Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild #COVID‐19 - Apple - - Annals of Clinical and Translational Neurology - Wiley Online Library ▻https://onlinelibrary.wiley.com/doi/10.1002/acn3.51498
Des anomalies du liquide céphalo-rachidien en faveur d’une inflammation découverts chez les patients #post-Covid léger, en sachant qu’ils avaient au départ plus de facteurs de risque de perturbation des fonctions cognitives ; les auteurs affirment qu’ils ne peuvent exclure l’existence de ces anomalies du LCR avant le Covid-19. Dans le cas contraire cela démontrerait, via l’existence d’un processus immuno-inflammatoire, l’organicité du #covid-long.
Cognitive post-acute sequelae of #SARS-CoV-2 (PASC) can occur after mild COVID-19. Detailed clinical characterizations may inform pathogenesis.
We evaluated 22 adults reporting cognitive PASC and 10 not reporting cognitive symptoms after mild SARS-CoV-2 infection through structured interviews, neuropsychological testing, and optional cerebrospinal fluid (CSF) evaluations (53%).
Delayed onset of cognitive PASC occurred in 43% and associated with younger age.
Cognitive PASC participants had a higher number of pre-existing cognitive risk factors (2.5 vs. 0; p = 0.03) and higher proportion with abnormal CSF findings (77% vs. 0%; p = 0.01) versus controls.
Cognitive risk factors and immunologic mechanisms may contribute to cognitive PASC pathogenesis.
Covid-19 et “brouillard cérébral” : des anomalies du liquide céphalo-rachidien pourraient expliquer cette séquelle
▻https://news.dayfr.com/nouvelles/264545.html