Decline of Humoral Responses against SARS-CoV-2 Spike in Convalescent Individuals | mBio
▻https://mbio.asm.org/content/11/5/e02590-20
IMPORTANCE
While waiting for an efficient vaccine to protect against #SARS-CoV-2 infection, alternative approaches to treat or prevent acute #COVID-19 are urgently needed. #Transfusion of #convalescent plasma to treat COVID-19 patients is currently being explored; neutralizing activity in convalescent plasma is thought to play a central role in the efficacy of this treatment. Here, we observed that plasma neutralization activity decreased a few weeks after the onset of the symptoms. If neutralizing activity is required for the efficacy of convalescent plasma transfer, our results suggest that convalescent plasma should be recovered rapidly after the donor recovers from active infection.