Attack rates amongst household members of outpatients with confirmed #COVID-19 in Bergen, Norway : A case-ascertained study - ScienceDirect
▻https://www.sciencedirect.com/science/article/pii/S2666776220300144
Attack rates = sujets asymptomatiques et symptomatiques
Seuls les symptomatiques ont eu un PCR, mais tous ont eu une sérologie.
La spécificité du test sérologique n’est pas discutée.
#SARS-CoV-2 specific antibodies were measured in sera collected 6–8 weeks after index patient nasopharyngeal testing to define household attack rates.
Findings
The overall attack rate was 45% (95% CI 38–53) assessed by serology, and 47% when also including seronegative RT-PCR positives. Serology identified a higher number of infected household members than RT-PCR [(44/70 vs. 32/70)],
Attack rates were equally high in children (48%) and young adults (42%). The attack rates was 16% in asymptomatic household members [8/49] and 42% in RT-PCR negative contacts [16/38]. [...]
Interpretation
Serological assays provide more sensitive and robust estimates of household attack rates than RT-PCR. Children are equally susceptible to infection as young adults . Negative RT-PCR or lack of symptoms are not sufficient to rule out infection in household members.
#sérologie #séroconversion #asymptomatiques #enfants #transmission #anticorps