organization:national institute of health

How Drug Companies Keep Medicine Out of Reach - Brian Till - The Atlantic
http://www.theatlantic.com/health/archive/2013/05/how-drug-companies-keep-medicine-out-of-reach/275853/?single_page=true

grosse enquête sur la manière dont les Etats-Unis tentent de faire dérailler le projet de #traité international sur la #recherche #pharmaceutique, avec, entre autres, un portrait de Jamie Love (défenseur du projet), un autre de Nils Daulaire (lobbyiste pour l’industrie), et la position pourrie de la fondation Gates...

In the current debate, documents submitted to WHO working groups attacking the idea were largely authored by individuals and groups that receive support from Gates.

The Gates Foundation was also the largest funder of Nils Daulaire’s Global Health Council. They donated more than $30 million.

Daulaire :
http://cdn.theatlantic.com/static/mt/assets/food/512px-Dr._Nils_Daulaire_at_May_17_Press_Conference_cropped.jpg

Jamie Love dans sa folle jeunesse :
http://cdn.theatlantic.com/static/mt/assets/food/jamiewithfish200.jpg

sur le traité lui-même on peut lire
http://www.monde-diplomatique.fr/2013/04/VELASQUEZ/48967

HIV vaccine study halted by US government over unsuccessful shots | Society | guardian.co.uk
http://www.guardian.co.uk/society/2013/apr/25/hiv-aids-vaccine-study-us-government?CMP=twt_fd

The US government halted a large HIV vaccine study on Thursday, saying the experimental shots were not successful in preventing infection.

Nor did the shots reduce the amount of the Aids virus in the blood when people who had been vaccinated later became infected, the National Institutes of Health said.

...

A safety review this week found that slightly more study participants who had received the vaccine later became infected with HIV. It’s not clear why. But the difference wasn’t statistically significant, meaning it may be due to chance.

Monsanto’s Dirty Dozen | GMO Awareness
http://gmo-awareness.com/2011/05/12/monsanto-dirty-dozen

When you take a moment to reflect on the history of product development at Monsanto, what do you find? Here are twelve products that Monsanto has brought to market. See if you can spot the pattern…

#Monsanto, a #serial_killer

R&D costs for Gleevec | Knowledge Ecology International
http://keionline.org/node/1697

Novartis was not “the innovative force.” Not only was all the basic research done in academic institutions, but so were the initial clinical investigations that showed STI 571 to be specifically effective against CML cells in vitro and in vivo. In fact, it took a few years for Brian Druker, the investigator most responsible for these latter studies, to convince Novartis that it should invest in a crash program to develop Gleevec and to undertake large-scale clinical trials.

#glivec (ou en américain #gleevec) et les #coûts réels de la #recherche #pharma
#santé #cancer #inde #brevets

US life expectancy lowest among industrialized countries - World Socialist Web Site

L’espérance de vie aux Etats-Unis : la plus basse de tous les pays industrialisés

http://www.wsws.org/en/articles/2013/01/11/life-j11.html

US life expectancy lowest among industrialized countries
By Kate Randall
11 January 2013

Life expectancy in the United States continues to lag behind that in Western Europe, Canada, Australia and Japan, according to a new report commissioned by the National Institutes of Health (NIH). The study’s findings are a stinging indictment of social inequality in the US and its impact on the conditions of life for wide layers of the American population, young and old.

The panel of experts from the National Research Council and the Institute of Medicine identified the inaccessibility of health care, high levels of poverty and income inequality, as well as the prevalence of gun violence as major contributing factors to the poor life expectancy rate in the US.

Neuroscience fiction

Toi, mon cerveau exporté | Passeur de sciences
http://passeurdesciences.blog.lemonde.fr/2012/12/12/toi-mon-cerveau-exporte-neurosciences

Je me souviens de cette phrase : « Sans nos souvenirs, nous ne sommes que des zombies. » Je me souviens que je l’ai lue dans Science en octobre 2012. Je venais d’avoir quarante-cinq ans. C’était il y a presque trois-quarts de siècle. Je me souviens que l’auteur de cette phrase, György Buzsáki, était chercheur en neurosciences à l’université de New York. En fait, je me souviens de tout.

C’est ce jour de 2012 que j’ai commencé à me dire que l’immortalité ne passerait sans doute pas par la préservation du corps. Qu’il existait un raccourci beaucoup plus élégant : copier sur un énorme disque dur la structure, le circuit, le contenu, le mode d’emploi de notre cerveau. Les réseaux de neurones où est stockée notre vie et l’hippocampe qui est le bibliothécaire de notre mémoire. Il a encodé nos souvenirs, il sait sur quelle étagère il les a rangés et il les ressort de la bibliothèque sur demande.

"The power of networks"
http://www.visualcomplexity.com/vc/blog/?p=1125
En continuant l’exploration des représentations de #réseaux. ►http://seenthis.net/messages/94454 je viens de regarder cette vidéo, http://www.youtube.com/watch?feature=player_embedded&v=nJmGrNdJ5Gw

Bref dans cette vidéo, il est notamment question d’un projet de #cartographie du #cerveau (et aussi d’arbre, de rhizome, de Guattari et de Darwin etc.) :

Human Connectome
http://www.humanconnectomeproject.org/wp-content/uploads/2010/01/Sidebar1-1.jpg
The NIH Human Connectome Project is an ambitious effort to map the neural pathways that underlie human brain function. The overarching purpose of the Project is to acquire and share data about the structural and functional connectivity of the human brain. It will greatly advance the capabilities for imaging and analyzing brain connections, resulting in improved sensitivity, resolution, and utility, thereby accelerating progress in the emerging field of human connectomics.
http://www.neuroscienceblueprint.nih.gov/connectome

Il y a une image qui m’a frappé, elle compare la plus petite échelle et la plus grande ; #scale (ça me rappelle ce truc « Scale of the universe » ►http://seenthis.net/messages/50591 ), bref la voici : https://dl.dropbox.com/s/qkpfn3j1lb5h64k/Capture%20d%E2%80%99%C3%A9cran%202012-11-05%20%C3%A0%2005.00.31.png

http://ogm.greenpeace.fr/du-riz-ogm-americain-teste-sur-des-enfants-chinois

U.S. Infectious Disease Chief Urges Flu Scientists to ’Engage,’ Support H5N1 Research Moratorium - ScienceInsider
http://news.sciencemag.org/scienceinsider/2012/07/us-infectious-disease-chief-urge.html

“The flu scientific community can no longer be the only player in the discussion about this research,” Fauci said. “You will unquestionably lose the battle for public support for your research if you ignore this issue.”

“There is a real and present danger of the natural evolution of the virus and that is why you do the experiments that might appear to be risky in the eyes of some,” he said. “You do the experiments so we can stay ahead of the naturally evolving risk.”

Many critics, however, have questioned whether such experiments are really useful, and whether scientists can safely contain potentially dangerous new pathogens. “The world sees it differently,” Fauci said, “and they ask the question, … namely: Should these experiments should have been performed and/or published in the first place?”

Scientists, he said, often "answer that the benefit outweighs the risk. … However, it is essential we respect the concern of the public domestically or globally, and not ask them to take the word of the influenza scientist.

"

Experts condemn plans to lift ban on research into deadly H5N1 birdflu virus - Science - The Independent
http://www.independent.co.uk/news/science/experts-condemn-plans-to-lift-ban-on-research-into-deadly-h5n1-birdfl

Richard Roberts, a Nobel prize-winning molecular biologist and expert in genetic engineering, said the moratorium should continue and that many experts are privately appalled that there are plans to lift it but are afraid of speaking out over fears that it might affect their funding from the NIH.

“It’s a big mistake at this point. The flu community is behaving as if they are the only show in town. I think for them to be allowed to create the most dangerous virus around is sheer lunacy,” said Dr Roberts (...).

“I’m not so much worried about terrorism but I am worried about an accidental escape from a laboratory. If it’s as dangerous as they believe, it could kill half the world’s population,” he said.

#h5n1 #recherche #censure #bioterrorisme #santé

Wonder if Android Jelly Bean MediaRouter API does anything that Pulseaudio through DLNA / UPNP cant do. NIH again ? The packaging may be better though - I have found easier to route audio through netcat than deal with Pulseaudio or Jack over the network (though I got horrible audio latency).

How Big Pharma and the Psychiatric Establishment Drugged Up Our Kids | | AlterNet
http://www.alternet.org/story/155459/how_big_pharma_and_the_psychiatric_establishment_drugged_up_our_kids?page=

Many people are aware of such Pharma/academia arrangements, since the 1980 Bayh-Dole law allowed universities to operate as patent and profit mills for industries “commercializing and transferring” technology. But fewer realize how much taxpayer money is part of the play-to-pay. The government gave Biederman and a colleague $287 million in 2005—on top of their Pharma sinecures—to be administered by Massachusetts General Hospital. (No wonder Harvard keeps Biederman on.) Biederman also received $14,000 from Eli Lilly the same year he got a grant from the National Institutes of Health (NIH) to study Lilly’s ADHD drug, Strattera®. Why does the government fund researchers already funded by Pharma? Not only do these researchers not need our tax dollars; working for Pharma is an overt conflict of interest that contaminates scientific results.

Un réquisitoire absolument effrayant sur les pratiques des Big Pharma envers les gamins traités de psychotiques et soumis toute leur vie à des médicaments qui les enferment dans leurs troubles... avec le soutien de l’Université, de l’Etat et de la bonne conscience.

NIH centre aims to match scientists with discarded drugs : Nature News Blog
http://blogs.nature.com/news/2012/05/nih-centre-aims-to-match-scientists-with-discarded-drugs.html

A cache of at least 24 drugs abandoned during development by three major pharmaceutical companies will become available to scientists seeking novel therapeutic uses for them under a new, competitive awards programme, the US National Institutes of Health (NIH) and executives from the drug companies announced today.

#recherche #pharma #santé #médicaments #pfizer

Academic publishers have become the enemies of science (The Guardian)
►http://www.guardian.co.uk/science/2012/jan/16/academic-publishers-enemies-science

The US Research Works Act would allow publishers to line their pockets by locking publicly funded research behind paywalls (...) Source: The Guardian

Academic publishers have become the enemies of science | Dr Mike Taylor | Science | guardian.co.uk
►http://www.guardian.co.uk/science/2012/jan/16/academic-publishers-enemies-science

The only winners would be publishing corporations such as Elsevier (£724m profits on revenues of £2b in 2010 – an astounding 36% of revenue taken as profit).

Since Elsevier’s obscene additional profits would be drained from America to the company’s base in the Netherlands if this bill were enacted, what kind of American politician would support it? The RWA is co-sponsored by Darrell Issa (Republican, California) and Carolyn B. Maloney (Democrat, New York). In the 2012 election cycle, Elsevier and its senior executives made 31 donations to representatives: of these, two went to Issa and 12 to Maloney, including the largest individual contribution.

Who Owns Government-Funded Research Papers?
http://www.miller-mccune.com/politics/who-owns-government-funded-research-papers-39192

The Research Works Act would prevent publicly funded research from automatically being available to the public for free. Private publishers back the bill, while open-access partisans are appalled.

Plagiarist or Puppet ? US Rep. Carolyn Maloney’s reprehensible defense of Elsevier’s Research Works Act
http://www.michaeleisen.org/blog/?p=846

Quand Elsevier, mastodonte capitaliste de l’édition scientifique, fait du lobbying au Sénat pour défendre ses intérêts directs et probablement écrit lui-même les lois empêchant le développement de l’open access.
#open_science
#accès_libre
#recherche
#science
#édition_électronique

Flu Season - by Laurie Garrett | Foreign Policy
http://www.foreignpolicy.com/articles/2012/01/05/flu_season?page=full

When flu scientist Ron Fouchier of Erasmus University in Rotterdam announced in September that he had made a highly contagious, supervirulent form of the bird-flu virus, a long chain of political events unfolded, mostly out of the public eye.

#h5n1 #grippe #bioterrorisme #armement #biologique

Does impatience make us fat ? - The Washington Post
http://www.washingtonpost.com/blogs/ezra-klein/post/does-impatience-make-us-fat/2011/10/10/gIQA1eMnaL_blog.html

A new study suggests that impatience has a lot to do with it. Economists Charles J. Courtemanche, Garth Heutel and Patrick McAlvanah combed through historical data on body mass index. They also looked at indicators of impatience for the same population, factoring in preferences on whether they’d want a small prize now or bigger prize later. They controlled for other factors that might come into play, such as demographics and financial characteristics.

With everything else held constant, the researchers found that impatient individuals are more likely to be obese than people who are good at waiting. Here’s how the two BMI distributions match up

Ça m’a fait penser à http://www.envrak.fr/carnets/le-test-du-chamallow (dont je croyais avoir référencé ou favorisé un compte rendu quelque part ici mais j’ai pas trouvé)

Biodefence since 9/11: The price of protection | Nature News
http://www.nature.com/news/2011/110907/full/477150a.html

Between 2001 and the end of this year, the federal government will have spent $60 billion on biodefence efforts, according to analyses from the Center for Biosecurity of the University of Pittsburgh Medical Center in Baltimore, Maryland. The money has helped to modernize the nation’s crumbling public-health system, and BioShield has invested in a stockpile of 20 million doses of smallpox vaccine, 28.75 million doses of #anthrax vaccine and 1.98 million doses of four medicines to treat complications of smallpox, anthrax and botulism. But few researchers or policy-makers seem happy with an arsenal of six drugs that address only three of the potential threats — even if they are among the most serious. “The pipeline we rely on to provide those critical countermeasures — diagnostics, vaccines, antivirals, antibiotics — is full of leaks, choke points and dead ends,” said Kathleen Sebelius, US Secretary of Health and Human Services, in a statement last year.

Critics say that the effort has been hobbled by a lack of strategic thinking, focus and coordination between the federal agencies involved, and by unrealistic expectations of what the money could buy. “There was no evidence that they looked at what our top priorities are and asked, ’What’s needed on the basic-science side?’, ’What’s needed on the development side?’, and ’What’s needed in the stockpile?’,” says Andrew Pavia, an infectious-diseases doctor at the University of Utah in Salt Lake City. Until earlier this year, Pavia served on the National Biodefense Science Board, which advises the US Department of Health and Human Services (DHHS) and in March last year released a report, Where Are The Countermeasures?, that was critical of the federal biodefence effort.

#armes #biologiques #etats-unis

Blacks less likely than whites to get NIH grants, study finds - The Washington Post
http://www.washingtonpost.com/national/health-science/blacks-less-likely-than-whites-to-get-nih-grants-study-finds/2011/08/15/gIQAJqoyNJ_story.html

Even after the researchers accounted for other factors that could help explain the discrepancy, such as differences in scientists’ education and training, black applicants were still about 10 percentage points less likely than whites to get NIH funding, the researchers reported. About 27 percent of white applicants’ requests were successful, compared with only about 17 percent of blacks’.

#racisme #discrimination #recherche #cdp

Government Lists Formaldehyde as Cancer Causer - WSJ.com
http://online.wsj.com/article/SB10001424052702304392704576379621369386578.html?mod=WSJ_hps_sections_he

The strong-smelling chemical formaldehyde causes cancer, while styrene, a second industrial chemical that’s used world-wide in the manufacture of fiberglass and food containers, may cause cancer, the National Institutes of Health says.

#chimie #cancer

par contre quand je lis :

The American Cancer Society estimates that only about 6% of cancers are related to environmental causes and most of that is on-the-job occupational exposure.

là personne n’en sait rien…

What Larry Page really needs to do to return Google to its startup roots | Slacy’s Blog
http://slacy.com/blog/2011/03/what-larry-page-really-needs-to-do-to-return-google-to-its-startup-roots

Quarraisha Abdool Karim: #HIV onslaught ‘decimating’ teenage girls in #South_Africa | Science Speaks: HIV & TB News
http://sciencespeaksblog.org/2011/03/09/karim-hiv-onslaught-‘decimating’-teenage-girls-in-south-africa

in #KwaZulu-Natal, what we are seeing is high, high incidence rates, driven by the age-sex difference with many women acquiring HIV almost around sexual debut, at 14 or 15 years. By the age of 20, one in three women is already infected with HIV. By the time they are 25, it’s one in two. You cannot sustain this kind of onslaught on our communities.

#femmes #sida #santé #épidémiologie

#NIH wants to know about your lags in productivity
http://blogs.nature.com/news/thegreatbeyond/2011/02/nih_wants_to_know_about_your_l.html

The biomedical funding agency is giving scientists the opportunity to explain lags in productivity in their grant applications.

Rather than a nod to Generation X scientists who grew up watching films like Slacker and Clerks, the policy is intended to help scientists balance their family and personal lives with research, without being penalized on grant applications.

#féminisme #carrières #science