Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

/333ra50

  • Sweet drug clears #cholesterol, reverses heart disease—and was found by parents
    http://arstechnica.com/science/2016/04/sweet-drug-clears-cholesterol-reverses-heart-disease-and-was-found-by-p

    Des parents de jumelles atteintes d’une maladie héréditaire grave ont fait des recherches tellement intenses sur la molécule qui a fini par être utilisée (avec un certain succès) pour combattre ladite maladie, qu’ils ont fini par trouver une autre indication thérapeutique à la molécule en question,

    Two parents’ quest to save their twin daughters’ lives from a rare, degenerative genetic disorder may end up saving and improving the lives of millions.

    After digging through medical literature and fitting pieces of data together, the non-medically trained couple contacted German researchers and suggested that a chemical called cyclodextrin may be able to treat atherosclerosis—the hardening of arteries with cholesterol-rich plaques, which is a precursor to heart attack, stroke, and other cardiovascular diseases.

    The researchers, Eicke Latz at the University of Bonn and colleagues, followed up on the parents’ hypothesis and found that in mice, cyclodextrin indeed blocked plaque formation, melted away plaques that had already formed in arteries, reduced atherosclerosis-associated inflammation, and revved up cholesterol metabolism—even in rodents fed cholesterol-rich diets. In petri dish-based tests, the researchers found that the drug seemed to have the same effects on human cells and plaques.

    Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
    http://stm.sciencemag.org/content/8/333/333ra50

    La maman, Chris Hempel, fait partie des auteurs de l’étude.

    #cyclodextrine #hypercholestérolémie #athérosclérose #infarctus #santé