• Étude des charges virales chez les enfants. C’est pas encourageant.

    Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses
    https://www.jpeds.com/action/showPdf?pii=S0022-3476%2820%2931023-4

    Results: A total of 192 children (mean age 10.2 +/- 7 years) were enrolled. Forty-nine children (26%) were diagnosed with acute SARS-CoV-2 infection; an additional 18 children (9%) met criteria for MIS-C. Only 25 (51%) of children with acute SARS-CoV-2 infection presented with fever; symptoms of SARS-CoV-2 infection, if present, were non-specific. Nasopharyngeal viral load was highest in children in the first 2 days of symptoms, significantly higher than hospitalized adults with severe disease (P = .002). Age did not impact viral load, but younger children had lower ACE2 expression (P=0.004). IgM and IgG to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein were increased in severe MIS-C (P<0.001), with dysregulated humoral responses observed.

    Conclusion: This study reveals that children may be a potential source of contagion in the SARS-CoV-2 pandemic in spite of milder disease or lack of symptoms, and immune dysregulation is implicated in severe post-infectious MIS-C.

    • J’avoue ne pas comprendre pourquoi ce sujet est aussi étudié. J’imagine que comme pour pas mal d’autres sujets, il y a un espoir - un petit peu enfantin - de croire que le virus, peut-être, ignorerait une partie de la population.

      Mais donc, finalement, après 6 à 8 mois de tergiversations en Occident, on va peut-être enfin conclure que ce n’est pas une grippette, que les enfants sont des humains comme les autres, sensibles au virus, que le virus n’a pas muté dans une version moins virulente, que l’on doit s’en protéger, et que l’on doit détecter les cas, leur demander de s’isoler, et qu’en définitive la seule façon de vraiment l’éliminer, ce virus, en l’état de nos connaissances, c’est de ne plus lui laisser l’opportunité de se propager.

      L’Occident, ce jour là aura atteint la sagesse des orientaux, qui depuis le mois de décembre dernier appliquent ces solutions avec succès.

      (Oui, je sais, les orientaux sont menteurs, et ils cachent leurs cadavres dans les placards, comme Staline et Hirohito le faisaient à leurs époques respectives...)

  • Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses - The Journal of Pediatrics
    https://www.jpeds.com/article/S0022-3476(20)31023-4/abstract

    Study design:
    Children ages 0-22 years with suspected severe acute respiratory syndrome coronavirus 2 (#SARS-CoV-2) infection presenting to urgent care clinics or being hospitalized for confirmed/suspected SARS-CoV-2 infection or multisystem inflammatory syndrome in children (MIS-C) at Massachusetts General Hospital (MGH) were offered enrollment in the MGH Pediatric #COVID-19 Biorepository. Enrolled children provided nasopharyngeal, oropharyngeal, and/or blood specimens. SARS-CoV-2 viral load, ACE2 RNA levels, and serology for SARS-CoV-2 were quantified.

    Results
    A total of 192 children (mean age 10.2 +/- 7 years) were enrolled. Forty-nine children (26%) were diagnosed with acute SARS-CoV-2 infection; an additional 18 children (9%) met criteria for MIS-C. Only 25 (51%) of children with acute SARS-CoV-2 infection presented with fever ; symptoms of SARS-CoV-2 infection, if present, were non-specific. Nasopharyngeal viral load was highest in children in the first 2 days of symptoms, significantly higher than hospitalized adults with severe disease (P = .002). Age did not impact viral load, but younger children had lower ACE2 expression (P=0.004). IgM and IgG to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein were increased in severe MIS-C (P<0.001), with dysregulated humoral responses observed.

    No SARS-CoV-2 RNA was detected in the serum of any children.

    #enfants #charge_virale #ace2

  • Thumb-suckers, nail-biters show fewer allergies | Otago Daily Times Online News : Otago, South Island, New Zealand & International News
    http://www.odt.co.nz/campus/university-otago/389963/thumb-suckers-nail-biters-show-fewer-allergies

    Children who suck their thumbs or bite their nails may be less likely to develop allergies, a new University of Otago study suggests.
    The finding emerges from the long-running Dunedin Multidisciplinary Study, which has followed the progress of 1037 participants born in 1972-1973 into adulthood.
    The study, which appears in the August issue of the US journal Pediatrics, suggests that childhood exposure to microbial organisms through thumb-sucking and nail-biting reduces the risk of developing allergies.

    Study lead author Professor Bob Hancox says this exposure may alter immune function so that children with these habits become less prone to developing allergy.

    Parents of Dunedin Study members reported their children’s thumb-sucking and nail-biting habits when their children were 5, 7, 9, and 11 years old.

    The members were checked at ages 13 and 32 years old for atopic sensitisation, defined as a positive skin prick test to at least one common allergen.

    At age 13, the prevalence of sensitisation was lower among children who had sucked their thumbs or bit their nails (38 percent) compared with those who did not (49 percent).

    Children who both bit their nails and sucked their thumbs had an even lower risk of allergy (31 percent), Professor Hancox says.

    The associations were still present at age 32 years and persisted even with adjustments for confounding factors such as sex, parental history of allergies, pet ownership, breast-feeding and parental smoking.

    "The findings support the “hygiene hypothesis”, which suggests that being exposed to microbes as a child reduces your risk of developing allergies," he says.

    Despite these findings, Professor Hancox and his co-authors do not suggest that children should be encouraged to take up these habits, because it is unclear if there is a true health benefit.