Evidence-based medicine lacks solid supporting evidence | #Science News
▻https://www.sciencenews.org/blog/context/evidence-based-medicine-lacks-solid-supporting-evidence
Apart from methodological weaknesses, clinical research also suffers from biases stemming from regulatory and commercial considerations. Drug companies typically test new products against placebos rather than head-to-head against other drugs, so doctors don’t get good evidence about which drug is the better choice. And restrictions on what patients are admitted to trials (...) make the test groups very unlike the people doctors actually treat. “As a result, drugs are approved on the basis of studies of very narrow clinical populations but are subsequently used much more broadly in clinical practice,” Naci and Ioannidis point out.