Longitudinal analysis reveals high prevalence of #Epstein-Barr #virus associated with multiple sclerosis
Article assez extraordinaire qui incrimine le virus Epstein-Barr, jusque-là connu comme un facteur de risque, comme la cause de la #sclérose_en_plaque.
Étude d’échantillons de sang prélevés (et conservés) de manière répétée sur une cohorte de plus de 10 millions de militaires en service actif entre 1993 et 2013
In a preliminary study, we found that 5.3% of individuals were EBV-negative at the time of first sample (11), corresponding to hundreds of thousands of EBV-negative young adults at risk of EBV infection and MS.
We documented 955 incident MS cases among active-duty military personnel [including 315 cases from our preliminary study (11)]. For each MS case, we identified up to three serum samples collected before the date of MS onset (the first available, the last collected before disease onset, and one in between). Cases were matched to two randomly selected individuals without MS of the same age, sex, race/ethnicity, branch of military service, and dates of collection of blood samples who were on active military duty when the case was diagnosed (Fig. 1A and fig. S1). There were 801 MS cases and 1566 controls with samples available to assess EBV infection status.
The high seroconversion rate among individuals who developed MS during follow-up (97%) contrasts with the 57% rate of seroconversion observed among individuals who did not develop MS (Fig. 2A), a rate consistent with previous reports among EBV-negative young adults (12).
The HR for MS comparing EBV seroconversion versus persistent EBV seronegativity was 32.4 (95% CI: 4.3 to 245.3, P < 0.001) (Fig. 2C).