Rare Gene Mutations Inspire New Heart Drugs - The New York Times
▻https://www.nytimes.com/2017/05/24/health/heart-drugs-gene-mutations.html
One sibling had been a heavy smoker, had high blood pressure and even had Type 2 diabetes, a powerful risk factor for heart disease. Yet there was no plaque in his arteries.
Dr. Stitziel went on to lead an international group of researchers who looked for mutations that destroyed the gene in 180,180 people. It was a rare event, occurring in just one in 309 people.