medicalcondition:heart attack

  • Liquid used in e-cigarettes damages cells crucial for a healthy heart - EHN
    https://www.ehn.org/vaping-hurts-your-heart-2638041485.html

    The flavors used in e-cigarettes—especially menthol and cinnamon—damage blood vessel cells and such impacts increase heart disease risk, according to a new study.

    The study, published today in the Journal of the American College of Cardiology, is the latest to link e-cigarettes, or vaping — which has been touted as a safer alternative to smoking cigarettes—to heart problems. It is the first study to test how e-liquids affect the endothelial cells that line the interior of blood vessels. These cells are crucial in delivering the blood supply to the bodies’ tissues and sending cells to promote healthy blood vessels, tissue growth and repair.

    E-cigarettes are small devices that heat up liquids (usually propylene glycol or glycerol) to deliver as aerosol (vape) mixture of nicotine and flavors.

    The study comes as e-cigarette use continues to rise. Roughly 1 in 20 U.S. adults now use e-cigarettes but the real growth is happening among youth: use among U.S. high school students went from 11.7 percent in 2017 to 20.8 percent in 2018, according to the U.S. Food and Drug Administration. In addition, about 4.9 percent of middle school students use e-cigarettes, the FDA found.

    The study was limited in that the e-liquids weren’t heated, which could alter how the exposed cells react. The research, however, is just the latest linking e-cigarettes to heart impacts.

    In March, researchers presented a study of nearly 100,000 Americans that found e-cigarette users are more likely to suffer heart attacks and strokes compared to non-users.

    Another large national study in January of 400,000 Americans reported e-cigarette users have a 70 percent higher risk of stroke and a 60 percent higher risk of heart attack, when compared to non-users.

    With use rising, health groups continue to push for more strict regulation. A judge this month ordered the FDA to review all U.S. e-cigarette products.

    The ruling was a response to a federal lawsuit filed by health groups, including the American Academy of Pediatrics and the Campaign for Tobacco-Free Kids, that alleged the FDA hasn’t adequately regulated e-cigarettes and is leaving a generation of U.S kids on the path to nicotine addiction.

    #Tabac #E_cigarettes #Vaping #Santé_publique

  • Long-Term Use of Antibiotics Tied to Heart Risks - The New York Times
    https://www.nytimes.com/2019/04/24/well/live/long-term-use-of-antibiotics-tied-to-heart-risks.html

    Using antibiotics for two months or longer may be linked to an increase in a woman’s risk for cardiovascular disease.

    The finding, published in the European Heart Journal, applied to women who used the drugs when they were 40 and older.

    Researchers used data on 36,429 women free of cardiovascular disease at the start of the study who were participating in a continuing long-term health study. Beginning in 2004, the women reported their use of antibiotics.

    Over seven years of follow-up, there were 1,056 cases of cardiovascular disease. Compared with women who never used them, women who used antibiotics for two months or longer during their 40s and 50s had a 28 percent increased risk for cardiovascular disease, and women over 60 who used them that long had a 32 percent increased risk.

    The study controlled for family history of heart attack, body mass index, hypertension, the use of other medications and other factors.

    “It’s difficult to distinguish the effect of the antibiotic on cardiovascular disease from the effect of the disease for which the antibiotic was taken, and that’s a potential limitation of the study,” said the lead author, Lu Qi, now a professor of epidemiology at Tulane University. “But that we are seeing the effect of the disease instead of the antibiotic is unlikely, because we see the effect in so many different diseases where antibiotics are used.”

    #antibiotique #risque_cardiovasculaire #femmes

  • A Wake Up Call to Hit the Sack | The Tyee
    https://thetyee.ca/Culture/2018/11/05/Why-We-Sleep-Science-Sleep-Dreams

    For a day or two after the end of daylight saving time, emergency rooms all over North America are a little less stressed. Very predictably, they have to deal with fewer heart attacks and fewer auto-accident injuries, because people will have had an extra hour of sleep on Nov. 4.

    (...) heart attacks and auto accidents spike just after daylight saving starts in the spring, and everyone is short an hour of sleep. We are indeed killing ourselves by not getting enough sleep

    #sommeil #santé

  • Harvard Calls for Retraction of Dozens of Studies by Noted Cardiologist - The New York Times
    https://www.nytimes.com/2018/10/15/health/piero-anversa-fraud-retractions.html

    A prominent cardiologist formerly at Harvard Medical School and Brigham and Women’s Hospital in Boston fabricated or falsified data in 31 published studies that should be retracted, officials at the institutions have concluded.

    The cardiologist, Dr. Piero Anversa, produced research suggesting that damaged heart muscle could be regenerated with stem cells, a type of cell that can transform itself into a variety of other cells.

    Although other laboratories could not reproduce his findings, the work led to the formation of start-up companies to develop new treatments for heart attacks and stroke, and inspired a clinical trial funded by the National Institutes of Health.

    “A couple of papers may be alarming, but 31 additional papers in question is almost unheard-of,” said Benoit Bruneau, associate director of cardiovascular research at the Gladstone Institutes in San Francisco. “It is a lab’s almost entire body of work, and therefore almost an entire field of research, put into question.”

    #Fraude_scientifique #Conflits_intérêt #Science

  • » Detainee ‘Oweisat Dies From His Serious Wounds Inflicted by Israeli Soldiers
    IMEMC News | May 21, 2018 3:22 AM
    http://imemc.org/article/detainee-oweisat-dies-from-his-serious-wounds-inflicted-by-israeli-soldiers

    The Palestinian Detainees’ Committee has reported that detainee Aziz ‘Oweisat, 53, died at an Israeli hospital from serious complications after he was assaulted by several Israeli soldiers in the prison, who claimed he attacked an officer with a sharp object.

    The Committee said ‘Oweisat, from Jabal al-Mokabber in occupied Jerusalem, was taken prisoner on March 24, 2014, and was sentenced to a life term.

    The Committee added that he suffered brain hemorrhage and a heart attack after the soldiers continuously assaulting him in Eshil Israeli prison, on May 2, 2018, and went into a coma before he was moved to Ramla Israeli Medical Center.

    Later, the detainee was moved to Assaf Harofeh Medical Center due to the seriousness of his condition, but he suffered further deterioration, and was transferred to Tal HaShomer Medical Center.

    On May 10th, 2018, he underwent heart surgery at Tal HaShomer Israeli Medical Center, and lasted for nearly three hours.

    Despite his serious condition, he was returned a few days ago to Assaf Harofeh Medical Center, after the Administration of Tal HaShomer refused to keep him hospitalized at their facility.

    The Detainees’ Committee said he died at Assaf Harofeh Medical Center, due to the seriousness of his condition.

    It is worth mentioning that the Detainees’ Committee filed an urgent appeal with an Israeli court asking for his release so that he could receive steady medical attention, and the court scheduled the hearing for May 25th. He did not make it to the hearing, however, since he died on May 20th.

    The detainees in Israeli prisons and detention camps declared a three-day mourning period, and demanded that Israel be held accountable for its violations and crimes.

    For its part, the Palestinian Prisoners’ Society (PPS) held Israel fully responsible for his death, especially since the Israeli Prison Authority refused to release him despite its knowledge of his serious condition.

    It added that seven Palestinian detainees have died in the last five years after being denied medical attention, in addition to ‘Oweisat.

    #Palestine_assassinée

  • The demise of the nation state | News | The Guardian

    https://www.theguardian.com/news/2018/apr/05/demise-of-the-nation-state-rana-dasgupta

    After decades of globalisation, our political system has become obsolete – and spasms of resurgent nationalism are a sign of its irreversible decline. By Rana Dasgupta

    Thu 5 Apr 2018 06.00 BST

    What is happening to national politics? Every day in the US, events further exceed the imaginations of absurdist novelists and comedians; politics in the UK still shows few signs of recovery after the “national nervous breakdown” of Brexit. France “narrowly escaped a heart attack” in last year’s elections, but the country’s leading daily feels this has done little to alter the “accelerated decomposition” of the political system. In neighbouring Spain, El País goes so far as to say that “the rule of law, the democratic system and even the market economy are in doubt”; in Italy, “the collapse of the establishment” in the March elections has even brought talk of a “barbarian arrival”, as if Rome were falling once again. In Germany, meanwhile, neo-fascists are preparing to take up their role as official opposition, introducing anxious volatility into the bastion of European stability.

    #état_nation #libéralisme #capitalisme #mondialisation

    • US : Poor Medical Care, Deaths, in Immigrant Detention

      Poor medical treatment contributed to more than half the deaths reported by US Immigration and Customs Enforcement (ICE) during a 16-month period, Human Rights Watch, the American Civil Liberties Union, Detention Watch Network, and National Immigrant Justice Center said in a report released today.

      Based on the analysis of independent medical experts, the 72-page report, “Code Red: The Fatal Consequences of Dangerously Substandard Medical Care in Immigration Detention,” examines the 15 “Detainee Death Reviews” ICE released from December 2015 through April 2017. ICE has yet to publish reviews for one other death in that period. Eight of the 15 public death reviews show that inadequate medical care contributed or led to the person’s death. The physicians conducting the analysis also found evidence of substandard medical practices in all but one of the remaining reviews.

      “ICE has proven unable or unwilling to provide adequately for the health and safety of the people it detains,” said Clara Long, a senior US researcher at Human Rights Watch. “The Trump administration’s efforts to drastically expand the already-bloated immigration detention system will only put more people at risk.”

      12 people died in immigration detention in fiscal year 2017, more than any year since 2009. Since March 2010, 74 people have died in immigration detention, but #ICE has released death reviews in full or in part in only 52 of the cases.

      Based on the death reviews, the groups prepared timelines of the symptoms shown by people who died in detention and the treatment they received from medical staff, along with medical experts’ commentary on the care documented by ICE and its deviations from common medical practice. The deaths detailed in the report include:

      Moises Tino-Lopez, 23, had two seizures within nine days, each observed by staff and reported to the nurses on duty in the Hall County Correctional Center in Nebraska. He was not evaluated by a physician or sent to the hospital after the first seizure. During his second seizure, staff moved him to a mattress in a new cell, but he was not evaluated by a medical practitioner. About four hours after that seizure, he was found to be unresponsive, with his lips turning blue. He was sent to the hospital but never regained consciousness and died on September 19, 2016.
      Rafael Barcenas-Padilla, 51, had been ill with cold symptoms for six days in the Otero County Processing Center in New Mexico when his fever reached 104, and nurses recorded dangerously low levels of oxygen saturation in his blood. A doctor, consulted by phone, prescribed a medication for upper respiratory infections. The ICE detention center didn’t have the nebulizer needed to administer one of the medicines, so he did not receive it, and he showed dangerously low oxygen readings that should have prompted his hospitalization. Three days later, he was sent to the hospital, where he died from bronchopneumonia on April 7, 2016.
      Jose Azurdia, 54, became ill and started vomiting at the Adelanto Detention Facility in California. A guard told a nurse about Azurdia’s condition, but she said that “she did not want to see Azurdia because she did not want to get sick.” Within minutes, his arm was numb, he was having difficulty breathing, and he had pain in his shoulder and neck – all symptoms of a heart attack. Due to additional delays by the medical staff, two hours passed before he was sent to the hospital, with his heart by then too damaged to respond to treatment. He died in the hospital four days later, on December 23, 2015.

      “Immigrant detention centers are dangerous places where lives are at risk and people are dying,” said Silky Shah, executive director of Detention Watch Network, a national coalition that exposes the injustices of the US’ immigration detention and deportation system. “The death toll amassed by ICE is unacceptable and has proven that they cannot be trusted to care for immigrants in their custody.”

      In fiscal year 2017, ICE held a daily average of nearly 40,500 people, an increase of nearly 500 percent since 1994. The Trump administration has asked Congress to allocate $2.7 billion for fiscal year 2019 to lock up a daily average of 52,000 immigrants in immigration detention facilities, a record number that would represent a 30 percent expansion from fiscal year 2017.

      “To the extent that Congress continues to fund this system, they are complicit in its abuses,” said Heidi Altman, policy director at the National Immigrant Justice Center, a nongovernmental group dedicated to ensuring human rights protections and access to justice for all immigrants, refugees, and asylum seekers. “Congress should immediately act to decrease rather than expand detention and demand robust health, safety, and human rights standards in immigration detention.”

      The new report is an update of a 2017 Human Rights Watch report that examined deaths in detention between 2012 and 2015, as well as a 2016 report by the American Civil Liberties Union, the Detention Watch Network, and the National Immigrant Justice Center that examined deaths in detention between 2010 and 2012.

      The medical experts who analyzed the death reviews for the groups include Dr. Marc Stern, the former health services director for the Washington State Department of Corrections; Dr. Robert Cohen, the former director of Montefiore Rikers Island Health Services; and Dr. Palav Babaria, the chief administrative officer of Ambulatory Services at Alameda Health System in Oakland, California, and assistant clinical professor in Internal Medicine at the University of California, San Francisco.

      Six of the new deaths examined occurred at facilities operated by the following private companies under contract with ICE: #CoreCivic, #Emerald_Correctional_Management, the #GEO_Group, and the #Management_and_Training_Corporation (#MTC).

      “ICE puts thousands of people’s health and lives at risk by failing to provide adequate medical care to the people it detains for weeks, months, and even years,” said Victoria Lopez, senior staff attorney at the American Civil Liberties Union.


      https://www.hrw.org/news/2018/06/20/us-poor-medical-care-deaths-immigrant-detention
      #privatisation #mourir_en_rétention #mourir_en_détention_administrative

      https://www.youtube.com/watch?v=VL9IKGoozII

  • Scientists Discover a Bone-Deep Risk for Heart Disease - The New York Times
    https://www.nytimes.com/2018/01/29/health/heart-disease-mutations-stem-cells.html

    L’accumulation d’un clone de cellules souches hématopoïétiques mutées appelées « #CHIP » (pour « Clonal hematopoiesis of indeterminate potential »), apparaît tôt ou tard avec l’âge et est un facteur de risque indépendant d’#athérosclérose.

    CHIP [...] increases a person’s risk of dying within a decade, usually from a heart attack or stroke, by 40 or 50 percent.

    The condition becomes more likely with age. Up to 20 percent of people in their 60s have it, and perhaps 50 percent of those in their 80s.

    But how might mutated white blood cells cause heart disease? One clue intrigued scientists.

    Artery-obstructing plaque is filled with white blood cells, smoldering with inflammation and subject to rupture. Perhaps mutated white cells were causing atherosclerosis or accelerating its development.

    In separate studies, Dr. Ebert and Dr. Walsh gave mice a bone-marrow transplant containing stem cells with a CHIP mutation, along with stem cells that were not mutated. Mutated blood cells began proliferating in the mice, and they developed rapidly growing plaques that were burning with inflammation.

    “For decades people have worked on #inflammation as a cause of atherosclerosis,” Dr. Ebert said. “But it was not clear what initiated the inflammation.”

    Now there is a possible explanation — and, Dr. Ebert said, it raises the possibility that CHIP may be involved in other inflammatory diseases, like arthritis.

    #santé

  • EXCLUSIVE: Senior Saudi royal on hunger strike over purge | Middle East Eye
    http://www.middleeasteye.net/news/senior-saudi-royal-hunger-strike-722949715
    http://www.middleeasteye.net/sites/default/files/main-images/Talal+bin%20Abdulaziz.AFP_.jpg

    Prince Talal bin Abdulaziz, the father of Alwaleed bin Talal and first progressive reformer in the House of Saud, has gone on a hunger strike in protest at the purge being carried out by his nephew Crown Prince Mohammed bin Salman and the detention of three of his own sons.

    The 86-year-old prince, who is the half brother of King Salman, stopped eating on 10 November, shortly after his first son, Alwaleed, was arrested on 4 November, and has lost 10 kilos in one month.

    Last week, a feeding tube was inserted into him, but his condition at the King Faisal Hospital in Riyadh remains weak, according to several people who have visited him.

    (...) Prince Talal is known as a liberal. A former finance minister in the government of King Saud (1953-64), he became known as the Red Prince in the 1960s for leading the Free Princes Movement which called for an end to the absolute monarchy.

    But the royal family rejected the movement and Talal was forced into exile in Cairo before his mother was able to engineer a reconciliation with the family.

    Talal campaigned for women’s rights long before the decision in September to allow Saudi women to drive. The prince said in one interview: “Saudi women will take their rights eventually... the march towards that should not stop and we have to accelerate this a bit."

    The prince has continued to campaign for a constitutional monarchy and the instigation of the separation of powers, which he claims is enshrined in the constitution.

    (...) In addition to Alwaleed and his brothers, other princes are still in detention. They include Turki bin Nasser, Turki bin Abdullah, and Fahd bin Abdullah bin Abdulrahman.

    There is no definitive word of the fate of Abdulaziz bin Fahd. There are persistent accounts that he resisted arrest, and during the fight that ensued, he suffered a stroke or a heart attack. He is believed still to be alive, but in a vegetative state, according to several sources.

    Mohammed bin Nayef, the former crown prince, ousted in a palace coup conducted before the November purge, and Prince Miteb bin Abdullah, who was arrested as part of the purge, have reportedly been released.

    Officials close to MbS have staged public appearances for Miteb, including an encounter in which bin Salman publicly kissed the man he imprisoned and had mistreated physically. This piece of theatre was staged at an annual horse race for locally bred and imported horses in Janadriyah.

    #prison_dorée #arabie_saoudite

  • Elderly Palestinian woman dies of heart attack during Israeli raid on her home
    Dec. 13, 2017 12:20 P.M. (Updated: Dec. 13, 2017 1:08 P.M.)
    http://www.maannews.com/Content.aspx?ID=779621

    JERICHO (Ma’an) — A 60-year-old Palestinian woman suffered a fatal heart attack overnight between Tuesday and Wednesday when Israeli army soldiers raided her home in the village of al-Zubeidat, north of Jericho in the northeastern occupied West Bank.

    Official Palestinian Authority (PA)-owned Wafa news agency reported that Hamda Zubeidat , 60, suffered a heart attack after Israeli soldiers threw a stun grenade at her house during a raid on the town.

    Despite efforts to revive her, Wafa reported, Zubeidat died shortly after.

    “The soldiers raided the village after midnight, causing panic and fear among residents, throwing stun grenades at homes,” Wafa reported, adding that “no reason was given for the raid.”

    #Palestine_assassinée

  • U.S. Black Mothers Die In Childbirth At Three Times The Rate Of White Mothers : NPR
    https://www.npr.org/2017/12/07/568948782/black-mothers-keep-dying-after-giving-birth-shalon-irvings-story-explains-why

    Black women are more likely to be uninsured outside of pregnancy, when Medicaid kicks in, and thus more likely to start prenatal care later and to lose coverage in the postpartum period. They are more likely to have chronic conditions such as obesity, diabetes and hypertension that make having a baby more dangerous. The hospitals where they give birth are often the products of historical #segregation, lower in quality than those where white mothers deliver, with significantly higher rates of life-threatening complications.

    Those problems are amplified by unconscious #biases that are embedded in the medical system, affecting quality of care in stark and subtle ways. In the more than 200 stories of #African-American mothers that ProPublica and NPR have collected over the past year, the feeling of being devalued and disrespected by medical providers was a constant theme.

    There was the new mother in Nebraska with a history of hypertension who couldn’t get her doctors to believe she was having a heart attack until she had another one. The young Florida mother-to-be whose breathing problems were blamed on obesity when in fact her lungs were filling with fluid and her heart was failing. The Arizona mother whose anesthesiologist assumed she smoked marijuana because of the way she did her hair. The Chicago-area businesswoman with a high-risk pregnancy who was so upset at her doctor’s attitude that she changed OB/GYNs in her seventh month, only to suffer a fatal postpartum stroke.
    Over and over, black women told of medical providers who equated being African-American with being poor, uneducated, noncompliant and unworthy. “Sometimes you just know in your bones when someone feels contempt for you based on your #race,” said one Brooklyn, N.Y., woman who took to bringing her white husband or in-laws to every prenatal visit. Hakima Payne, a mother of nine in Kansas City, Mo., who used to be a labor and delivery nurse and still attends births as a midwife-doula, has seen this cultural divide as both patient and caregiver. “The nursing culture is white, middle-class and female, so is largely built around that identity. Anything that doesn’t fit that #identity is suspect,” she said. Payne, who lectures on unconscious bias for professional organizations, recalled “the conversations that took place behind the nurse’s station that just made assumptions; a lot of victim-blaming — ’If those people would only do blah, blah, blah, things would be different.’”
    ...
    But it’s the discrimination that black women experience in the rest of their lives — the double whammy of race and gender — that may ultimately be the most significant factor in poor maternal outcomes.

    “It’s chronic stress that just happens all the time — there is never a period where there’s rest from it. It’s everywhere; it’s in the air; it’s just affecting everything,” said Fleda Mask Jackson, an Atlanta researcher who focuses on birth outcomes for middle-class black women.

    It’s a type of stress for which education and class provide no protection. “When you interview these doctors and lawyers and business executives, when you interview African-American college graduates, it’s not like their lives have been a walk in the park,” said Michael Lu, a longtime disparities researcher and former head of the Maternal and Child Health Bureau of the Health Resources and Services Administration, the main federal agency funding programs for mothers and infants. “It’s the experience of having to work harder than anybody else just to get equal pay and equal respect. It’s being followed around when you’re shopping at a nice store, or being stopped by the police when you’re driving in a nice neighborhood.”

    #racisme #États_Unis #maternité

  • Facebook & Russian election meddling: The FEC’s Ann Ravel sounded the alarm in 2015 — Quartz
    https://qz.com/1076964/this-us-official-warned-about-russia-using-the-internet-to-skew-us-elections-yea
    https://qzprod.files.wordpress.com/2017/10/ap_358110062825-e1508362801776.jpg?quality=80&strip=all&w=16

    In October 2014, vice commissioner Ann M. Ravel wrote a statement (pdf) accusing the FEC of turning a “blind eye” to the growing force of the internet in politics, and explaining the reason she and two of her co-commissioners, all Democrats, had voted for more disclosure of funding of political material on the web:

    Some of my colleagues seem to believe that the same political message that would require disclosure if run on television should be categorically exempt from the same requirements when placed on the internet alone. As a matter of policy, this simply does not make sense. … This effort to protect individual bloggers and online commentators has been stretched to cover slickly produced ads aired solely on the internet but paid for by the same organizations and the same large contributors as the actual ads aired on TV.

    The FEC had just undertaken a vote on the topic that ended in a deadlock, with three Republicans voting against their Democratic colleagues, a common impasse in the increasingly dysfunctional agency tasked with keeping US elections fair and transparent. Nonetheless, Ravel’s statement sparked outcry and anger, especially from conservatives who equated money spent on political advertising on the internet to “free speech”—the same argument that won the landmark 2010 “Citizens United” Supreme Court case, sending a torrent of cash into political elections.

    A day after Ravel published her statement, co-commissioner Lee Goodman, a Republican, appeared on Fox & Friends (video) to warn that the three Democrats wanted to censor free speech online, and set up a “regulatory regime” that would reach deep into the internet. “Boy, I thought Democrats were for free speech,” commentated the Fox anchor interviewing him, Tucker Carlson. “That was obviously an earlier species.”

    Ravel says Goodman’s Fox appearance unleashed a torrent of abuse. The issue was picked up by Drudge Report, Breitbart, and other right-wing news sites, which singled her out. Responses poured in from Twitter and e-mail, ranging from death threats to misogyny, everything from “stick it up your c-nt,” she recalled this week, to “You’re the kind of person the Second Amendment was made for.” They also included “Hope you have a heart attack,” and “You will more than likely find the ‘Nazi’ scenario showing its ugly head,” the Center for Public Integrity, a nonpartisan group that investigates democracy, reported (Ravel is Jewish).

    Despite the backlash to her 2014 push to get Facebook and other internet companies to be more transparent about where their ad revenue was coming from, Ravel kept pursuing the issue. In 2015, the FEC grappled with the topic of how to make sure foreign money wasn’t being used to pay for political advertisements on the internet, a clear violation of a federal law.

    In doing so, Ravel even anticipated Putin’s influence. “I mean, think of it, do we want Vladimir Putin or drug cartels to be influencing American elections?” Ravel asked in an October of 2015 meeting, while pushing for the commission to require state and local campaigns to declare foreign contributions. The commission tried once again to hash out what was “local” or “national” given the internet’s global reach.

    #Publicité #Politique #USA #Régulation #Menaces

  • Global cost of obesity-related illness to hit $1.2tn a year from 2025 | Society | The Guardian
    https://www.theguardian.com/society/2017/oct/10/treating-obesity-related-illness-will-cost-12tn-a-year-from-2025-expert

    The cost of treating ill health caused by obesity around the world will top $1.2tn every year from 2025 unless more is done to check the rapidly worsening epidemic, according to new expert estimates.

    Obesity and smoking are the two main drivers behind the soaring numbers of cancers, heart attacks, strokes and diabetes worldwide, grouped together officially as non-communicable diseases. They are the biggest killers of the modern world.
    Supersize us: upselling is fuelling the obesity epidemic, warns report
    Read more

    #santé #obésité

  • Is fat bad for you ? — Quartz
    https://qz.com/969095/is-fat-bad-for-you
    https://qzprod.files.wordpress.com/2017/04/look-at-all-that-good-fat-edit.jpg?quality=80&strip=all&w=16

    In all the studies they could find, lowering fat levels in diets failed to reduce heart attacks, strokes, or other kinds of heart disease. Although cholesterol from fats is bad, it’s been overly vilified.

    (…) The authors of the review don’t specifically say why there’s been a reporting bias around the risk of cholesterol, fats, and heart health. But they do make a point to say there’s “no business model or market” for promoting good diet and exercise.
    The global market for statins, the drugs that lower LDL cholesterol, was $20.5 billion in 2011.

    #pharma #gras #cœur #santé

  • Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease
    http://www.nejm.org/doi/full/10.1056/NEJMoa1615664#t=article

    Pratiquement toujours en prévention secondaire et presque toujours associé à une #statine,

    Il ressort que la réduction du risque cardio-vasculaire est loin d’être à la hauteur de la réduction du taux de LDL et ... du prix de ce médicament (14.000 USD/an)

    • An End to Heart Disease? Not Quite
      https://www.nytimes.com/2017/03/20/health/ldl-cholesterol-heart-disease-drugs-pcsk9-inhibitors.html

      On Friday, investigators reported the results of a highly anticipated trial of a PCSK9 inhibitor called evolocumab (brand name Repatha). This medication reduced LDL levels to an almost unfathomable 30 mg/dl from about 90 mg/dl on average, which is typically considered low.

      Over about two years of study, the researchers found that the new drug, when added to statin therapy, further reduced the risk of heart attack or stroke by about 15 percent. For about every 70 people treated with the drug, one person benefited in this way. This is not far off the size of the benefit that statins provide.

      So the drug works, which is good news for patients. And no safety concerns emerged. But the applause from heart experts has been muted, because expectations were so much higher. Their hope had been that drastically low LDL cholesterol levels would make it difficult — or even impossible — to have a heart attack.

  • Serving the Leviathan | Jacobin
    https://www.jacobinmag.com/2017/01/iran-rafsanjani-ahmadinejad-khamenei-reform

    Akbar Hashemi Rafsanjani, the chairman of Iran’s Expediency Discernment Council, died of a heart attack on January 8, 2017. Various factions immediately tried to claim this “pillar of the revolution” in the name of their competing political objectives. The wily politician would have surely recognized this technique of marshaling the spirits of the dead to score points for short-term political gain.

    Temperate “principalists” (usulgarayan), technocratic conservatives (eʿtedaliyyun), and reformists (eslahtalaban) — that is, much of the Iranian political class — saw something in the elderly statesman’s legacy worth appropriating. In this way, his death mirrors his life: during his sixty-plus years of political activity, he became many things to many people, while his ultimate objectives often remained opaque, if not virtually impossible to discern.

    Mahmoud Ahmadinejad and others often painted this postrevolutionary pragmatist as a corrupt and arrogant patrician who had cast aside revolutionary austerity in favor of decadent opulence. The accusation resonated far beyond Ahmadinejad’s supporters, aligning with popular slogans that denounced the two-time president as “Akbar Shah” (meaning King Akbar, Great Shah) and compelling ordinary citizens to scrawl dozd (thief) on many of his campaign posters during the 2005 presidential campaign. He was also known to many as “the shark” (kuseh) on account of his inability to grow a fully fledged beard, though others felt it described his political modus operandi to a tee.

    By 2009, however, he seemed to have aligned himself with the Green Movement, drawing closer to the reformists he once opposed. His intermittent criticisms of the Ahmadinejad government endeared him to many, who began to see him as one of the few establishment voices willing to openly defy the administration and by extension, his old ally, the Supreme Leader Ali Khamenei. He became inextricably linked with the trope of “moderation,” a powerful idea in a country on the precipice, especially after the UN imposed sanctions of 2006.

    Many others remained skeptical, however, unable to forget his reputation as an arch-Machiavellian. They recycled urban legends about his family’s wealth, reinforcing his image as a power-obsessed wheeler-and-dealer.
    Resisting the Shah

    Born in 1934, Akbar Hashemi Bahremani grew up on his family’s small farm in the village of Bahreman in the Nuq district of Rafsanjan, Kerman province. At the behest of his father, he studied in a traditional maktab, but was still expected to help tend to the animals and orchards in a region renowned for its prized pistachio. His paternal uncle was a cleric who often took to the village pulpit, and at the age of fourteen, he left for Qom to study at the Shiʿi seminary, the chief center of Islamic learning in Iran.

    Through the Maraʿshi brothers (Akhavan-e Maraʿshi), Kazem and Mehdi, fellow Rafsanjanis, with whom he lived for a number of years, Akbar quickly came to know Seyyed Ruhollah Khomeini, then a relatively junior mojtahed and esteemed teacher of philosophy and mysticism. In Rafsanjani’s memoir, The Period of Struggle, he recalls how he was immediately captivated by the “majesty” of Khomeini’s visage and demeanor. Thus began an extremely close and fruitful relationship that would last the remainder of Khomeini’s lifetime. Indeed, Rafsanjani’s final resting place is alongside his political and spiritual patron.

    In Qom, Rafsanjani rapidly got involved in political life and activism and found himself attracted to the militant Devotees of Islam (Fadaʾiyan-e Islam), led by Seyyed Mojtaba Mirlowhi, better known as Navvab-e Safavi or “Prince of the Safavids,” whose meetings he would attend at every opportunity. The group tried to convince the Qom seminary to agitate for a strict and unforgiving nomocratic order, but with little success. Under the guidance of Grand Ayatollah Boroujerdi, the overwhelming majority of the Qom seminary rejected the message of the Fadaʾiyan, at one point running them out of town.

    Rafsanjani was studying in Qom during the years of anticolonial fervor after Prime Minister Mosaddeq nationalized the Anglo-Iranian Oil Company (BP). He encountered Mosaddeq’s one-time clerical ally, Ayatollah Seyyed Abolqasem Kashani, who became one of the Fadaʾiyan’s initial patrons. Kashani eventually turned on Mosaddeq, and, in August 1953, a joint CIA-MI6 orchestrated coup d’état ousted the prime minister.

    After the revolution, even while expressing his support for the national movement, Rafsanjani blamed Mosaddeq’s National Front and the communist Tudeh Party for their role in weakening the seminary during this period. But he still recalled with pride how the former prime minister contributed to printing and distributing his translation of The Journey of Palestine, a translation of a popular book on Palestine written in Arabic by Akram Zwayter, a Jordanian ambassador to Tehran. Published in semi-illicit form in 1961, this book marked the beginning of a long career in which he became the most prolific statesman-cum-author of the postrevolutionary era.

    In 1955, Navvab was executed by firing squad, but vestiges of the Fadaʾiyan persisted, creating a vital network of clerical and lay activists in the country’s mosques and bazaars. Rafsanjani became an important organizer inside the country, following Khomeni’s exile in 1964. In January 1965, he was arrested by the Shah’s infamous secret police, SAVAK, for his role in the assassination of the pro-American premier, Hassan ʿAli Mansur. Later recollections by members of the Islamic Coalition Society have since admitted it was Rafsanjani who supplied the weapon. From 1958 until the revolution he was arrested on several occasions. He persisted in his activism despite the abuse and torture he suffered at the hands of the SAVAK, publishing illegal periodicals and distributing Khomeini’s communiqués from Najaf. It was also in 1958 that he married ʿEffat Maraʿshi, the daughter of a fellow cleric from Rafsanjan. His companion of almost sixty years, she would come to exude a formidable matriarchal presence on the Iranian political scene throughout the 1990s and 2000s.

    Rafsanjani also managed to travel to the United States and Japan during these years. Many regard the latter as especially formative for his worldview and proclivity toward the seemingly indigenous, albeit technologically advanced, version of modernization he would seek to exact during his own time in power. He also penned a volume on the nationalist icon Amir Kabir (who died in 1852), who tried to streamline the Qajar court’s expenditures, consolidating the weak Iranian state in Tehran while importing technical and military know-how. That Rafsanjani died on the anniversary of Amir Kabir’s murder has only fueled the flood of hagiographies.
    Internal Divisions

    On February 5, 1979, Rafsanjani made his first public appearance facing the world’s media with Khomeini during Mehdi Bazargan’s introduction as prime minister of the Provisional Revolutionary Government. He began his government apprenticeship as deputy interior minister, and soon found common ground with another junior minister, Seyyed Ali Khamenei, who held the same role in defense. More importantly, Rafsanjani also served on the revolutionary council, a secretive body dominated by clerics loyal to Khomeini that was created in lieu of a legislative branch of state.

    Rafsanjani and Khamenei were on a pilgrimage to Mecca when they learned that radical students, who called themselves the Muslim Student Followers of the Imam’s Line, had overrun the United States embassy on November 4, 1979. They had by this time become leading officials of the Islamic Republic Party (IRP), and Bazargan’s resignation thrust both men into the limelight. Rafsanjani took over the interior ministry and organized the first presidential elections of 1980. In the spring of that year, he was elected to the Majlis (parliament) and became speaker, a post he turned into a personal stronghold for most of the following decade.

    Rafsanjani remained steadfastly loyal to Khomeini and led the clerical front that ultimately marginalized competing revolutionary organizations in the early 1980s. But their relationship was not always easy. Together with Khamenei, Rafsanjani lobbied Khomeini to allow clerical candidates into the first presidential election; his mentor’s refusal paved the way for the victory of layman Abolhasan Bani-Sadr. Only after much of the IRP leadership was killed in the Hafte Tir bombing did Khomeini relent and allow Khamenei to run for president in the summer of 1980.

    They also seem to have disagreed about the war with Iraq. According to various sources, including Khomeini’s son Ahmad, the Grand Ayatollah wanted to bring the conflict to an end after taking back the southwestern city of Khorramshahr in April 1982, but Rafsanjani, among others, prevailed on him to prepare an offensive into Iraqi territory.

    As the 1980s progressed, Rafsanjani’s role within the state system far surpassed his formal title of parliamentary speaker. In international settings, he was treated like the state’s foremost figure. The West — including the Reagan administration — relied on him to end kidnappings in Lebanon, and he became known as the real power behind the scenes.

    By 1985, the fervent anti-Americanism he had previously displayed gave way to the realization that a tactical accommodation with the “Great Satan” was necessary. In a risky and ultimately unsuccessful move, he agreed to hold talks with a delegation led by national security adviser Robert McFarlane, which surreptitiously visited Tehran in October 1986 with much-needed weapons for the war effort. The Iran-Contra revelations severely embarrassed both Reagan and Rafsanjani, and the whole affair had major repercussions for the domestic scene. Nevertheless, two decades later, the Rafsanjani clan published a book including the delegation’s fake passports and the inscribed Bible Reagan gave to Rafsanjani to underscore the cooperation between these erstwhile adversaries.

    Rafsanjani was at the heart of several crucial developments during the last years of Khomeini’s life. Many believe he took part in the efforts lead by Ahmad Khomeini and minister of intelligence, Mohammad Reyshahri, to persuade the revolutionary leader to withdraw his support for his designated successor, Hossein ʿAli Montazeri. He certainly had motivation: Montazeri’s relative and close associate, Seyyed Mehdi Hashemi, and his people were responsible for leaking the details of McFarlane’s visit. In early 1988, Rafsanjani had to navigate a major internal crisis when Prime Minister Mir-Hossein Mousavi resigned and noted — in a secret letter to Khamenei — that other figures, including Rafsanjani, had gravely eroded his authority.

    That same year, the USS Vincennes shot down Iran Air Flight 655 over the Persian Gulf, killing almost three hundred civilians. Rafsanjani gloomily indicated during a Friday prayer speech that the tragedy was not an accident and warned that the United States would now intensify its involvement in the Iran-Iraq conflict. This likely contributed to Khomeini’s acceptance of UN Security Council Resolution 598, which initiated the ceasefire between the two countries and which he famously compared to drinking a “poisoned chalice.”
    Consolidation

    Following the Iran-Iraq War and the death of the revolutionary patriarch in June 1989, many wondered if the revolutionary state and its institutions could survive without the uniquely charismatic Ayatollah Khomeini. Even before his death, the ruling establishment proved vulnerable as militant groups such as the People’s Mojahedin Organization and the Forqan, which opposed the political clerisy’s ascent, had assassinated several senior figures in the regime. Khamenei and Rafsanjani both survived attempts on their lives in this period, ensuring that these two friends would decisively shape the post-Khomeini political order.

    Rafsanjani played a key role in elevating Khamenei as Khomeini’s successor, but the more intimate details of his lobbying have yet to be fully revealed. It occurred as the Iranian elite was reeling, both politically and emotionally. Khomeini’s death came after a period of incapacitation, but it nevertheless caught senior state figures unprepared. As a result, the Assembly of Experts, the clerical body in charge of selecting and supervising the guardian jurist (vali-ye faqih), had to decide how best to handle the succession. Rafsanjani took to the podium and declared that Khomeini had stated his preference for Khamenei, despite his lack of clerical rank and authority. The latter was not an Ayatollah, let alone a marjaʿ al-taqlid (source of emulation or Grand Ayatollah).

    Khamenei’s accession unfolded in tandem with major constitutional amendments and changes in the revolutionary state’s institutional structure. The position of vali-ye faqih (often referred to nowadays as the “supreme leader”) was radically revised. No longer was his capacity to act as a source of emulation for the faithful, namely the criterion of marjaʿiyyat a prerequisite for the office. Instead, Khamenei had an “absolute mandate” to rule. At the same time, the office of prime minister was abolished, leaving a directly elected president, which Rafsanjani promptly assumed. These moves quickly consolidated power between the longstanding allies.

    At this moment, Rafsanjani was at the peak of his powers. Many have speculated that he placed his ally in this role because he was counting on Khamenei’s lack of religious credentials and limited influence among the clergy, to keep him relatively weak. Arguably, it was a calculation that would come back to haunt him in the last decade of his life.

    His two presidential terms have become associated with the period of the nation’s reconstruction. In the first few years, his partnership with Khamenei proved most efficacious. First in the 1990 Assembly of Experts’ elections — but most decisively in the 1992 Majles elections — they used the guardian council’s arrogation of the prerogative to supervise elections and thereby disqualify candidates to rapidly marginalize the so-called Islamic left, which included groups like the Association of Combatant Clerics, the so-called Imam’s Line, and the Mojahedin Organization of the Islamic Revolution. All of whose members had been Ayatollah Khomeini’s stalwart supporters and advocated for anti-imperialism and a radical foreign policy, state control of the economy, and the egalitarian redistribution of wealth.

    In response to the country’s very real internal and external economic and political challenges, Rafsanjani and Khamenei conspired to cast aside the Left. Thus, in 1992, they either saw disqualified or campaigned against a raft of sitting MPs and left-leaning regime loyalists, including Behzad Nabavi, Asadollah Bayat, Hadi Ghaffari, Ebrahim Asgharzadeh, and the infamous Ayatollah Sadeq Khalkhali. In fact, only 20 percent of incumbents earned reelection that year.

    Consequently, the traditional right dominated the Fourth Majles, adding to the duo’s firm grip on the intelligence and security apparatuses, the state institutions regulating the Shiʿi clergy, the levers of economic power and patronage — including the ministry of petroleum — and a vast network of religious endowments. Despite starting from a position of weakness, Khamenei began to strengthen his hold on economic and military power. In Rafsanjani’s second term, a mild rivalry started to color their relationship.

    With the Left on the sidelines, Rafsanjani pursued what amounted to a neoliberal agenda of privatization and structural adjustment. He also created a regional détente with the Gulf states, above all Saudi Arabia and Kuwait, which had bankrolled Saddam Hussein’s war effort with US support. Journalist Mohammad Quchani approvingly called Rafsanjani’s tenure the era of “depoliticization,” where “expertise” firmly supplanted “commitment.” Technocratic competency and state-directed economic liberalization without corresponding political reforms became the order of the day. Saʿid Hajjarian — a former intelligence officer who became a preeminent reformist strategist — recalled a meeting with Rafsanjani in which the president disdainfully shrugged off the very notion of political development, a euphemism for “democratization.”

    But after ejecting much of the Islamic left from the ranks of government, Rafsanjani was himself forced to cede primacy over the cultural and intellectual spheres to the traditional right. His brother Mohammad had to give up his long-standing control of state radio and television, while the future president Mohammed Khatami publicly resigned from the Ministry of Culture and Islamic Guidance, replaced by arch-conservative Ali Larijani (who has since joined the ranks of centrist principalists).

    The traditional right’s own predominantly mercantilist interests often conflicted with Rafsanjani’s efforts at economic liberalization. As a result, he had to pursue a more modest reform program. Resistance from below also appeared. In 1992, a tentative subsidy reform on foodstuffs and energy — which would only be implemented, ironically, under the Ahmadinejad government — coincided with inflation hovering around 50 percent, leading to tumultuous provincial bread riots.

    Moreover, the privatizations that did take place were far from straightforward. Selling shares to para-statal and quasi-statal organizations sparked allegations of crony capitalism and corruption that the Fourth Majles eventually had to redress through legislation, even if the issue was never satisfactorily resolved. Moreover, one of Rafsanjani’s key allies, Gholam Hossein Karbaschi — mayor of Tehran from 1989 to 1998 — played a crucial role in the capital city’s “urban renewal.” He sold off state-owned land below market value to the connected and well-heeled and exempted large developers from zoning laws, creating a speculative real-estate boom in which certain segments of the political and economic elite were seen to massively profit.

    Rafsanjani also helped create the Islamic Free University, which provided higher education to hundreds of thousands of students unable to enter the state system because of the competitive national examinations. Nevertheless, the university has been criticized for introducing market logic into education and thus exacerbating existing class divisions.

    As Kaveh Ehsani writes, the Rafsanjani administration had decided that “the Islamic Republic needed to first create its own loyal, Islamic (but neoliberal) middle class.” Rafsanjani, however, ultimately failed to develop an entrepreneurial class that could fully implement his neoliberal agenda. Attempts to do so — particularly through his half-hearted wooing of expatriate businessmen who had fled on the eve of the Islamic Republic — were largely met with scorn. The Executives of Reconstruction Party, heavily populated by the president’s kin, including his outspoken daughter Faʾezeh, would belatedly attempt to consolidate this new technocratic order in 1996.

    Meanwhile, the Islamic Revolutionary Guard Corps (IRGC) was invited by the government as a quid pro quo for its services during the war, to help reconstruct the country’s severely depleted infrastructure. Khamenei shrewdly capitalized on this development to augment his institutional power.

    This period also saw a slew of intellectuals, writers, and activists assassinated, arrested, and/or tortured. The long list even extends into the Khatami era and includes ʿAli Akbar Saʿidi Sirjani, Faraj Sarkuhi, Shapur Bakhtiar — the Shah’s last prime minister, who had tried to oust the Islamic Republic with Saddam Hussein’s support — and Sadeq Sharafkandi, secretary-general of the Kurdistan Democratic Party of Iran. These killings have been strongly linked to the Iranian security apparatus, but the extent of Rafsanjani’s involvement remains unclear. Regardless, his objective of consolidating the regime he had been instrumental in building extended — with or without his direct participation — into neutralizing, by any means, dissenting and subversive voices.
    Between the Establishment and Reform

    When Mohammad Khatami became president in the June 1997 elections, many observers — including Rafsanjani — were surprised. In fact, the departing president would eventually admit that he had voted for Ali Akbar Nateq Nuri, the establishment candidate. Nor was he temperamentally disposed to the ethos of the emerging “reformist” camp, which rallied around Khatami. Their emphasis on political, rather than economic, change and openness in the media and intellectual spheres starkly contrasted with the ambitions and priorities of his own administration.

    In fact, between 1997 and 2001, the former president tilted more toward the conservatives, when the right wing became concerned the reformist coalition was taking control of the chief reins of government. In 2000, Rafsanjani ran for parliament in Tehran and sparked a major political crisis. He initially did not rank among the first thirty seats, but was reinstated after a known dissident was disqualified. The media waged a campaign against what they regarded as brazen interference, and Rafsanjani relinquished his seat at a high cost to the Khatami front.

    Entrenched as leader of the expediency council — a body whose influence grew in periods of mediation between parliament and the guardian council — Rafsanjani effectively helped stymie the reformist-dominated Sixth Majles, repeatedly kicking key reforms into the long grass. As a result, the public grew disenchanted with the reformers, seeing them as incapable of implementing their program.

    In 2005, Rafsanjani once again ran for president, arguing that only he could fix a deadlocked political system. His quixotic campaign used roller-skating young women to hand out posters to bemused drivers in Tehran. But Ahmadinejad’s insurgent candidacy derailed his plans and forced an unprecedented run-off. Rafsanjani scrambled and succeeded in winning the support of many moderates, dissidents, and artists, including the late ʿAbbas Kiarostami, who warned of a Chirac-Le Pen scenario.

    When the veteran candidate appeared at Tehran University to this end, he responded to students chanting the name of Akbar Ganji — an imprisoned journalist and public intellectual, who had famously characterized Rafsanjani as Iran’s very own Cardinal Richelieu — by saying conditions in prisons today were far better than under the Shah’s regime. In his final televised campaign interview, he unpersuasively apologized for not holding events outside Tehran in what appeared to be a last-ditch pledge to improve the plight of the neglected provinces.

    His defeat — which he half-heartedly attributed to security forces’ interference — effectively aligned him with the reformist camp he had previously been at odds with. By 2006, he recognized that Ahmadinejad threatened both the Iranian state and the fragile détente with the West that he and Khatami had laboriously engineered. For the last decade of his life, he would repeatedly call for moderation, speaking out against excesses and cautiously supporting Mir-Hossein Mousavi in the 2009 elections.

    Despite warning Khamenei about possible tampering on the eve of the vote and using his Friday prayer address to call for the release of scores of reformists in July 2009, Rafsanjani managed to keep his place within the state apparatus. Rather than directly challenge Khamenei — as Mousavi and Karroubi would — he retained his position as head of the expediency council.

    During the second Ahmadinejad administration, Rafsanajani stayed in the media spotlight, published his much-anticipated annual volumes of political diaries, and continued to lobby at the regime’s highest levels. Despite having few obvious cards to play, Rafsanjani drew on his myriad relationships across ministries, economic institutions, political factions, the bazaar, the clergy, and even the IRGC. He also compelled his son, Mehdi, to return home and face a jail sentence so that opponents couldn’t use the charge that his child was abroad and in the pay of foreigners against him politically.
    Transformation or Rebranding?

    In 2013, after remaining on the fence until the last hours of the registration window, Rafsanjani announced his bid for president without securing the customary approval from Khamenei, who rebuffed his attempts to discuss the matter. The guardian council rejected him on health grounds, paving the way for his protégé Hassan Rouhani, whom Rafsanjani had persuaded not to drop out, to carry the centrist ticket and win in the first round.

    Even in his final years, after he had lost many of the institutional levers he had once wielded so dexterously, Rafsanjani managed to interject himself at crucial political moments and tilt the balance of forces in one direction or another. These interventions were not without significance or merit. His continued support for Rouhani and the nuclear accord with the P5+1 helped alleviate the atmosphere of securitization, economic distress, and growing militarization that had characterized the Ahmadinejad years. When he decried the Western sanctions that “had broken the back” of the nation, he belittled the conservative attempts to portray the accord as a sellout.

    In recent years, prominent intellectuals like Akbar Ganji and Sadeq Zibakalam have debated whether Rafsanjani’s apparent “conversion” to reform represented a truly genuine transformation or another example of his essential Machiavellianism. But a more pertinent question would be what opportunities for contestation and increasing democratic accountability and pluralism were engendered as a result of his interventions and the unforeseen repercussions of elite competition and cleavage.

    On the one hand, his role as mediator between the ruling establishment and the reformists in these final years played an important part in assuaging the contradictions between popular expectations and the reality of regime governance. Since the late 1990s elite competition has taken place on the terrain of electoral and constitutional politics, and Iran’s sizeable urban population and middle classes were periodically summoned to provide momentum to their own mediated demands. A process that also harbored the potential for sparking deeper political transformation, and a renegotiation of the social contract defining the relationship of government and the governed.

    In the short term, reforms included resolving the nuclear impasse; returning to competent, technocratic economic management; lowering inflation and youth unemployment; releasing Green Movement leaders Mir Hossein Mousavi, Mehdi Karroubi, and Zahra Rahnavard; and loosening political and cultural restrictions.

    But in the long term, the reformist horizon strove for something like a new constitutional settlement that would place the supreme leader under close supervision — if not call for his direct election — hold the security apparatuses accountable, and reverse the guardian council’s powers over elections. Reformist activists, as well as political currents with negligible official representation, saw Rafsanjani’s funeral procession as one more opportunity to articulate these manifold demands, proving even his posthumous relevance to the political balance of power.

    Rafsanjani initiated a deeply personal form of statecraft, one that could not bring about a structured perestroika, but did enable the Islamic Republic to survive crises and challenges. Rafsanjani and Khamenei’s chief objective had always preserving the regime they helped build. The question of how to achieve this — and their material and institutional stake in it — rankled their relationship in later life and still divides the country.

    https://en.wikipedia.org/wiki/Akbar_Hashemi_Rafsanjani

    #Iran #politique #islam

  • Sweet drug clears #cholesterol, reverses heart disease—and was found by parents
    http://arstechnica.com/science/2016/04/sweet-drug-clears-cholesterol-reverses-heart-disease-and-was-found-by-p

    Des parents de jumelles atteintes d’une maladie héréditaire grave ont fait des recherches tellement intenses sur la molécule qui a fini par être utilisée (avec un certain succès) pour combattre ladite maladie, qu’ils ont fini par trouver une autre indication thérapeutique à la molécule en question,

    Two parents’ quest to save their twin daughters’ lives from a rare, degenerative genetic disorder may end up saving and improving the lives of millions.

    After digging through medical literature and fitting pieces of data together, the non-medically trained couple contacted German researchers and suggested that a chemical called cyclodextrin may be able to treat atherosclerosis—the hardening of arteries with cholesterol-rich plaques, which is a precursor to heart attack, stroke, and other cardiovascular diseases.

    The researchers, Eicke Latz at the University of Bonn and colleagues, followed up on the parents’ hypothesis and found that in mice, cyclodextrin indeed blocked plaque formation, melted away plaques that had already formed in arteries, reduced atherosclerosis-associated inflammation, and revved up cholesterol metabolism—even in rodents fed cholesterol-rich diets. In petri dish-based tests, the researchers found that the drug seemed to have the same effects on human cells and plaques.

    Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
    http://stm.sciencemag.org/content/8/333/333ra50

    La maman, Chris Hempel, fait partie des auteurs de l’étude.

    #cyclodextrine #hypercholestérolémie #athérosclérose #infarctus #santé

  • Heartburn Drugs Linked to Heart Attacks - NYTimes.com
    http://well.blogs.nytimes.com/2015/06/10/gastric-reflux-drugs-linked-to-heart-attacks

    Previous studies have found that P.P.I.’s are associated with poor outcomes for people with heart disease, probably because of an interaction with clopidogrel, a drug commonly prescribed after a heart attack. This new study examines the heart attack risk in otherwise healthy people.

    The researchers used data-mining, a mathematical method of looking at trends in large amounts of data, to analyze the use of the drugs over time. Evidence that they were increasing the risk for heart attack was clear as early as 2000.

    “This is the kind of analysis now possible because electronic medical records are widely available,” said the lead author, Nigam H. Shah, an assistant professor of medicine at Stanford. “It’s a benefit of the electronic records system that people are always talking about.”

    There was no association of heart attack with another class of drugs used to treat gastric reflux, H2 blockers like Zantac, Tagamet and Pepcid. The researchers suggest that P.P.I.’s promote inflammation and clots by interfering with the actions of protective enzymes.

    A significant limitation of the study, in PLOS One, is that P.P.I. usage may be a marker of a sicker patient population, more subject to heart disease in any case.

    #IPP #santé

  • Nestle, PepsiCo and others use public funds to develop harmful snacks | Society | The Guardian
    http://www.theguardian.com/society/2015/mar/14/nestle-pepsico-and-others-use-public-funds-to-develop-harmful-snacks

    Snack food and confectionery companies, including Nestlé and PepsiCo, are paid substantial government subsidies to help them make products that will damage the nation’s health, according to charities involved in heart attack prevention and obesity.

    Mondelez, which split from Kraft and owns the Cadbury’s brand, was given nearly £638,000 by Innovate UK – formerly known as the Technology Strategy Board – from 2013 to 2015 to help the multinational giant develop a process to distribute nuts and raisins more regularly in its chocolate bars.

    Nestlé received more than £487,000 to invent an energy-efficient machine for making chocolate, while PepsiCo was awarded £356,000 to help develop new ways of drying potatoes and vegetables to make crisps.

    The Coronary Prevention Group, in association with the World Obesity Federation, says government money should not be spent on initiatives that will produce unhealthy snack foods and worsen the country’s serious obesity and disease problems.

    #subventions #mal_bouffe #alimentation #santé

  • Palestinian official: PA can’t halt security coordination with Israel - we rely on it
    Declarations on suspending security cooperation were intended first and foremost to rein in the anger within the Fatah movement, and stemmed from internal needs within the Palestinian leadership, official says.
    By Amira Hass | Dec. 14, 2014 |Haaretz
    http://www.haaretz.com/news/diplomacy-defense/.premium-1.631570

    Following a request by U.S. Secretary of State John Kerry, the Palestinian leadership has postponed its discussions on a response to the death of Minister Ziad Abu Ein, who died of a heart attack after a confrontation with Israel Defense Forces troops last Wednesday.

    Kerry’s request was considered “American pressure,” a senior Palestinian official involved in the leadership meetings told Haaretz. But he added that there had never been any intention on the part of the Palestinians to carry out its threats to suspend or halt security cooperation with Israel.

    The postponement of any decision is part of Palestinian President Mahmoud Abbas’ ongoing tactics, which involve waiting for the United States to act and find an acceptable solution to the conflict, said the official.

    The Palestinian leadership met last Wednesday evening to discuss the response to the death of Abu Ein, who died after a protest was blocked by the IDF in Yurmus Aya, near Ramallah.

    Israeli medical sources said the primary cause of death was a heart attack caused by stress, but Palestinian officials said Abu Ein had died from being struck and inhaling tear gas.

    It was announced after the meeting that the discussion about an official response would be postponed until Friday.

    But none of the proposals raised on Wednesday were new, and have been brought up time and again over the past few months, said the Palestinian official. For example, signing on international covenants such as the Rome Statute of the International Criminal Court or a UN Security Council Resolution on setting a date for an Israeli withdrawal from the occupied territories.

    Talk of suspending security cooperation with Israel had also been raised in the past, he said.

    The declarations on suspending security cooperation were intended first and foremost to rein in the anger within the Fatah movement, and stemmed from internal needs within the Palestinian leadership.

    “A few of the people who spoke in the media in favor of suspending security coordination speak completely differently in closed meetings and are asking to act with restraint and caution,” the official said.

    “The Israelis know that very well, and Defense Minister Moshe Ya’alon said more or less that these were empty threats.

    “These are threats that have stopped being threatening. The Palestinian Authority cannot end the security coordination because of the many economic and personal interests – not only security ones – that rely on it,” he added.

    Hamas arrests

    In recent months, the Palestinian security services have conducted many arrests among members of Hamas and Islamic Jihad – many among the students at the various universities in the West Bank.

    Some were released after a few days, others are summoned daily to one of the Palestinian security organizations and released in the evening, without even being questioned.

    Over the weekend, the PA arrested 21 Hamas members in Hebron.

    A Hamas member said the arrests were meant to silence any other viewpoint.

    “Between the Israeli detentions and the PA campaign to silence [dissent], it is impossible to speak today about the existence of the Hamas organization in the West Bank,” he said.

    However, the PA claims the reason for the arrests was holding weapons or the financing of banned activities.

    Many of the arrests were meant to deter or intimidate, but others are based on information concerning weapons and transfers of money whose purpose is unknown, the senior Palestinian official told Haaretz.

    “These are arrests that it was possible to carry out without security coordination with Israel, but with the security coordination it is easier,” he said.

    Some 1,000 Hamas supporters in Hebron planned to hold a march and rally on Friday, to mark 27 years since the organization’s foundation.

    IDF soldiers destroyed the stage and confiscated banners and flags, and then dispersed the gathering with tear gas and rubber-covered bullets, which injured at least two, according to Palestinian reports.

    Hamas sources said the PA placed roadblocks in the streets leading to the rally and arrested activists who were on their way to the demonstration.

    Media outlets close to the PA reported widely yesterday about the dozen demonstrations that the IDF dispersed Friday, and the dozens of Palestinians injured by tear gas and a few who were wounded by bullets.

    But the Palestinian media also played down reports on the use of force to disperse the Hamas gathering.

    Even if the Palestinian and Israeli security forces did not act with prior coordination, the dispersal of the Hamas gathering, the arrests and the silencing of the media reflect their mutual interest in silencing the group.

    Ya’alon spoke dismissively on Friday evening about the Palestinian officials’ threats to end the security coordination.

    “The security coordination is more important to the [Palestinian] Authority than it is to us,” he said in an interview with Channel 2. “We will get by without security coordination. These are empty threats.”

  • Study Finds Alternative to Statins in Preventing Heart Attacks and Strokes
    http://www.nytimes.com/2014/11/18/health/study-finds-alternative-to-statins-in-preventing-heart-attacks-and-strokes.

    L’étude citée n’avait pas pour objet de prouver que le produit testé (Ezetimibe) pouvait constituer un substitut aux statines contrairement à ce qu’affirme le titre de l’article (qui prend bien soin de donner le nom commercial du produit)

    L’élément interessant, lu en fin d’article, est que l’Ezetimibe avait été jusque là promu et commercialisé (30 milliards USD de ventes) sans preuve réelle de son efficacité :

    “Now we have the result,” Dr. Nissen said. “They were successful, and that’s great. But at this point, it really doesn’t matter. They made their $30 billion.” The drug will be available as a generic in 2016, Merck says.

    The fact that the drug was promoted and sold for so many years without evidence that it helped was inexcusable, Dr. Krumholz said.

    “The fact that the trial exists says there was uncertainty,” Dr. Krumholz said. “The company and the investigators and the scientific community were uncertain about it. This is a cautionary tale,” he added. “The results could easily have gone the other way.”

  • HRW-murder’s apologists; Joe Stork-Judas | Norman G. Finkelstein
    http://normanfinkelstein.com/2014/hrw-murders-apologists-joe-stork-judas

    It takes considerable talent to describe Hamas’s firing of pre-Stone Age “rockets” that to date have indirectly killed one person (she died of a heart attack) as a “war crime,” while describing Israel’s killing to date of 120 Palestinians, overwhelmingly civilians, and its systematic targeting of civilian infrastructure, as mere “collective punishment.”

  • #Palestinian woman, 78, dies of heart attack in Israeli #raid
    http://english.al-akhbar.com/content/palestinian-woman-78-dies-heart-attack-israeli-raid

    The mother (R) of Mustafa Aslan, a 20-year-old Palestinian man who died from his wounds after he was shot by Israeli troops during clashes, mourn while waiting for his body to arrive at the family’s house on June 25, 2014 in Qalandiya refugee camp just north of Jerusalem. (Photo: AFP - Ahmad Gharabli) The mother (R) of Mustafa Aslan, a 20-year-old Palestinian man who died from his wounds after he was shot by Israeli troops during clashes, mourn while waiting for his body to arrive at the family’s house on June 25, 2014 in Qalandiya refugee camp just north of Jerusalem. (Photo: AFP - Ahmad Gharabli)

    An old Palestinian woman who suffered a heart attack during an Israeli raid on a refugee camp north of Hebron died early (...)

    #Israel #west_bank

  • Palestinian man dies of heart attack in Israeli raid
    http://english.al-akhbar.com/content/palestinian-man-dies-heart-attack-israeli-raid

    A Palestinian employee gathers up documents in an office of the Orphan Care Association that is in a mess after Israeli forces ransacked it on June 20, 2014. (Photo: AFP - Musa al-Shaer) A Palestinian employee gathers up documents in an office of the Orphan Care Association that is in a mess after Israeli forces ransacked it on June 20, 2014. (Photo: AFP - Musa al-Shaer)

    A Palestinian man in his sixties died of a heart attack early Saturday after Israeli forces raided his #west_bank home, local media reported. The man reportedly fought to keep the occupation forces from breaking into his home in the central West Bank town of Salfit. Ma’an news agency cited Palestinian security sources who said the soldiers prevented his (...)

    #Israel