Several #SARS-CoV-2 #Variants Are Resistant to the Pfizer/BioNTech and Moderna Vaccines - Mass General Advances in Motion
▻https://advances.massgeneral.org/research-and-innovation/journal.aspx?id=1940
This study quantified neutralizing antibodies against pseudoviruses mimicking SARS-CoV-2 variants in 99 individuals who had received one or two doses of the Pfizer/BioNTech or Moderna COVID-19 vaccines
Neutralization against many variants , such as B.1.1.7 (U.K.), was largely the same as with SARS-CoV-2 wild-type virus
However, the P.2/P.1 (Brazilian/Japanese) and B.1.351 (South African) variants exhibited significant resistance even in fully vaccinated individuals, with decreases in neutralization antibodies of 3- to 7-fold and 19- to 42-fold, respectively
Individuals who had received only a single recent vaccine dose had weaker neutralization titers overall, and most of them showed no neutralization at all against certain B.1.351 variants
These results support the reformulation of existing vaccines to include diverse spike sequences; ultimately, development of new COVID-19 vaccines capable of eliciting broadly neutralizing antibodies may be necessary
Source: Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity - ScienceDirect
▻https://www.sciencedirect.com/science/article/pii/S0092867421002981
