#oléocanthal

  • Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization

    http://www.tandfonline.com/doi/full/10.1080/23723556.2015.1006077

    Extra-virgin olive oil (EVOO), a central component of the Mediterranean diet, contains an abundance of phenolic antioxidants that are potent inhibitors of reactive oxygen species and is associated with a reduced risk for several types of human cancer.1 Giacosa A, Barale R, Bavaresco L, Gatenby P, Gerbi V, Janssens J, Johnston B, Kas K, La Vecchia C, Mainguet P, et al. Cancer prevention in Europe: the Mediterranean diet as a protective choice. Eur J Cancer Prev 2013; 22:90–5; PMID:22644232; http://dx.doi.org/10.1097/CEJ.0b013e328354d2d7[CrossRef], [PubMed], [Web of Science ®], [Google Scholar] Polyphenolic secoiridoids of EVOO have been shown to decrease viability of HER2-overexpressing breast cancer cells by selectively inducing apoptotic cell death.2 Menendez JA, Vazquez-Martin A, Colomer R, Brunet J, Carrasco-Pancorbo A, Garcia-Villalba R, Fernandez-Gutierrez A, Segura-Carretero A. Olive oil’s bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells. BMC Cancer 2007; 7:80; PMID:17490486; http://dx.doi.org/10.1186/1471-2407-7-80[CrossRef], [PubMed], [Web of Science ®], [Google Scholar] (-)-Oleocanthal (OC), a di-aldehydic form of ligostride aglycone that has been isolated from EVOO, possesses a wide range of biological effects. Previous studies have reported its activity as a potent antioxidant; a nonsteroidal anti-inflammatory agent that inhibits COX-1 and COX-2; a neuroprotectant that alters the structure and function of the neurotoxins β-amyloid and Tau, which are associated with the debilitating effects of Alzheimer disease; an inhibitor of proliferation, migration, and invasion of human breast and prostate cancer cells through c-Met inhibition; an inhibitor of AMPK in colon cancer cells; and an inhibitor of macrophage inflammatory protein-1α in multiple myeloma.3-8 Beauchamp GK, Keast RS, Morel D, Lin J, Pika J, Han Q, Lee CH, Smith AB, Breslin PA. Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature 2005; 437:45–6; PMID:16136122; http://dx.doi.org/10.1038/437045a
    Busnena BA, Foudah AI, Melancon T, El Sayed KA. Olive secoiridoids and semisynthetic bioisostere analogues for the control of metastatic breast cancer. Bioorg Med Chem 2013; 21:2117–27; PMID:23403296; http://dx.doi.org/10.1016/j.bmc.2012.12.050
    Elnagar AY, Sylvester PW, El Sayed KA. (-)-Oleocanthal as a c-Met inhibitor for the control of metastatic breast and prostate cancers. Planta Med 2011; 77:1013–9; PMID:21328179; http://dx.doi.org/10.1055/s-0030-1270724
    Monti MC, Margarucci L, Riccio R, Casapullo A. Modulation of tau protein fibrillization by oleocanthal. J Nat Prod 2012; 75:1584–8; PMID:22988908; http://dx.doi.org/10.1021/np300384h
    Scotece M, Gomez R, Conde J, Lopez V, Gomez-Reino JJ, Lago F, Smith AB 3rd, Gualillo O. Oleocanthal inhibits proliferation and MIP-1a expression in human multiple myeloma cells. Curr Med Chem 2013; 20:2467–75; PMID:23521677; http://dx.doi.org/10.2174/0929867311320190006
    Pitt J, Roth W, Lacor P, Smith AB 3rd, Blankenship M, Velasco P, De Felice F, Breslin P, Klein WL. Alzheimer’s-associated Ab oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal. Toxicol Appl Pharmacol 2009; 240:189–97; PMID:19631677; http://dx.doi.org/10.1016/j.taap.2009.07.018

    To investigate the anticancer effects of OC, we examined its effect on the viability and survival of cancerous and non-cancerous cells.

    #cancer_recherche #anticancer #huile_d'olive #oléocanthal #inhibiteurs