and cultures, producers and purveyors of drugs and potions purported to enhance the individual’s cognitive state have been able to do a tidy trade, as the many references to magic potions and fountains of youth in literature and the fine arts testify. Nowadays, one substance with this kind of mythical status is ginkgo. Billions of dollars worth of ginkgo-biloba preparations are sold in the USA every year; and if ginkgo really did have any significant effect on cognition or memory, it would be a classic case of the widespread, unchecked use of a compensatory neuro-enhancer. As it is, however, the myth and commercial success of ginkgo are more a testament to the perhaps universal human need for a better attention span, memory and mental powers, and to the willingness to pay good money to preserve and enhance them.

    For the attainment of happiness as the aim of a good life, Aristotle recommended cultivating a virtuous mind and virtuous character. This is precisely what some neuro-psychotropic drugs are designed to do. The virtues of the mind are generally understood to be instrumental traits like memory and attention span. The extent to which these traits are innate or acquired varies from person to person. After adolescence, their efficiency gradually goes into decline at individually varying rates. Inequality and the threat of loss are strong motivations for action. The current consensus on the ethics of neuro-enhancement seems to be that as long as the fundamental medical principles of self-determination, non-harm (nil nocere) and benefit (salus aegroti) are adhered to, rejecting pharmacological intervention in the instrumental traits of the brain would be at odds with a liberal understanding of democracy.

    A more complex ethical problem would seem to be the improvement of so-called character virtues, which we shall refer to here as socio-affective traits. Unlike instrumental traits such as attention span and memory, traits like temperament, self-confidence, trust, willingness to take risks, authenticity and so on are considered to be crucial to the personality. Pharmacological intervention that alters these traits therefore affects a person’s psychological integrity. While such interventions may facilitate and accelerate self-discovery and self-realisation (see the large body of literature on experience with Prozac, e.g. Peter D. Kramer, Listening to Prozac: Psychiatrist Explores Antidepressant Drugs and the Remaking of the Self , they may also do the exact opposite. We will never be able to predict with any certainty how altering instrumental and socio-affective traits will ultimately affect the reflexively structured human personality as a whole. Today’s tacit assumption that neuro-psychotropic interventions are reversible is leading individuals to experiment on themselves. Yet even if certain mental states are indeed reversible, the memory of them may not be.

    The barriers to neuro-enhancement actually fell some time ago, albeit in ways that for a long time went unnoticed. Jet-lag-free short breaks to Bali, working for global companies with a twenty-four hour information flow from headquarters in Tokyo, Brussels and San Francisco, exams and assessments, medical emergency services – in all of these situations it has become routine for people with no medical knowledge to use chemical substances to influence their ability to pay attention. The technologies that have sped up our lives in the era of globalisation – the Internet, mobile phones, aeroplanes – are already a daily reality for large numbers of people and are interfering with their biologically and culturally determined cycles of activity and rest.

    That is not to say that the popularisation of these findings has had no effect at all. Reconceptualising joy as dopamine activity in the brain’s reward centres, melancholy as serotonin deficiency, attention as the noradrenalin-induced modulation of stimulus-processing, and, not least, love as a consequence of the secretion of centrally acting bonding hormones, changes not only our perspective on emotional and mental states, but also our subjective experience of self. That does not mean that we experience the physiological side of feelings like love or guilt any differently, but it does make us think about them differently. This, in turn, changes the way we perceive, interpret and order them, and hence the effect they have on our behaviour. By viewing emotions in general terms rather than as singular events taking place in a unique temporal and spatial context, the neurosciences have created a rational justification for trying to influence them in ways other than by individual and mutual care.

    The possibility of pharmacological intervention thus expands the subjective autonomy of people to act in their own best interests or to their own detriment. This in turn is accompanied by a new form of self-reflection, which encompasses both structural images of the brain and the ability to imagine the neuro-chemical activity that goes on there. What is alarming is that many of the neuroscientific findings that have triggered a transformation in our perception of ourselves are linked with commercial interests.

    It is already clear that global capitalism will make excessive demands on our material, and even more so on our human-mental resources. This is evident from the oft-used term “information society”, since information can only function as a commodity if it changes human behaviour, and it can only do this if we accord it our attention and engage with it emotionally.

    #Neurocapitalisme #Neurosciences

  • Valium: It’s more addictive than heroin, with horrifying side-effects, so why is it still given to millions? | Daily Mail Online
    http://www.dailymail.co.uk/femail/article-2289311/Valium-Its-addictive-heroin-horrifying-effects-given-millions.html

    One of the first - and most infamous - of the ‘benzos’ was Valium. Launched in the 1960s it quickly became the pill for every ill, dished out in profligate quantities to anyone struggling with the travails of daily life. Sixty per cent of users were women and Valium was soon dubbed ’mother’s little helper’.

    But Valium and the other benzos are derived from chemical compounds which make some of them more addictive even than heroin.

    And their legacy is a vast group of people suffering appalling withdrawal symptoms so severe they are unfit for work, relationships or even independent living. Some have also been left with permanent effects, including memory loss.

    Increasingly worried about what the drug might be doing to her after six years on it, Baylissa started researching clonazepam-type drugs on the internet and was shocked by what she read. People reported memory loss, dementia, paranoia, hallucinations and excruciating pain, either as a result of being on the drug or coming off it.

    Valium’s pernicious legacy has touched everyone from schoolgirls and poverty stricken single mothers to middle-class divorcees and wealthy socialites. In some cases, distraught addicts resort to suicide: Department of Health figures show the drug is implicated in 300-500 deaths a year in this country.

    But the scale of the problem has been largely ignored. Despite guidelines dating back to 1988, which warn doctors to limit the prescribing of this potent and controversial drug, clinicians have found it an effective way to handle many hard-to-diagnose, hard-to-treat patients.

    There are now 183 different formulations of Valium-derived medications. Doctors in Britain issue almost 18 million prescriptions a year for benzodiazepiones, and every GP has at least 180 long-term users on their books.

    Despite being highly addictive and having alarming side-effects, Valium had become one of the world’s best-selling drugs by the mid-Seventies. It was originally manufactured by Hoffmann La Roche, but the company lost its patent protection in 1985. Some 500 different versions of the drug were subsequently marketed by different companies worldwide.

    It was on a holiday to France in April 2011 that Fiona made the life-changing decision to stop taking Valium. ’I didn’t take enough with me — I don’t know if that was on purpose or not — and we were sitting in a cafe one day when I had a panic attack, mewling like a puppy.

    ’People were staring and it was awful, but it took about three weeks for the real withdrawal symptoms to appear. By then I was whimpering and shaking the whole time, I couldn’t sleep, I was depressed and just exhausted.’

    Back home, with no further help from her GP, Fiona sought information about Valium withdrawal on the internet and tackled her long-term dependency by gradually reducing her dose to zero over five months.

    ’It was absolute hell,’ she says. ’I felt sick, I had long periods of shaking uncontrollably, excruciating muscle cramps, and all the symptoms of severe flu. I couldn’t go out, leave the house at all, or do anything at all.’

    #Opioides #Sackler #Valium

  • North Korea calls Trump ’lunatic’ over nuclear tweet | Daily Mail Online
    http://www.dailymail.co.uk/news/article-5273853/North-Korea-scoffs-Trumps-nuclear-button-tweet.html

    North Korea’s state-run media says President Trump’s tweet about having a bigger nuclear button than Kim Jong Un’s is the ’spasm of a lunatic.

    State-run newspaper Rodong Sinmun dismissed Trump’s ’swaggering’ as the ’bark of a rabid dog’ and said he is frightened by North Korea’s power.

    It added that Trump’s tweet ’reflects the desperate mental state of a loser who failed to check the vigorous advance of the army and people of [North Korea].

    ’He is making [a] bluff only to be diagnosed as a psychopath,’ the paper said.

    In a separate editorial also published on Tuesday, Rodong Sinmun called Trump ’a lunatic president whose thinking faculty is at the level of preschooler and who has the symptom of dementia.

  • Alzheimer’s : Will experimental blood test be a game-changer ? - CNN
    http://edition.cnn.com/2017/09/04/health/alzheimers-blood-test-study/index.html

    An experimental blood test can accurately diagnose Alzheimer’s disease, the most common form of dementia, according to a study published Monday in the journal Proceedings of the National Academy of Sciences. Though still in development, the test may someday be used to diagnose other degenerative brain disorders and even mild cognitive impairment resulting from head injuries.

    The researchers say that using the test, they were able to identify Alzheimer’s patients with up to 86% sensitivity and specificity. (Sensitivity refers true positives identified by the test, while specificity refers to true negatives.) The test also differentiated Alzheimer’s from dementia with Lewy bodies, a related condition, with 90% sensitivity and specificity.

    #Alzheimer #test_sanguin

  • Warnings over shock dementia revelations from ancestry DNA tests | #Science | The Guardian
    https://www.theguardian.com/science/2017/aug/26/alzheimers-disease-shock-for-genetic-ancestry-hunters

    People who use genetic tests to trace their ancestry only to discover that they are at risk of succumbing to an incurable illness are being left to suffer serious psychological problems. Dementia researchers say the problem is particularly acute for those found to be at risk of Alzheimer’s disease, which has no cure or effective treatment. Yet these people are stumbling upon their status inadvertently after trying to find their Viking, Asian or ancient Greek roots.

    “These tests have the potential to cause great distress,” said Anna Middleton, head of society and ethics research at the Wellcome Genome Campus in Cambridge. “Companies should make counselling available, before and after people take tests.” The issue is raised in a paper by Middleton and others in the journal Future Medicine.

    #génétique #tests_génétiques #alzheimer #démence

  • 6 million adults do not do a monthly brisk 10 minute walk - GOV.UK
    https://www.gov.uk/government/news/6-million-adults-do-not-do-a-monthly-brisk-10-minute-walk

    Over 6.3 million adults aged 40 to 60 do not achieve 10 minutes of continuous brisk walking over the course of a month and are missing out on important health benefits, according to the Public Health England (PHE) 10 minutes brisk walking recommendations: evidence summary.

    The findings also reveal how lifestyles have changed over time, showing that people in the UK are 20% less active now than they were in the 1960s and on average walk 15 miles less a year than 2 decades ago. The sedentary nature of modern, busy lives makes it difficult for many to find the time for enough exercise to benefit their health.
    […]
    Taking at least 1 brisk 10 minute walk a day has been shown to reduce the risk of early death by 15%. A 10 minute walk can contribute to meeting the CMO’s physical activity guidance of 150 minutes of moderate to vigorous exercise each week. This can lead to health benefits including a lowered risk of type 2 diabetes (by 40%), cardiovascular disease (by 35%), dementia (by 30%) and some cancers (by 20%).

    The severity of the current physical inactivity epidemic amongst adults contributes to 1 in 6 deaths in the UK and is costing the NHS over £0.9 billion per year.

    Repris en français avec le titre

    Les Anglais confrontés à une #épidémie_de_sédentarité chez les adultes
    https://www.pourquoidocteur.fr/Articles/Question-d-actu/22632-Les-Anglais-confrontes-epidemie-sedentarite-adultes

  • Higher dementia risk linked to living near heavy traffic, research shows - ABC News (Australian Broadcasting Corporation)
    http://www.abc.net.au/news/2017-01-05/scientists-link-dementia-risk-to-living-near-heavy-traffic/8164054

    People who live near busy roads laden with heavy traffic face a higher risk of developing dementia than those living further away, according to researchers in Canada.

    A study published in The Lancet medical journal found that people who lived within 50 metres of high-traffic roads had a 7 per cent higher chance of developing dementia compared to those who lived more than 300 metres away from busy roadways.

    Air pollutants can get into the blood stream and lead to inflammation, which is linked with cardiovascular disease and possibly other conditions such as diabetes,” said Ray Copes, an environmental and occupational health expert at Public Health Ontario.

    Researchers at Public Health Ontario conducted the study with colleagues from Canada’s Institute for Clinical Evaluative Sciences.

    This study suggests air pollutants that can get into the brain via the blood stream can lead to neurological problems,” Mr Copes said.

    • Résumé sur The Lancet

      Living near major roads and the incidence of dementia, Parkinson’s disease, and multiple sclerosis: a population-based cohort study - The Lancet
      http://thelancet.com/journals/lancet/article/PIIS0140-6736(16)32399-6/fulltext

      Summary
      Background
      Emerging evidence suggests that living near major roads might adversely affect cognition. However, little is known about its relationship with the incidence of dementia, Parkinson’s disease, and multiple sclerosis. We aimed to investigate the association between residential proximity to major roadways and the incidence of these three neurological diseases in Ontario, Canada.

      Methods
      In this population-based cohort study, we assembled two population-based cohorts including all adults aged 20–50 years (about 4·4 million; multiple sclerosis cohort) and all adults aged 55–85 years (about 2·2 million; dementia or Parkinson’s disease cohort) who resided in Ontario, Canada on April 1, 2001. Eligible patients were free of these neurological diseases, Ontario residents for 5 years or longer, and Canadian-born. We ascertained the individual’s proximity to major roadways based on their residential postal-code address in 1996, 5 years before cohort inception. Incident diagnoses of dementia, Parkinson’s disease, and multiple sclerosis were ascertained from provincial health administrative databases with validated algorithms. We assessed the associations between traffic proximity and incident dementia, Parkinson’s disease, and multiple sclerosis using Cox proportional hazards models, adjusting for individual and contextual factors such as diabetes, brain injury, and neighbourhood income. We did various sensitivity analyses, such as adjusting for access to neurologists and exposure to selected air pollutants, and restricting to never movers and urban dwellers.

      Findings
      Between 2001, and 2012, we identified 243 611 incident cases of dementia, 31 577 cases of Parkinson’s disease, and 9247 cases of multiple sclerosis. The adjusted hazard ratio (HR) of incident dementia was 1·07 for people living less than 50 m from a major traffic road (95% CI 1·06–1·08), 1·04 (1·02–1·05) for 50–100 m, 1·02 (1·01–1·03) for 101–200 m, and 1·00 (0·99–1·01) for 201–300 m versus further than 300 m (p for trend=0·0349). The associations were robust to sensitivity analyses and seemed stronger among urban residents, especially those who lived in major cities (HR 1·12, 95% CI 1·10–1·14 for people living <50 m from a major traffic road), and who never moved (1·12, 1·10–1·14 for people living <50 m from a major traffic road). No association was found with Parkinson’s disease or multiple sclerosis.

      Interpretation
      In this large population-based cohort, living close to heavy traffic was associated with a higher incidence of dementia, but not with Parkinson’s disease or multiple sclerosis.

      Funding
      Health Canada (MOA-4500314182).

  • Alzheimer’s Disease: Period Pain Drug Cures Symptoms In Mice, New Research Shows
    http://www.ibtimes.com/alzheimers-disease-period-pain-drug-cures-symptoms-mice-new-research-shows-

    The incurable Alzheimer’s disease may now have a cure. A new research by the University of Manchester shows that the most common form of dementia can be fully cured with an anti-inflammatory drug, commonly used for period pain.

    Almost 7.5 million new cases of Alzheimer’s — a disease that causes acute problems with memory, thinking ability and behavior — diagnosed around the world every year. In the United States, about five million people currently suffer from the degenerative disease that has claimed one in three senior citizens with some form of dementia.

    The team, led by Dr. David Brough, worked with mice to find that a common Non-Steroidal Anti Inflammatory Drug (NSAID) routinely used to relieve menstrual pain — mefenamic acid — completely reversed the inflammation of the brain and lost memory in the specimen.

    For the study, 20 mice were genetically altered to exhibit symptoms of Alzheimer’s. Ten of these were treated with mefenamic acid by using a mini-pump under their skin for one month, while the other 10 mice were treated in the same way with a placebo.

    Researchers found that the mice treated with mefenamic acid saw a complete reversal of memory loss, while the placebo group’s condition remained unchanged.

    #Alzheimer

  • Doctors should prescribe gardening for patients more often, says report | Society | The Guardian
    http://www.theguardian.com/society/2016/may/17/doctors-should-prescribe-gardening-for-patients-more-often-says-report?

    Doctors should prescribe gardening far more often for patients with cancer, dementia and mental health problems, the NHS has been urged in a new report.

    Outdoor spaces including gardens can reduce social isolation among older people as well as help patients recover and manage conditions such as dementia, according to the influential King’s Fund health thinktank.

    Jane Ellison, the public health minister, backed the plan, which could see GPs in particular advising patients to spend more time outside as a way of alleviating their symptoms. “[Gardening] is profoundly good for you … [it] is a great way of keeping people active, of keeping them outside and keeping their sense of wellbeing very high,” she said. “There are things we can do around physical activity in particular that bring immediate payback ... I’m trying to put this right across the agenda of dementia and cancer.”

    #jardinage #santé #bien-être #vie

  • Mobile phones DON’T increase the risk of brain cancer, University of Sydney study concludes | Daily Mail Online
    http://www.dailymail.co.uk/health/article-3576681/Mobile-phones-DON-T-increase-risk-brain-cancer-30-year-study-concludes.

    There is no link between mobile phones and brain cancer, a landmark study has revealed.

    Researchers found no increase in tumours over the last 29 years, despite an enormous increase in the use of the devices.

    In Australia, where the study was conducted, 9 per cent of people had a mobile phone in 1993 - a number which has shot up to 90 per cent today.

    But in the same period, cancer rates in people aged 20 - 84 rose only slightly in men and remained stable in women.

    There were ’significant’ rises in tumours in the elderly, but the increase began five years before mobile phones arrived in Australia in 1987, the researchers said. 

    The study’s author, Professor Simon Chapman, of the University of Sydney, said phones emit non-ionising radiation that is not currently thought to damage DNA - and his findings make him even more confident the devices are not li[n]ked to cancer.
    […]
    We examined the link between age and incidence rates of 19,858 men and 14,222 women diagnosed with brain cancer in Australia between 1982-2012, and national mobile phone usage data from 1987-2012.
    Extremely high proportions of the population have used mobile phones across some 20-plus years -from about 9 per cent in 1993 to about 90 per cent today.
    We found age-adjusted brain cancer incidence rates (in those aged 20-84 years, per 100,000 people) had risen only slightly in males but were stable over 30 years in females.
    There were significant increases in brain cancer incidence only in those aged 70 years or more.
    But the increase in incidence in this age group began from 1982, before the introduction of mobile phones in 1987 and so could not be explained by it.

    Here, the most likely explanation of the rise in this older age group was improved diagnosis.
    Computed tomography (CT), magnetic resonance imaging (MRI) and related techniques, were introduced in Australia in the late 1970s.
    They are able to discern brain tumours which could have otherwise remained undiagnosed without this equipment.
    It has long been recognised that brain tumours mimic several seemingly unrelated symptoms in the elderly - including stroke and dementia - and so it is likely that their diagnosis had been previously overlooked.
    Next, we also compared the actual incidence of brain cancer over this time with the numbers of new cases of brain cancer that would be expected if the ’mobile phones cause brain cancer’ hypothesis was true.
    Here, our testing model assumed a ten-year lag period from the start of mobile phone usage to evidence of a rise in brain cancer cases.
    Our model assumed that mobile phones would cause a 50 per cent increase in incidence of brain cancer.
    This was a conservative estimate that we took from a study by Lennart Hardell and colleagues (who reported even higher rates from two studies).
    The expected number of cases in 2012 (had the phone hypothesis been true) was 1,866 cases, while the number recorded was 1,435.

    • Ce qui est accessible de l’étude

      Has the incidence of brain cancer risen in Australia since the introduction of mobile phones 29 years ago? - Cancer Epidemiology
      http://www.cancerepidemiology.net/article/S1877-7821(16)30050-9/abstract

      Abstract
      Background
      Mobile phone use in Australia has increased rapidly since its introduction in 1987 with whole population usage being 94% by 2014. We explored the popularly hypothesised association between brain cancer incidence and mobile phone use.

      Study methods
      Using national cancer registration data, we examined age and gender specific incidence rates of 19,858 male and 14,222 females diagnosed with brain cancer in Australia between 1982 and 2012, and mobile phone usage data from 1987 to 2012. We modelled expected age specific rates (20–39, 40–59, 60–69, 70–84 years), based on published reports of relative risks (RR) of 1.5 in ever-users of mobile phones, and RR of 2.5 in a proportion of ‘heavy users’ (19% of all users), assuming a 10-year lag period between use and incidence.

      Summary answers
      Age adjusted brain cancer incidence rates (20–84 years, per 100,000) have risen slightly in males (p < 0.05) but were stable over 30 years in females (p > 0.05) and are higher in males 8.7 (CI = 8.1–9.3) than in females, 5.8 (CI = 5.3–6.3). Assuming a causal RR of 1.5 and 10-year lag period, the expected incidence rate in males in 2012 would be 11.7 (11–12.4) and in females 7.7 (CI = 7.2–8.3), both p < 0.01; 1434 cases observed in 2012, vs. 1867 expected. Significant increases in brain cancer incidence were observed (in keeping with modelled rates) only in those aged ≥70 years (both sexes), but the increase in incidence in this age group began from 1982, before the introduction of mobile phones. Modelled expected incidence rates were higher in all age groups in comparison to what was observed. Assuming a causal RR of 2.5 among ‘heavy users’ gave 2038 expected cases in all age groups.

      Limitations
      This is an ecological trends analysis, with no data on individual mobile phone use and outcome.

      What this study adds
      The observed stability of brain cancer incidence in Australia between 1982 and 2012 in all age groups except in those over 70 years compared to increasing modelled expected estimates, suggests that the observed increases in brain cancer incidence in the older age group are unlikely to be related to mobile phone use. Rather, we hypothesize that the observed increases in brain cancer incidence in Australia are related to the advent of improved diagnostic procedures when computed tomography and related imaging technologies were introduced in the early 1980s.

  • Common medicines tied to changes in the brain | Reuters
    http://in.reuters.com/article/us-health-brain-otc-drugs-idINKCN0XH1Y8

    Commonly used drugs for problems like colds, allergies, depression, high blood pressure and heart disease have long been linked to cognitive impairment and dementia. Now researchers have some fresh evidence that may help explain the connection.

    The drugs, known as anticholinergics, stop a chemical called acetylcholine from working properly in the nervous system. By doing so, they can relieve unpleasant gastrointestinal, respiratory or urinary symptoms, for example.

    The list of such drugs is long. Among them: Benadryl for allergies, the antidepressant Paxil and the antipsychotic Zyprexa, Dimetapp for colds and the sleep aid Unisom.

    • JAMA Network | JAMA Neurology | Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults
      http://archneur.jamanetwork.com/article.aspx?articleid=2514553

      Importance The use of anticholinergic (AC) medication is linked to cognitive impairment and an increased risk of dementia. To our knowledge, this is the first study to investigate the association between AC medication use and neuroimaging biomarkers of brain metabolism and atrophy as a proxy for understanding the underlying biology of the clinical effects of AC medications.
      […]
      Conclusions and Relevance The use of AC medication was associated with increased brain atrophy and dysfunction and clinical decline. Thus, use of AC medication among older adults should likely be discouraged if alternative therapies are available.

  • A history of sugar – the food nobody needs, but everyone craves
    https://theconversation.com/a-history-of-sugar-the-food-nobody-needs-but-everyone-craves-49823

    It seems as though no other substance occupies so much of the world’s land, for so little benefit to humanity, as sugar. According to the latest data, sugarcane is the world’s third most valuable crop after cereals and rice, and occupies 26,942,686 hectares of land across the globe. Its main output – apart from commercial profits – is a global public health crisis, which has been centuries in the making.

    The obesity epidemic – along with related diseases including cancer, dementia, heart disease and diabetes – has spread across every nation where sugar-based carbohydrates have come to dominate to the food economy.

    So at this time, it pays to step back and consider the ancient origins of sugar, to understand how it has grown to present an imminent threat to our landscapes, our societies and our health.

    #sucre #agro-industrie #santé

  • The most dangerous man in the world ? | Voices | The Independent

    http://www.independent.co.uk/voices/the-most-dangerous-man-in-the-world-a6803191.html

    When Mohammed bin Salman was just 12 he began sitting in on meetings led by his father Salman, the then governor of Saudi Arabia’s Riyadh Province. Some 17 years later, at 29 and already the world’s youngest defence minister, he plunged his country into a brutal war in Yemen with no end in sight.

    #arabie_saoudite

    • Toujours sur The Independent et sur le même Mohammed bin Salman, rhabillé pour l’hiver :
      Prince Mohammed bin Salman : Naive, arrogant Saudi prince is playing with fire par Patrick Cockburn :
      http://www.independent.co.uk/news/world/middle-east/prince-mohammed-bin-salman-naive-arrogant-saudi-prince-is-playing-wit

      At the end of last year the BND, the German intelligence agency, published a remarkable one-and-a-half-page memo saying that Saudi Arabia had adopted “an impulsive policy of intervention”. It portrayed Saudi defence minister and Deputy Crown Prince Mohammed bin Salman – the powerful 29-year-old favourite son of the ageing King Salman, who is suffering from dementia – as a political gambler who is destabilising the Arab world through proxy wars in Yemen and Syria.
      Spy agencies do not normally hand out such politically explosive documents to the press criticising the leadership of a close and powerful ally such as Saudi Arabia.

  • Costs for Dementia Care Far Exceeding Other Diseases, Study Finds
    http://www.nytimes.com/2015/10/27/health/costs-for-dementia-care-far-exceeding-other-diseases-study-finds.html

    The study looked at patients on Medicare. The average total cost of care for a person with dementia over those five years was $287,038. For a patient who died of heart disease it was $175,136. For a cancer patient it was $173,383. Medicare paid almost the same amount for patients with each of those diseases — close to $100,000 — but dementia patients had many more expenses that were not covered.

    On average, the out-of-pocket cost for a patient with dementia was $61,522 — more than 80 percent higher than the cost for someone with heart disease or cancer. The reason is that dementia patients need caregivers to watch them, help with basic activities like eating, dressing and bathing, and provide constant supervision to make sure they do not wander off or harm themselves. None of those costs were covered by Medicare.

    #démence #coût #santé

  • Eating brains helped Papua New Guinea tribe resist disease, research shows | Science | The Guardian
    http://www.theguardian.com/science/2015/jun/10/brains-helped-papua-new-guinea-tribe

    Voilà, il y a des traditions qui se perdent !

    Research involving a former brain-eating tribe from Papua New Guinea is helping scientists better understand mad cow disease and other so-called prion conditions and may also offer insights into Parkinson’s and dementia.

    People of the Fore tribe, studied by scientists from Britain and Papua New Guinea, have developed genetic resistance to a mad cow-like disease called kuru, which was spread mostly by the now abandoned ritual of eating relatives’ brains at funerals.

    #prion #santé

  • Fruits and Vegetables Are Trying to Kill You - Issue 15: Turbulence
    http://nautil.us/issue/15/turbulence/fruits-and-vegetables-are-trying-to-kill-you

    You probably try to exercise regularly and eat right. Perhaps you steer toward “superfoods,” fruits, nuts, and vegetables advertised as “antioxidant,” which combat the nasty effects of oxidation in our bodies. Maybe you take vitamins to protect against “free radicals,” destructive molecules that arise normally as our cells burn fuel for energy, but which may damage DNA and contribute to cancer, dementia, and the gradual meltdown we call aging. Warding off the diseases of aging is certainly a worthwhile pursuit. But evidence has mounted to suggest that antioxidant vitamin supplements, long assumed to improve health, are ineffectual. Fruits and vegetables are indeed healthful but not necessarily because they shield you from oxidative stress. In fact, they may improve health for quite the (...)

  • ▶ What is Alzheimer’s disease ? - Ivan Seah Yu Jun - YouTube

    https://www.youtube.com/watch?v=yJXTXN4xrI8

    Alzheimer’s disease is the most common cause of dementia, affecting over 40 million people worldwide. And though it was discovered over a century ago, scientists are still grappling for a cure. Ivan Seah Yu Jun describes how Alzheimer’s affects the brain, shedding light on the different stages of this complicated, destructive disease.

    Lesson by Ivan Seah Yu Jun, animation by STK Films.

    #santé #alzheimer

  • New data confirms a dementia epidemic as the Baby Boomers age - Your Houston News : Living
    http://www.yourhoustonnews.com/humble/living/new-data-confirms-a-dementia-epidemic-as-the-baby-boomers/article_35b99796-cd80-51c7-8f81-9b6632a1a763.html

    Voilà un…
    En fait, et contrairement à ce que suggère ce titre pas du tout inquiétant, « l’épidémie » de démences correspond simplement à l’arrivée des classes pleines à l’âge où celles-ci se manifestent…

    According to survey results of 21 states, nearly 13 percent of Americans aged 60 years or older (1 in 8) reported confusion or memory loss happening more often or getting worse in the previous 12 months.
    (…)
    “Unfortunately, the number of people affected by dementia is growing at an alarming rate as the baby boomer population grows older,” said Richard Elbein, CEO of the Alzheimer’s Association, Houston & Southeast Texas Chapter. “Most people don’t know when forgetting becomes a serious health problem. By putting off learning more about their condition, people impacted by dementia are being diagnosed too late and miss the opportunity to get the best help possible.”

    Donc, l’info provient d’une association spécialisée dont la vision est

    Our vision is a world without Alzheimer’s

    et qui justifie le dépistage des troubles de mémoire par l’accès aux traitements disponibles… dont la caractéristique principale est de ne pas exister…

    Early detection allows people to get the maximum benefit from available treatments, consider participating in a clinical trial, establish a support network and plan for the future.

  • Au R.-U. plus de la moitié des cas de démence ne sont pas diagnostiqués.
    Le gouvernement britannique fixe un objectif quantitatif : 160 000 diagnostics à établir dans les deux ans, soit la moitié des cas non diagnostiqués.
    David Cameron compte profiter de sa présidence du G8 pour faire avancer la coordination internationale sur le sujet.

    Doctors told to improve dementia diagnosis rates | Society | guardian.co.uk
    http://www.guardian.co.uk/society/2013/may/15/doctors-told-improve-dementia-diagnosis

    Doctors will be set a target to diagnose another 160,000 dementia sufferers in a government drive to tackle the incurable brain condition. Jeremy Hunt, the health secretary, says the NHS has shockingly low dementia diagnosis rates, with 350,000 of the estimated 670,000 people with dementia unknowingly living with the condition.
    (…)
    The prime minister David Cameron said he was determined to use Britain’s chairmanship of the G8 to forge a more co-ordinated international approach to the problem.

    A summit on dementia will be held in London in September, bringing together health and science ministers, senior industry figures and the Organisation for Economic Co-operation and Development (OECD).