Antibody responses to #SARS-CoV-2 in patients of novel #coronavirus disease 2019
▻https://www.medrxiv.org/content/10.1101/2020.03.02.20030189v1.full.pdf
Le dosage des anticorps aurait une valeur diagnostique et pronostique
Leur persistance n’a pas été étudiée
Our results demonstrated an excellent sensitivity of Ab test in detections of patient’s samples after 1-week since onset. Notably, even in the early stages of the illness within 7-day, some patients with negative nucleic acid findings could be screened out through antibody testing. Combining RNA test and antibody test significantly raised the sensitivity for detecting patients (p < 0.001). Above findings indicate that the antibody detection be an important supplement to RNA detection during the illness course.
The results suggested that a high titer of total antibodies against the virus may be considered as a risk factor of critical illness, independently from older age, male gender and comorbidities (Table 4).
It should be noted that there were some limitations of this study. First, for most of RNA tests of the patients were based on upper respiratory tract specimens, the positive rate may be higher in detection using lower respiratory tract specimens, such as bronchoalveolar lavage fluid, deep tracheal aspirates, and induced sputum may yield higher sensitivity for RNA tests. Second, we cannot evaluate the persistence of antibodies because samples were collected during the acute illness course of patients.