• #COVID-19 neutralizing antibodies predict disease severity and survival : Cell

    Les taux d’#anticorps, y compris neutralisant, sont d’autant plus élevés que la maladie est sévère et les décès sont nombreux ;

    Le taux de survie dépend de la puissance des anticorps neutralisant

    Pas d’#immunité croisée avec des coronavirus qui n’ont pas (encore) franchi la barrière d’espèce.

    We examined antibody responses in 113 COVID-19 patients and found that severe cases resulting in intubation or death exhibited increased inflammatory markers, lymphopenia, pro-inflammatory cytokines, and high anti-RBD antibody levels.

    While anti-RBD IgG levels generally correlated with neutralization titer, quantitation of neutralization potency revealed that high potency was a predictor of survival. In addition to neutralization of wild-type SARS-CoV-2, patient sera were also able to neutralize the recently emerged SARS-CoV-2 mutant D614G, suggesting cross-protection from reinfection by either strain. However, SARS-CoV-2 sera generally lacked cross-neutralization to a highly-homologous pre-emergent bat coronavirus, WIV1-CoV, that has not yet crossed the species barrier. These results highlight the importance of neutralizing humoral immunity on disease progression and the need to develop broadly protective interventions to prevent future coronavirus pandemics.