Cancer constantly mutates. Now scientists are learning to exploit it
▻https://massivesci.com/articles/cancer-diversity-treatment-evolution
Researchers are reckoning with the disease as a sprawling metropolis
Cancer constantly mutates. Now scientists are learning to exploit it
▻https://massivesci.com/articles/cancer-diversity-treatment-evolution
Researchers are reckoning with the disease as a sprawling metropolis
The Military-Industrial Complex Is Fundamentally Changing the European Union | The Nation
With the Eurozone in permanent crisis, Brexit on the horizon, and far-right parties on the rise from Germany to the Czech Republic, the future of the European Union has never seemed so much in doubt. There’s no shortage of leaders aspiring to reboot the unification project that helped Europeans leave behind the terrors of two world wars. But whether it’s the old federalist president of the European Commission, Jean-Claude Juncker, the solid German Chancellor Angela Merkel, or the maverick French President Emmanuel Macron leading the discussion about Europe’s future, there’s a recurring theme at the top of the priority list: defense.
In his ambitious Sorbonne University speech on the future of Europe in September, Macron expressed his grand vision: “At the beginning of the next decade Europe must have a joint intervention force, a common defense budget and a joint doctrine for action.” This is not merely a political wish list: Both the financing plans and institutional infrastructure for just such a consolidation of European military policy are being put in place at an astonishing speed. Billions of euros have been put on the table for R&D and weapons procurement; plans to militarize development aid, circumvent constitutional restraints, and bring European forces to the battleground are on paper and ready to go. EU members states will meet next Monday in Brussels to sign a defense pact (#PESCO -Permanent Structure Co-operation) calling for a massive increase in military investment and to pave the way for the deployment of European forces....
▻https://www.thenation.com/article/the-military-industrial-complex-is-fundamentally-changing-the-european-un
Pharmaceutical Founder Arrested In Alleged Nationwide Opioid Scheme : The Two-Way : NPR
►http://www.npr.org/sections/thetwo-way/2017/10/26/560263997/pharmaceutical-founder-arrested-in-alleged-nationwide-opioid-scheme
On the same day President Trump declared the opioid epidemic a public health emergency, the co-founder of a prominent opioid medication manufacturer has been arrested on fraud and racketeering charges. John Kapoor, former CEO of Insys Therapeutics, has been charged with conspiring to push the company’s signature drug for unacceptable uses through a series of bribes and kickbacks.
Subsys, as the drug is known, transmits the extremely powerful narcotic fentanyl in spray form, allowing it to be placed beneath the tongue for fast, potent pain relief. It is meant only for treating cancer patients suffering from severe pain.
But according to prosecutors, Kapoor and several other former high-ranking executives at the company conspired to bribe doctors to write “large numbers of prescriptions for the patients, most of whom were not diagnosed with cancer.” They also allegedly “conspired to mislead and defraud health insurance providers who were reluctant to approve payment for the drug when it was prescribed for non-cancer patients.”
Pharmaceutical Founder Arrested In Alleged Nationwide Opioid Scheme : The Two-Way : NPR
►http://www.npr.org/sections/thetwo-way/2017/10/26/560263997/pharmaceutical-founder-arrested-in-alleged-nationwide-opioid-scheme
Subsys, as the drug is known, transmits the extremely powerful narcotic fentanyl in spray form, allowing it to be placed beneath the tongue for fast, potent pain relief. It is meant only for treating cancer patients suffering from severe pain.
But according to prosecutors, Kapoor and several other former high-ranking executives at the company conspired to bribe doctors to write “large numbers of prescriptions for the patients, most of whom were not diagnosed with cancer.” They also allegedly “conspired to mislead and defraud health insurance providers who were reluctant to approve payment for the drug when it was prescribed for non-cancer patients.”
CAR-T could revolutionize cancer treatment. It can also be fatal
▻https://massivesci.com/articles/car-t-cancer-leukemia-immunotherapy-novartis-gilead-effects
Nearly 70 years after the invention of chemotherapy, new treatments still come with dangerous risks
Global cost of obesity-related illness to hit $1.2tn a year from 2025 | Society | The Guardian
▻https://www.theguardian.com/society/2017/oct/10/treating-obesity-related-illness-will-cost-12tn-a-year-from-2025-expert
The cost of treating ill health caused by obesity around the world will top $1.2tn every year from 2025 unless more is done to check the rapidly worsening epidemic, according to new expert estimates.
Obesity and smoking are the two main drivers behind the soaring numbers of cancers, heart attacks, strokes and diabetes worldwide, grouped together officially as non-communicable diseases. They are the biggest killers of the modern world.
Supersize us: upselling is fuelling the obesity epidemic, warns report
Read more
Misuse of Meta-analysis in #Nutrition Research | Nutrition | JAMA | The JAMA Network
▻http://jamanetwork.com/journals/jama/fullarticle/2654401
A 2014 meta-analysis examined the relationship between saturated fat intake and coronary artery disease.2 One of the included prospective studies, the Oxford Vegetarian Study,3 included vegans, ovolacto vegetarians, fish eaters, and meat eaters, with reported saturated fat intake ranging from 6% to 7% of energy in vegan participants to approximately twice that amount in the other diet groups. Those in the highest tertile of saturated fat intake had nearly triple the risk of fatal ischemic heart disease compared with the lowest tertile.
In contrast, another study included in the meta-analysis, the Malmö Diet and Cancer cohort study,4 had no groups at the lower end of saturated fat intake, which ranged from 13% to more than 22% for the lowest to the highest quintiles, and no significant association between saturated fat intake and risk of cardiovascular events was detected. The Malmö authors cautioned, “only 1.2 percent of the present study population actually followed national Swedish recommendations (less than 10 energy percent) on saturated fat intake. Strictly speaking, the SFA-CVD [saturated fatty acids-cardiovascular disease] hypothesis is thus not fully testable in this population.”
Nevertheless, the Malmö study was given substantial weight in the meta-analysis, which concluded that available evidence did not support limiting saturated fat, a conclusion repeated in a New York Times commentary proclaiming “Butter is Back” and a Time magazine cover displaying an artistic butter swirl and the bold headline “Eat Butter,” and cited by the 2015 Dietary Guidelines Advisory Committee. The following year, a Gallup poll registered a sharp decline in the number of US adults limiting fat in their diets.
Caught on tape: Pharma rep lies to get opioid tied to Cherry Hill death
▻http://www.philly.com/philly/health/addiction/senate-mccaskill-hearing-on-opioids-fentanyl-insys-subsys-purdue-teva-endo-a
Deborah Fuller is clear about what she will tell Sen. Claire McCaskill next week about the pharmaceutical industry’s role in her daughter’s overdose last year:
“Basically, you know, they set her up to die.”
She will say this in Washington on Tuesday because she has proof: a 2015 audio recording of a drug industry representative pretending to work for the Cherry Hill doctor who was treating Sarah Fuller. On the recording, the rep can be heard misrepresenting Sarah’s diagnosis so that she could receive one of the most powerful and deadly opioids on the market. The motivation? This drug, approved only for cancer patients, costs over $20,000 a month. In Sarah Fuller’s case, the bill to taxpayers came to more than a quarter-million dollars, since she was disabled and covered by Medicare.
Report: Drug company faked cancer patients to sell drug - CNNPolitics
▻http://www.cnn.com/2017/09/06/politics/insys-cancer-drug-company-faked-cancer-patients-to-sell-drug/index.html
Insys got around this by finding calculated ways for its employees to create the impression on the phone calls that the answer was yes, they did have cancer, without explicitly saying so, according to the report.
A recording of a such a call, obtained by McCaskill’s investigators and released Wednesday, shows the wordplay Insys employees engaged in.
The call involves a New Jersey woman named Sarah Fuller, who did not have cancer but was nevertheless prescribed Subsys by her doctor. Fuller died last year of a Subsys overdose, and state authorities later petitioned to have her doctor’s license temporarily suspended.
Caught on tape: Pharma rep lies to get opioid tied to Cherry Hill death
▻https://seenthis.net/messages/628222
IBM pitched Watson as a revolution in cancer care. It’s nowhere close
▻https://www.statnews.com/2017/09/05/watson-ibm-cancer
three years after IBM began selling Watson to recommend the best cancer treatments to doctors around the world, a STAT investigation has found that the supercomputer isn’t living up to the lofty expectations IBM created for it. It is still struggling with the basic step of learning about different forms of cancer. Only a few dozen hospitals have adopted the system, which is a long way from IBM’s goal of establishing dominance in a multibillion-dollar market. And at foreign hospitals, physicians complained its advice is biased toward American patients and methods of care.
@anne #machine_learning #cancer #santé #IBM
The Problem with the Mutation-Centric View of Cancer - Facts So Romantic
▻http://nautil.us/blog/the-problem-with-the-mutation_centric-view-of-cancer
Smoking is doing to the lung what the dinosaur-killing meteor did to Earth. It’s stimulating evolution—somatic cell evolution—that can lead to cancer.Photograph by NIH Image Gallery / FlickrTo better understand and treat cancer, physicians need to stop oversimplifying its causes. Cancer results not solely from genetic mutations but by adapting to and thriving in micro-environments in the body. That’s the point of view of James DeGregori, a professor in the Department of Biochemistry and Molecular Genetics at the University of Colorado School of Medicine. In a recent Cancer Research paper, DeGregori took a trio of researchers—Cristian Tomasetti, Lu Li, and Bert Vogelstein—to task for their assessment of cancer risk. “Cancers,” they wrote in Science, “are caused by mutations that may be (...)
Darkwood dev pirates own game a week after launch
▻http://www.gamesindustry.biz/articles/2017-08-28-darkwood-dev-pirates-own-game-a-week-after-launch
Acid Wizard says it would rather give game to those who can’t afford it than see them turn to key re-sellers, “the cancer that is leeching off this industry”
6 million adults do not do a monthly brisk 10 minute walk - GOV.UK
▻https://www.gov.uk/government/news/6-million-adults-do-not-do-a-monthly-brisk-10-minute-walk
Over 6.3 million adults aged 40 to 60 do not achieve 10 minutes of continuous brisk walking over the course of a month and are missing out on important health benefits, according to the Public Health England (PHE) 10 minutes brisk walking recommendations: evidence summary.
The findings also reveal how lifestyles have changed over time, showing that people in the UK are 20% less active now than they were in the 1960s and on average walk 15 miles less a year than 2 decades ago. The sedentary nature of modern, busy lives makes it difficult for many to find the time for enough exercise to benefit their health.
[…]
Taking at least 1 brisk 10 minute walk a day has been shown to reduce the risk of early death by 15%. A 10 minute walk can contribute to meeting the CMO’s physical activity guidance of 150 minutes of moderate to vigorous exercise each week. This can lead to health benefits including a lowered risk of type 2 diabetes (by 40%), cardiovascular disease (by 35%), dementia (by 30%) and some cancers (by 20%).
The severity of the current physical inactivity epidemic amongst adults contributes to 1 in 6 deaths in the UK and is costing the NHS over £0.9 billion per year.
Repris en français avec le titre
Les Anglais confrontés à une #épidémie_de_sédentarité chez les adultes
▻https://www.pourquoidocteur.fr/Articles/Question-d-actu/22632-Les-Anglais-confrontes-epidemie-sedentarite-adultes
Gene Editing for ‘Designer Babies’? Highly Unlikely, Scientists Say - The New York Times
▻https://www.nytimes.com/2017/08/04/science/gene-editing-embryos-designer-babies.html
Here is what science is highly unlikely to be able to do: genetically predestine a child’s Ivy League acceptance letter, front-load a kid with Stephen Colbert’s one-liners, or bake Beyonce’s vocal range into a baby.
That’s because none of those talents arise from a single gene mutation, or even from an easily identifiable number of genes. Most human traits are nowhere near that simple.
“Right now, we know nothing about genetic enhancement,” said Hank Greely, director of the Center for Law and the Biosciences at Stanford. “We’re never going to be able to say, honestly, ‘This embryo looks like a 1550 on the two-part SAT.’”
Even with an apparently straightforward physical characteristic like height, genetic manipulation would be a tall order. Some scientists estimate height is influenced by as many as 93,000 genetic variations. A recent study identified 697 of them.
Talents and traits aren’t the only thing that are genetically complex. So are most physical diseases and psychiatric disorders. The genetic message is not carried in a 140-character tweet — it resembles a shelf full of books with chapters, subsections and footnotes.
So embryonic editing is unlikely to prevent most medical problems.
But about 10,000 medical conditions are linked to specific mutations, including Huntington’s disease, cancers caused by BRCA genes, Tay-Sachs disease, cystic fibrosis, sickle cell anemia, and some cases of early-onset Alzheimer’s. Repairing the responsible mutations in theory could eradicate these diseases from the so-called germline, the genetic material passed from one generation to the next. No future family members would inherit them.
A composite image showing the development of embryos after injection of a gene-correcting enzyme and sperm from a donor with a genetic mutation known to cause hypertrophic cardiomyopathy. Credit Oregon Health & Science University
But testing editing approaches on each mutation will require scientists to find the right genetic signpost, often an RNA molecule, to guide the gene-snipping tool.
Le #gui pour soigner le cancer ?
Survival of cancer patients treated with mistletoe extract (Iscador): a systematic literature review
▻https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-9-451
In conclusion, pooled analysis of clinical studies suggests that adjuvant treatment of cancer patients with Iscador is associated with a reduction in mortality rates. Having in mind the limitations found here, future studies evaluating the effects of Iscador should continue to address this question, with a particular focus on a transparent design and description of endpoints in order to provide greater insight into a treatment often being depreciated as ineffective. The information and considerations from this analysis should be taken seriously not only for a better study quality but also to provide the best possible care for cancer patients.
Weleda #iscador #viscum_album
#cancer_soin_alternatif
This Man’s Immune System Got a Cancer-killing Update - Facts So Romantic
▻http://nautil.us/blog/this-mans-immune-system-got-a-cancer_killing-update
William Ludwig was almost dead when he became Patient Number One in a radical new cancer treatment, one that’s just won the endorsement of F.D.A. advisors.Photograph by sebastianosecondi / ShutterstockWilliam Ludwig was a 64-year-old retired corrections officer living in Bridgeton, New Jersey, in 2010, when he received a near-hopeless cancer prognosis. The Abramson Cancer Center at the University of Pennsylvania had run out of chemotherapeutic options, and Ludwig was disqualified from most clinical trials since he had three cancers at once—leukemia, lymphoma, and squamous cell skin cancer. In a later interview, the scientist Carl June described Ludwig’s condition as “Almost dead.” Alison Loren, an oncologist at Penn, had been taking care of Ludwig for five painful years. If chemotherapy is (...)
What Medicine Is Learning from Animals That Resist Cancer - Facts So Romantic
▻http://nautil.us/blog/what-medicine-is-learning-from-animals-that-resist-cancer
Beating cancer might come from animals that evolved defenses against it.Photograph by Patrick Bouquet / FlickrIn recent years, naked mole rats, elephants, and bowhead whales have caught the attention of cancer researchers. At first glance, these three don’t have much in common: naked mole rats are subterranean rodents; elephants roam above ground; and bowhead whales spend their lives in the sea. But they do. For one, they all have relatively long lifespans. Naked mole rats can live just over three decades, much longer than most other creatures their size; some elephants can live up to 70 years; and the average lifespan of a bowhead whale is two centuries. For another, these three species are also practically immune to cancer. It can be easy to forget that animals other than humans (...)
Trump’s New CDC Chief Championed Partnership with Coca-Cola to Solve Childhood Obesity
▻https://theintercept.com/2017/07/08/trumps-new-cdc-chief-championed-partnership-with-coca-cola-to-solve-ch
The new chief of the Centers for Disease Control and Prevention, which monitors significant public health concerns, including the impact of sugary beverages on obesity and heart disease, will be led by Brenda Fitzgerald, a Georgia physician whose signature childhood obesity project was underwritten by Coca-Cola.
Coca-Cola was so fond of Fitzgerald’s approach to obesity issues that an opinion column authored by Fitzgerald is featured prominently on Coca-Cola’s website.
Public health officials around the country have made obesity a top issue of concern. The United States has the distinction of having the highest rate of childhood obesity in the world, according to a recent report from the New England Journal of Medicine. And multiple reports have found that regular consumption of sugary beverages is a leading driver of obesity, which is linked to heart disease, diabetes, kidney diseases, cancers and hypertension.
More exercise, of course, is a good thing, but the Georgia SHAPE program notably eschewed another well-known step toward healthier living: curbing sugary beverage consumption
The CDC in particular has also been targeted by Coca-Cola, which has long disclosed attempts to lobby the agency to influence public health policy.
Emails obtained by U.S. Right to Know revealed that executives from Coca-Cola and the International Life Sciences Institute — an organization founded with support from Coca-Cola — had pressured the agency to partner with the soda giant and allow it to weigh in on debates over sugary soft drinks. In one particular email chain with a CDC official, a former Coca-Cola executive discussed strategies for influencing the World Health Organization’s call for greater regulation of soft drinks. The former Coca-Cola executive called the WHO’s efforts a “threat to our business,” and invited the CDC official out for dinner to further discuss ways to sway decisions at the international body. Clyde Tuggle, the former Coca-Cola executive, was included in the email chain.
Doctors raked in cash to push fentanyl as N.J. death rate exploded | NJ.com @fil
▻http://www.nj.com/healthfit/index.ssf/2017/06/doctors_raked_in_cash_to_push_powerful_fentanyl_as_nj_death_rate_soared.html
The most powerful opioid ever mass-marketed was designed to ease cancer patients into death.
It’s ideal for that: the drug is fast acting, powerful enough to tame pain that other opioids can’t and comes in a variety of easy delivery methods — from patches to lollipops.
But a dose the size of a grain of sand can kill you.
Meet fentanyl. It’s heroin on steroids. It’s killing people in droves. And, in New Jersey, you can get it after having your tonsils removed.
In fact, doctors who treat children’s colds and adult’s sore knees are prescribing it with alarming frequency, far more than oncologists easing end-of-life cancer pain.
The surge is stoked by companies that shell out hundreds of thousands of dollars a year to doctors, wining and dining them in hopes of convincing them that their particular brand of fentanyl is the solution to all their patients’ pain problems.
Evidently, it’s working.
An NJ Advance Media analysis has found that eight medical specialties in New Jersey have filed more Medicare claims for fentanyl than those by oncologists. Family practitioners, for example, filed at least five times as many claims for fentanyl from 2013 to 2015 than did cancer doctors.
“There are some powerful drivers of opioid prescriptions that have little to do with the presence of pain in the population,” said Dr. Caleb Alexander, co-director of the Center for Drug Safety and Effectiveness at Johns Hopkins University.
The investigation also reveals:
From 2013 to 2015, doctors in New Jersey were paid at least $1.67 million by pharmaceutical companies marketing various forms of fentanyl. In the same time period, fentanyl deaths in New Jersey increased from 42 in 2013 to 417 in 2015.
Since late 2011, enough fentanyl has been dispensed to allow every person who has died of cancer in New Jersey to fill a prescription for the drug eight times.
Doctors are being disciplined for improperly prescribing fentanyl, in several cases losing their licenses after their patients die while taking the drug.
#fentanyl #pharma #folie #corruption #santé
Pearlman was one of six INSYS employees arrested late in 2016 for allegedly running a cash-for-prescriptions scheme that paid off and bullied doctors into improperly prescribing Subsys
Sur le site de ▻http://www.subsys.com il y a un bandeau gris dépliable
Never give anyone else your SUBSYS. They could die from taking it. Store SUBSYS away from children and in a safe place to prevent stealing or abuse.
Selling or giving away SUBSYS is against the law.
3D-printed ovaries allow infertile mice to give birth | Science | The Guardian
▻https://www.theguardian.com/science/2017/may/16/3d-printed-ovaries-allow-infertile-mice-to-give-birth
Infertile mice have given birth to healthy pups after having their fertility restored with ovary implants made with a 3D printer.
Researchers created the synthetic ovaries by printing porous scaffolds from a gelatin ink and filling them with follicles, the tiny, fluid-holding sacs that contain immature egg cells.
In tests on mice that had one ovary surgically removed, scientists found that the implants hooked up to the blood supply within a week and went on to release eggs naturally through the pores built into the gelatin structures.
The work marks a step towards making artificial ovaries for young women whose reproductive systems have been damaged by cancer treatments, leaving them infertile or with hormone imbalances that require them to take regular hormone-boosting drugs.
[…]
Of seven mice that mated after receiving the artificial ovaries, three gave birth to pups that had developed from eggs released by the implants. The mice fed normally on their mother’s milk and went on to have healthy litters of their own later in life.
L’article de Nature (mai 2017) est entièrement accessible
A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice | Nature Communications
▻https://www.nature.com/articles/ncomms15261
Abstract
Emerging additive manufacturing techniques enable investigation of the effects of pore geometry on cell behavior and function. Here, we 3D print microporous hydrogel scaffolds to test how varying pore geometry, accomplished by manipulating the advancing angle between printed layers, affects the survival of ovarian follicles. 30° and 60° scaffolds provide corners that surround follicles on multiple sides while 90° scaffolds have an open porosity that limits follicle–scaffold interaction. As the amount of scaffold interaction increases, follicle spreading is limited and survival increases. Follicle-seeded scaffolds become highly vascularized and ovarian function is fully restored when implanted in surgically sterilized mice. Moreover, pups are born through natural mating and thrive through maternal lactation. These findings present an in vivo functional ovarian implant designed with 3D printing, and indicate that scaffold pore architecture is a critical variable in additively manufactured scaffold design for functional tissue engineering.
C’est dingue ! Je comprend que la première phrase mais faire développer des ovules dans une souris stérile et d’une espèce aussi éloignée de la souris que le chien c’est bleuffant.
Est-ce qu’une souris pourrait faire un ovule de #mammouth ?
J’ai eu le même reflexe que toi @mad_meg , mais en fait dans ce contexte, je crois que « pup » veut simplement dire « bébé » (donc « bébé souris »), pas « bébé chien »...
arf domage ^^
Bon une souris stérile qui fait des souriceaux avec un implant 3D ca reste quand même bleuffant
Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization
▻http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1006077
Extra-virgin olive oil (EVOO), a central component of the Mediterranean diet, contains an abundance of phenolic antioxidants that are potent inhibitors of reactive oxygen species and is associated with a reduced risk for several types of human cancer.1 Giacosa A, Barale R, Bavaresco L, Gatenby P, Gerbi V, Janssens J, Johnston B, Kas K, La Vecchia C, Mainguet P, et al. Cancer prevention in Europe: the Mediterranean diet as a protective choice. Eur J Cancer Prev 2013; 22:90–5; PMID:22644232; ▻http://dx.doi.org/10.1097/CEJ.0b013e328354d2d7[CrossRef], [PubMed], [Web of Science ®], [Google Scholar] Polyphenolic secoiridoids of EVOO have been shown to decrease viability of HER2-overexpressing breast cancer cells by selectively inducing apoptotic cell death.2 Menendez JA, Vazquez-Martin A, Colomer R, Brunet J, Carrasco-Pancorbo A, Garcia-Villalba R, Fernandez-Gutierrez A, Segura-Carretero A. Olive oil’s bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells. BMC Cancer 2007; 7:80; PMID:17490486; ▻http://dx.doi.org/10.1186/1471-2407-7-80[CrossRef], [PubMed], [Web of Science ®], [Google Scholar] (-)-Oleocanthal (OC), a di-aldehydic form of ligostride aglycone that has been isolated from EVOO, possesses a wide range of biological effects. Previous studies have reported its activity as a potent antioxidant; a nonsteroidal anti-inflammatory agent that inhibits COX-1 and COX-2; a neuroprotectant that alters the structure and function of the neurotoxins β-amyloid and Tau, which are associated with the debilitating effects of Alzheimer disease; an inhibitor of proliferation, migration, and invasion of human breast and prostate cancer cells through c-Met inhibition; an inhibitor of AMPK in colon cancer cells; and an inhibitor of macrophage inflammatory protein-1α in multiple myeloma.3-8 Beauchamp GK, Keast RS, Morel D, Lin J, Pika J, Han Q, Lee CH, Smith AB, Breslin PA. Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature 2005; 437:45–6; PMID:16136122; ▻http://dx.doi.org/10.1038/437045a
Busnena BA, Foudah AI, Melancon T, El Sayed KA. Olive secoiridoids and semisynthetic bioisostere analogues for the control of metastatic breast cancer. Bioorg Med Chem 2013; 21:2117–27; PMID:23403296; ▻http://dx.doi.org/10.1016/j.bmc.2012.12.050
Elnagar AY, Sylvester PW, El Sayed KA. (-)-Oleocanthal as a c-Met inhibitor for the control of metastatic breast and prostate cancers. Planta Med 2011; 77:1013–9; PMID:21328179; ▻http://dx.doi.org/10.1055/s-0030-1270724
Monti MC, Margarucci L, Riccio R, Casapullo A. Modulation of tau protein fibrillization by oleocanthal. J Nat Prod 2012; 75:1584–8; PMID:22988908; ▻http://dx.doi.org/10.1021/np300384h
Scotece M, Gomez R, Conde J, Lopez V, Gomez-Reino JJ, Lago F, Smith AB 3rd, Gualillo O. Oleocanthal inhibits proliferation and MIP-1a expression in human multiple myeloma cells. Curr Med Chem 2013; 20:2467–75; PMID:23521677; ▻http://dx.doi.org/10.2174/0929867311320190006
Pitt J, Roth W, Lacor P, Smith AB 3rd, Blankenship M, Velasco P, De Felice F, Breslin P, Klein WL. Alzheimer’s-associated Ab oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal. Toxicol Appl Pharmacol 2009; 240:189–97; PMID:19631677; ▻http://dx.doi.org/10.1016/j.taap.2009.07.018
To investigate the anticancer effects of OC, we examined its effect on the viability and survival of cancerous and non-cancerous cells.
#cancer_recherche #anticancer #huile_d'olive #oléocanthal #inhibiteurs
milouse shared a status by st0m@mamot.fr
▻https://mamot.fr/@st0m
Aller, un autre truc bien optimiste pour cette matinée (en anglais) :▻https://tnw.to/2smawIe"Big data is like big tobacco. Presumed to be safe for decades and when we understood the cancer it brought, it was hard for people to quit."merci pour le lien @ervin
Cancer Isn’t a Logic Problem - Facts So Romantic
▻http://nautil.us/blog/cancer-isnt-a-logic-problem
The impulse that disruptive technologies employed by software engineers can be applied to biology, as an analog to a machine or computer with bugs which can be hacked or solved—suggested in “hacking cancer”—is deeply engrained. The problem goes back centuries.Photograph by N.I.H. Image Gallery / FlickrA year ago, Joe Biden launched his “cancer moonshot,” a major national push to improve the prevention, detection, and treatment of cancer, a plan that was widely recognized to be incremental. “I believe that we need an absolute national commitment to end cancer as we know it,” Biden said while he was on his tour to cancer centers at Penn and Duke University. “I’m not naïve. I didn’t think we could ‘end cancer.’ I’m not looking for a silver bullet. There is none.” Many thought the “moonshot” risked (...)
Boom in human gene editing as 20 CRISPR trials gear up | New Scientist
▻https://www.newscientist.com/article/2133095-boom-in-human-gene-editing-as-20-crispr-trials-gear-up
The CRISPR genome editing revolution continues to advance at an astounding pace. As many as 20 human trials will be under way soon, mostly in China, New Scientist has learned.
One of these trials will involve the first-ever attempt to edit cells while they are inside the body. The aim is to prevent cervical cancers by using CRISPR to target and destroy the genes of the human papillomavirus (HPV) that cause tumour growth. This study is due to begin in July at the First Affiliated Hospital of Sun Yat-Sen University in China.
Gene therapy, which involves adding extra genes to cells, was first used to cure people in 1990, but it is mainly useful for treating rare genetic disorders. In contrast, gene-editing, which involves altering existing genes inside cells, promises to treat or cure a much wider range of conditions, from HIV infection to high blood cholesterol.
The HPV trial, meanwhile, will break new ground. Instead of editing cells outside the body, a gel containing DNA coding for the CRISPR machinery will be applied to the cervix. The CRISPR machinery should leave the DNA of normal cells untouched, but in cells infected by HPV, it should destroy the viral genes, preventing them from turning cancerous.
“Targeting HPVs seems a sensible approach if they can deliver the genome-editing components to sufficient numbers of cells,” says Robin Lovell-Badge of the Crick Institute in the UK.
#génomique #médecine
“It is tricky to do these experiments in animals as they are not infectable by HPV,” says Bryan Cullen of Duke University Medical Center in North Carolina, whose group also hopes to use gene editing to get rid of HPV. But there is a risk of off-target mutations leading to cancer, he warns.