Pre-existing immunity to #SARS-CoV-2: the knowns and unknowns | Nature Reviews Immunology
▻https://www.nature.com/articles/s41577-020-0389-z
In conclusion, it is now established that SARS-CoV-2 pre-existing immune reactivity exists to some degree in the general population. It is hypothesized, but not yet proven, that this might be due to immunity to CCCs [‘common cold’ coronaviruses]. This might have implications for #COVID-19 disease severity, herd immunity and vaccine development, which still await to be addressed with actual data.