• Long COVID brain fog may be due to damaged blood vessels in the brain
    https://www.sciencenews.org/article/long-covid-brain-fog-blood-brain-barrier-damage

    The result suggests there is a biological basis for this symptom
    Leakiness in the brain could explain the memory and concentration problems linked to long COVID.

    In patients with brain fog, MRI scans revealed signs of damaged blood vessels in their brains, researchers reported February 22 in Nature Neuroscience. In these people, dye injected into the bloodstream leaked into their brains and pooled in regions that play roles in language, memory, mood and vision.

    It’s the first time anyone’s shown that long #COVID patients can have leaky blood brain barriers, says study coauthor Matthew Campbell, a geneticist at Trinity College Dublin in Ireland. That barrier, tightly knit cells lining blood vessels, typically keeps riffraff out of the brain, like bouncers guarding a nightclub.

    #maladie_vasculaire #covid_long #barrière_hémato-encéphalique #cerveau #neurologie

  • #Ikea, le seigneur des forêts

    Derrière son image familiale et écolo, le géant du meuble suédois, plus gros consommateur de bois au monde, révèle des pratiques bien peu scrupuleuses. Une investigation édifiante sur cette firme à l’appétit démesuré.

    C’est une des enseignes préférées des consommateurs, qui équipe depuis des générations cuisines, salons et chambres d’enfants du monde entier. Depuis sa création en 1943 par le visionnaire mais controversé Ingvar Kamprad, et au fil des innovations – meubles en kit, vente par correspondance, magasins en self-service… –, la petite entreprise a connu une croissance fulgurante, et a accompagné l’entrée de la Suède dans l’ère de la consommation de masse. Aujourd’hui, ce fleuron commercial, qui participe pleinement au rayonnement du pays à l’international, est devenu un mastodonte en expansion continue. Les chiffres donnent le tournis : 422 magasins dans cinquante pays ; près d’un milliard de clients ; 2 000 nouveaux articles au catalogue par an… et un exemplaire de son produit phare, la bibliothèque Billy, vendu toutes les cinq secondes. Mais le modèle Ikea a un coût. Pour poursuivre son développement exponentiel et vendre toujours plus de meubles à bas prix, le géant suédois dévore chaque année 20 millions de mètres cubes de bois, soit 1 % des réserves mondiales de ce matériau… Et si la firme vante un approvisionnement responsable et une gestion durable des forêts, la réalité derrière le discours se révèle autrement plus trouble.

    Greenwashing
    Pendant plus d’un an, les journalistes d’investigation Xavier Deleu (Épidémies, l’empreinte de l’homme) et Marianne Kerfriden ont remonté la chaîne de production d’Ikea aux quatre coins du globe. Des dernières forêts boréales suédoises aux plantations brésiliennes en passant par la campagne néo-zélandaise et les grands espaces de Pologne ou de Roumanie, le documentaire dévoile les liens entre la multinationale de l’ameublement et l’exploitation intensive et incontrôlée du bois. Il révèle comment la marque au logo jaune et bleu, souvent via des fournisseurs ou sous-traitants peu scrupuleux, contribue à la destruction de la biodiversité à travers la planète et alimente le trafic de bois. Comme en Roumanie, où Ikea possède 50 000 hectares de forêts, et où des activistes se mobilisent au péril de leur vie contre une mafia du bois endémique. Derrière la réussite de l’une des firmes les plus populaires au monde, cette enquête inédite éclaire l’incroyable expansion d’un prédateur discret devenu un champion du greenwashing.

    https://www.arte.tv/fr/videos/112297-000-A/ikea-le-seigneur-des-forets
    #film #film_documentaire #documentaire #enquête
    #greenwashing #green-washing #bois #multinationale #meubles #Pologne #Mazovie #Mardom_House #pins #Ingvar_Kamprad #délocalisation #société_de_consommation #consumérisme #résistance #justice #Fondation_Forêt_et_citoyens #Marta_Jagusztyn #Basses-Carpates #Carpates #coupes_abusives #exploitation #exploitation_forestière #consommation_de_masse #collection #fast-furniture #catalogue #mode #marketing #neuro-marketing #manipulation #sous-traitance #chaîne_d'approvisionnement #Sibérie #Russie #Ukraine #Roumanie #accaparement_de_terres #Agent_Green #trafic_de_bois #privatisation #Gabriel_Paun #pillage #érosion_du_sol #image #prix #impact_environnemental #FSC #certification #norme #identité_suédoise #modèle_suédois #nation_branding #Estonie #Lettonie #Lituanie #lobby #mafia_forestière #coupes_rases #Suède #monoculture #sylviculture #Sami #peuples_autochtones #plantation #extrême_droite #Brésil #Parcel_Reflorestadora #Artemobili #code_de_conduite #justice #responsabilité #abattage #Nouvelle-Zélande #neutralité_carbone #compensation_carbone #maori #crédits-carbone #colonisation

    • #fsc_watch

      This site has been developed by a group of people, FSC supporters and members among them, who are very concerned about the constant and serious erosion of the FSC’s reliability and thus credibility. The group includes Simon Counsell, one of the Founder Members of the FSC; Hermann Edelmann, working for a long term FSC member organisation; and Chris Lang, who has looked critically at several FSC certifications in Thailand, Laos, Brazil, USA, New Zealand, South Africa and Uganda – finding serious problems in each case.

      As with many other activists working on forests worldwide, we share the frustration that whilst the structural problems within the FSC system have been known for many years, the formal mechanisms of governance and control, including the elected Board, the General Assembly, and the Complaints Procedures have been highly ineffective in addressing these problems. The possibility of reforming – and thus ‘saving’ – the FSC through these mechanisms is, we feel, declining, as power within the FSC is increasingly captured by vested commercial interest.

      We feel that unless drastic action is taken, the FSC is doomed to failure. Part of the problem, in our analysis, is that too few FSC members are aware of the many profound problems within the organisation. The FSC Secretariat continues to pour out ‘good news stories’ about its ‘successes’, without acknowledging, for example, the numerous complaints against certificates and certifiers, the cancellation of certificates that should never have been awarded in the first place, the calls for FSC to cease certifying where there is no local agreement to do so, the walk-outs of FSC members from national processes because of their disillusionment with the role of the economic chamber, etc. etc. etc.

      There has been no honest evaluation of what is working and what is not what working in the FSC, and no open forum for discussing these issues. This website is an attempt to redress this imbalance. The site will also help people who are normally excluded from the FSC’s processes to express their views and concerns about the FSC’s activities.

      Please share your thoughts or information. Feel free to comment on our postings or send us any information that you consider valuable for the site.

      UPDATE (25 March 2010): A couple of people have requested that we explain why we are focussing on FSC rather than PEFC. Shortly after starting FSC-Watch we posted an article titled: FSC vs PEFC: Holy cows vs the Emperor’s new clothes. As this is somewhat buried in the archives, it’s reproduced in full here (if you want to discuss this, please click on the link to go to the original post):
      FSC vs PEFC: Holy cows vs the Emperor’s new clothes

      One of the reasons I am involved in this website is that I believe that many people are aware of serious problems with FSC, but don’t discuss them publicly because the alternative to FSC is even worse. The alternative, in this case is PEFC (Programme for the Endorsement of Forest Certification schemes) and all the other certification schemes (Cerflor, Certflor, the Australian Forestry Standard, the Malaysian Timber Certification Council and so on). One person has suggested that we should set up PEFC-Watch, in order “to be even-handed”.

      The trouble with this argument is that PEFC et al have no credibility. No NGOs, people’s organisations or indigenous peoples’ organisations were involved in setting them up. Why bother spending our time monitoring something that amounts to little more than a rubber stamp? I can just see the headlines: “Rubber stamp PEFC scheme rubber stamps another controversial logging operation!” Shock, horror. The Emperor is stark bollock naked, and it’s not just some little boy pointing this out – it’s plain for all to see, isn’t it?

      One way of countering all these other schemes would be to point out that FSC is better. But, if there are serious problems with FSC – which there are, and if we can see them, so can anyone else who cares to look – then the argument starts to look very shaky.

      FSC standards aren’t bad (apart from Principle 10, which really isn’t much use to anyone except the pulp and paper industry). They say lots of things we’d probably want forest management standards to say. The trouble is that the standards are not being applied in practice. Sure, campaign against PEFC, but if FSC becomes a Holy Cow which is immune to criticism (not least because all the criticism takes place behind closed doors), then we can hardly present it as an alternative, can we?…”

      By the way, anyone who thinks that PEFC and FSC are in opposition should read this interview with Heiko Liedeker (FSC’s Executive Director) and Ben Gunneberg (PEFC’s General Secretary). In particular this bit (I thought at first it must be a mix up between FSC and PEFC, or Liedeker and Gunneberg):

      Question: As a follow-up question, Heiko Liedeker, from your perspective, is there room ultimately for programs like the Australian Forestry Standard, Certfor and others to operate under the FSC umbrella?

      Heiko Liedeker: Absolutely. FSC was a scheme that was set-up to provide mutual recognition between national standard-setting initiatives. Every national initiative sets its standard. Some of them are called FSC working groups, some of them are called something else. In the UK they are called UKWAS. We’ve been in dialogue with Edwardo Morales at Certfor Chile. They are some of the FSC requirements listed for endorsement, we certainly entered into discussion. We’ve been in discussion with the Australian Forestry Standard and other standard-setting initiatives. What FSC does not do is, it has one global scheme for recognizing certification. So we do not, and that’s one of the many differences between FSC and PEFC, we do not require the development of a certification program as such. A standard-setting program is sufficient to participate in the network.

      https://fsc-watch.com

    • Complicit in destruction: new investigation reveals IKEA’s role in the decimation of Romania’s forests

      IKEA claims to be people and planet positive, yet it is complicit in the degradation and destruction of Romania’s forests. A new report by Agent Green and Bruno Manser Fonds documents this destruction and presents clear requests to the furniture giant.

      A new investigative report (https://www.bmf.ch/upload/Kampagnen/Ikea/AG_BMF_report_IKEA_web_EN.pdf) by Agent Green and Bruno Manser Fonds shows a consistent pattern of destructive logging in IKEA-linked forests in Romania, with massive consequences for nature and climate. The findings are based on an analysis of official documents and field investigations of nine forest areas in Romania. Seven of them are owned by the IKEA-related company Ingka Investments and two are public forests supplying factories that produce for IKEA. The analysis uncovers over 50 suspected law violations and bad forest management practices. Biodiversity rich forest areas cut to the ground, intensive commercial logging conducted in ecologically sensitive or even old-growth forests without environmental assessments, dozens of meters deep tractor roads cutting through the forest are just a few of the issues documented.

      Most of the visited forests are fully or partially overlapping with EU protected areas. Some of these forests were strictly protected or under low-intensity logging before Ingka took over. Now they are all managed to maximize wood extraction, with no regard to forest habitats and their vital role for species. Only 1.04% of the total Ingka property in Romania are under a strict protection regime and 8.24% under partial protection. This is totally insufficient to meet EU goals. The EU biodiversity strategy requires the protection of a minimum of 30% of EU land area, from which 10% need to be strictly protected. One key goal is to strictly protect all remaining primary and old-growth forests in the EU.

      At the press conference in Bucharest Gabriel Păun, President of Agent Green, stated: “IKEA/Ingka seem to manage their forests like agricultural crops. Letting trees grow old is not in their culture. Removing entire forests in a short period of time is a matter of urgency for IKEA, the tree hunter. The entity disregards both the written laws and the unwritten ways of nature. IKEA does not practice what they preach regardless of whether it is the European Union nature directives, Romanian national legislation, or the FSC forest certification standard. But as a company with revenues of billions of Euros and Romania’s largest private forest owner, IKEA / Ingka should be an example of best practice.”

      Ines Gavrilut, Eastern Europe Campaigner at the Bruno Manser Fonds, added: “It is high time that IKEA started to apply its declared sustainability goals. IKEA could do so much good if it really wanted to set a good example as a forest owner, administrator, and large wood consumer in Romania and beyond. Needs could also be covered without resorting to destructive logging, without converting natural forests into plantations – but this requires tackling difficult issues such as the core of IKEA’s business model of “fast furniture”. Wood products should not be for fast consumption but should be made to last for decades.”

      Agent Green and Bruno Manser Fonds urge IKEA and the Ingka Group to get a grip on their forest operations in Romania to better control logging companies, not to source wood from national or natural parks, to effectively increase protection and apply forestry close to nature in own forests, to ensure full traceability and transparency of the IKEA supply chain, and allow independent forest oversight by civil society and investigative journalists.

      In August 2021, Agent Green published its first report documenting destruction in IKEA-linked forests in Romania. In May 2023, Agent Green and Bruno Manser Fonds sent an open letter of concern to the Ingka Group and IKEA Switzerland. BMF also started a petition demanding IKEA to stop deforestation in Romania’s protected forest areas and other high conservation value forests.

      The ARTE documentary IKEA, the tree hunter brilliantly tells the story of the real cost of IKEA furniture, the uncontrolled exploitation of wood and human labour.

      https://bmf.ch/en/news/neue-untersuchung-belegt-ikeas-beteiligung-an-der-waldzerstorung-in-rumanien-256

      #rapport

  • Sans titre
    https://pouet.chapril.org/@deylord/111937484481989886

    Via Rx3, Gus vient de publier son TOP 10 2023 :Chez Real Rebel Radio, on a une seule vraie ligne directrice : on ne parle que de la musique qu’on a aimée. Je me suis posé la question de ce choix en voyant le succès des compilations « pires albums de l’année » un peu partout. Pourquoi ne pas parler du pire et bien se marrer ?https://www.real-rebel-radio.net/2024/02/15/top-10-2023-version-gus#2023 #album #CodeOrange #DankoJones #Eclipse #HoldingAbsence #LordOfTheLost #Neuromancer #review #SleepToken #Starbenders #Sup #TheHives #Top10

  • TOP 10 2023 / Version Gus

    Via Rx3, Gus vient de publier son TOP 10 2023 :

    Chez Real Rebel Radio, on a une seule vraie ligne directrice : on ne parle que de la musique qu’on a aimée. Je me suis posé la question de ce choix en voyant le succès des compilations « pires albums de l’année » un peu partout. Pourquoi ne pas parler du pire et bien se marrer ?

    La réponse tient en deux temps : d’une part je n’ai pas envie de perdre du temps avec ce qui ne m’a pas plu et d’autre part vu le nombre d’albums qui sortent, je préfère mettre en lumière la crème de la crème. Et comme j’ai pris trois plombes à faire mon classement, parce que 2023 était sacrément qualitative, je suis à la bourre. Donc c’est parti, sans plus attendre et pour la première fois depuis très longtemps, un vrai top 10 sans tricher.

    https://www.real-rebel-radio.net/2024/02/15/top-10-2023-version-gus

    #2023 #album #CodeOrange #DankoJones #Eclipse #HoldingAbsence #LordOfTheLost #Neuromancer #review #SleepToken #Starbenders #Sup #TheHives #Top10

  • Les troubles du neurodéveloppement chez les enfants, un enjeu de santé publique
    https://www.lemonde.fr/societe/article/2024/02/06/autisme-dys-tdah-les-troubles-du-neurodeveloppement-enjeu-de-sante-publique_

    Autisme, « dys », TDAH… en première ligne en ce qui concerne le dépistage, les médecins, psychiatres et pédiatres interrogent la prévalence de ces troubles et leur écho à l’école.

    Troubles du spectre de l’autisme (TSA), trouble déficit de l’attention avec – ou sans – hyperactivité (TDAH), dyslexie mais aussi dyscalculie, dysorthographie, dyspraxie ou dysgraphie, troubles du développement intellectuel (#TDI)… Dans les salles de classe, nombre d’enseignants ont le sentiment d’être face à un « envol » des cas. Du côté des médecins psychiatres, pédiatres et autres acteurs de la santé, on évoque les chiffres avec prudence, aussi parce qu’« il n’existe pas à proprement parler d’étude épidémiologique spécifique à la France et [qu’]il nous faut encore raisonner en transposant des études internationales à la situation démographique française », explique le médecin de santé publique Etienne Pot, nommé, en novembre 2023, délégué interministériel à la stratégie nationale pour les troubles du #neurodéveloppement, ou « TND », les trois lettres qui renvoient à l’ensemble de ces affections.

    Il n’empêche, par extrapolation d’enquêtes menées aux Etats-Unis, et convergeant avec d’autres résultats au Royaume-Uni, au Canada et en Australie notamment, les cliniciens font état d’une incidence forte. Et même, semble-t-il, de plus en plus forte : aux Etats-Unis, 17,8 % des enfants étaient affectés de TND durant la période 2015-2017, contre 16,2 % dans les années 2009-2011, selon l’étude du chercheur et statisticien en santé Benjamin Zablotsky publiée dans Pediatrics, en 2019, qui fait référence.

    Dans de nombreux pays depuis une vingtaine d’années, la prévalence de ces troubles semble suivre une tendance haussière, particulièrement pour les #TSA et #TDAH. Au point qu’on évoque, sur le terrain, jusqu’à une personne sur six qui pourrait être concernée. Un enjeu de #santé publique.
    [...]
    Une urgence autour de laquelle enseignants et soignants se rejoignent. « Dans une classe ordinaire de 25 à 30 élèves, vous avez toutes les probabilités statistiques d’avoir au moins un #enfant présentant l’un de ces troubles, relève la pédopsychiatre Frédérique Bonnet-Brilhault, responsable du Centre d’excellence EXAC-T du CHRU de Tours et des Hôpitaux universitaires du Grand-Ouest. Le dépistage précoce fait qu’on accompagne sans doute aujourd’hui plus longuement dans les parcours scolaires des enfants qui, il y a vingt ans, sans diagnostic, avec des troubles plus bruyants, ont probablement été plus rapidement en décrochage ou écartés de l’#école. »

    Les progrès du dépistage expliquent-ils, alors, la courbe haussière ? Oui, répondent les spécialistes. Mais sans doute pas à eux seuls. « Les critères et les bornes diagnostiques ont évolué, de même que nos connaissances scientifiques, reprend la professeure Bonnet-Brilhault. Mais on ne peut pas exclure le rôle de facteurs environnementaux, sur lequel la recherche scientifique a commencé à se pencher. Ils ne sont jamais “causaux” à eux seuls, mais ils peuvent jouer sur les vulnérabilités génétiques établies. »
    Alimentation, modes de vie, exposition à certains polluants ou à des perturbateurs endocriniens… ces « nouveaux » risques sont sous les projecteurs. Le lancement en 2023 de la cohorte Marianne, qui vise, en suivant plus de 1 700 familles, à renforcer les données épidémiologiques françaises, doit aussi permettre d’évaluer les facteurs multiples – et le rôle de chacun – dans la survenue des #TND. Dans l’optique de pouvoir agir dans le domaine de la prévention dès la grossesse, la prématurité étant un facteur de risque important des TND.

    https://justpaste.it/ezcls

    Ecole inclusive : un système qui craque et varia
    https://seenthis.net/messages/1040363

    #AESH

  • Testez votre jugement des caractères


    Est-ce que vous acheteriez une voiture d’occasion à cet homme ?

    Est-ce que vous lui feriez confiance sachant que les pires génocidaires du vingtième siècle se sont inspirés de ses idées ?

    Monty Python Philosophy Football
    https://www.youtube.com/watch?v=LfduUFF_i1A&pp=ygUfbW9udHkgcHl0aG9uIG1hdGNoIHBoaWxvc29waGVycw%3D%3D

    #philosophie #neurosyphilis #maladie

  • [Teratoma] #drum_and_bass de festoche
    https://www.radiopanik.org/emissions/teratoma/drum-and-bass-de-festoche

    Camo & Krooked - All Night John B - Numbers TC feat. Sub Focus - Borrowed Time VIP Shameboy - Strobot - Netsky Remix Chase & Status - Pieces (feat. Plan B) Wilkinsonn TC - Hit The Floor M.O - For a Minute - Drumsound & Bassline Smith Remix DC Breaks - Swag - Original Mix Joe Ford - Knock Down Hamilton - Feel The Fury Mob Tactics - LDN Bass Mob Tactics - Dirtgrub Gancher & Ruin - Kickback Audio - Heads Up - Original Mix Dub Motion - Dun Watch It Frankee - Harlequin VIP Wilkinson - Direction VIP Dimension - Crowd Reaction RAM Records - Wilkinson - Perforation Sub Focus - Timewarp (Dimension Remix) The Prototypes - Lights Chase & Status - Count On Me - Andy C Remix Chase & Status - Baddadan (feat. IRAH, Flowdan, Trigga & Takura) Chase & Status - Say The (...)

    #dnb #neurofunk #drum_and_bass,dnb,neurofunk
    https://www.radiopanik.org/media/sounds/teratoma/drum-and-bass-de-festoche_16832__1.mp3

  • L’accueil, une clinique d’hospitalité

    L’Utopie concrète du soin psychique

    A la suite de l’essai Emancipation de la psychiatrie qui remet en perspective les acquis institutionnels de la psychothérapie institutionnelle et du secteur de psychiatrie publique généraliste, L’accueil, une clinique d’hospitalité, utopie concrète du soin psychique, le reprend à partir de pratiques cliniques d’accueil du soin psychique émancipatrice de la « valeur humaine » en psychiatrie. L’humain, technique alternative en est l’enjeu politique majeur d’accès inconditionnel aux soins psychique dans la société, que ce soit pour les populations autochtones ou pour les réfugiés et exilés migrant de l’humanitaire.

    https://entreleslignesentrelesmots.wordpress.com/2023/11/15/laccueil-une-clinique-dhospitalite

    #santé

  • COVID-19 pandemic is not over | The Kingston Whig Standard
    https://www.thewhig.com/opinion/covid-19-pandemic-is-not-over

    Is it acceptable for governments and public health officials to ignore the urgent need for pandemic mitigation measures as the virus spreads unchecked? How can individuals assess their personal risks when the powers that be no longer provide: PCR testing, regular COVID-19 case counts or science-based public health guidance?

    Not the ‘summer flu’

    COVID-19 is a serious disease caused by SARS-CoV-2, an airborne virus.

    Earlier this year, the Heart and Stroke Foundation of Canada warned that the vascular system, which is “the foundation” of heart and brain health, is “under threat from COVID.” According to a May 3 statement posted on the charity’s website, blood, oxygen and nutrients are delivered throughout the body by the vascular system.
    Article content

    “Inflammation, injury or other problems can cause the vascular system to either get clogged up or become leaky — yes, just like pipes,” the Heart and Stroke statement reads. “In atherosclerosis, the endothelium gets sticky and builds up plaque. That can lead to a clot causing a heart attack or a stroke.”

    “Because of the vascular connection with COVID-19, people with existing heart disease, a previous stroke or those with risk factors such as high blood pressure should consider themselves high risk for complications,” the Heart and Stroke Foundation warns. “It remains important to get vaccinated, avoid risky situations and wear a mask in crowded situations.”

  • Mieux que Neuralink : à Lausanne, un patient paralysé remarche par la pensée - Heidi.news
    https://www.heidi.news/sciences/mieux-que-neuralink-a-lausanne-un-patient-paralyse-remarche-par-la-pensee

    Deux #implants sont fixés, de part et d’autre du crâne, pour piloter chacune des jambes. Ceux-ci ne sont pas implantés dans le cerveau, mais sur son enveloppe la plus extérieure, la dure-mère, juste au-dessus du cortex moteur — la partie du cerveau qui pilote les mouvements volontaires.

    Concrètement, une petite portion d’os du crâne a été découpée et retirée, puis remplacée par l’implant.

    […]

    Les coups d’annonces d’Elon Musk avec son dispositif implantable Neuralink rythment le monde des #neurotechnologies. La technologie présentée ici est bien plus intéressante, insiste Jocelyne Bloch, parce qu’elle est non invasive – là où Elon Musk se base sur une technologie d’électrodes qui doivent pénétrer le cerveau en profondeur.

    « Guillaume (Charvet, du CEA, ndlr) est modeste, mais ce dispositif est le premier capteur cérébral sans fil, bien avant Elon Musk », insiste Grégoire Courtine.

  • The functional and structural changes in the hippocampus of COVID-19 patients | SpringerLink
    https://link.springer.com/article/10.1007/s13760-023-02291-1

    Since the hippocampus is predominantly susceptible to injuries caused by COVID-19, there are increasing data indicating the likelihood of post-infection memory loss and quickening neurodegenerative disorders, such as Alzheimer’s disease. This is due to the fact that the hippocampus has imperative functions in spatial and episodic memory as well as learning. COVID-19 activates microglia in the hippocampus and induces a CNS cytokine storm, leading to loss of hippocampal neurogenesis. The functional and structural changes in the hippocampus of COVID-19 patients can explain neuronal degeneration and reduced neurogenesis in the human hippocampus. This will open a window to explain memory and cognitive dysfunctions in “long COVID” through the resultant loss of hippocampal neurogenesis.

    [...]

    The proliferation and neuronal differentiation of neural stem cells can be suppressed by increased amounts of proinflammatory cytokines due to the pathogenic course of neurological disorders and anomalous amounts of stress hormones [5, 35, 108]. These factors can also interrupt the efficient incorporation of newborn neurons in the hippocampus in due course [5, 35, 108,109,110,111,112]. Impaired neurogenesis is known to be coupled with memory loss in neurological disorders due to neuroinflammation [3, 113]. This is also the case for COVID-19 where SARS-CoV-2 has the potential to infect neural stem cells in the hippocampus and brain organoids [3, 65, 108, 114, 115]. Clinical data also support the notion that Alzheimer’s disease can be initiated [116] or deteriorated [117] in COVID-19 patients.

    #covid-19 #hyppocampe #neurologie #dégénerescence_neuronale

  • ‘Too greedy’ : mass walkout at global science journal over ‘unethical’ fees

    Entire board resigns over actions of academic publisher whose profit margins outstrip even Google and Amazon.

    More than 40 leading scientists have resigned en masse from the editorial board of a top science journal in protest at what they describe as the “greed” of publishing giant Elsevier.

    The entire academic board of the journal #Neuroimage, including professors from Oxford University, King’s College London and Cardiff University resigned after Elsevier refused to reduce publication charges.

    Academics around the world have applauded what many hope is the start of a rebellion against the huge profit margins in academic publishing, which outstrip those made by Apple, Google and Amazon.

    Neuroimage, the leading publication globally for brain-imaging research, is one of many journals that are now “open access” rather than sitting behind a subscription paywall. But its charges to authors reflect its prestige, and academics now pay over £2,700 for a research paper to be published. The former editors say this is “unethical” and bears no relation to the costs involved.

    Professor Chris Chambers, head of brain stimulation at Cardiff University and one of the resigning team, said: “Elsevier preys on the academic community, claiming huge profits while adding little value to science.”

    He has urged fellow scientists to turn their backs on the Elsevier journal and submit papers to a nonprofit open-access journal which the team is setting up instead.

    He told the Observer: “All Elsevier cares about is money and this will cost them a lot of money. They just got too greedy. The academic community can withdraw our consent to be exploited at any time. That time is now.”

    Elsevier, a Dutch company that claims to publish 25% of the world’s scientific papers, reported a 10% increase in its revenue to £2.9bn last year. But it’s the profit margins, nearing 40%, according to its 2019 accounts, which anger academics most. The big scientific publishers keep costs low because academics write up their research – typically funded by charities and the public purse – for free. They “peer review” each other’s work to verify it is worth publishing for free, and academic editors collate it for free or for a small stipend. Academics are then often charged thousands of pounds to have their work published in open-access journals, or universities will pay very high subscription charges.

    Stephen Smith, professor of biomedical engineering at Oxford University and formerly editor-in-chief at Neuroimage, said: “Academics really don’t like the way things are, but individuals feel powerless to get the huge publishers to start behaving more ethically.”

    Researchers put up with it because they want to publish in established journals that will be widely read, he added.

    But he warned publishers: “Enough is enough. By taking the entire set of editors across to start the new journal, we are taking the reputation with us.”

    A spokesperson for Elsevier said: “We value our editors very highly and are disappointed [with the resignations], especially as we have been engaging constructively with them over the last couple of years.”

    He said the company was “committed to advancing open-access research” and its article publishing charges were “below the market average relative to quality. The fee for NeuroImage is below that of the nearest comparable journal in its field.”

    Meanwhile, university libraries are angry about the cost of the online textbooks they say students now overwhelmingly want to read – often many times more expensive than their paper equivalent. Professor Chris Pressler, director of Manchester University Library, said: “We are facing a sustained onslaught of exploitative price models in both teaching and research.”

    According to a spreadsheet of costs quoted to university librarians, Manchester University gave a recent example of being quoted £75 for a popular plant biology textbook in print, but £975 for a three-user ebook licence. Meanwhile Learning to Read Mathematics in the Secondary School, a textbook for trainee teachers published by Routledge, was £35.99 in print and £560 for a single user ebook.

    A spokesperson for Taylor and Francis, which owns Routledge, said: “We strive to ensure that book prices are both affordable and a fair representation of their value.” He said a print book could be checked out for weeks at a time whereas ebooks could be checked in and out rapidly and had a much wider distribution.

    He added: “Academic publishers provide services that are essential to a well-functioning research and scholarly communication ecosystem, and most researchers recognise this is a valuable service worth paying for. “

    Caroline Ball, librarian at Derby University and co-founder of the academic campaign EbookSOS, said: “This is creating a digital hierarchy of haves and have-nots. There are institutions that just can’t afford these prices for texts.”

    https://www.theguardian.com/science/2023/may/07/too-greedy-mass-walkout-at-global-science-journal-over-unethical-fees

    #démission #Elsevier #édition_scientifique #recherche #résistance

    –-

    ajouté à la métaliste sur l’éditions scientifique :
    https://seenthis.net/messages/1036396

  • Dyspraxie à l’âge adulte : Les points sur les I.
    https://sylphelinetoujoursdanslaluneoudanslesnuageswordpre.wordpress.com/2019/09/18/dyspraxie-a-lage-adulte-les-points-sur-les-i

    En général les diagnostics, aides et outils d’accessibilité pour dyspraxique ne sont disponibles qu’à partir de 3 ans et en moyenne la plupart des dyspraxiques ne reçoivent tout cela qu’à l’âge de 8 ans. Dès entre 3 et 6 ans certains enfants dyspraxiques peuvent être frustrés et manquer de confiance en eux du fait de leurs difficultés à faire une dizaine d’activités qui sont des compétences qu’ont les enfants ordinaires au même âge.

    Les suivantes :

    1-Taper du pied.

    2-Se tordre les mains.

    3-Taper dans ses mains.

    4-Rester immobile.

    5-Contrôler le volume de sa voix.

    6-Tomber sur des objets et tomber par terre trop souvent par rapport à un enfant ordinaire est usuel aux dyspraxiques de cet âge là.

    7-Difficulté à apprendre le vélo.

    8-Difficulté d’évaluation du danger. Saute depuis des très grandes hauteurs car il évalue mal les distances et les hauteurs.

    9-Mange malproprement.

    10-Evitement des jeux de construction.

    11-Pauvres coordinations fines. Cela veut dire difficulté à prendre un objet et s’en servir pour des activités motrices pointues par exemple à écrire avec un stylo ou découper une feuille avec des ciseaux car on ne les appréhende pas comme ils sont prévus pour l’être.

    12-Difficultés d’habillage.

    13-Isolation fréquente consécutive d’être rejetés par les enfants ordinaires de même âge, cela fait que les petits enfants dyspraxiques tendent à leur préférer la compagnie des adultes, ou quand ceux ci ne sont pas davantage compréhensifs la solitude. Attention cependant les dyspraxiques ont comme tout le monde des personnalités et on peut aussi être introverti et préférer la solitude par gout et caractère.

    14-Latéralité, choix de main gauche ou droite, pas établie à cet âge.

    15-Des difficultés persistantes plus ou moins importantes d’un cas à l’autre d’acquisition du langage.

    16-Une hypersensibilité sensorielle qui se manifeste de façon variée mais dont les cas les plus courants sont trouver les bruits forts insupportables, détesté être touché et ne pas supporter la sensation tactile du contact de certains habits. (Cela s’est forcément à vie une fois qu’on l’a en revanche et à vrai dire il est plus que probable que ce soit de naissance et simplement pas repérable plus jeune car ce n’est qu’à cet âge que l’enfant sait s’exprimer d’une façon qui permet aux professionnels (rares) au fait de l’hypersensibilité sensorielle de comprendre que ces personnes en ont une).

    17-Réponse limitée aux instructions verbales auxquelles il nous est souvent difficile de répondre aussi vite que d’autres à la fois par problèmes moteurs à les effectuer, mémoire à court terme verbale souvent défaillante et fréquentes difficulté à les comprendre au sens d’à envisager comment organiser ses prochains gestes pour parvenir à y obéir.

    18-Concentration limitée.

    19-Tâches souvent laissée en plan que ce soit par manque de concentration, difficulté motrice trop importante, fatigue, ras le bol ou oubli de la suite de la tâche pendant qu’on la réalise.

    Tout les petits enfants dyspraxiques n’ont pas toutes ces difficultés mais tous en ont la majorité. Moi par exemple j’avais des difficultés à taper dans mes mains en rythme, je ne contrôlais pas le volume de ma voix correctement, je tombais par terre et je faisais tomber des objets par terre extrêmement souvent, je ne savais pas faire de vélo, j’avais quelques difficultés à évaluer le danger par difficulté d’évaluation de la distance et des hauteurs, je mangeais malproprement, j’avais de pauvres coordinations fines, des difficultés d’habillage, des problèmes de latéralité, des légers retards d’acquisition de langage confondant les sons cheu et keu et une hypersensibilité sensorielle mais qui n’a été repérée qu’à l’âge adulte mais pas le reste.

    –—

    Et le problème c’est qu’à 7-10 ans on rencontre aussi d’autres difficultés quand on est dyspraxique, notamment les suivantes :

    1-Maladaptation aux routines qui structurent l’école.

    2-Difficultés en cours de sport.

    3-Incapacité à mettre ses lacets.

    4-L’écriture est illisible.

    5-Usage littéral du langage.

    6-Lenteur à faire ses devoirs.

    7-Fatigue. (Due au fait que tout ça est bien trop à gérer en tant que dyspraxique comme adaptation systématique à des normes sociales conçues pour des gens qui ne le sont pas)

    –---

    Bon du coup en fait étudiante entre 20 et 21 ans j’avais peu de fatigue liée à ma dyspraxie, mes soucis de latéralité étaient toujours là mais gérable et j’étais toujours inapte à faire du vélo mais dans ma situation d’étudiante en filière littéraire ce n’était pas gênant du tout donc mon handicap je le croyais à tort « léger ». C’est quand à 22 ans j’ai commencé à me voir exiger d’être une adulte autonome et indépendante que j’ai compris ma douleur.

    C’est une chose bien trop souvent omise dans la littérature sur la dyspraxie qu’à l’âge de devenir autonome et indépendant d’un coup on nous exige plein de compétences optionnelles avant cette période de la vie en fait et qui sont bien plus dures à réaliser pour des dyspraxiques. Enfin plein, 5 mais des tâches qui pour des dyspraxiques sont d’une difficulté forte, les suivantes rangées de la plus à la moins dure pour la plupart des jeunes adultes dyspraxiques (source : https://www.understood.org/en/learning-attention-issues/child-learning-disabilities/dyspraxia/everyday-challenges-for-young-adults-with-dyspraxia) :

    1-Conduire 2-Problèmes économiques et administratifs 3-Hygiène corporelle et présentation 4-Tâches ménagères 5-Trouver une emploi

    Personnellement j’ai de telles difficultés pour certaines choses que l’on m’a déclarée être en incapacité à vie de faire du vélo et de conduire. Une reconnaissance qui m’a été d’un grand soulagement d’un lourd poids. Au passage une chose curieuse et que presque aucun dyspraxique quel que soit son âge ne sait à la fois nager et faire du vélo mais on est divisés plus ou moins à 50/50 entre ceux qui savent faire du vélo et ceux qui savent nager. J’ai un pote dyspraxique lui aussi qui est dans la première catégorie et moi je suis dans la seconde. C’est aussi tout le problème pour comprendre cette condition dont les difficultés varient beaucoup au cas par cas.

    Alors pourquoi est ce que conduire une voiture est jugé par la plupart des dyspraxiques comme la chose la plus difficile pour nous ? Et bien car cela exige d’organiser, de coordonner et d’exécuter beaucoup d’actions en même temps. Les dyspraxiques qui peuvent et veulent apprendre à conduire n’y parviennent en général qu’avec un moniteur d’auto-école spécialement formé au minimum pour l’accompagnement dans l’apprentissage de la conduite des personnes handicapées, idéalement dans celui spécifique des dyspraxiques. Les adresses de ces moniteurs d’auto-écoles spécialisés sont parfois connues des ergothérapeutes qui peuvent être sur cela bonne source de renseignements. Les associations d’handicapés, surtout celles de dyspraxiques bien sûr sont aussi parfois en mesure d’en fournir de bonnes adresses.

    Les problèmes économiques et administratifs suite à cela sont la seconde pire difficulté des adultes dyspraxiques pour acquérir leur autonomie et indépendance. Cela est principalement du aux troubles des fonctions exécutives entrainés par la dyspraxie principalement les problèmes de planification/d’organisation que cela cause. Le résultat concret de cela étant une incapacité à remplir ses papiers administratifs, à gérer ses économies et des rendez vous manqués à la pelle. Voilà ça c’est mon plus gros souci dans la vie en fait en ce moment.

    Hélas la plupart des dyspraxiques pour cela il leur suffit de noter leurs rdv sur des calendriers, se mettre des alarmes et des pense bêtes, s’auto envoyer des messages pour ne pas zapper sur leurs adresses mails et leurs téléphones, planifier un mois ou une semaine à l’avance selon les tâches à faire. Ouais mais tout ça j’ai déjà testé et ça n’a fonctionné qu’à moitié pour moi. Il y a des ergothérapeutes censés aider pour ça mais hélas c’est trop cher pour moi.

    3-Hygiène personnelle et présentation : Visiblement la plupart des dyspraxiques arrivent à tout faire à l’âge adulte hormis conduire et s’organiser (c’est à dire gérer leur budget, leurs problèmes administratifs et leurs RDV) ce qui requière le plus souvent pour nous une aide professionnelle en ce sens. Cependant une minorité d’entre nous avons aussi toujours à l’âge adulte et j’en fais clairement parti des soucis de maintien d’hygiène personnelle et de présentation à cause des troubles de coordination (dans mon cas c’est ça) ou de motricité fine (pas pour moi) qui posent aussi du coup des soucis de présentation. De plus même si moi ça ne m’a jamais intéressé les filles qui mettent des accessoires et cosmétiques en étant dyspraxiques trouvent aussi que c’est une sacré galère. Il parait que des outils spécialisés pour aider face à cela sont vendus en boutique mais c’est fort cher et proposé par peu de magasins qui de plus ne sont pas très connus.

    4-Les tâches ménagères : Posent aussi à une minorité de dyspraxiques adultes des problèmes d’organisation (oui pour moi) et de motricité fine (non pour moi je gère là dessus), donc sur ça aussi nous galérons.

    La liste des tâches ménagères et trucs à faire pour l’hygiène est la présentation m’est un premier outil indispensable mais à lui seul pleinement insuffisant ; je sais aussi heureusement faire attention aux dates d’expiration même si on m’a appris à le faire en me terrorisant là dessus méthode déconseillée mieux vaut juste répéter ce geste jusqu’à ce qu’il rentre, faire des recettes de cuisine simples et rapides bien sur aussi avec des outils de cuisine adaptés j’ai aussi et je sais aussi plier mes habits. Seulement tout ça ne fonctionne que quand je suis en forme…la fatigue me fait perdre toutes ces capacités et je suis nettement plus souvent fatiguée qu’en forme.

    5-Trouver un emploi : Ceci et en une moindre mesure le conserver sont des choses dures à beaucoup d’adultes dyspraxiques dont moi à cause de nos problèmes d’organisation (pour moi ce n’est que pour cette raison) et pour beaucoup de soucis pour conduire (je ne sais pas le faire mais là où je vis et dans mon domaine de travail c’est très optionnel comme compétence donc je m’en fous), écrire à la main et taper à la machine. De plus certaines personnes avec dyspraxie ont du mal à s’exprimer clairement (ce n’est pas mon cas) ce qui leur rend encore plus difficile qu’aux autres dyspraxiques de trouver un traval.

    On dit qu’il faut faire du étape par étape dans sa recherche de travail je le fais mais ça ne m’a jamais suffit. Et presque toujours en fait pour travailler les dyspraxiques ont besoin de l’aide de quelqu’un pour l’organisation et je n’ai jamais rencontré quelqu’un de compétent pouvant m’aider en ce domaine et le problème que j’ai ce situe essentiellement là en terme de handicap en fait. S’entrainer aux entretiens d’embauche améliore les chances d’être pris mais seul ça ne suffit guère. Se faire des plans clairs et simples pour ne pas se paumer en cours de route vers le boulot de même. Ensuite bien sur il faut décider de si on se révèle comme dyspraxique ou pas à son employeur (bon moi vu que je ne peux pas bosser sans aménagements qui nécessitent de leur révéler ma RQTH la vie a décidé pour moi ; justement d’ailleurs la plupart des adultes dyspraxiques sont aptes à travailler mais si et seulement si les aménagements leur étant nécessaires sont vraiment mis en place.

    Et tout ça c’est cool mais pour moi c’est pas suffisant en fait je galère quand même sans y arriver malgré toutes ces aides déjà en place pour moi et que ma latéralité que partiellement acquise ne m’est pas vraiment un problème, mais en fait mon vrai souci de fond c’est que tout ça m’est impossible au quotidien car ça demande pour moi des efforts énormes que je peux faire que quand je suis très en forme et quand je les fais le résultat est la plupart du temps que je reste ensuite et la plupart des jours extrêmement fatiguée. Genre en gros je suis au mieux apte à ça une fois par semaine quoi. Le reste de la semaine je suis une loque sans énergie pour en récupérer.

    #dys #dyspraxie #neurodéveloppement

  • For many neurodiverse people, ’The Sims’ has been a lifelong comfort - CNN
    https://www.cnn.com/2022/08/18/us/sims-autism-adhd-video-games-community-wellness-cec/index.html

    (CNN)Life would be much more simple with a few directions. A status bar, for instance, to remind you to take care of yourself. Perhaps a few clues about other people’s intentions. Oh, and it wouldn’t hurt to have a place to experiment with it all, free from real-world consequences and the awkwardness of choices gone wrong.

    […]

    The notion that “The Sims” offers a neater, easier version of our own world is built into the game’s DNA. Game creator Will Wright lost his home in California’s 1991 Oakland-Berkeley firestorm. While rebuilding, he was moved to consider what life was really made of. A series of needs to be met? Items to own? People to love?

    #jeu_vidéo #jeux_vidéo #culture #rétrospective #jeu_vidéo_the_sims #jeu_vidéo_les_sim #neurodiverse #neurodivergent #neuroatypique #autisme #tdah #will_wright #helen_ashcroft #benji #cleveland_clinic #university_of_pittsburgh #university_of_kentucky #lgbt #lgbtq #ea #electronic_arts #longévité

  • Pourquoi détruit-on la planète ? Les dangers des explications pseudo-neuroscientifiques

    Des chercheurs en neurosciences et sociologie mettent en garde contre la thèse, qu’ils jugent scientifiquement infondée, selon laquelle une de nos #structures_cérébrales nous conditionnerait à surconsommer.

    Selon Thierry Ripoll et Sébastien Bohler, les ravages écologiques liés à la surconsommation des ressources planétaires seraient dus aux #comportements_individuels déterminés par notre cerveau. Une structure, le striatum, piloterait par l’intermédiaire d’une #molécule_neurochimique, la #dopamine, le désir de toujours plus, sans autolimitation, indiquaient-ils récemment dans un entretien au Monde.

    (#paywall)
    https://www.lemonde.fr/sciences/article/2022/07/07/pourquoi-detruit-on-la-planete-les-dangers-des-explications-pseudo-scientifi

    –—

    Tribune longue :

    Dans un entretien croisé pour Le Monde, Thierry Ripoll et Sébastien Bohler présentent leur thèse commune, développée dans deux ouvrages récents et que Bohler avait résumée dans un ouvrage précédent sous le titre évocateur de « bug humain » : les ravages écologiques liés à la surconsommation des ressources planétaires seraient dus aux comportements individuels déterminés par la structure même du cerveau. Précisément, le dogme de la croissance viendrait du striatum. Selon lui, cette structure cérébrale piloterait par l’intermédiaire d’une molécule neurochimique, la dopamine, le désir de toujours plus, sans autolimitation. Ripoll reprend cette thèse à son compte, et il affirme que la décroissance économique, qu’il appelle de ses vœux pour limiter les catastrophes en cours, bute ainsi sur des limites psychobiologiques.

    Cette thèse est très forte et a des conséquences politiques très préoccupantes : la #nature_humaine, ou plus précisément notre #programmation_biologique, conditionnerait le champ des possibles concernant l’organisation socio-économique. Le modèle de croissance économique serait le seul compatible avec le #fonctionnement_cérébral humain. Cela disqualifie les projets politiques de #décroissance ou de stabilité basés sur la #délibération_démocratique. Cela déresponsabilise également les individus[i] : leur #comportement destructeur de l’#environnement n’est « pas de leur faute » mais « celle de leur #striatum ». Une conséquence logique peut être la nécessité de changer notre nature, ce qui évoque des perspectives transhumanistes, ou bien des mesures autoritaires pour contraindre à consommer moins, solution évoquée explicitement par les deux auteurs. Les neurosciences et la #psychologie_cognitive justifient-elles vraiment de telles perspectives ?

    Nous souhaitons ici solennellement informer les lectrices et les lecteurs de la totale absence de fondement scientifique de cette thèse, et les mettre en garde contre ses implications que nous jugeons dangereuses. Ce message s’adresse également à ces deux auteurs que nous estimons fourvoyés, sans préjuger de leur bonne foi. Nous ne doutons pas qu’ils soient sincèrement et fort justement préoccupés des désastres environnementaux mettant en danger les conditions d’une vie décente de l’humanité sur Terre, et qu’ils aient souhaité mobiliser leurs connaissances pour aider à trouver des solutions. Les arguments déployés sont cependant problématiques, en particulier ceux relevant des neurosciences, notre domaine principal de compétence.

    Tout d’abord, le striatum ne produit pas de #dopamine (il la reçoit), et la dopamine n’est pas l’#hormone_du_plaisir. Le neuroscientifique #Roy_Wise, qui formula cette hypothèse dans les années 70, reconnut lui-même « je ne crois plus que la quantité de plaisir ressentie est proportionnelle à la quantité de dopamine » en… 1997. L’absence de « fonction stop » du striatum pour lequel il faudrait toujours « augmenter les doses » est une invention de #Bohler (reprise sans recul par #Ripoll) en contresens avec les études scientifiques. Plus largement, la vision localisationniste du xixe siècle consistant à rattacher une fonction psychologique (le #plaisir, le #désir, l’#ingéniosité) à une structure cérébrale est bien sûr totalement obsolète. Le fonctionnement d’une aire cérébrale est donc rarement transposable en termes psychologiques, a fortiori sociologiques.

    Rien ne justifie non plus une opposition, invoquée par ces auteurs, entre une partie de #cerveau qui serait « récente » (et rationnelle) et une autre qui serait « archaïque » (et émotionnelle donc responsable de nos désirs, ou « instinctive », concept qui n’a pas de définition scientifique). Le striatum, le #système_dopaminergique et le #cortex_frontal, régions du cerveau présentes chez tous les mammifères, ont évolué de concert. Chez les primates, dont les humains, le #cortex_préfrontal a connu un développement et une complexification sans équivalent. Mais cette évolution du cortex préfrontal correspond aussi à l’accroissement de ses liens avec le reste du cerveau, dont le système dopaminergique et le striatum, qui se sont également complexifiés, formant de nouveaux réseaux fonctionnels. Le striatum archaïque est donc un #neuromythe.

    Plus généralement, les données neuroscientifiques ne défendent pas un #déterminisme des comportements humains par « le striatum » ou « la dopamine ». Ce que montrent les études actuelles en neurosciences, ce sont certaines relations entre des éléments de comportements isolés dans des conditions expérimentales simplifiées et contrôlées, chez l’humain ou d’autres animaux, et des mesures d’activités dans des circuits neuronaux, impliquant entre autres le striatum, la dopamine ou le cortex préfrontal. Le striatum autocrate, dont nous serions l’esclave, est donc aussi un neuromythe.

    Par ailleurs, Bohler et Ripoll font appel à une lecture psycho-évolutionniste simpliste, en fantasmant la vie des êtres humains au paléolithique et en supposant que les #gènes codant pour les structures du cerveau seraient adaptés à des conditions de vie « primitive », et pas à celles du monde moderne caractérisé par une surabondance de biens et de possibles[ii]. Il y a deux problèmes majeurs avec cette proposition. Tout d’abord, les liens entre les gènes qui sont soumis à la sélection naturelle, les structures cérébrales, et les #comportements_sociaux sont extrêmement complexes. Les #facteurs_génétiques et environnementaux sont tellement intriqués et à tous les stades de développement qu’il est impossible aujourd’hui d’isoler de façon fiable des #déterminismes_génétiques de comportements sociaux (et ce n’est pourtant pas faute d’avoir essayé). Poser la surconsommation actuelle comme sélectionnée par l’évolution, sans données génétiques, est une spéculation dévoyée de la #psychologie_évolutionniste. Le second problème concerne les très faibles connaissances des modes d’#organisation_sociale des peuples qui ont vécu dans la longue période du paléolithique. Il n’existe pas à notre connaissance de preuves d’invariants ou d’un mode dominant dans leur organisation sociale. Les affirmations évolutionnistes de Bohler et Ripoll n’ont donc pas de statut scientifique.

    Il est toujours problématique de privilégier un facteur principal pour rendre compte d’évolutions historiques, quel qu’il soit d’ailleurs, mais encore plus quand ce facteur n’existe pas. Les sciences humaines et sociales montrent la diversité des modèles d’organisation sociale qui ont existé sur Terre ainsi que les multiples déterminismes socio-historiques de la « grande accélération » caractéristique des sociétés modernes dopées aux énergies fossiles. Non, toutes les sociétés n’ont pas toujours été tournées vers le désir de toujours plus, vers le progrès et la croissance économique : on peut même argumenter que la « religion du #progrès » devient dominante dans les sociétés occidentales au cours du xixe siècle[iii], tandis que le modèle de la #croissance_économique (plutôt que la recherche d’un équilibre) n’émerge qu’autour de la seconde guerre mondiale[iv]. Invoquer la « #croissance » comme principe universel du vivant, comme le fait Ripoll, abuse du flou conceptuel de ce terme, car la croissance du PIB n’a rien à voir avec la croissance des plantes.

    Il peut certes sembler légitime d’interroger si le fonctionnement du cerveau a, au côté des multiples déterminismes sociohistoriques, une part de #responsabilité dans l’état de la planète. Mais la question est mal posée, l’activité de « milliards de striatum » et les phénomènes socioéconomiques ne constituant pas le même niveau d’analyse. Bohler et Ripoll ne proposent d’ailleurs pas d’explications au niveau cérébral, mais cherchent à légitimer une explication psychologique prétendument universelle (l’absence d’#autolimitation) par la #biologie. Leurs réflexions s’inscrivent donc dans une filiation ancienne qui cherche une explication simpliste aux comportements humains dans un #déterminisme_biologique, ce qu’on appelle une « #naturalisation » des #comportements. Un discours longtemps à la mode (et encore présent dans la psychologie populaire) invoquait par exemple le « #cerveau_reptilien » à l’origine de comportements archaïques et inadaptés, alors que cette pseudo-théorie proposée dans les années 60 a été invalidée quasiment dès son origine[v]. Le « striatum », la « dopamine », le « #système_de_récompense », ou le « #cerveau_rapide et le #cerveau_lent » sont en fait de nouvelles expressions qui racontent toujours à peu près la même histoire. Loin d’être subversive, cette focalisation sur des déterminismes individuels substitue la #panique_morale [vi] à la #réflexion_politique et ne peut mener, puisque nous serions « déterminés », qu’à l’#impuissance ou à l’#autoritarisme.

    Les erreurs des arguments développés par Bohler et Ripoll ont d’ores et déjà été soulignées à propos d’ouvrages précédents de Bohler[vii]. Nous souhaitons également rappeler qu’il existe un processus d’évaluation des productions scientifiques (y compris théoriques) certes imparfait mais qui a fait ses preuves : la revue par les pairs. Aucun de ces deux auteurs ne s’y est soumis pour avancer ces propositions[viii]. Il n’est pas sûr que notre rôle de scientifiques consiste à évaluer les approximations (et c’est un euphémisme) qui sont en continu publiées dans des livres ou dans la presse. Notre réaction présente est une exception justifiée par une usurpation des neurosciences, la gravité des enjeux écologiques dont ces auteurs prétendent traiter, ainsi que par la popularité grandissante que ces thèses semblent malheureusement rencontrer[ix].

    _____________________

    Ce texte n’est pas issu des travaux de l’atelier d’écologie politique mais il résonne fortement avec d’autres travaux de l’atécopol. Il a été rédigé par Etienne Coutureau, chercheur CNRS en neurosciences (Bordeaux), Jean-Michel Hupé, chercheur CNRS en neurosciences et en écologie politique et membre de l’atécopol (Toulouse), Sébastien Lemerle, enseignant-chercheur en sociologie (Paris-Nanterre), Jérémie Naudé, chercheur CNRS en neurosciences (Montpellier) et Emmanuel Procyk, chercheur CNRS en neurosciences (Lyon).

    [i] Jean-Michel Hupé, Vanessa Lea, « Nature humaine. L’être humain est-il écocidaire par nature ? », dans Greenwashing : manuel pour dépolluer le débat public, Aurélien Berlan, Guillaume Carbou et Laure Teulières (coords.), Paris, Le Seuil, 2022, p. 150-156.

    [ii] Philippe Huneman, Hugh Desmond, Agathe Du Crest, « Du darwinisme en sciences humaines et sociales (1/2) », AOC, 15 décembre 2021.

    [iii] François Jarrige, Technocritiques, Paris, La Découverte, 2014.

    [iv] Timothy Mitchell, « Economentality : how the future entered government », Critical inquiry, 2014, vol. 40, p. 479-507. Karl Polanyi a par ailleurs montré comment l’économie de marché est une construction socio-historique : La Grande Transformation, Aux origines politiques et économiques de notre temps, Paris, Gallimard, (1944) 1983.

    [v] Sébastien Lemerle, Le cerveau reptilien. Sur la popularité d’une erreur scientifique, Paris, CNRS éditions, 2021.

    [vi] Jean-Michel Hupé, Jérôme Lamy, Arnaud Saint-Martin, « Effondrement sociologique ou la panique morale d’un sociologue », Politix, n° 134, 2021. Cet article témoigne également que Bohler et Ripoll ne sont pas les seuls intellectuels mobilisant les neurosciences de façon très contestable.

    [vii] Jérémie Naudé (2019), « Les problèmes avec la théorie du "bug humain", selon laquelle nos problème d’écologie viendraient d’un bout de cerveau, le striatum » ; Thibault Gardette (2020), « La faute à notre cerveau, vraiment ? Les erreurs du Bug humain de S. Bohler » ; Alexandre Gabert (2021), « Le cortex cingulaire peut-il vraiment "changer l’avenir de notre civilisation" ? », Cortex Mag, interview d’Emmanuel Procyk à propos de Sébastien Bohler, Où est le sens ?, Paris, Robert Laffont, 2020.

    [viii] Le bug humain de Sébastien Bohler (Paris, Robert Laffont, 2019) a certes obtenu « le Grand Prix du Livre sur le Cerveau » en 2020, décerné par la Revue Neurologique, une revue scientifique à comité de lecture. Ce prix récompense « un ouvrage traitant du cerveau à destination du grand public ». Les thèses de Bohler n’ont en revanche pas fait l’objet d’une expertise contradictoire par des spécialistes du domaine avant la publication de leurs propos, comme c’est la norme pour les travaux scientifiques, même théoriques.

    [ix] La thèse du bug humain est ainsi reprise dans des discours de vulgarisation d’autorité sur le changement climatique, comme dans la bande dessinée de Christophe Blain et Jean-Marc Jancovici, Le monde sans fin, Paris, Dargaud, 2021.

    https://blogs.mediapart.fr/atelier-decologie-politique-de-toulouse/blog/070722/pourquoi-detruit-la-planete-les-dangers-des-explications-pseudo-neur
    #neuro-science #neuroscience #critique #écologie #surconsommation #politisation #dépolitisation #politique

  • De la #démocratie en #Pandémie. #Santé, #recherche, #éducation

    La conviction qui nous anime en prenant aujourd’hui la parole, c’est que plutôt que de se taire par peur d’ajouter des polémiques à la confusion, le devoir des milieux universitaires et académiques est de rendre à nouveau possible la discussion scientifique et de la publier dans l’espace public, seule voie pour retisser un lien de confiance entre le savoir et les citoyens, lui-même indispensable à la survie de nos démocraties. La stratégie de l’omerta n’est pas la bonne. Notre conviction est au contraire que le sort de la démocratie dépendra très largement des forces de résistance du monde savant et de sa capacité à se faire entendre dans les débats politiques cruciaux qui vont devoir se mener, dans les mois et les années qui viennent, autour de la santé et de l’avenir du vivant.

    https://www.gallimard.fr/Catalogue/GALLIMARD/Tracts/De-la-democratie-en-Pandemie

    –-

    Et une citation :

    « La conviction qui nous anime en prenant aujourd’hui la parole, c’est que plutôt que de se taire par peur d’ajouter des #polémiques à la #confusion, le devoir des milieux universitaires et académiques est de rendre à nouveau possible la discussion scientifique et de la publier dans l’espace public, seule voie pour retisser un lien de confiance entre le #savoir et les citoyens, lui-même indispensable à la survie de nos démocraties. La stratégie de l’ _#omerta_ n’est pas la bonne. Notre conviction est au contraire que le sort de la démocratie dépendra très largement des forces de résistance du monde savant et de sa capacité à se faire entendre dans les débats politiques cruciaux qui vont devoir se mener, dans les mois et les années qui viennent, autour de la santé et de l’avenir du vivant. »

    #syndémie #désert_médical #zoonose #répression #prévention #confinement #covid-19 #coronavirus #inégalités #autonomie #état_d'urgence #état_d'urgence_sanitaire #exception #régime_d'exception #Etat_de_droit #débat_public #science #conflits #discussion_scientifique #résistance #droit #santé #grève #manifestation #déni #rationalité #peur #panique #colère #confinement #enfermement #défiance #infantilisation #indiscipline #essentiel #responsabilité #improvisation #nudge #attestation_dérogatoire_de_déplacement #libéralisme_autoritaire #autoritarisme #néolibéralisme #colloque_Lippmann (1938) #économie_comportementale #Richard_Thaler #Cass_Sunstein #neuroscience #économie #action_publique #dictature_sanitaire #consentement #acceptabilité_sociale #manufacture_du_consentement #médias #nudging #consulting #conseil_scientifique #comité_analyse_recherche_et_expertise (#CARE) #conseil_de_défense #hôpitaux #hôpital_public #système_sanitaire #éducation #destruction #continuité_pédagogique #e-santé #université #portefeuille_de_compétences #capital_formation #civisme #vie_sociale #déconfinement #austérité #distanciation_sociale #héroïsation #rhétorique_martiale #guerre #médaille_à_l'engagement #primes #management #formations_hybrides #France_Université_Numérique (#FUN) #blended_learning #hybride #Loi_de_programmation_de_la_recherche (#LPR ou #LPPR) #innovation #start-up_nation #couvre-feu #humiliation #vaccin #vaccination
    #livre #livret #Barbara_Stiegler

    • secret @jjalmad
      https://twitter.com/jjalmad/status/1557720167248908288

      Alors. Pour Stiegler je veux bien des ref si tu as ça, j’avais un peu écouté des conf en mode méfiance mais il y a un moment, sans creuser, et je me disais que je devais pousser parce qu’en effet grosse ref à gauche

      @tapyplus

      https://twitter.com/tapyplus/status/1557720905828253698

      Check son entretien avec Desbiolles chez les colibris par ex. T’as aussi ses interventions à ASI, son entretien avec Ruffin, etc. C’est une philosophe médiatique, on la voit bcp. Et elle dit bien de la merde depuis qq tps. Aussi un live de la méthode scientifique avec Delfraissy

      Je suis pas sur le PC mais je peux te lister pas mal de sources. D’autant plus pbtk parce que « réf » à gauche. Mais dans le détail elle dit de la merde en mode minimiser le virus + méconnaissance de l’antivaccinisme. Et du « moi je réfléchit » bien claqué élitiste et méprisant.

      Quelques interventions de B Stiegler (en vrac) :
      Alors la première m’avait interpellée vu qu’elle était partie en HS complet à interpeller Delfraissy sur les effets secondaires des vaccins : https://radiofrance.fr/franceculture/podcasts/la-methode-scientifique/et-maintenant-la-science-d-apres-8387446
      (le pauve N Martin se retrouvait sur un débat complètement HS)

      Il y a d’une part la critique politique (rapport à la démocratie en santé publique), mais pour Stiegler outre la position « le gvt en fait trop, c’est des mesures autoritaires inutiles » elle se positionne par ailleurs sur des choix

      Parler des EI des vaccins sans balancer avec les effets de la maladie. Utilisation de la santé mentale des enfants pour critiquer le port du masque à l’école, lecture de la situation où il n’y aurait que gvt vs libertay, et en omettant complètement toutes les positions développées par l’autodéfense sanitaire et les militants antivalidistes et de collectifs de patients (immunodéprimés, covid long, ...) quand ils ne vont pas dans son narratif.

      Elle met de côté toutes les lectures matérialistes de la situation et sort clairement de son champ de compétence sur certains points, tout en ne donnant que très peu de sources et de points de référence pour étayer ses propos.

      Genre elle critique la pharmacovigilance et les EI mais elle ne donne jamais aucune source ni aucune information sur les outils, méthodes et acteurs qui travaillent ces sujets. Pareil quand elle dit découvrir les critiques des vaccination. Il y a de quoi faire avec les travaux historique sur la #santé_publique et la vaccination. A t elle interrogé des spécialiste de ces sujets, notamment les spécialistes qui ne vont pas que dans le sens de son propos. Elle semble manquer cruellement de référence historique sur le sujet alors qu’elle s’en saisit et qu’elle a une aura d’#intellectuelle_de_gauche, donc plein de monde lui accorde une confiance et trouve qu’elle est très pertinente sur certains sujets. Mais sur le traitement des points techniques elle me semble plutôt à la ramasse et ce qui ne va pas dans son sens est renvoyé à la doxa gouvernementale ou technoscientiste liberale, sans apparemment regarder les contenus eux même. Et Desbiolles c’est pareil. Alla je connais moins et je l’ai entendu dire qq trucs pertinents (sur les profils des non vaccines par exemple) mais le fait qu’il cite Desbiolles devant l’opecst, alors que celle ci racontait des trucs bien limites sur les masques et les enfants, ça me met des warnings.

      Je rajouterai 2 points : 1) il y a des sujets super intéressants à traiter de trouver comment on construit une position collective sur des questions de santé publique, ni individualiste ni subissant l’autorité de l’état. Genre comment penser une réflexions sur les vaccinations (en général, pas spécifiquement covid) dans une perspective émancipatrice et libertaire, comment on fait collectif, comment on mutualise des risques, comment on se donne des contraintes individuelles pour soutenir celles et ceux qui en ont plus besoin.

      Stiegler ne fait que critiquer l’autoritarisme d’état, parle de démocratie, mais ne propose aucune piste concrète ni axe de réflexion pour développer cela. D’autres personnes le font et développent cela, et c’est des sujets non triviaux sur lesquels il est important de délibérer.

      2) Un autre point c’est son discours, comme ceux d’autres intellectuels, est surtout axé sur la partie « choix libre » de la phrase « choix libre et éclairé », et n’évoquent pas vraiment la manière dont on construit collectivement la partie « éclairé »

      Il y a des sujets super importants à traiter sur le rapport aux paroles d’expert, de la place des scientifiques dans un débat public, de la dialectique entre connaissance scientifique et choix politiques et éthiques, bref plein d’enjeux d’éducation populaire

      Ah et aussi dernier point que j’ai déjà évoqué par le passé : l’axe « liberté » sur les questions de vaccination, c’est un argument central des discours antivaccinaux, qui axent sur le fait que les individus peuvent choisir librement etc. C’est assez documenté et c’est par exemple un registre argumentaire historique de la Ligue Nationale Pour la Liberté de Vaccination (LNPLV), qui défend le rapport au choix, défendant les personnes qui ont refusé les vaccinations obligatoires. Mais sous couvert de nuance et de démocratie, ce sont des positions antivaccinales assez claires qui sont défendues. Ce truc de la nuance et de la liberté, tu la retrouves par exemple également chez les anthroposophes (j’en parlais récemment dans un thread).

      j’ai enfin compris pourquoi on dit intellectuel de gauche : c’est pour indiquer avec quel pied leur marcher dessus.

  • Brain imaging and neuropsychological assessment of individuals recovered from mild to moderate #SARS-CoV-2 infection | medRxiv
    https://www.medrxiv.org/content/10.1101/2022.07.08.22277420v1

    Conclusions and Relevance :

    […] in our sample, a mild to moderate SARS-CoV-2 infection was not associated with neuropsychological deficits, significant changes in cortical structure or vascular lesions several months after recovery. External validation of our findings and longitudinal follow-up investigations are needed.

    #neurologie

  • HPI et surdoués, un diagnostic qui sert les intérêts d’une classe sociale
    https://www.ladn.eu/nouveaux-usages/non-votre-enfant-nest-pas-hpi-vous-etes-juste-riche

    La question n’est pas de remettre en cause l’existence de niveaux intellectuels différents, car la sociologie l’explique simplement : le cerveau étant plastique, plus les gens seront entraînés, plus ils seront forts. Les études montrent en effet que le quotient intellectuel (QI) est corrélé avec la classe sociale et le niveau de diplôme de parents. Mais là où les psychologues diront que le QI est le meilleur prédicteur de la réussite sociale ou scolaire, les sociologues avanceront l’inverse : l’accumulation de ressources culturelles fait le QI. Si la question est de savoir si les enfants identifiés comme HPI sont nés comme ça, plusieurs éléments tendent à prouver le contraire. Les statistiques indiquent qu’ils sont généralement issus des classes supérieures, qu’ils sont HPI à certains « moments » et pas à d’autres (la plupart des enfants testés le sont principalement en CE1 pour sauter le CE2, et à la fin de la moyenne section pour sauter la grande section), et qu’ils sont à 75 % des garçons. Ce dernier point crée une contrainte argumentative certaine, pour ceux qui « croient » aux HPI : les garçons seraient intrinsèquement plus intelligents que les filles ? En outre, se demander si les HPI sont vraiment HPI, c’est déjà se tromper de question. Il est plus judicieux de se demander pourquoi certains parents font tester leurs enfants, vont s’investir de cette question, et ce qu’ils en retirent.

  • Le virus mangeur de cerveau | Nature | oct. 2021

    https://www.nature.com/articles/s41593-021-00926-1

    The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

    Abstract

    Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and cause neurological symptoms. Here we describe structural changes in cerebral small vessels of patients with COVID-19 and elucidate potential mechanisms underlying the vascular pathology. In brains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals and animal models, we found an increased number of empty basement membrane tubes, so-called string vessels representing remnants of lost capillaries. We obtained evidence that brain endothelial cells are infected and that the main protease of SARS-CoV-2 (Mpro) cleaves NEMO, the essential modulator of nuclear factor-κB. By ablating NEMO, Mpro induces the death of human brain endothelial cells and the occurrence of string vessels in mice. Deletion of receptor-interacting protein kinase (RIPK) 3, a mediator of regulated cell death, blocks the vessel rarefaction and disruption of the blood–brain barrier due to NEMO ablation. Importantly, a pharmacological inhibitor of RIPK signaling prevented the Mpro-induced microvascular pathology. Our data suggest RIPK as a potential therapeutic target to treat the neuropathology of COVID-19.

    • Des preuves d’invasion cérébrale | JEM | janvier 2021

      https://rupress.org/jem/article-standard/218/3/e20202135/211674/Neuroinvasion-of-SARS-CoV-2-in-human-and-mouse

      Neuroinvasion of SARS-CoV-2 in human and mouse brain

      Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects multiple organ systems including the central nervous system (CNS). Yet, there is no consensus on the consequences of CNS infections. Here, we used three independent approaches to probe the capacity of SARS-CoV-2 to infect the brain. First, using human brain organoids, we observed clear evidence of infection with accompanying metabolic changes in infected and neighboring neurons. However, no evidence for type I interferon responses was detected. We demonstrate that neuronal infection can be prevented by blocking ACE2 with antibodies or by administering cerebrospinal fluid from a COVID-19 patient. Second, using mice overexpressing human ACE2, we demonstrate SARS-CoV-2 neuroinvasion in vivo. Finally, in autopsies from patients who died of COVID-19, we detect SARS-CoV-2 in cortical neurons and note pathological features associated with infection with minimal immune cell infiltrates. These results provide evidence for the neuroinvasive capacity of SARS-CoV-2 and an unexpected consequence of direct infection of neurons by SARS-CoV-2.

      via @Dowser

  • Une étude sur des primates infectés avec le #coronavirus a permis de voir en détail quelles zones du #cerveau sont les plus touchées et l’ampleur de ces dégâts.

    Les dégâts cérébraux observés chez les primates étaient causés par l’infection au coronavirus, mais pas directement, car le #virus n’était pas trouvé en grandes quantités dans le cerveau, à l’exception des vaisseaux sanguins. C’est dans les cellules endothéliales qui tapissent les vaisseaux sanguins que le virus se concentrait. Mais l’infection de ces cellules pourrait entrainer les problèmes vasculaires observés, générant les micro-hémorragies et l’ischémie qui ensuite vont causer l’inflammation et la mort cellulaire des #neurones. Effet aggravé par la baisse d’oxygénation du sang causée par le #Covid et l’hypoxie qui s’ensuit. Cependant, le bulbe olfactif n’a pas été analysé dans cette étude, donc il est possible que le virus puisse entrer dans le système nerveux central par cette voie. Il reste à savoir maintenant comment ces dommages cérébraux entraînent les problèmes neurologiques observés dans le Covid et le Covid long.

    https://www.sciencesetavenir.fr/sante/cerveau-et-psy/covid-19-voici-comment-le-coronavirus-affecte-le-cerveau_162914

  • London taxi drivers: A review of neurocognitive studies and an exploration of how they build their cognitive map of London - Griesbauer - 2022 - Hippocampus - Wiley Online Library
    https://onlinelibrary.wiley.com/doi/10.1002/hipo.23395

    Eva-Maria Griesbauer,Ed Manley,Jan M. Wiener,Hugo J. Spiers
    First published: 16 December 2021 https://doi.org/10.1002/hipo.23395

    Abstract
    Licensed London taxi drivers have been found to show changes in the gray matter density of their hippocampus over the course of training and decades of navigation in London (UK). This has been linked to their learning and using of the “Knowledge of London,” the names and layout of over 26,000 streets and thousands of points of interest in London. Here we review past behavioral and neuroimaging studies of London taxi drivers, covering the structural differences in hippocampal gray matter density and brain dynamics associated with navigating London. We examine the process by which they learn the layout of London, detailing the key learning steps: systematic study of maps, travel on selected overlapping routes, the mental visualization of places and the optimal use of subgoals. Our analysis provides the first map of the street network covered by the routes used to learn the network, allowing insight into where there are gaps in this network. The methods described could be widely applied to aid spatial learning in the general population and may provide insights for artificial intelligence systems to efficiently learn new environments.

    1 INTRODUCTION
    The ability to navigate an environment depends on the knowledge of that environment. This knowledge can be gained in multiple ways, such as via instructions on GPS devices, memorizing a cartographic map, or through exploration. The knowledge formed can vary from very imprecise to extremely accurate, depending on the complexity of the environment, the level of exposure to the environment and individual differences (Ekstrom et al., 2018; Schinazi et al., 2013; Weisberg et al., 2014; Weisberg & Newcombe, 2016). Over the last decades, there has been increasing interest in understanding how different methods for learning impact the acquisition of spatial knowledge (e.g., Balaguer et al., 2016; Dahmani & Bohbot, 2020; Gardony et al., 2013; Hejtmánek et al., 2018; Ishikawa et al., 2008; Münzer et al., 2006, 2012; Siegel & White, 1975; Streeter & Vitello, 1986) and how individuals differ in their capacity to learn to navigate new environments (Burles & Iaria, 2020; Coutrot et al., 2018, 2019, 2020; Feld et al., 2021; Newcombe, 2018; Weisberg & Newcombe, 2016).

    Despite GPS devices being a preferred method of navigation for many (McKinlay, 2016), the increased use of GPS devices appears to have a negative impact on spatial memory (Dahmani & Bohbot, 2020; Ruginski et al., 2019) and is associated with habitual learning of a particular route (Münzer et al., 2006). In contrast to GPS-based instruction-guided navigation, “map-based navigation” (relying on memory for the map) has been found to support spatial learning, knowledge acquisition of the environment and improved flexible navigation performance (e.g., Ishikawa et al., 2008; Münzer et al., 2006, 2012). Such flexible navigation relying on long-term memory is associated with the construction of a cognitive map, which stores the allocentric information about the structure of the environment enabling shortcuts and efficient detours around unexpected obstacles (O’Keefe & Nadel, 1978; Tolman, 1948).

    A range of evidence indicates that within the brain the hippocampus provides a cognitive map of the environment to support memory and navigation (Epstein et al., 2017; Gahnstrom & Spiers, 2020; O’Keefe & Nadel, 1978) and damage to the hippocampus disrupts navigation (Morris et al., 1982; Spiers, Burgess, Hartley, et al., 2001). Hippocampal neurons encode spatial information (O’Keefe & Nadel, 1978) and for a selected group of individuals, who spend their daily lives navigating using map-based recall of space, their posterior hippocampal gray matter volume increases with years of experience and is larger than in the general population (Maguire et al., 2000). These individuals are licensed London taxi drivers. Here, we review the past literature from studies of London taxi drivers and explore how they learn the large amount of knowledge required to navigate London, which evidence suggests drives the changes in their hippocampus (Woollett & Maguire, 2011).

    2 A REVIEW OF RESEARCH ON LONDON TAXI DRIVERS
    Licensed London taxi drivers are unusual among taxi drivers. They are able to mentally plan routes across an environment that contains more than 26,000 streets within the six-mile area around Charing Cross, the geographic center of London (A to Z from Collins The Knowledge, 2020). They are required to have sufficient knowledge to also navigate main artery roads in the suburbs—known as “The Knowledge.” This area covers almost 60,000 roads within the circular M25 (The London Taxi Experience—The Knowledge, 2020; numbers may vary depending on sources, road types and the definition of the boundary of London). What makes licensed London taxi drivers unique is that they have to accomplish this using their own memory, without relying on physical maps or navigation aids. They are also the only taxi drivers permitted to pick up customers when hailed in the street, due to their license to operate. In the rest of this article, we refer to them as London taxi drivers, but readers should note that our analysis pertains only to licensed taxi drivers, who are also referred to as “London cabbies.”

    Changes in the hippocampal gray matter density in London taxi drivers were first reported by Maguire et al. (2000) using a cross-sectional study of London taxi drivers and magnetic resonance imaging (MRI) measures, including voxel-based morphometry (VBM). Maguire et al. (2000) speculated that because rodent and avian species can show variation in the size of their hippocampus with the demand on spatial memory (Lee et al., 1998; Smulders et al., 1995), it might be possible that London taxi drivers would show similar differences due to their profession. There were two main findings from this study: (i) compared to age and gender matched control participants, London taxi drivers had an increased gray matter density in their posterior hippocampus and a decreased gray matter density in their anterior hippocampus, (ii) years of experience was positively correlated with gray matter density in the right posterior hippocampus and negatively correlated with anterior cross sectional volume. Thus, there is no evidence for a globally larger hippocampus, but rather more experienced taxi drivers show a significant difference in the amount of gray matter along the long-axis of the hippocampus.

    Following the discovery of differences in hippocampal size in London taxi drivers by Maguire et al. (2000) numerous studies have explored their brain function and cognition. MRI has provided further evidence of structural differences in their hippocampus, with three further studies supporting the initial findings (Maguire, Woollett, & Spiers, 2006; Woollett et al., 2009; Woollett & Maguire, 2011). To provide a more precisely matched control group to London taxi drivers, MRI structural measures were contrasted between London taxi drivers and London bus drivers. If the gray matter changes in taxi drivers are driven by daily driving and/or daily exposure to London, then bus drivers should have a similar hippocampal size to taxi drivers as they daily drive routes through London. However, if it is using extensive spatial knowledge that underlies the differences in gray matter density then London taxi drivers and bus drivers should differ. Results revealed that compared to London bus drivers, London taxi drivers have increased posterior hippocampus gray matter density, decreased anterior hippocampal gray matter density (Maguire, Woollett, & Spiers, 2006), replicating previous results (Maguire et al., 2000). While bus drivers show no relationship between hippocampal volume and years of experience, London taxi drivers were again found to show a positive correlation between posterior hippocampal gray matter volume and years of experience (Maguire, Woollett, & Spiers, 2006).

    While cross-sectional studies of gray matter density provide evidence that changes in hippocampal volume may occur with exposure over time, they do not track individuals over time to provide a more reliable measure of structural changes with experience. Examining brain changes longitudinally within subjects, Woollett and Maguire (2011) found that an increase in the posterior hippocampus gray matter density after the years spent learning the Knowledge and passing the exam required to become a licensed taxi driver (Woollett & Maguire, 2011). Notably, taxi drivers showed no differences in hippocampal volume prior to starting training to non-taxi drivers, indicating that taxi drivers may not be predisposed to having a larger hippocampus as part of what predisposes someone to choose to train as a taxi driver. Intriguingly, those who failed to qualify did not show a change in their hippocampal size, indicating that it is not sufficient to spend time training, training must be applied effectively for changes in posterior gray matter density to become evident. Furthermore, cross-sectional evidence from measuring hippocampal size in medical professionals revealed no correlation between years of experience and hippocampal structural measures (Woollett et al., 2008). This suggests that it is unlikely to be storing the memory of all the street names that underlies the correlation between hippocampal volume and years of experience operating a London taxi.

    Following the discovery of gray matter differences in London taxi drivers a number of studies have explored the extent to which hippocampal size might predict navigation ability. The first study to explore this in a sample of 23 participants found no association between posterior gray matter volume and navigation ability on a virtual navigation task (Maguire et al., 2003). However, a number of subsequent studies have reported a relationship between measures of hippocampal structure and navigation performance (Bohbot et al., 2007; Brunec et al., 2019; Chrastil et al., 2017; He & Brown, 2020; Hodgetts et al., 2020; Konishi & Bohbot, 2013; Schinazi et al., 2013; Sherrill et al., 2018; see also Hao et al., 2017). More recently, two studies with larger samples have found no relationship between hippocampal structure and either navigation (Weisberg et al., 2019) or route sequencing (Clark et al., 2020). Thus it remains a matter of debate whether in non-taxi drivers there is a link between hippocampal structure and navigation performance (see Weisberg & Ekstrom, 2021 for review).

    Acquiring the Knowledge of London seems to come at a cost of learning and retaining new visuo-spatial information, which co-occurs with a concurrent volume decrease in the anterior hippocampus (Maguire, Woollett, & Spiers, 2006; Woollett & Maguire, 2009, 2012). However, in the small sample studied by Maguire, Woollett, and Spiers (2006) no significant correlation was present between anterior gray matter density reduction and the performance on visuospatial tasks. Functional neuroimaging studies have shown engagement of their posterior hippocampus when verbally recalling routes (Maguire et al., 1997) and at the start of the route when navigating a highly detailed virtual simulation of London (Spiers & Maguire, 2006a, 2007a). Other research with London taxi drivers has revealed insight into spontaneous mentalizing (Spiers & Maguire, 2006b), remote spatial memory (Maguire, Nannery & Spiers, 2006), emotions during navigation (Spiers & Maguire, 2008), the neural basis of driving a vehicle (Spiers & Maguire, 2007b), the features of street network that define a boundaries for navigation (Griesbauer et al., 2021) and the route planning process (Spiers & Maguire, 2008). London taxi drivers have also been shown to be better than non-taxi drivers at learning new routes (Woollett & Maguire, 2009).

    Despite the numerous studies exploring London taxi drivers, little attention has been paid to how London taxi drivers learn and memorize the layout and landmarks in London (Skok, 1999). Many questions arise when considering this. How is their exploration structured? What do they study when examining maps? How are map and physical travel experience integrated? What role does mental imagery play in aiding their learning? How do they exploit the hierarchical structure of London’s layout? Are major roads mastered before minor roads? In this observational report we provide the first investigation of London taxi driver’s learning process and the methods and techniques that enable them to retain and use such a large amount of real-world spatial information for efficient navigation.

    3 METHODS TO STUDY LEARNING OF THE KNOWLEDGE
    To understand the learning process of taxi drivers, different types of sources of information have been consulted. These sources included (a) a semi-structured interview (ethics approval was obtained under the ethics number CPB/2013/150) with a teacher from a London Knowledge school (here referred to as K.T. for “Knowledge Teacher”), (b) an email exchange with Robert Lordan, the author of “The Knowledge: Train Your Brain Like A London Cabbie” (Lordan, 2018), (c) an open introductory class of the Knowledge of London and regular scheduled classes for current students, (d) school specific study material, and (e) online information from the TfL (Learn the Knowledge of London, Transport for London, n.d.; Electronic blue book, 2019).

    The interview with the teacher from the Knowledge school was audio-recorded and transcribed. The transcription of the interview can be found in Appendix S1. The teacher gave written consent for the content of this interview to be cited and published. Additionally, attendances of Knowledge school training classes, including an introductory class and several classes with more advanced students, allowed us to observe and understand the training process in more detail.

    The information collected from these sources was systematically reviewed to report on (a) the ways spatial information is structured and presented for the learning process, (b) the techniques and methods used to learn this spatial information, and (c) how this knowledge is tested and the later perception of this knowledge as a taxi driver. A summary for each of these categories was created, starting with verbal reports (interview [Appendix S1], Knowledge school classes). This information was cross-referenced with and extended by unreported information from other, published, or official sources (e.g., study material, online booklets by TfL).

    4 OBSERVATIONS
    Taxi drivers in London have to demonstrate a thorough Knowledge of London within the six-mile radius originating at Charing Cross (see Figure 1a) to earn the green badge that qualifies them to drive a “black cab” taxi (Electronic blue book, 2019). Within this area, taxi drivers are expected to plan a route (i.e., the “runs”) based on the shortest distance between any two potential places of interest (i.e., the “points”) their customers might travel from or to, such as restaurants, theaters, hospitals, sports centers, schools or parks (cf. Electronic blue book, 2019, for a complete list). Taxi drivers are also expected to name all roads or streets that are part of that run in the correct, sequential order, including traveling instructions, such as turns (Electronic blue book, 2019).

    FIGURE 1


    The Knowledge of London and the Blue Book. (a) London taxi driver students are expected to learn the street network and all potential points of interest within the six-mile radius around Charing Cross (black circle), which is called the “Knowledge of London.” (b) To support the learning process of this area, the Blue Book was created. It contains 320 origin–destination pairs and the shortest route (i.e., “run”) connecting those pairs. When mapped chronologically in groups of 80 runs, the network of origin–destination pairs starts overlapping and becomes denser. Red: The first layer of the first 80 origin–destination pairs. Black: The second layer of the origin–destination pairs for runs 81–160. Purple: The third layer of origin–destination pairs for runs 161–240. Blue: The final layer of the last 80 origin–destination pairs for runs 241–320.
    Map sources: (a) Mapbox (2020) and (b) My Maps by Google Maps

    Historically, the exact roots of the Knowledge of London are unclear as written evidence is mostly missing. The first licenses and regulations for horse-driven carriages date back to the early 1600s by Oliver Cromwell (June 1654: An Ordinance for the Regulation of Hackney-Coachmen in London and the places adjacent, 1911; London Metropolitan Archives, 2013; Lordan, 2018; Newton, 1857). However, in 1851 the Great Exhibition in Hyde Park revealed incompetent navigation skills of the carriage drivers of those days. These initiated a series of complaints and forced authorities in the following years to set up stricter qualification requirements for drivers to test their knowledge of important streets, squares and public buildings (A to Z from Collins—The Knowledge, 2020; Lordan, 2018; Rosen, 2014). This scheme was officially introduced in 1865 (Learn the Knowledge of London, Transport for London, n.d.). The requirements in relation to the content of the Knowledge have since hardly changed and remained in place (The Knowledge, 2020) despite the technological innovations that have produced navigation aids, such as GPS devices, that facilitate and guide navigation. The following sections will outline how this is achieved by taxi drivers.

    4.1 Presentation of spatial information in Knowledge schools
    To help students to acquire the fundamentals of the Knowledge of London, the Blue Book (the origin of this name is unclear) was designed, which, in its current form, was put into place in 2000 (interview with K.T., Appendix S1). It contains 320 origin–destination pairs, their corresponding runs, as well as additional points related to tourism, leisure, sports, housing, health, education, and administration (Electronic blue book, 2019). In total, there are about 26,000 different streets and roads (Eleanor Cross Knowledge School, 2017) and more than 5000 points (Full set of Blue Book Runs, 2020) listed in the Knowledge schools’ versions of the Blue Book. However, this knowledge is incomplete. By the time students qualify, they will have extended their knowledge to identify more than 100,000 points (The London Taxi Experience—The Knowledge, 2020) in a street network of about 53,000 streets (OS MasterMap Integrated Transport Network, 2018). This covers not only the six-mile area, but extends to all London boroughs, including major routes in the suburbs.

    The 320 origin–destination pairs of the Blue Book with their corresponding runs are structured into 20 lists of 16 pairs each, which are designed to systematically cover the six-mile radius: In a chronological order, as listed in the Blue Book, the majority of origin–destination pairs have an origin in the same postal districts as the destination of the previous origin–destination pair and spread across London throughout each list (Electronic blue book, 2019). When mapped in layers of four, the first 80 runs (i.e., five lists) provide an initial rough coverage of London. This coverage becomes denser with each of the remaining three layers that are shifted slightly against each other to fill in the gaps (Figure 1b).

    Each of the origins and destinations in the Blue Book also require students to learn the nearby environment within the quarter mile range. That area around a Blue Book point is called the “quarter mile radius,” or in short: the “quarter-miles” and is considered as ideal for learning small areas of the environment without overloading students with information (interview with K.T., Appendix S1; Learn the Knowledge of London, Transport for London, n.d.; Electronic blue book, 2019). For the first and most famous run, which connects Manor House Station to Gibson Square, the quarter-mile radius is illustrated in Figure 2a. It contains about 8 additional points, numbered 1–8. These are chosen by each Knowledge school individually and can differ between schools. The additional points serve as initial motivation for students to explore the quarter-miles and learn which streets link these points to each other. Knowledge of the remaining, unmentioned points in the area will be obtained by each student gradually as they progress through the Knowledge of London by studying maps and exploring the quarter-miles in person.

    FIGURE 2


    Example of Knowledge school material in use. In Knowledge schools, wallpaper maps (a) are used to illustrate the coverage of London within the six-mile area by the quarter mile radii (b). These maps support the learning of relations between two places and clear up misconceptions such as Victoria being located further north than Waterloo, which is owed to a change in direction of the River Thames (c). “The cottoning up of two points,” a piece of string that is used to create a direct line between the points, is a common method to help with directional studies (c) and planning the most direct routes (d, e). Additionally, students use 50% and 75% markers along the direct line (e) to create subgoals that help to plan the runs
    Source: Knowledge Point School, Brewery Road, London, UK

    Mapping the origin–destination pairs with their corresponding quarter-miles, highlights how the areas locally link to each other (Figure 2b). To create such an overlap that sufficiently covers the whole six-mile area around Charing Cross (also see Figure 2a), 640 points are required, thus explaining the total number of 320 Blue Book runs. Since each point is closely surrounded by nearby origins and destinations of other runs, information is provided about how an area can be approached from or left in different directions. For Manor House (Figure 2b) these points have been indicated by blue and red quarter-miles for nearby origins and destinations, respectively, in Figure 2b. To visualize this information across the entire six-mile area of London and keep track of their progress while learning the Blue Book, trainee taxi drivers mark the origins and destinations, including the quarter-miles, in a large, all London map (Figure 2a,b; Source: Knowledge Point Central, Brewery Road, London, UK).

    Studying maps by visualizing the topological relationship between areas also helps to avoid misconceptions about the city’s geography that could lead to mistakes in route planning. For instance, deviations from the more generally perceived west–east alignment of the river Thames can cause distortions (cf. Stevens & Coupe, 1978). Often Victoria station, located north of the river, is incorrectly perceived further north than Waterloo Station, which is on the southern side of the river, but further east then Victoria (see Figure 2c). This misconception is due to a bend of the river Thames, that causes the river to flow north (instead of east) between Victoria and Waterloo.

    In the Blue Book, the 320 runs connect the origin–destination pairs through the route along the shortest distance for each pair (Electronic blue book, 2019). These pairs were chosen to create runs that are about two to three miles long and mainly follow trunk or primary roads. Here, trunk roads are the most important roads in London after motorways, providing an important link to major cities and other places of importance, with segregated lanes in opposite directions (Key:highway, 2020). Primary roads are defined as the most important roads in London after trunk roads, usually with two lanes and no separation between directions, linking larger towns or areas (Key:highway, 2020). Since these are often printed in orange and yellow in paper maps, taxi drivers also refer to them as “Oranges and Lemons” (interview with K.T., Appendix S1). Trainee taxi drivers visualize these runs on all London maps to learn and practice recalling them (Figure 2d, credit: Knowledge Point Central, Brewery Road, London, UK). Knowledge schools provide the 320 runs for the points of the Blue Book but encourage students to plan these runs before checking the up-to-date solution. To plan a run using the shortest distance and avoid major deviations (as required for the examinations), drawing the direct line (i.e., “as the crow would fly”) or spanning a piece of cotton between the points is essential (Figure 2e). This so-called “cottoning up” also helps students to learn relations between places (Figure 2c) and visualize the map to find ways around obstacles, such as Regent’s Parks, or to select bridges for crossing the river (Figure 2e) during the “call out” of the run (i.e., the recall of the street names in order along shortest route without using a map). Additionally, it provides opportunities to set subgoals, the “50% and 75% markers.” These markers are set where the line coincides with major roads or bridges, about halfway or three quarters along the line. These distances are guidelines only, and sometimes bullets are set at other distances for streets and places along the direct line that facilitate planning in stages. These markers help students to stay close to the direct line, while breaking down longer runs in smaller sections and reduce the number of steps they have to plan for at a time (Figure 2e). Due to one-way streets and turning restrictions, reverse runs from the initial destination to the initial origin can differ. Therefore, the streets and roads cannot simply be called in reverse order but have to be learned separately (Figure 3).

    FIGURE 3


    Runs and reverses runs. Due to one-way systems or turning restrictions, some runs differ when planned in reverse (dashed line), not allowing to simply invert the original sequence of streets taken (black line). This is the case for the run from Islington Police station (P) to the British Museum (B). When reversed, the one-way systems at Russell Square (1) and at Margery Street (2) require adaptation to traffic rules, resulting in differences between the runs and its reverse run. Figure is based on learning material from Taxi Trade Promotions
    The runs of the Blue Book form a network of routes that covers the six-mile area centered around Charing Cross (Figure 4a). However, the coverage of the London street network by the Blue Book runs systematically varies in density with respect to the distribution of points and the complexity of the street network: At its boundaries (Figure 4b) this network is less dense than in central London, where the runs are also overlapping more often (Figure 4c). This also reflects that more points are located closer to the center of London, whereas residential areas are more likely to cover larger regions at the boundaries of the six-mile radius. Similarly, areas of London with a more regular street network, such as in Marylebone and Fitzrovia, are covered by less runs (Figure 4d) than areas with a more complex and irregular street network, such as South Kensington and Chelsea (Figure 4e). These might require more practice to learn.

    FIGURE 4


    Network of Blue Book runs. A visualization of the 320 runs that connect the corresponding origin–destination pairs of the Blue Book forms a dense network of routes that overlaps, similar to the quarter mile radii (a). Across the network, density varies and is less dense closer to the six-mile boundary (b) then in Central London (c). This overlap also shows that more routes run through areas with higher irregularity in the street network (d) than areas of a more regular street network (e) in Central London
    Source: Adapted from Blue Book mapping by Prof Ed Manley, University of Leeds

    The Blue Book runs focus on connecting origin–destination pairs about three miles apart from each other. Since these are mostly main artery roads, they provide the main grid for efficient traveling between those origin–destination pairs. In contrast, minor roads and the areas between the Oranges and Lemons (i.e., main roads that are printed in yellow and orange in most maps) are learnt by studying the quarter-miles and linking the additional points in those areas (Figures 2a and 5b). Further understanding and flexible linking is gained from the Blue Book runs as students start considering continuations between them. For instance, one Blue Book run would have continued along a sequence of straight streets, but the run required a turn off from this straight sequence of streets to reach a destination. In contrast to the previous example, parts of a different run might continue straight, where the initial run required to turn off the straight sequence of roads. Both examples highlight the importance of the ability to flexibly use individual runs as part of the “bigger picture” (interview with K.T., Appendix S1).

    FIGURE 5


    The points of the Blue Book. Each origin–destination pair of the Blue Book is presented in relation to its quarter mile area. The origin of a run, here run 1 (a), Manor House Station, and the corresponding quarter mile radius (black circle) with additional eight other points of interest (numbered 1–8) are marked in a map. Labels are provided in a legend (left) and the most direct route (i.e., “run”) to the destination, including driving instructions (L on L: leave on left, L: left, R: right; F: forward) are listed on the right. The dense network of origin–destination pairs (b) results in an overlay of the neighboring quarter mile radii (black circles around purple arrows). For Manor House Station (purple circle) neighboring quarter-mile origins and destinations are highlighted in blue and red, respectively. These quarter-miles are covering the six-mile radius in London by linking places of interest through linking runs (c) as indicated by the dashed lines connecting run 1 (#) from Manor House Station and run 80 (!"), ending at Harringay Green Lanes Station.
    Source: Figures are based on learning material from Taxi Trade Promotions

    Ultimately, they cover large distances across London as such a combination of knowledge enables trainee drivers to link the Blue Book runs efficiently where they intersect, or through minor roads of the quarter miles where no intersection is available (Figure 2c). Over time, links become more efficient as the Knowledge is “ingrained” and minor roads are integrated to create shortcuts where possible. At this point, the Blue Book is no longer perceived as a list of individual routes, but as an entire network of runs (interview with K.T., Appendix S1).

    4.2 Learning methods
    The progress that Knowledge students have to make from learning the first points and runs to flexibly plan routes all across London is supported through a range of learning techniques as listed in Table 1. These methods can be categorized into theoretical, map-related studies and practical, “in situ” experiences (interview with K.T., Appendix S1; Lordan, 2018). Both support the development of planning strategies that are later used in situations where route planning is required. These include practicing the planning of Blue Book runs and general runs with a “call over partner” (i.e., a Knowledge school study partner) in preparation for exams and when driving a taxi as a qualified driver.

    TABLE 1. Learning techniques used in Knowledge schools
    Learning technique Supported skill and knowledge
    (A) Map study Bird’s eye view:
    General use of maps
    Visualizing street network
    Relational knowledge of streets and areas
    Areal knowledge (e.g., quarter miles)
    Traffic rules (e.g., one-way systems, turning restrictions)
    Sequential order of streets
    Dumbbell methoda,b
    Relational knowledge of places
    Areal knowledge
    Linking runs
    Flexible and efficient route planning
    Cottoning up
    Efficient route planning
    Relational knowledge of places
    50% and 75% markers
    Efficient route planning
    Relational knowledge of places
    Memory techniquesa:
    Acronyms and mnemonics
    Short stories
    Method of loci
    Historical connections
    Personal connections
    Memorizing groups of streets in consecutive order (1–3)
    Relational knowledge of streets in an area (e.g., quarter miles) (4)
    Visualizing street network (4)
    Relation to personal memories (5)
    (B) In situ experience In-street view
    Traveling in street
    Sequential order of streets
    Experience
    Mental simulation
    Visualizing places and streets
    Sequential order of streets
    (C) Combination of the above Bird’s eye and in-street view
    Call over partner
    Combination of all to simulate examination and fares
    Practice material
    Exam questions
    a Lordan (2018). b Learn the Knowledge of London.
    In general, maps are used to learn the structure of the street network from a bird’s eye view. They help obtain knowledge about relations between places and areas (e.g., quarter-miles and boroughs) and learn traffic rules that can limit route planning due to one-way systems and turning restrictions. Additionally, maps facilitate a better understanding of the sequential order of streets that are part of a run.

    Initially, when studying the Knowledge, this information is obtained mainly through the “dumbbell method.” This requires students to identify the quarter-miles of the origin and the destination and visualize the connecting Blue Book run by tracing it on the map. By including variations of origins and destinations from the quarter-miles on the map, students start to connect nearby points with the original Blue Book origins and destinations and create a network that is forming the “dumbbell” (Figure 3). This method is later extended to other places, as students learn to flexibly link runs and cover larger distances across London. This is also supported by the “cottoning-up” and the use of subgoals, called the “50% markers,” which are not included in the blue book and must be determined by the trainee (interview with K.T., Appendix S1). These 50% markers (not always chosen halfway along the direct line) are bridges if the river needs to be crossed to ensure efficient planning through these bottlenecks at early stages, or other major roads and places. Additional subgoals are added before and after, as needed, to help give initial direction for the route planning without overwhelming the students. Both methods, the “cottoning-up” and the “50% markers,” when used during initial stages of the training, help students to correctly visualize the map and relations between places. At a later stage of the Knowledge, when route planning is carried out mentally and without a physical map, these methods are integrated in the planning process automatically. Notably, the process involves focusing on distance rather than time between locations. The route with the shortest distance might be extremely slow, but during the training taxi drivers are required to find this route. This relates to the assessment used which uses distance to determine the correct answer (see Section 4.3). After qualifying drivers taxi drivers describe incorporating time into their choice of routes.

    To help students memorize sequences of street names that are often used for runs, different memory techniques are applied during the learning process and often remembered years after obtaining the license. The most common techniques are creations of acronyms and mnemonics, inventions of short stories that contain street name references, mental walks through rooms of an imaginary house, historical connections and personal memories that logically structure (cf. Table 2, Lordan, 2018). Trainees use the range of techniques in combination to learn, rather than starting with one method and moving to another. Thus, the learning techniques listed in Table 2 provide a set of cognitive tools for learning the layout of London.

    TABLE 2. Common memory techniques to learn runs
    Technique name Example Streets or places Run Book reference
    Acronym “MEG”
    (1) Melton St

    (2) Euston Rd

    (3) Gower St

    (4) …

    121 p. 22
    Mnemonic
    A: “bask under nice fair weather”

    (1) Blackfriars Bridge

    (2) Unilever Circus

    (3) New Bridge St

    (4) Farringdon St

    (5) West Smithfield

    153 p. 26
    B: “little apples grow quickly please”
    Lyric, Apollo, Gielgud

    Queen’s, Palace

    (order of Shaftesbury Av theaters)

    – p. 20
    Short story “In the scary monster film (1), the creatures burst out from behind the closed doors, riling (2) their victims with sheer terror (3). […]”
    (1) Munster Rd, Filmer Rd

    (2) Rylston Rd, Dawes Rd

    (3) Sherbrooke Rd

    (4) …

    20 p. 92
    Method of loci “On the wall of the lobby are several framed certificates (1). Below them is a bookcase where a guide to New York City sticks out, the cover of which is illustrated with an image of Park Avenue (2). A train ticket to Macclesfield is tucked inside as a bookmark (3). […]”
    (1) College Crescent

    (2) Avenue Rd

    (3) Macclesfield Bridge

    (4) …

    7 p. 148
    History
    “It’s believed that Copenhagen House was named either in honor of the King of Denmark or the Danish Ambassador, both of whom stayed there in the 17th century.

    Consequently the first roads on this run have a Danish theme. Matilda Street is named after Queen Caroline Matilda who was born in London but became Queen consort to Denmark after her marriage to Christian VII. […]”

    (1) Matilda St

    (2) Copenhagen St

    (3) …

    2 p. 106
    Experience
    “I remember arriving at Manor House very early one Sunday morning; it was cold and misty and, as I expected many fellow students did, had a brief moment of crisis when I asked myself what on earth I was getting myself into.

    But this thought was quickly expelled when I stood up to stretch my legs – and promptly trod in some dog mess, which in hindsight was probably a symbol of good luck although it certainly did not feel like that at that time. […]”

    (1) Manor House

    (2) …

    1 p. 190
    Source: Adapted from Lordan (2018).
    Location specific information from an in-street view is learnt through “in situ” visits to the 320 origin–destination pairs of the Blue Book, their quarter-miles and driving the corresponding runs. These visits—carried out multiple times, often on a scooter with a map of the Blue Book run attached to the windscreen—are essential to learning and recalling the Knowledge. These experiences of runs and the quarter miles create memories that drivers use to later recall sequences of streets (Table 2, Lordan, 2018) and visualize routes during planning (interview with K.T., Appendix S1). For instance, memories of traveling a run for the first time might help the recall of sequences of streets, places of interest and specific traffic rules that must be obeyed. These memories become an essential source of information when planning and calling out similar runs, linked to the original. Students use them for mental simulations that facilitate decisions about where to pick up or set down passengers, in which direction to leave or to approach an area and how to find the most optimal route. Thus, students incorporate their study from maps into egocentric representations of directions and turns when driving the runs in situ and this is vital for the planning process. Trainees are not paid so the process of learning is expensive as well as time consuming.

    4.3 Assessment scheme
    The assessment scheme for trainee taxi drivers in London was designed to support the learning process and guide students from early stages of learning the initial Blue Book runs to final stages, where their knowledge of London and suburban artery roads is rigorously challenged (Figure 6; interview with K.T., Appendix S1, Learn the Knowledge of London, Transport for London, n.d.). Initially, Knowledge schools offer an introductory class to provide basic information and an overview of the content of the Knowledge. This introductory class includes expectations, procedures, and requirements of the qualification process, before preparatory examinations (Figure 6, light gray) can be taken. Within the first 6 months of starting the Knowledge, students are expected to sit an assessment that is testing the Knowledge on the initial 80 runs (five lists) of the Blue Book. Even though this assessment is unmarked, it is obligatory and of supportive and informative purpose at the same time (i.e., formative assessment). Feedback is given and the performance is discussed with teachers to help students identify problems in their learning process that need adjustment at an early stage to enable students to successfully progress at later stages. Following this initial self-assessment, students have 18 months to sit a marked multiple-choice exam that tests their knowledge of the Blue Book, to ensure they have acquired the basics that are necessary to progress to the appearance stages (Figure 6, dark gray). To test this, the multiple-choice exams consist of two parts, where (a) the shortest, legal route out of three possibilities has to be identified for 5 randomly chosen Blue Book runs, and (b) the correct location out of six possible locations has to be selected for 25 points of interest that are likely to be part of the learning of the Blue Book runs.

    FIGURE 6


    Knowledge examination process. The initial stage (light gray) of the Knowledge examination process provides feedback (Self-Assessment) on the individual progress of learning the first 80 runs of the Blue Book and assesses the minimum knowledge on all 320 Blue Book runs needed (Multiple Choice Exam) to start the oral examination (Appearances). The main part of the examination process (dark gray) consists of a series of oral examinations, the so-called “appearances,” consisting of three different stages (the 56s, 28s, and 21s, named after the intervals between each exam in the corresponding stage). Even though the requirements to students sitting these exams become more rigorous as they proceed, there are general rules that apply across all stages. These are related to the general layout of each appearance (e.g., duration, number of runs), expectations (e.g., shortest route), format of call out (e.g., identifying the location of origin and destination, sequentially naming streets and providing turning instructions), penalties (e.g., traffic rule violations, deviations from shortest route, hesitations), awarded points and progressing to the next stage. Following the appearances, students are required to pass an exam on suburban Knowledge before they obtain their license
    Source: Adapted from Learn the Knowledge of London; Knowledge of London learning and examination process, p. 21

    After passing the two entry assessments, trainee taxi drivers enter what is known as the “appearances,” a set of oral examinations. At each appearance, students are expected to call runs from any two points that the examiner names. The appearances also comprise the longest and most difficult part of the Knowledge examination process. It is quite common that several of the stages have to be retaken by students due to shorter intervals between appearances coupled with the growing expectations of the examiners as they proceed. In total, there are three stages of appearances, the 56s, 28s, and 21s, which correspond to the number of days between any two appearances in that stage.

    Even though the requirements for students sitting these exams become more rigorous as they proceed, there are general rules that apply across all stages: Each appearance is about 20 min long and can consist of up to 4 runs that students have to call, using the shortest route, disregarding traffic and temporary roadworks. The call outs (i.e., naming streets in sequential order) include identifying the location (i.e., the correct street) of the origin and destination (points of interest), naming streets and giving turning directions along the run in correct sequential order, as well as including instructions for leaving and setting down passengers. Possible errors that will cause deductions of points are incorrect street names, any divergence from the shortest route, violation of traffic rules, impossible leaving or setting down instructions and hesitations during the call of the run. In each appearance, 3–6 points are awarded and 12 points are needed to progress to the next stage. Per stage, students are allowed to fail a maximum of three appearances, before the stage has to be repeated (first time) or students have to go back to a previously successfully passed stage (failing second time), limiting the number of exams per stage to a maximum of seven appearances.

    In contrast to later appearance stages, the “‘56s” are very closely related to the Knowledge obtained from the Blue Book. Here, examiners closely stick to runs from the Blue Book, which reflects a good knowledge of primary and secondary roads (i.e., the “oranges and lemons”). At this stage, examiners also take into account differences in the choice of additional points of the quarter-miles that different Knowledge schools provide in their version of the Blue Book (Figure 2a). Additionally, runs are structured in a way that they will not contain obstacles (e.g., road closures), special requirements (e.g., requests to avoid traffic lights) or theater shows and temporary events (e.g., Chelsea Flower Show). Students are also allowed to correct mistakes by going back in their call out and changing their run. At the next stage, the “28s,” examinees are expected to be able to link runs, using some minor roads and avoid obstacles or comply with special requests without being granted a chance of correcting faulty runs. At the final stage, the 21 s, trainee drivers have to demonstrate an overarching knowledge that is up to date and can additionally refer to particular topics (e.g., new tourist attractions, changes in hotel names) and temporary events, such as the Chelsea Flower Show.

    After passing all appearances, the final exam is set to test the knowledge of suburban London. This knowledge covers 22 specific routes, including major points along those routes, radiating from the six-mile radius to the borough boundaries of London. In this final appearance, trainee drivers will be asked six questions relating to the 22 routes and points along those routes.

    For the learning process of a Knowledge student, the Blue Book is central, as it provides them with “the ability to know where streets and roads are going to and where all those places are” (interview with K.T., Appendix S1). However, over the course of obtaining the Knowledge and learning how to link Blue Book runs efficiently, there seems to be a change in the perception of London. Initially it consists of distinct routes and locally focused areas on a map. Over the course of time, this fades into a connected, large-scale, inseparable network of streets and places in the real world (Appendix S1). During consulting conversations with taxi drivers, they reported that they just knew where they had to go without much planning. For well-known places, Robert Lordan described the planning and execution of a run as “I wouldn’t even have to think; my brain would be on autopilot. […] like a moth drawn to a light!” (email conversation with Robert Lordan, Appendix S2). For longer distances, subgoals (as trained with the 50% markers) are used automatically: “I’d find that my brain would often plan in stages; essentially I’d envision a set of waypoints and the route would then come to me as I progressed” (email conversation with Robert Lordan, Appendix S2).

    The overall impact of the Knowledge also seems to foster a deeper connection (“I already loved the city, but in studying it I now love it all the more. It feels like an old, familiar friend,” email conversation with Robert Lordan, Appendix S2). It provides a constant drive to stay up to date with changes in the city (“The Knowledge made me crave detail! To this day I want to know as much as I can about London,” email conversation with Robert Lordan, Appendix S2) and new curiosity (“The Knowledge also makes you want to know as much as you can about new locations that you’ve never been to before,” email conversation with Robert Lordan, Appendix S2).

    5 DISCUSSION
    Here we examined the process by which licensed London taxi drivers learn and are examined on the Knowledge of London, which includes the network of ~26,000 streets and thousands of points of interest. In summary, to learn the Knowledge of London, taxi drivers use a wide range of theoretical and practical methods and learn specific methods for efficient planning. Such training primarily includes map-related study, based on an overlapping network of basic points of interest and list of routes (Blue Book) that systematically covers London. This knowledge is combined with visits to the locations used in the routes and retracing of the theoretically learnt routes on motorbikes. Both experiences are reported to be vital for linking theoretically learned information to specific real-world locations and flexible navigation in London. We also observed a range of techniques to improve memory, such as acronyms and stories linked to sequences of streets, visualizing the locations and travel along streets, and the strategic use of subgoals. We discuss: (i) how these findings relate to other studies examining spatial learning, (ii) how the learning compares with taxi drivers in other cities, (iii) why the knowledge is still required and trained when GPS aided navigation systems exist, and (iv) how these methods and techniques might benefit the general population in spatial learning.

    Research based studies of spatial navigation have employed a variety of methods to train participants learning unfamiliar environments. These include instructed learning of paths (e.g., Brunec et al., 2017; Meilinger et al., 2008; Meilinger, Frankenstein, & Bülthoff, 2014; Meilinger, Riecke, & Bülthoff, 2014; Wiener et al., 2013), learning from cartographic maps (e.g., Coutrot et al., 2018, 2019; Grison et al., 2017; Hölscher et al., 2006, 2009), landmark-based navigation (e.g., Astur et al., 2005; Newman et al., 2007; Wiener et al., 2004, 2012, 2013; Wiener & Mallot, 2003), exploration of the environment without a map (e.g., de Cothi et al., 2020; Hartley et al., 2003; Spiers, Burgess, Hartley, et al., 2001; Spiers, Burgess, Maguire, et al., 2001) or a combination of map study with in situ exploration (e.g., Javadi et al., 2017; Javadi, Patai, Marin-Garcia, Margois, et al., 2019; Javadi, Patai, Marin-Garcia, Margolis, et al., 2019; Newman et al., 2007; Patai et al., 2019; Spriggs et al., 2018; Warren et al., 2017; Wiener et al., 2004; Wiener & Mallot, 2003). The general assumption is that the method used for learning is efficient, or a standard way of learning the environment. Here we found that for London taxi drivers the training is significantly more intensive and elaborate than any of these studies, which relates to the dramatically increased demands of learning 26,000 streets and thousands of points of interest.

    Several methods for learning, such as guided turn-based navigation (e.g., Wiener et al., 2013), have not found an application in the training phase of London taxi drivers. The absence of this approach might be explained through the advantage of in situ experience, understanding the changes with lighting over day time and the very regular changes to the environment (e.g., temporary road closures, name changes of hotels or restaurants, and temporary events). Indeed, being able to adapt to these changes and being aware of some of the temporary events are considered essential knowledge, especially at later stages of the training process.

    Successfully recalling mental images of locations, retrieving specific street names and judicious uses of subgoal planning were described as key to being a London taxi driver. These observations help to explain results of by Spiers and Maguire (2008) where London taxi drivers were asked to recall their thoughts watching video replay of their navigation of a highly detailed virtual reality simulation of London. London taxi drivers often reported sequential planning to subgoals along the route, comparison of route alternatives or mental visualizations of places and route sequences. Many taxi drivers reported “picturing the destination,” planning with a bird’s eye view, and “filling-in” the plan as they navigated, which indicate a use of mental visualization as trained through the Knowledge. We found teachers and examiners claim to know when students “see the points” as they actively visualize origins and destinations as part of their planning process. It may be that trainee taxi drivers need some ability with mental imagery to succeed in the train process. Not all trainees will pass the examination process (Woollett & Maguire, 2011). The ability to use spatial visualization strategies has been found to differ between individuals and vary with age and experience (Salthouse et al., 1990), education levels or gender differences (e.g., Coluccia & Louse, 2004; Fennema & Sherman, 1977; Moffat et al., 1998; Montello et al., 1999; Wolbers & Hegarty, 2010). There is also evidence that certain spatial visualization skills can be improved through training (Sorby, 2009). In our study we found that it was expected that the visualization improves with the training. Further investigation of the visualization process in novice trainees and expert drivers would be useful and may relate to the changes in the hippocampus observed in those that past the exam to obtain a license (Woollett & Maguire, 2011). The multifaceted learning approach reported here may relate to why changes in gray matter density have consistently been observed in taxi drivers.

    Further evidenced use of mental simulation during navigation was found in the way taxi drivers are required to call out the runs in the exam by using instructions and phrases such as “forward,” “left/right into,” and “comply” (traffic rules). These provide an egocentric description of movement through London. Conversely, during the early stages of the Knowledge training, the planning process is reported to rely on an allocentric reference frame by studying maps to train students on planning shortest paths. At later stages, as experience is gained from planning runs and through in situ visits to locations, the aim is to build an automatic awareness of the direction of travel or a particular route. This is consistent with the reports that experienced taxi drivers very rapidly determined the direction to a requested destination (Spiers & Maguire, 2006a, 2008).

    We found that the examination process appears to provide a layered approach to learning the London street network. There is an initial focus on testing the Blue Book routes (runs) or routes along main arterial roads (i.e., “oranges and lemons”) and only at later stages are minor roads integrated into the assessments. However, we found the actual learning process requires students to learn minor roads in the quarter-miles from the beginning (i.e., with the first run). This differs from the requirements in other cities, such as Paris, where drivers have to demonstrate knowledge of a limited number of major points of interest, as well as predefined major routes. There, taxi drivers are expected to expand their knowledge to the minor street network through experience while working as a taxi driver (Préfecture de Police, Démarches, & Services, 2020; Skok, 2004). Similar to the “oranges and lemons” of the London street network, the Parisian street network covers the city in two layers: The base network, an uneven grid-like pattern that allows travel on major roads, helps to reduce traffic on the secondary network, a network of minor streets (Chase, 1982; Pailhous, 1969, 1970, 1984). For Parisian taxi drivers, such a selective learning of the base network was found to be also reflected in their mental representation of the street network in form of these two layers (Pailhous, 1969, 1970, 1984). In contrast to London taxi drivers, Parisian taxi drivers’ awareness of the secondary network only grows and becomes more efficient and optimal through experience rather than in the training and is almost nonexistent at the beginning of their career (Chase, 1982; Giraudo & Peruch, 1988, 1988b; Peruch et al., 1989).

    The approach that London has taken to train and test their taxi drivers on the Knowledge as described above, is historically motivated and has been retained over centuries since its implementation, only allowing for adaptations and improvements. This concept of learning all possible points, their locations, the street names and how to flexibly plan routes and adjust to specific requirements is globally unique. In contrast, other cities, such as Paris (Préfecture de Police, Démarches, & Services, 2020) or Madrid (Federación Profesional del Taxi de Madrid: Departamento de Formación, 2010; Skok & Martinez, 2010), often only require applicants of the trait to learn the major grid of the street network (i.e., the base network) and expect the knowledge of the minor street network (i.e., the secondary network) to be obtained through experience. Instead, taxi drivers are also required to demonstrate knowledge on other trade related areas, such as knowledge related to driving a car, professional regulations, safety and business management, a language test (Skok, 2004), fares and legislations (Skok & Martinez, 2010). Considering these alternative qualification requirements for Paris or Madrid, the London qualification scheme, that relies on a thorough knowledge of London streets, can be questioned as regards to its adequacy and value, in times of GPS systems that can guide navigation.

    Given that GPS in general successfully supports navigation and thus is omnipresent in daily life, it remains a key question as to why London taxi drivers continue to rely on their own abilities to plan routes. We found that this to be their sense of accomplishment of a difficult, and in this case, almost impossible task. They often find pride in their ability to master challenging navigation tasks in a complex city only by using their spatial memory independently from external devices that could be sources of mistakes (McKinlay, 2016). This ability to flexibly navigate beyond a base network of major streets, enables London taxi drivers to rapidly follow their route plan even to points in the secondary network, quickly adapt to any changes on-route due to customer preferences or traffic flow (i.e., congestion or road closures) and avoid errors that might result from incorrect instructions given by passengers (e.g., Lordan, 2018). For instance, they might confuse Chelsea’s buzzing shopping mile, King’s Road, with the quiet King Street near St James’s Park, Westminster. These adaptations, that taxi drivers can make instantly, might even outperform GPS systems that sometimes need manual adjustments and additional information input to get to a similar result. In contrast to London, it takes taxi drivers in Paris, Madrid and other cities years to acquire this type of knowledge in their cities and in the end, they might never achieve a similar, highly accurate knowledge of their cities as some areas might be less frequently traveled. Moreover, their experience to filling the gaps in their knowledge might strongly rely on their use of GPS devices, which have been found to impair spatial learning (e.g., Ishikawa et al., 2008) and interfere with spatial navigation (Johnson et al., 2008; McKinlay, 2016). These methods of training taxi drivers might be less efficient and it is thus not surprising that there have been requests from taxi trades of cities like Tokyo, asking London Knowledge teachers to develop a similar method for their taxi schools (interview with K.T., Appendix S1).

    How might the Knowledge training process be improved? The Knowledge in its current form, based on the 320 Blue Book runs, has been in place for about two decades, but the study methods have remained the same over many more decades. However, there has been a tendency of involving new technologies and creating online resources, such as apps that can hold and test students on the Blue Book runs. By providing the first plot of all the blue book runs we were able to identify regions in the road network that were poorly sampled and it may be possible for this information to be useful should new routes be required in updating the runs.

    It is possible that a database of videos of Blue Book runs would be useful. However, updating this database is a challenge due to the regular change in London’s appearance and layout. Online maps and applications could provide a platform that could be regularly updated. Here, the focus could be on Knowledge requirements that allow general contribution, similar to OpenStreetMaps (n.d.), and individual modification, as with Google My Maps (Google Maps. My Maps, n.d.), to support the individual learning process. Such a platform could include updates on points asked in recent appearances that students use for preparation or an option to train with and challenge other students, as well as their call-over partner. Past research has shown it is possible to probe navigation effectively using Google Street View (Brunec et al., 2018, 2019; Patai et al., 2019). However, these platforms would not be able to replace the social situations that students find themselves in at Knowledge schools and when practicing face to face with their call-over partners. These social interactions also have a psychologically motivating, supportive effect. Neither can these digital maps overcome some obvious visual limitations due to screen sizes. These will not allow for a similar view of the “bigger picture” that a wallpaper map is able to convey.

    How might the learning process described here be exploited for the general population to learn new places, or emergency workers, or those with wayfinding difficulties caused by a clinical condition? A number of recommendations could be made. One is the focus on street-names. Much navigation in cities can be based on landmarks and the rough knowledge of the area. Recent work has explored how navigation could be improved by enhanced acquisition of landmark knowledge using audio information (Gramann et al., 2017; Wunderlich et al., 2020; Wunderlich & Gramann, 2019). While landmark acquisition is important for navigation (points of interest for the taxi drivers), our analysis of how London taxi drivers learn shows the extra value of learning street names. Learning the street names makes it possible to plan precise paths through the network of streets. This allows for flexible planning that goes beyond chaining sets of landmarks together. This learning can be enhanced by a focus on methods to draw out the street names such as acronyms and rhymes (“East to West Embankment Best”). The memory techniques used in Knowledge schools to memorize sequences of streets such as the “dumbbell method” that links small areas through routes, or mental visualizations of familiar places could initiate new ways of displaying spatial information in maps or GPS devices. A focus on mental imagery is also worth considering in future research to explore how this may benefit new navigation. Finally, teaching a method for efficient planning of longer routes would be a benefit. More research will be required to fully explore these possibilities and understand how they may be integrated with other technology for efficient spatial learning. In such research understanding the order in which information and training is provided would be an important step. Trainee taxi drivers do not have a set order by which they use the different methods, other than the prescribed order in which they learn the blue book runs. Future route guidance systems for learning a new environment might exploit the approach of integrating a set of routes as taxi drivers do here.

    Another question arising is how might these discoveries be useful for researchers seeking to build efficient artificial intelligence systems capable of rapid learning and planning? Recent work has explored methods for learning environments and navigating them from street view data or video (Hermann et al., 2020; Mirowski et al., 2016; Xu et al., 2021). The main discoveries here that may be relevant are (1) the organized learning of a set of interconnected routes that allows for flexible planning in the future, (2) the focus on learning a route and then exploring the points at the start and end and then connecting the route to other routes, and (3) learning to create subgoals during the planning process. These approaches to learning may extend not just to improving guidance for how humans learn but for considering the construction of agents that optimally learn structures in the layout of a large city network.

    In conclusion, studying the training process of licensed London taxi drivers has provided a useful opportunity to better understand learning strategies and methods that efficiently support the learning process of a large and complex environment. In this observational report, information was gathered on licensed London taxi drivers, who acquire unique spatial knowledge to navigate an enormous street network independently from external support, such as GPS. Forming such mental representations of real-world spaces is essential for the job they perform. Essential strategies include memory techniques, map-based strategies using tactical subgoal selection to improve planning efficiency and mental visualization of places and routes based on experiences. Further research is needed to understand the mental representation that results from these training methods and how this representation affects navigation related planning in brain circuits including the hippocampus.

    #Taxi #Neurologie #Hirnforschung

  • London taxi drivers: A review of neurocognitive studies and an exploration of how they build their cognitive map of London - PubMed
    https://pubmed.ncbi.nlm.nih.gov/34914151

    Eva-Maria Griesbauer 1, Ed Manley 2 3 4, Jan M Wiener 5, Hugo J Spiers 1, PMID: 34914151 DOI: 10.1002/hipo.23395

    Abstract
    Licensed London taxi drivers have been found to show changes in the gray matter density of their hippocampus over the course of training and decades of navigation in London (UK). This has been linked to their learning and using of the “Knowledge of London,” the names and layout of over 26,000 streets and thousands of points of interest in London. Here we review past behavioral and neuroimaging studies of London taxi drivers, covering the structural differences in hippocampal gray matter density and brain dynamics associated with navigating London. We examine the process by which they learn the layout of London, detailing the key learning steps: systematic study of maps, travel on selected overlapping routes, the mental visualization of places and the optimal use of subgoals. Our analysis provides the first map of the street network covered by the routes used to learn the network, allowing insight into where there are gaps in this network. The methods described could be widely applied to aid spatial learning in the general population and may provide insights for artificial intelligence systems to efficiently learn new environments.

    Keywords: cognitive maps; learning strategies; navigation; spatial cognition; spatial learning; wayfinding.

    #Taxi #Neurologie #Hirnforschung

  • London taxi drivers and bus drivers: a structural MRI and neuropsychological analysis - PubMed
    https://pubmed.ncbi.nlm.nih.gov/17024677

    Eleanor A Maguire 1, Katherine Woollett, Hugo J Spiers, PMID: 17024677 DOI: 10.1002/hipo.20233

    Abstract
    Licensed London taxi drivers show that humans have a remarkable capacity to acquire and use knowledge of a large complex city to navigate within it. Gray matter volume differences in the hippocampus relative to controls have been reported to accompany this expertise. While these gray matter differences could result from using and updating spatial representations, they might instead be influenced by factors such as self-motion, driving experience, and stress. We examined the contribution of these factors by comparing London taxi drivers with London bus drivers, who were matched for driving experience and levels of stress, but differed in that they follow a constrained set of routes. We found that compared with bus drivers, taxi drivers had greater gray matter volume in mid-posterior hippocampi and less volume in anterior hippocampi. Furthermore, years of navigation experience correlated with hippocampal gray matter volume only in taxi drivers, with right posterior gray matter volume increasing and anterior volume decreasing with more navigation experience. This suggests that spatial knowledge, and not stress, driving, or self-motion, is associated with the pattern of hippocampal gray matter volume in taxi drivers. We then tested for functional differences between the groups and found that the ability to acquire new visuo-spatial information was worse in taxi drivers than in bus drivers. We speculate that a complex spatial representation, which facilitates expert navigation and is associated with greater posterior hippocampal gray matter volume, might come at a cost to new spatial memories and gray matter volume in the anterior hippocampus.

    (c) 2006 Wiley-Liss, Inc.

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  • Changes in London taxi drivers’ brains driven by acquiring ‘the Knowledge’, study shows
    https://wellcome.org/press-release/changes-london-taxi-drivers-brains-driven-acquiring-%E2%80%98-knowledge-st

    9.12.2011 - Acquiring ‘the Knowledge’ - the complex layout of central London’s 25,000 streets and thousands of places of interest - causes structural changes in the brain and changes to memory in the capital’s taxi drivers, new research funded by the Wellcome Trust has shown.

    The study, published today in the journal ’Current Biology’, supports the increasing evidence that even in adult life, learning can change the structure of the brain, offering encouragement for lifelong learning and the potential for rehabilitation after brain damage.

    To qualify as a licensed London taxi driver, a trainee must acquire ’the Knowledge’ of the capital’s tens of thousands of streets and their idiosyncratic layout. This training typically takes between three and four years, leading to a stringent set of examinations that must be passed to obtain an operating licence; only around half of trainees pass. This comprehensive training and qualification procedure is unique among taxi drivers anywhere in the world.

    Previous studies of qualified London taxi drivers, led by Professor Eleanor Maguire from the Wellcome Trust Centre for Neuroimaging at UCL (University College London), have shown a greater volume of grey matter - the nerve cells in the brain where processing takes place - in an area known as the posterior hippocampus and less in the anterior hippocampus relative to non-taxi drivers.

    The studies also showed that although taxi drivers displayed better memory for London-based information, they showed poorer learning and memory on other memory tasks involving visual information, suggesting that there might be a price to pay for acquiring the Knowledge. The research suggested that structural brain differences may have been acquired through the experience of navigating and to accommodate the internal representation of London.

    To test whether this was the case, Professor Maguire and colleague Dr Katherine Woollett followed a group of 79 trainee taxi drivers and 31 controls (non-taxi drivers), taking snapshots of their brain structure over time using magnetic resonance imaging (MRI) and studying their performance on certain memory tasks. Only 39 of the group passed the tests and went on to qualify as taxi drivers, giving the researchers the opportunity to divide the volunteers into three groups for comparison: those that passed, those that trained but did not pass, and the controls who never trained.

    The researchers examined the structure of the volunteers’ brains at the start of the study, before any of the trainees had begun their training. They found no discernible differences in the structures of either the posterior hippocampus or the anterior hippocampus between the groups, and all groups performed equally well on the memory tasks.

    Three to four years later - when the trainees had either passed the test or had failed to acquire the Knowledge - the researchers again looked at the brain structures of the volunteers and tested their performance on the memory tasks. This time, they found significant differences in the posterior hippocampus - those trainees that qualified as taxi drivers had a greater volume of grey matter in the region than they had before they started their training.

    This change was not apparent in those who failed to qualify or in the controls. Interestingly, there was no detectable difference in the structure of the anterior hippocampus, suggesting that these changes come later, in response to changes in the posterior hippocampus.

    On the memory tasks, both qualified and non-qualified trainees were significantly better at memory tasks involving London landmarks than the control group. However, the qualified trainees - but not the trainees who failed to qualify - were worse at the other tasks, such as recalling complex visual information, than the controls.

    “The human brain remains ’plastic’, even in adult life, allowing it to adapt when we learn new tasks,” explains Professor Maguire, a Wellcome Trust Senior Research Fellow. "By following the trainee taxi drivers over time as they acquired - or failed to acquire - the Knowledge, a uniquely challenging spatial memory task, we have seen directly and within individuals how the structure of the hippocampus can change with external stimulation. This offers encouragement for adults who want to learn new skills later in life.

    “What is not clear is whether those trainees who became fully fledged taxi drivers had some biological advantage over those who failed. Could it be, for example, that they have a genetic predisposition towards having a more adaptable, ’plastic’ brain? In other words, the perennial question of ’nature versus nurture’ is still open.”

    In the research paper, Professor Maguire and Dr Woollett speculate on the biological mechanisms that may underpin the changes to the brain they observed.

    One theory, supported by studies in rodents, is that when learning that requires cognitive effort takes place and is effective, there is an increase in the rate at which new nerve cells are generated and survive. The hippocampus is one of the few brain areas where the birth of new nerve cells is known to take place.Alternatively, it could be that the synapses, or connections, between existing nerve cells grew stronger in the trainees who qualified.

    Dr John Williams, Head of Neuroscience and Mental Health at the Wellcome Trust, says: “The original study of the hippocampi of London taxi drivers provided tantalising hints that brain structure might change through learning, and now Eleanor’s follow-up study, looking at this directly within individual taxi trainees over time, has shown this is indeed the case. Only a few studies have shown direct evidence for plasticity in the adult human brain related to vital functions such as memory, so this new work makes an important contribution to this field of research.”

    Reference
    Woollett K and Maguire EA. Acquiring ’the Knowledge’ of London’s layout drives structural brain changes. Curr Biol 2011 (epub ahead of print).

    About University College London
    Founded in 1826, University College London (UCL) was the first English university established after Oxford and Cambridge, the first to admit students regardless of race, class, religion or gender, and the first to provide systematic teaching of law, architecture and medicine. UCL is among the world’s top universities, as reflected by performance in a range of international rankings and tables. Alumni include Marie Stopes, Jonathan Dimbleby, Lord Woolf, Alexander Graham Bell, and members of the band Coldplay. UCL currently has over 13,000 undergraduate and 9,000 postgraduate students. Its annual income is over £700 million.

    ’Understanding the brain’ is one of the Wellcome Trust’s key strategic challenges. At the Wellcome Trust Centre for Neuroimaging at UCL, where Professor Maguire is based, clinicians and scientists study higher cognitive function to understand how thought and perception arise from brain activity, and how such processes break down in neurological and psychiatric disease.

    #Taxi #Neurologie #Hirnforschung