• On aurait trouvé le remède contre la gueule de bois (et qui diminue le besoin du «  raccord  »…)
    C’est en Finlande where else ?.

    Notez les difficultés méthodologiques d’une telle étude (randomisée en double aveugle…)

    Hangover Cure Successfully Tested on Drunk Subjects in Finland - Bloomberg
    https://www.bloomberg.com/news/articles/2020-08-19/hangover-cure-successfully-tested-on-drunk-subjects-in-finland

    A group of Finnish researchers believe they’ve discovered what people have spent centuries searching for: a cure for hangovers.

    A dose of 1,200 milligrams of amino acid L-cysteine was found to reduce alcohol-related nausea and headache, while a dose of 600 milligrams helped alleviate stress and anxiety, according to a study published in the journal Alcohol and Alcoholism by researchers at the University of Helsinki and the University of Eastern Finland.

    The randomized, double-blind study had 19 healthy male volunteers consuming alcohol doses of 1.5 grams per kilogram over three hours in a controlled setting. The subjects were then asked to swallow placebo or L-cysteine tablets containing vitamin supplements.

    Researchers say that as well as reducing or even eliminating hangovers entirely, L-cysteine also helps “reduce the need of drinking the next day,” thereby cutting the risk of alcohol addiction.

    Binge drinking is common in Finland, with more than half a million Finns considered at risk from excessive drinking.

    The researchers received funding from Catapult Cat Oy, which sells the L-cysteine supplements.

    The study ran into certain difficulties. Some participants weren’t able to consume all the alcohol required and had to be excluded, some had such high tolerance levels that they experienced no hangover symptoms; and some were sidelined because they insisted on topping up the dose by heading for the bar, researcher Markus Metsala told local media.

    • étude sous #paywall publiée dans Alcohol and Alcoholism

      L-Cysteine Containing Vitamin Supplement Which Prevents or Alleviates Alcohol-related Hangover Symptoms: Nausea, Headache, Stress and Anxiety | Alcohol and Alcoholism | Oxford Academic
      https://academic.oup.com/alcalc/alcalc/advance-article-abstract/doi/10.1093/alcalc/agaa082/5893464

      Abstract
      Aims
      Alcohol-related hangover symptoms: nausea, headache, stress and anxiety cause globally considerable amount of health problems and economic losses. Many of these harmful effects are produced by alcohol and its metabolite, acetaldehyde, which also is a common ingredient in alcohol beverages. The aim of the present study is to investigate the effect of the amino acid L-cysteine on the alcohol/acetaldehyde related aftereffects.

      Methods
      Voluntary healthy participants were recruited through advertisements. Volunteers had to have experience of hangover and/or headache. The hangover study was randomized, double-blind and placebo-controlled. Nineteen males randomly swallowed placebo and L-cysteine tablets. The alcohol dose was 1.5 g/kg, which was consumed during 3 h.

      Results
      The primary results based on correlational analysis showed that L-cysteine prevents or alleviates hangover, nausea, headache, stress and anxiety. For hangover, nausea and headache the results were apparent with the L-cysteine dose of 1200 mg and for stress and anxiety already with the dose of 600 mg.

      Conclusions
      L-cysteine would reduce the need of drinking the next day with no or less hangover symptoms: nausea, headache, stress and anxiety. Altogether, these effects of L-cysteine are unique and seem to have a future in preventing or alleviating these harmful symptoms as well as reducing the risk of alcohol addiction.