Malawi : le paludisme recule - Malawi / Santé - RFI
Un rapport de la situation du paludisme au Malawi de RBM, Roll Back Malaria, est publié le 2 mai, une semaine après la journée mondiale du paludisme. Un pays fortement touché par le paludisme puisque près de la moitié de la population est infectée par le parasite, mais les résultats progressent.
Cheap drugs a bitter pill for the West | Mail & Guardian
http://mg.co.za/article/2013-03-08-00-cheap-drugs-a-bitter-pill-for-the-west
The Ugandan government faced an easy choice when it decided to start producing its own version of a key malaria treatment, rather than continuing to rely on expensive imports. Since the country began making its own medicine in 2007, Uganda has produced not only anti-malarials, but also antiretrovirals (ARVs) used to treat HIV. The public-private company, Quality Chemicals, plans to roll out more ARVs, anti-malarials and antibiotics in the coming months and years.
The venture, a shining example of African pharmaceutical manufacturing, was made possible in part because Uganda is considered a “least-developed country”. As such, it doesn’t yet have to respect international intellectual property laws (...)
But least-developed countries may be running out of time. They have until July to adopt the agreement’s measures into their own laws and a continued extension for pharmaceutical products until 2016.
Counterfeit medicine from Asia threatens lives in Africa | The Guardian
http://www.guardian.co.uk/world/2012/dec/23/africa-counterfeit-medicines-trade
Though it may seem like an immense amount of trouble to counterfeit a £3 packet of malaria pills, Lulukay noted that the global trade was estimated at £46bn a year. Counterfeiters know their markets well and target medications accordingly. Efforts to combat the activity are in their infancy. (...) India has stepped up oversight, “China is only now just catching on”
China rejects claims of producing fake medicine for Africa | World news | guardian.co.uk
http://www.guardian.co.uk/world/2012/dec/28/china-rejects-fake-medicine-africa
China has denied allegations that it has been exporting huge amounts of counterfeit medication to Africa, threatening public health in east Africa, five days after the Guardian published a front page exposé on the phenomenon.
The official Xinhua news agency said a foreign ministry spokeswoman rejected the accusation, but “called on foreign traders to procure medicines from legitimate companies through standardised channels”.
India rejects claims it exported fake medicine to Africa | World news | guardian.co.uk
http://www.guardian.co.uk/world/2013/jan/02/india-rejects-fake-medicine-africa
India has denied claims that it has exported large quantities of counterfeit medication to Africa, after the Guardian published a front-page exposé on the phenomenon.
“No fake medicines have been sent from India to the continent of Africa,” a spokesman for the ministry of external affairs in Delhi said.
Israelis find possible cure for malaria
http://www.israeltoday.co.il/NewsItem/tabid/178/nid/23552/Default.aspx
The body’s immune system sends antibodies to combat the disruptive proteins, but the Plasmodium parasite is able to use one type of protein to keep the antibodies busy while producing a different protein to continue the infection.
The Israeli researchers have unlocked the unique DNA sequence that allows the Plasmodium parasite to do this.
Rapid action needed to halt malaria in Greece, say scientists | Reuters
http://www.reuters.com/article/2012/11/23/us-malaria-greece-idUSBRE8AM0BC20121123
Greek authorities must urgently step up control of mosquitoes and surveillance of infected people to stop malaria from re-establishing itself in the crisis-hit country
#Malaria programme gets kiss of death from #Global_Fund : Nature
http://blogs.nature.com/news/2012/11/malaria-medicines-venture-gets-kiss-of-death-from-global-fund.html
The Global Fund’s press release detailing its plans is entitled “Board Approves Integration of AMF-m into Core Global Fund Grant Processes“, and much of its soothingly reassuring content would perhaps have many thinking that the AMF-m’s integration into the Global Fund’s core grants system is good news. But it is in effect being killed. There’s will be no new money ringfenced for the AMF-m once it runs through it’s current funding up to the end of 2013, which means that any countries wanting to set aside cash for the private sector will be required to take this from their country grants from the Global Fund. In reality, that will likely translate into AMF-m activities simply being terminated in most countries, leading to local price rises in ACTs, and the drugs disappearing off the shelves of local pharmacies. AMF-m’s clout in negotiating bulk pricing deals internationally will also likely be weakened.
WHO | Atlas of health and climate
http://www.who.int/globalchange/publications/atlas/report/en/index.html
The Atlas of health and climate is a product of this unique collaboration between the meteorological and public health communities. It provides sound scientific information on the connections between weather and climate and major health challenges. These range from diseases of poverty to emergencies arising from extreme weather events and disease outbreaks. They also include environmental degradation, the increasing prevalence of noncommunicable diseases and the universal trend of demographic ageing.
#santé #changement_climatique #rapport #cartographie #données #paludisme #malaria #choléra #sanitation #assainissement #eau #dengue #méningite #inondations #cyclones #sécheresse #feu #forêts #pollution #allergies
Le bon mobile du chasseur de moustiques | Nicolas Patte
http://owni.fr/2012/10/23/bon-mobile-chasseur-moustiques
Une étude universitaire a scruté une année entière de données personnelles de 15 millions de clients mobile au Kenya pour améliorer la lutte contre le #paludisme. Malgré des résultats encourageants et l’anonymisation des données, des questions de vie privée pourraient mettre un grain de sable dans le projet.
#Cultures_numériques #Opendata #Récit #big_data #kenya #malaria #médecine #médecine_2.0 #mHealth #mobile_crowdsourcing #open_data #opendata #téléphonie_mobile #vie_privée
Tracking Malaria With Cell Phones - ABC News
http://abcnews.go.com/blogs/health/2012/10/11/tracking-malaria-with-cell-phones
Harvard researchers found they could track the spread of malaria in Kenya using phone calls and text messages from 15 million mobile phones.
“Before mobile phones, we had proxies for human travel, like road networks, census data and small-scale GPS studies,” said study author Caroline Buckee, an assistant professor of epidemiology at the Harvard School of Public Health. “But now that mobile phones have spread throughout the world, we can start using these massive amounts of data to quantify human movements on a larger scale and couple this data with knowledge of infection risk.” (...) By studying networks of human and parasite movement, the team could then determine primary sources of #malaria and who was most likely to become infected.
#téléphonie #mobile #santé #épidémiologie #kenya #paludisme via @confluences
#Malaria returns to crisis-torn Greece - Telegraph
http://www.telegraph.co.uk/news/worldnews/europe/greece/9626423/Malaria-returns-to-crisis-torn-Greece.html
Malaria has returned to Greece as financial cuts contribute to the re-emergence of a once extinct disease.
#Nigeria: Artequick promises 24-hr treatment for #malaria, elimination in 20 years
http://crofsblogs.typepad.com/h5n1/2012/09/nigeria-artequick-promises-24-hr-treatment-for-malaria-eliminati
Chinese researchers say with Artequick, a fixed-dose combination of artemisinin and piperaquine, malaria can be effectively treated within 24 hours and possibly eliminated from human population in 20 years.
Is this the Holy Grail of #malaria cures? - IOL SciTech | IOL.co.za
http://www.iol.co.za/scitech/science/news/is-this-the-holy-grail-of-malaria-cures-1.1371631
Researchers at UCT are optimistic they have found a drug that can cure all strains of malaria with a single oral dose.
Some scientists have called the breakthrough drug discovery a gift to Africa, where malaria kills a million people every year.
#paludisme #santé #recherche #afrique_du_sud #MMV390048
http://www.mmv.org/sites/default/files/uploads/docs/news/Background_MMV390048.pdf
In September 2010, a compound code named MMV390048, which subsequently displayed exceptional potency against the parasite, was first designed and made. The compound is stable, and showed significant promise in an in vitro experiment. It was tested in animals in early 2011. The resultant data was even more encouraging as MMV390048 displayed a complete cure of animals infected with malaria parasites when given orally (by mouth) at a low (20 mg/kg) dose. More importantly, the drug remained in the animal for a long time – preventing any potential regrowth of the parasite.
#Nigeria: Genetically Engineered Bacteria Prevent Mosquitoes From Transmitting #Malaria
http://allafrica.com/stories/201207240738.html
In a renewed hope to eliminate the menace of malaria on human health, researchers at the Johns Hopkins Malaria Research Institute have genetically modified a bacterium commonly found in the mosquito’s midgut, to kill the malaria parasite before it is transmitted.
(...) According to a study published by PNAS, the modified bacteria were 98 percent effective (...).
Drug-resistant #malaria strain in Myanmar is global threat
http://www.trust.org/alertnet/news/drug-resistant-malaria-strain-in-myanmar-is-global-threat-expert
The world must help Myanmar fight a drug-resistant strain of malaria that could kill up to 200,000 children a year if it reaches India and Africa, a veteran health worker in the Southeast Asian country has warned.
But Frank Smithuis, former head of medical charity Medecins Sans Frontieres (MSF) in Myanmar, said major donors had excluded the country from their anti-malaria programmes, seriously jeopardising a concerted international effort to contain the epidemic.
Cambodge : les fausses pilules pullulent - Libération
http://www.liberation.fr/monde/2012/05/10/cambodge-lesfausses-pilulespullulent_817834
Les #contrefaçons de médicaments se sont multipliées ces quinze dernières années. Un trafic juteux que Phnom Penh a du mal à endiguer dans un contexte de corruption et à l’heure d’Internet.
La frontière établie par l’OMS entre les faux médicaments et les génériques, produits localement avec le même principe actif que des médicaments de marque encore sous protection de la propriété intellectuelle, paraît parfois floue. Sanofi-Aventis s’est ainsi indigné de l’apparition du médicament Plarax au Vietnam. Ce dernier présente les mêmes vertus - et le même emballage - que son Plavix…
Uganda : #Malaria Medicines Most Counterfeited
http://allafrica.com/stories/201204170444.html ?
In our market alone, about 20-30% of drugs are fake, it’s even much more when it comes to Malaria drugs.
pas sûr que la solution adoptée soit bonne (casser les prix serait sans doute bcp plus efficace) ; mais l’état des lieux est effrayant
[Artemisinin] #Resistance spread ’compromising’ fight against #malaria
http://www.bbc.co.uk/news/health-17628172
Scientists have found new evidence that resistance to the front-line treatments for malaria is increasing.
They have confirmed that resistant strains of the malaria parasite on the border between Thailand and Burma, 500 miles (800km) away from previous sites.
Researchers say that the rise of resistance means the effort to eliminate malaria is “seriously compromised”.
Greece on the breadline: #HIV and #malaria make a comeback | World news | The Guardian
http://www.guardian.co.uk/world/blog/2012/mar/15/greece-breadline-hiv-malaria?
The incidence of HIV/Aids among intravenous drug users in central Athens soared by 1,250% in the first 10 months of 2011 compared with the same period the previous year, according to the head of Médecins sans Frontières Greece, while malaria is becoming endemic in the south for the first time since the rule of the colonels.
Reveka Papadopoulos said that following savage cuts to the national health service budget, including heavy job losses and a 40% reduction in funding for hospitals, Greek social services were “under very severe strain, if not in a state of breakdown. What we are seeing are very clear indicators of a system that cannot cope.”
Malaria : Sensationelle Entdeckung | rbb Rundfunk Berlin-Brandenburg
http://www.rbb-online.de/abendschau/archiv/archiv.media.%21etc%21medialib%21rbb%21rbb%21abendschau%21abendschau_2012
http://www.rbb-online.de/etc/medialib/rbb/rbb/layout/headerimage/abendschau.file.jpg
Malaria: Sensationelle Entdeckung
Die Freie Universität hat ein revolutionäres Verfahren zur preiswerten Herstellung von Malaria-Medikamenten entwickelt. Das könnte viele Leben retten: Eine Million Menschen sterben bislang jährlich an der Krankheit, darunter viele Kinder im Alter zwischen zwei und fünf Jahren.
Zehn Dollar kostet im Durchschnitt in Afrika eine Therapie. Die Erfindung aus Dahlem könnte den Preis auf rund drei Euro drücken.
La dernière phrase dit l’essentiel : L’invention a le potentiel de faire baisser le coût du traitement du paludisme à trois dollars par cas.
Anti-malaria Drug Synthesised with the Help of Oxygen and Lighrug Synthesised with the Help of Oxygen and Light http://www.fu-berlin.de/en/presse/informationen/fup/2012/fup_12_010/index.html
http://www.fu-berlin.de/images/fu-berlin/fu_logo.gif
In the future it should be possible to produce the best anti-malaria drug, artemisinin, more economically and in sufficient volumes for all patients
The most effective anti-malaria drug can now be produced inexpensively and in large quantities. This means that it will be possible to provide medication for the 225 million malaria patients in developing countries at an affordable price. Researchers at the Max Planck Institute of Colloids and Interfaces in Potsdam and Freie Universität Berlin have developed a very simple process for the synthesis of artemisinin, the active ingredient that pharmaceutical companies could only obtain from plants up to now. The chemists use a waste product from current artemisinin production as their starting substance. This substance can also be produced biotechnologically in yeast, which the scientists convert into the active ingredient using a simple yet very ingenious method.
There is an effective treatment against malaria, but it is not accessible to all of the more than 200 million people worldwide who are affected by the disease. Millions, especially in the developing world, cannot afford the combination drug preparation, which consists mainly of artemisinin. Moreover, the price for the medication varies, as this substance is isolated from sweet wormwood (Artemisia annua) which grows mainly in China and Vietnam, and varies seasonally in its availability. To make the drug affordable for at least some patients in developing countries, the Clinton Foundation, for example, subsidises its cost to the tune of several million dollars per year. Nevertheless, over one million people die of malaria each year because they do not have access to effective drugs.
Lu dans le supplément (consacré au Fonds mondial de lutte contre le #sida, la #tuberculose & le #paludisme) du dernier @mdiplo reçu aujourd’hui :
Entre les années 2000 et 2002 en Afrique du Sud :
La mobilisation paie : le lobby phamaceutique finit par jeter l’éponge. On va enfin pouvoir soigner les malades. Pourtant, pour les militants qui ont défendu le gouvernement, la désillusion est rapide et profonde : fidèle du président Thabo Mbeki, la ministre de la santé Manto Tshabalala-Msimang n’a aucune intention d’organiser la distribution d’anti-rétroviraux dans le secteur public de la santé. Elle argue qu’ils sont toxiques ou qu’on peut se soigner en adoptant un régime nutritif à la base d’huile d’holive, d’ail et de citron
Sinon, les firmes pharmaceutiques rachètent les firmes fabricant des génériques, l’OMC a fait « disparaitre » deux Etats ne respectant pas les brevets (Thaïlande & Inde). La tuberculose devient de plus en plus résistante.
Jeffrey Sachs: Washington Leaves Millions to Die
http://www.huffingtonpost.com/jeffrey-sachs/washington-leaves-million_b_1112746.html
The wonder of our world is that scientific knowledge is now so powerful that we can save millions of children, mothers, and fathers from killer diseases each year at little cost. The Global Fund to Fight AIDS, TB, and Malaria has mobilized that knowledge over the past decade to save more than 7 million lives and to protect the health of hundreds of millions more. Yet now the #Global_Fund is under mortal threat because of budget cuts approved by President Obama and the Congress.
Reorienting less than 1 day’s military budget to help save millions of lives (in conjunction with the efforts of other countries) is not only a great humanitarian step but also the most cost-effective step we can take for our own security.
#Malaria #vaccine hope after blood entry route discovered - BBC News
http://www.bbc.co.uk/news/health-15624363
The route all strains of the most deadly malaria parasite use to enter red blood cells has been identified by researchers at the Sanger Institute in Cambridge.
le #vaccin anti-#paludisme RTS,S annoncé trop tôt ?
http://www.nature.com/news/2011/111026/full/478439a.html
Malaria #vaccine results face scrutiny : Nature News
it is too early to tell whether RTS,S actually protects against #malaria, or merely delays infection
Malaria vaccine : many in scientific community thought it was impossible | Society | The Guardian
http://www.guardian.co.uk/society/2011/oct/19/malaria-vaccine-immune-parasite-key
gros dossier du Guardian sur l’essai RTS,S ; ici interview avec le chercheur de GSK qui a le premier eu l’idée d’explorer l’immunité cellulaire
GlaxoSmithKline research head Moncef Slaoui explains how change of focus to cellular immunity was key to breakthrough