SARS-CoV-2 Reinfection : A Case Series from a 12-Month Longitudinal Occupational Cohort | Clinical Infectious Diseases

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  • #SARS-CoV-2 #Reinfection: A Case Series from a 12-Month Longitudinal Occupational Cohort
    https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab738/6359055

    Out of 7,980 individuals monitored during the six-month study period, 768 team staff, arena staff, third-party vendors, players, or household members of any of these groups reported or were found to have recovered from a prior infection defined as a confirmed positive RT-PCR test result plus symptoms, sequential positive RT-PCR, and/or presence of antibodies (in unvaccinated individuals) at any point since the emergence of the COVID-19 pandemic; seven of these experienced reinfections after a documented first infection. The reliable documentation of first infection coupled with serial testing, during, and after reinfection, maximized the likelihood of detecting reinfections.

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    The average time between primary infection and reinfection was 152 days (median=182; range: 25 to 204 including the immunocompromised case) which is consistent with a previous study on reinfection [2].

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    The presence of antibodies at time of reinfection in these cases highlights the question: to what degree do certain quantitative results from commercially available antibody tests indicate protection from SARS-CoV-2 infection? Spike protein-directed antibody levels correlate well with virus-neutralizing titers [5], but the precise level of neutralizing antibodies necessary for protection from reinfection, and the translation of such levels to commercially available antibody tests remains unclear.