La #charge_virale salivaire serait plus fiable que celle naso-pharyngée pour prédire la #sévérité de la #covid-19.
Prof. Akiko Iwasaki sur Twitter :
Saliva (top panels) but not NP (btm panels) viral load was elevated in hospitalized, severe and deceased patients." / Twitter
▻https://twitter.com/VirusesImmunity/status/1348289323247022086
Elle serait corrélée à une production tardive d’#anticorps.
“Patients with high saliva viral load developed antiviral antibodies with significantly delayed kinetics than those who had low viral load.” / Twitter
▻https://twitter.com/VirusesImmunity/status/1348289340565176324
Explication potentielle quant à cette différence
Prof. Akiko Iwasaki sur Twitter : “Why is saliva viral load a better correlate of disease than NP load? We think that NP only reflects upper respiratory tract (URT) viral replication, while saliva represents both URT and lower respiratory tract. Mucociliary clearance propels virus from LRT to oral cavity.” / Twitter
▻https://twitter.com/VirusesImmunity/status/1348289350304477187
La charge virale naso-pharyngée serait un indicateur de #contagiosité, celle salivaire de sévérité,
Prof. Akiko Iwasaki sur Twitter :
"URT virus is key to transmission, but LRT is key to severe #COVID19. Saliva appears to be better at capturing the critical viral source driving severe disease.
►https://twitter.com/VirusesImmunity/status/1348289351894134785
#PCR