Scent of a vaccine | Science
▻https://science.sciencemag.org/content/373/6553/397.full
À propos de la #vaccination par voie nasale
Compared to intramuscular vaccines, intranasal vaccines provide two additional layers of protection: Vaccine-elicited IgA and resident memory B and T cells in the respiratory mucosa provide an effective barrier to infection at those sites; and, even if infection does occur, perhaps by a viral variant, cross-reactive, resident memory B and T cells, which encounter antigen earlier and respond more quickly than systemic memory cells, impede viral replication and reduce viral shedding and transmission (see the figure).
Routes of vaccination
Immunoglobulin A (IgA) and resident memory B and T cells in the nasal passages and upper airways are elicited by intranasal vaccination and prevent infection and reduce virus shedding. Serum IgG elicited by intramuscular vaccination transudates into the lungs and prevents pulmonary infection but allows infection in the nasal passages and virus shedding.
GRAPHIC: KELLIE HOLOSKI/SCIENCE