Immunity to #SARS-CoV-2 #variants of concern | Science
▻https://science.sciencemag.org/content/371/6534/1103.full
Vaccine-induced protection
Loss of neutralizing epitopes in the spike protein in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants could reduce protection induced by vaccination based on wild-type spike. Most vaccinated people develop neutralizing antibody (Ab) with an IC50 (half maximal inhibitory concentration) within the protective margin, although precise correlates of protection (CoP) are unknown. Variants with E484K mutations and future escape mutants may bring protection below this margin, prompting the need for new vaccines.