Thread by florian_krammer on Thread Reader App – Thread Reader App
Sur les #vaccins en cours de fabrication ;
Concernant les vaccins “modernes”, dont certains selon une technique inédite (vaccin à ARN) :
...these injected vaccines are poor inducers of mucosal antibodies in the upper respiratory tract which is mostly protected by secretory IgA1. This might lead to immunity that protects the lung (mild/no disease) but still allows for infection and potentially for onward transmission of the virus.
Concernant les classiques vaccins vivants atténués :
.... live attenuated vaccines might be much better in inducing sterilizing immunity in the upper respiratory tract.
Unfortunately, only three live attenuated vaccines are in development for SARS-CoV-2 and they are far behind.
By not developing live attenuated vaccines we might end up with vaccines that protect us from disease but not infection and we might still be able to pass on the virus to others.