medicalcondition:tumors

» Palestinian Dies From Wounds Suffered In April Of 2018
May 21, 2019 1:28 PM - IMEMC News
▻https://imemc.org/article/palestinian-dies-from-wounds-suffered-in-april-of-2018

https://imemc.org/wp-content/uploads/2019/05/MohammadZorob-e1558434189628.jpg

A young Palestinian man died, on Tuesday morning, from complications resulting to wounds he suffered in April of the year 2018, after Israeli soldiers shot him during the Great Return March processions in the Gaza Strip.

His family said their son, Mohammad Abdul-Jawad Zo’rob , 30, from Rafah in the southern part of the Gaza Strip, was shot by Israeli army fire on April 27th, 2018.

They added that he suffered various complications since then, and developed tumors that eventually led to his death, especially amidst the lack of medical supplies in the besieged and impoverished Gaza Strip.

He was shot with an expanding bullet, and underwent several surgeries, but also suffered several infections in the wound area, leading to cancer. (...)

#Palestine_assassinée #marcheduretour

Study of Cellphone Risks Finds ‘Some Evidence’ of Link to #Cancer, at Least in Male Rats - The New York Times
▻https://www.nytimes.com/2018/11/01/health/cellphone-radiation-cancer.html

https://static01.nyt.com/images/2018/11/02/science/02cellphones-print/02CELLPHONES-facebookJumbo.jpg

For decades, health experts have struggled to determine whether or not cellphones can cause cancer. On Thursday, a federal agency released the final results of what experts call the world’s largest and most costly experiment to look into the question. The study originated in the Clinton administration, cost $30 million and involved some 3,000 rodents.

The experiment, by the National Toxicology Program, found positive but relatively modest evidence that radio waves from some types of cellphones could raise the risk that male rats develop brain cancer.

“We believe that the link between radio-frequency radiation and tumors in male rats is real,” John Bucher, a senior scientist at the National Toxicology Program, said in a statement.

But he cautioned that the exposure levels and durations were far greater than what people typically encounter, and thus cannot “be compared directly to the exposure that humans experience.” Moreover, the rat study examined the effects of a radio frequency associated with an early generation of cellphone technology, one that fell out of routine use years ago. Any concerns arising from the study thus would seem to apply mainly to early adopters who used those bygone devices, not to users of current models.

#cellulaires

Measuring #financial_toxicity as a clinically relevant patient-reported outcome: The validation of the COmprehensive Score for financial Toxicity (COST) - Souza - 2016 - Cancer
▻http://onlinelibrary.wiley.com/doi/10.1002/cncr.30369/full

#Cancer and its treatment lead to increased financial distress for patients. To the authors’ knowledge, to date, no standardized patient-reported outcome measure has been validated to assess this distress.

METHODS

Patients with AJCC Stage IV solid tumors receiving chemotherapy for at least 2 months were recruited. Financial toxicity was measured by the COmprehensive Score for financial Toxicity (COST) measure.

(...)

CONCLUSIONS

The COST measure demonstrated reliability and validity in measuring financial toxicity. Its correlation with HRQOL indicates that financial toxicity is a clinically relevant patient-centered outcome.

#santé #finance #sécurité_sociale #États-Unis

Le ver solitaire transmet son cancer au porteur humain.

A Tapeworm With Cancer Gave Its Tumors to Someone - NBC News
▻http://www.nbcnews.com/health/health-news/tapeworm-cancer-gave-its-tumors-someone-n457586

Tapeworms are bad enough. They get inside people, lay their eggs, and cause symptoms such as diarrhea and weakness. And they can infest a body for a lifetime.

But doctors were stunned to find out they can do something worse: infect people with tumors.

La publication et son résumé (qui fait la une du NEJM). L’article entier est accessible.
Malignant Transformation of Hymenolepis nana in a Human Host — NEJM
▻http://www.nejm.org/doi/full/10.1056/NEJMoa1505892#t=abstract

Neoplasms occur naturally in invertebrates but are not known to develop in tapeworms. We observed nests of monomorphic, undifferentiated cells in samples from lymph-node and lung biopsies in a man infected with the human immunodeficiency virus (HIV). The morphologic features and invasive behavior of the cells were characteristic of cancer, but their small size suggested a nonhuman origin. A polymerase-chain-reaction (PCR) assay targeting eukaryotes identified Hymenolepis nana DNA. Although the cells were unrecognizable as tapeworm tissue, immunohistochemical staining and probe hybridization labeled the cells in situ. Comparative deep sequencing identified H. nana structural genomic variants that are compatible with mutations described in cancer. Invasion of human tissue by abnormal, proliferating, genetically altered tapeworm cells is a novel disease mechanism that links infection and cancer.

New #cancer modeling videos - Business Insider
▻http://www.businessinsider.com/new-cancer-modeling-videos-2015-9

http://static2.businessinsider.com/image/55e9d59fdd089594398b4654/an-awesome-new-technique-is-giving-doctors-an-unprecedented-look-at-cancer.jpg

After being treated, the tumor areas that grow back tend to be the ones that have genetic mutations that allow them to resist that treatment. The researchers say that modeling and knowing the genetics of the tumors could help doctors predict how cancers will respond to different combinations of therapies, allowing them to develop treatment strategies specifically targeted to each cancer.

▻https://www.youtube.com/watch?v=lpytoIxRu0o

#santé

Tackling Tumors With Space Station Research
▻http://www.nasa.gov/mission_pages/station/research/news/tackling_tumors/index.html

In space, things don’t always behave the way we expect them to. In the case of cancer, researchers have found that this is a good thing: some tumors seem to be much less aggressive in the microgravity environment of space compared to their behavior on Earth.

(...)

Research in the weightlessness of space offers unique insight into genetic and cellular processes that simply can’t be duplicated on Earth, even in simulated microgravity. “Microgravity can be approximated on Earth, but we know from the literature that simulated microgravity isn’t the same as the real thing,” says Daniela Gabriele Grimm, M.D., a researcher with the Department of Biomedicine, Pharmacology at Aarhus University in Aarhus, Denmark, and an author of the FASEB paper.

True weightlessness affects human cells in a number of ways. For one thing, cells grown in space arrange themselves into three-dimensional groupings, or aggregates, that more closely resemble what happens in the body. “Without gravitational pull, cells form three-dimensional aggregates, or spheroids,” Grimm explains. “Spheroids from cancer cells share many similarities with metastases, the cancer cells which spread throughout the body.” Determining the molecular mechanisms behind spheroid formation might therefore improve our understanding of how cancer spreads.

▻http://www.fasebj.org/content/28/2/813.abstract

#cancer #santé

Cancer du sein : inutilité de la mammographie par rapport à un examen sans mammographie. Au contraire, effet négatif puisqu’un cancer sur cinq détecté par mammographie serait un «sur-diagnostic».
Suivi sur 25 ans de cinq ans de dépistage en 1980-85 au Canada
Twenty five year follow-up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: randomised screening trial | BMJ
▻http://www.bmj.com/content/348/bmj.g366
(l’ensemble de l’article est consultable)

Results
During the five year screening period, 666 invasive breast cancers were diagnosed in the mammography arm (n=44 925 participants) and 524 in the controls (n=44 910), and of these, 180 women in the mammography arm and 171 women in the control arm died of breast cancer during the 25 year follow-up period. The overall hazard ratio for death from breast cancer diagnosed during the screening period associated with mammography was 1.05 (95% confidence interval 0.85 to 1.30). The findings for women aged 40-49 and 50-59 were almost identical. During the entire study period, 3250 women in the mammography arm and 3133 in the control arm had a diagnosis of breast cancer, and 500 and 505, respectively, died of breast cancer. Thus the cumulative mortality from breast cancer was similar between women in the mammography arm and in the control arm (hazard ratio 0.99, 95% confidence interval 0.88 to 1.12). After 15 years of follow-up a residual excess of 106 cancers was observed in the mammography arm, attributable to over-diagnosis.

Conclusion
Annual mammography in women aged 40-59 does not reduce mortality from breast cancer beyond that of physical examination or usual care when adjuvant therapy for breast cancer is freely available. Overall, 22% (106/484) of screen detected invasive breast cancers were over-diagnosed, representing one over-diagnosed breast cancer for every 424 women who received mammography screening in the trial.

▻http://www.bmj.com/highwire/filestream/686204/field_highwire_fragment_image_m/0/F3.medium.gif
Fig 3 Breast cancer specific mortality, by assignment to mammography or control arms (all participants)

Siemens abandons cancer therapy project | WSWS
►http://www.wsws.org/articles/2012/feb2012/siem-f02.shtml

The construction of the #cancer treatment centre in Kiel was begun in August 2008 and is nearing completion. The plan was to use the new precision methods of particle therapy in the Kiel centre to treat tumors in 3,000 patients per year, attracting patients from northern Germany and the Scandinavian countries.
It has since been found, however, that the large-scale facility can only treat 1,000 patients per year, and not 3,000. With this number of patients, the operation of the facility is not economically viable for the consortium of bidders including Siemens, Bilfinger Berger and HSG Technical Service, which had set up the particle therapy center as a public private partnership project with an investment of €250 million.
(...)
Before pulling out of the facility in Kiel, Siemens had already withdrawn from a project in July 2011 for a similar particle therapy facility in Marburg.

#santé via @reka

Immune System, Loaded With Remade T-cells, Vanquishes Cancer - NYTimes.com
►http://www.nytimes.com/2011/09/13/health/13gene.html?_r=1

Le New York Times guérit (encore une fois) le #cancer, cette fois par thérapie #génique :

Doctors removed a billion of [Mr. Ludwig’s] T-cells — a type of white blood cell that fights viruses and tumors — and gave them new genes that would program the cells to attack his cancer. Then the altered cells were dripped back into [his] veins.

#recherche

How Do Tumors Grow?: Scientific American
►http://www.scientificamerican.com/article.cfm?id=how-do-tumors-grow

Although imatinib keeps Elliott—and some 22,000 other CML patients in the U.S.—alive and healthy, the drug’s inability to eradicate the cancer suggests that perhaps the standard model that most researchers use to visualize how tumors grow—and the treatments that have arisen from that model—is flawed. An alternative hypothesis has recently gained traction; if it proves to be more accurate, physicians may need to adjust their therapeutic approaches, targeting their treatments to destroy particular subsets of cells within the tumor.

#medecine #cancer