There won’t be a cure for Alzheimer’s disease in our lifetime
▻https://massivesci.com/articles/alzheimers-cure-lifetime-brain-neuro-mind-control-amyloid-tau
A century of research later, and we’re still not sure what causes it
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Pulling all-nighters may damage your brain
▻https://massivesci.com/articles/sleep-brain-damage-staying-upNew research suggests bad sleep causes a build-up of plaque associated with Alzheimer’s
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Alzheimer’s disease reversed in mice, offering hope for humans, new research shows - ABC News
▻http://abcnews.go.com/Health/alzheimers-disease-reversed-mice-offering-hope-humans-research/story?id=53114260By using #BACE1 inhibitors to gradually lower the enzyme’s levels, researchers saw reduced neuron loss and better brain function in the mice, offering hope for human subjects down the line, according to the study.
Merck BACE1 drug fails in prodromal Alzheimer’s phase 3 | FierceBiotech
▻https://www.fiercebiotech.com/biotech/merck-bace1-drug-fails-prodromal-alzheimer-s-phase-3Merck has stopped a phase 3 trial of BACE1 inhibitor verubecestat in prodromal Alzheimer’s patients following an interim review. News of the setback comes 12 months after Merck pulled the plug on a trial in patients with more advanced forms of the disease after seeing similarly lackluster data.
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Alzheimer’s : Will experimental blood test be a game-changer ? - CNN
▻http://edition.cnn.com/2017/09/04/health/alzheimers-blood-test-study/index.htmlAn experimental blood test can accurately diagnose Alzheimer’s disease, the most common form of dementia, according to a study published Monday in the journal Proceedings of the National Academy of Sciences. Though still in development, the test may someday be used to diagnose other degenerative brain disorders and even mild cognitive impairment resulting from head injuries.
The researchers say that using the test, they were able to identify Alzheimer’s patients with up to 86% sensitivity and specificity. (Sensitivity refers true positives identified by the test, while specificity refers to true negatives.) The test also differentiated Alzheimer’s from dementia with Lewy bodies, a related condition, with 90% sensitivity and specificity.
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Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization
▻http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1006077
Extra-virgin olive oil (EVOO), a central component of the Mediterranean diet, contains an abundance of phenolic antioxidants that are potent inhibitors of reactive oxygen species and is associated with a reduced risk for several types of human cancer.1 Giacosa A, Barale R, Bavaresco L, Gatenby P, Gerbi V, Janssens J, Johnston B, Kas K, La Vecchia C, Mainguet P, et al. Cancer prevention in Europe: the Mediterranean diet as a protective choice. Eur J Cancer Prev 2013; 22:90–5; PMID:22644232; ▻http://dx.doi.org/10.1097/CEJ.0b013e328354d2d7[CrossRef], [PubMed], [Web of Science ®], [Google Scholar] Polyphenolic secoiridoids of EVOO have been shown to decrease viability of HER2-overexpressing breast cancer cells by selectively inducing apoptotic cell death.2 Menendez JA, Vazquez-Martin A, Colomer R, Brunet J, Carrasco-Pancorbo A, Garcia-Villalba R, Fernandez-Gutierrez A, Segura-Carretero A. Olive oil’s bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells. BMC Cancer 2007; 7:80; PMID:17490486; ▻http://dx.doi.org/10.1186/1471-2407-7-80[CrossRef], [PubMed], [Web of Science ®], [Google Scholar] (-)-Oleocanthal (OC), a di-aldehydic form of ligostride aglycone that has been isolated from EVOO, possesses a wide range of biological effects. Previous studies have reported its activity as a potent antioxidant; a nonsteroidal anti-inflammatory agent that inhibits COX-1 and COX-2; a neuroprotectant that alters the structure and function of the neurotoxins β-amyloid and Tau, which are associated with the debilitating effects of Alzheimer disease; an inhibitor of proliferation, migration, and invasion of human breast and prostate cancer cells through c-Met inhibition; an inhibitor of AMPK in colon cancer cells; and an inhibitor of macrophage inflammatory protein-1α in multiple myeloma.3-8 Beauchamp GK, Keast RS, Morel D, Lin J, Pika J, Han Q, Lee CH, Smith AB, Breslin PA. Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature 2005; 437:45–6; PMID:16136122; ▻http://dx.doi.org/10.1038/437045a
Busnena BA, Foudah AI, Melancon T, El Sayed KA. Olive secoiridoids and semisynthetic bioisostere analogues for the control of metastatic breast cancer. Bioorg Med Chem 2013; 21:2117–27; PMID:23403296; ▻http://dx.doi.org/10.1016/j.bmc.2012.12.050
Elnagar AY, Sylvester PW, El Sayed KA. (-)-Oleocanthal as a c-Met inhibitor for the control of metastatic breast and prostate cancers. Planta Med 2011; 77:1013–9; PMID:21328179; ▻http://dx.doi.org/10.1055/s-0030-1270724
Monti MC, Margarucci L, Riccio R, Casapullo A. Modulation of tau protein fibrillization by oleocanthal. J Nat Prod 2012; 75:1584–8; PMID:22988908; ▻http://dx.doi.org/10.1021/np300384h
Scotece M, Gomez R, Conde J, Lopez V, Gomez-Reino JJ, Lago F, Smith AB 3rd, Gualillo O. Oleocanthal inhibits proliferation and MIP-1a expression in human multiple myeloma cells. Curr Med Chem 2013; 20:2467–75; PMID:23521677; ▻http://dx.doi.org/10.2174/0929867311320190006
Pitt J, Roth W, Lacor P, Smith AB 3rd, Blankenship M, Velasco P, De Felice F, Breslin P, Klein WL. Alzheimer’s-associated Ab oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal. Toxicol Appl Pharmacol 2009; 240:189–97; PMID:19631677; ▻http://dx.doi.org/10.1016/j.taap.2009.07.018To investigate the anticancer effects of OC, we examined its effect on the viability and survival of cancerous and non-cancerous cells.
#cancer_recherche #anticancer #huile_d'olive #oléocanthal #inhibiteurs
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Culprit hidden in plain sight in #Alzheimer disease development
▻https://medicalxpress.com/news/2017-06-culprit-hidden-plain-sight-alzheimer.htmlhighly oxidative, combustion nanoparticles entering young developing brains—the culprit hidden in plain sight in Alzheimer’s disease development—constitute a very serious public health issue, with grave social and economic consequences.
Efforts should also be aimed to identify and neuroprotect high risk young populations. Unfortunately, to date that is not happening. -
Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells — ScienceDaily
▻https://www.sciencedaily.com/releases/2016/06/160629095609.htmBrain cells have switches known as receptors that can be activated by endocannabinoids, a class of lipid molecules made by the body that are used for intercellular signaling in the brain. The psychoactive effects of marijuana are caused by #THC, a molecule similar in activity to endocannabinoids that can activate the same receptors. Physical activity results in the production of endocannabinoids and some studies have shown that exercise may slow the progression of Alzheimer’s disease.
Schubert emphasized that his team’s findings were conducted in exploratory laboratory models, and that the use of THC-like compounds as a therapy would need to be tested in clinical trials.
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Stanford researchers ‘stunned’ by stem cell experiment that helped stroke patient walk
▻https://www.washingtonpost.com/news/to-your-health/wp/2016/06/02/stanford-researchers-stunned-by-stem-cell-experiment-that-helped-strDes #cellules_souches de la moelle osseuse dont le mode d’action ne se fait pas via leur transformation en tissu nerveux.
While the research involved only 18 patients and was designed primarily to look at the safety of such a procedure and not its effectiveness, it is creating significant buzz in the neuroscience community because the results appear to contradict a core belief about brain damage — that it is permanent and irreversible.
The results, published in the journal Stroke, could have implications for our understanding of an array of disorders including traumatic brain injury, spinal cord injury and Alzheimer’s if confirmed in larger-scale testing.
The work involved patients who had passed the critical six-month mark when recoveries generally plateau and there are rarely further improvements. [...]
The one-time therapy involved surgeons drilling a hole into the study participants’ skulls and injecting stem cells in several locations around the area damaged by the stroke. These stem cells were harvested from the bone marrow of adult donors. While the procedure sounds dramatic, it is considered relatively simple as far as brain surgery goes. The patients were conscious the whole time and went home the same day.
[...]
“Their recovery was not just a minimal recovery like someone who couldn’t move a thumb now being able to wiggle it. It was much more meaningful. One 71-year-old wheelchair-bound patient was walking again,” said [Gary] Steinberg [the study’s lead author and chair of neurosurgery at Stanford] who personally performed most of the surgeries.
[...]
Steinberg said that the study does not support the idea that the injected stem cells become neurons, as has been previously thought. Instead, it suggests that they seem to trigger some kind of biochemical process that enhances the brain’s ability to repair itself.
“A theory is that they turn the adult brain into the neonatal brain that recovers well,” he explained.
[...]
Nicholas Boulis, a neurosurgeon and researcher at Emory University, said the study appears to support the idea that there may be latent pathways in the brain that can be reactivated — a theory that has been “working its way to the surface” over the past few years.
#AVC
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I Remember
▻http://i-remember.fr“I remember” is a blessing most of us take for granted. Share your memories and help to fight Alzheimer’s disease.
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A doctor chronicled the progression of Alzheimer’s disease in one of his patients by collecting her signatures from medical forms over several years.
▻http://www.reddit.com/r/pics/comments/2ennv0/a_doctor_chronicled_the_progression_of_alzheimers
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▶ What is Alzheimer’s disease ? - Ivan Seah Yu Jun - YouTube
►https://www.youtube.com/watch?v=yJXTXN4xrI8
Alzheimer’s disease is the most common cause of dementia, affecting over 40 million people worldwide. And though it was discovered over a century ago, scientists are still grappling for a cure. Ivan Seah Yu Jun describes how Alzheimer’s affects the brain, shedding light on the different stages of this complicated, destructive disease.
Lesson by Ivan Seah Yu Jun, animation by STK Films.
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Concussions may lead to Alzheimer’s plaque buildup for some - CBS News
▻http://www.cbsnews.com/news/concussions-may-lead-to-alzheimers-plaque-buildup-for-someConcussions have already been linked to the Alzheimer’s-like degenerative brain disease chronic traumatic encephalopathy (CTE) in athletes and military members who have experienced repeated head blows and traumatic brain injuries.
Now, a new study links concussions to Alzheimer’s disease itself.
Mayo Clinic researchers gave brain scans to 141 Minnesotans who had been experiencing memory problems, and found those who had suffered a brain injury that caused them to black-out had more amyloid plaques in their brain than those who hadn’t.
Amyloid plaque is the telltale sign of Alzheimer’s disease, formed by pieces of a sticky protein that break off in the brain and clump together. Some clumps may form in brain regions involved in learning, memory and thinking, the Alzheimer’s Association explains. More plaques form as the disease progresses.
Researchers gave brain scans to 448 people without any memory or cognitive problems, and 141 people who had mild cognitive impairment (MCI), a condition characterized by declines in memory and thinking skills that aren’t caused by aging. They were also asked whether they had ever experienced a brain injury that caused them to lose consciousness. People with MCI are at a heightened risk of developing Alzheimer’s or another type of dementia, but not everyone with the condition will get worse.......
#health
#Alzheimer
#Concussions may #lead to #Alzheimer's-plaque-buildup for some -
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Alzheimer’s gene ’diabetes link’
►http://www.bbc.co.uk/news/health-18445701Scientists say they have identified a possible genetic link between diabetes and Alzheimer’s disease.
It has been known for some time that people with diabetes have a much higher risk of developing Alzheimer’s, but not why this is so.
Now US researchers writing in Genetics say a study of worms has indicated a known Alzheimer’s gene also plays a role in the way insulin is processed.
Dementia experts said more work in humans was now needed.
Alzheimer’s is the most common cause of dementia, which affects 820,000 people in the UK.
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Green #tea could help ward off dementia, scientists show | Society | The Guardian
►http://www.guardian.co.uk/society/2011/jan/06/green-tea-alzheimers-cancer"Chemicals produced during digestion may protect brain against #Alzheimer's and #cancer, say Newcastle University researchers"
