Thread by florian_krammer : 1) There is a lot of talk about decaying antibodies. I would like to walk you through a few findings about antibodies to SARS-CoV-2 that we…
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La neutralisation du #sars-cov2 est proportionnelle à la quantité d’#anticorps.
Now, what are these antibodies doing? They bind to the spike and spike antibodies can potentially neutralize the virus. So, we tested a range of titers for neutralization of real SARS-CoV-2 in a microneutralization assay. First, ELISA titers and neutralization correlate well.
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17) Now, when looking at proportion of individuals who have any neutralizing activity, we see that about 50% of the 1:80-1:160 titers have neutralizing activity, 90% of the 1:320 titers have it and 100% of the titers above that have it.
Une quantité d’anticorps faible au départ augmente par la suite, cela se voit surtout dans les cas légers de la #COVID-19 (ce qui confirme les résultats d’études antérieures)
People with moderate to low titers however, hat increases. Again, they were not huge but for sure there was an upwards trend. As mentioned earlier, mild cases often need time until their antibody titers go up.