organization:university of pittsburgh

  • The United Nations backs seed sovereignty in landmark small-scale farmers’ rights declaration

    On Dec. 17, the United Nations General Assembly took a quiet but historic vote, approving the Declaration on the Rights of Peasants and other People Working in Rural Areas by a vote of 121-8 with 52 abstentions. The declaration, the product of some 17 years of diplomatic work led by the international peasant alliance La Via Campesina, formally extends human rights protections to farmers whose “seed sovereignty” is threatened by government and corporate practices.

    “As peasants we need the protection and respect for our values and for our role in society in achieving food sovereignty,” said #Via_Campesina coordinator Elizabeth Mpofu after the vote. Most developing countries voted in favor of the resolution, while many developed country representatives abstained. The only “no” votes came from the United States, United Kingdom, Australia, New Zealand, Hungary, Israel and Sweden.

    “To have an internationally recognized instrument at the highest level of governance that was written by and for peasants from every continent is a tremendous achievement,” said Jessie MacInnis of Canada’s National Farmers Union. The challenge, of course, is to mobilize small-scale farmers to claim those rights, which are threatened by efforts to impose rich-country crop breeding regulations onto less developed countries, where the vast majority of food is grown by peasant farmers using seeds they save and exchange.
    Seed sovereignty in Zambia

    The loss of seed diversity is a national problem in Zambia. “We found a lot of erosion of local seed varieties,” Juliet Nangamba, program director for the Community Technology Development Trust, told me in her Lusaka office. She is working with the regional Seed Knowledge Initiative (SKI) to identify farmer seed systems and prevent the disappearance of local varieties. “Even crops that were common just 10 years ago are gone.” Most have been displaced by maize, which is heavily subsidized by the government. She’s from Southern Province, and she said their survey found very little presence of finger millet, a nutritious, drought-tolerant grain far better adapted to the region’s growing conditions.

    Farmers are taking action. Mary Tembo welcomed us to her farm near Chongwe in rural Zambia. Trained several years ago by Kasisi Agricultural Training Center in organic agriculture, Tembo is part of the SKI network, which is growing out native crops so seed is available to local farmers. Tembo pulled some chairs into the shade of a mango tree to escape the near-100-degree Fahrenheit heat, an unseasonable reminder of Southern Africa’s changing climate. Rains were late, as they had been several of the last few years. Farmers had prepared their land for planting but were waiting for a rainy season they could believe in.

    Tembo didn’t seem worried. She still had some of her land in government-sponsored hybrid maize and chemical fertilizer, especially when she was lucky enough to get a government subsidy. But most of her land was in diverse native crops, chemical free for 10 years.

    “I see improvements from organic,” she explained, as Kasisi’s Austin Chalala translated for me from the local Nyanja language. “It takes more work, but we are now used to it.” The work involves more careful management of a diverse range of crops planted in ways that conserve and rebuild the soil: crop rotations; intercropping; conservation farming with minimal plowing; and the regular incorporation of crop residues and composted manure to build soil fertility. She has six pigs, seven goats, and 25 chickens, which she says gives her enough manure for the farm.

    She was most proud of her seeds. She disappeared into the darkness of her small home. I was surprised when she emerged with a large fertilizer bag. She untied the top of the bag and began to pull out her stores of homegrown organic seeds. She laughed when I explained my surprise. She laid them out before us, a dazzling array: finger millet; orange maize; Bambara nuts; cowpea; sorghum; soybeans; mung beans; three kinds of groundnuts; popcorn; common beans. All had been saved from her previous harvest. The contribution of chemical fertilizer to these crops was, clearly, just the bag.

    She explained that some would be sold for seed. There is a growing market for these common crops that have all but disappeared with the government’s obsessive promotion of maize. Some she would share with the 50 other farmer members of the local SKI network. And some she and her family happily would consume. Crop diversity is certainly good for the soil, she said, but it’s even better for the body.
    Peasant rights crucial to climate adaptation

    We visited three other Kasisi-trained farmers. All sang the praises of organic production and its diversity of native crops. All said their diets had improved dramatically, and they are much more food-secure than when they planted only maize. Diverse crops are the perfect hedge against a fickle climate. If the maize fails, as it has in recent years, other crops survive to feed farmers’ families, providing a broader range of nutrients. Many traditional crops are more drought-tolerant than maize.

    Another farmer we visited already had planted, optimistically, before the rains arrived. She showed us her fields, dry and with few shoots emerging. With her toe, she cleared some dirt from one furrow to reveal small green leaves, alive in the dry heat. “Millet,” she said proudly. With a range of crops, she said, “the farmer can never go wrong.”

    I found the same determination in Malawi, where the new Farm-Saved Seed Network (FASSNet) is building awareness and working with government on a “Farmers’ Rights” bill to complement a controversial Seed Bill, which deals only with commercial seeds. A parallel process is advancing legislation on the right to food and nutrition. Both efforts should get a shot in the arm with the U.N.’s Peasants’ Rights declaration.

    The declaration gives such farmers a potentially powerful international tool to defend themselves from the onslaught of policies and initiatives, led by multinational seed companies, to replace native seeds with commercial varieties, the kind farmers have to buy every year.

    Kasisi’s Chalala told me that narrative is fierce in Zambia, with government representatives telling farmers such as Tembo that because her seeds are not certified by the government, they should be referred to only as “grain.”

    Eroding protection from GMOs

    As if to illustrate the ongoing threats to farm-saved seed, that same week in Zambia controversy erupted over two actions by the government’s National Biosafety Board to weaken the country’s proud and clear stance against the use of genetically modified crops. The board quietly had granted approval for a supermarket chain to import and sell three products with GMOs, a move promptly criticized by the Zambian National Farmers Union.

    Then it was revealed that the board secretly was drawing up regulations for the future planting of GM crops in the country, again in defiance of the government’s approved policies. The Zambian Alliance for Agroecology and Biodiversity quickly denounced the initiative.

    The U.N. declaration makes such actions a violation of peasants’ rights. Now the task is to put that new tool in farmers’ hands. “As with other rights, the vision and potential of the Peasant Rights Declaration will only be realized if people organize to claim these rights and to implement them in national and local institutions,” argued University of Pittsburgh sociologists Jackie Smith and Caitlin Schroering in Common Dreams. “Human rights don’t ‘trickle down’ — they rise up!”

    https://www.greenbiz.com/article/united-nations-backs-seed-sovereignty-landmark-small-scale-farmers-rights-
    #ONU #semences #déclaration #souveraineté #souveraineté_semencière (?) #agriculture #paysannerie #Zambie #OGM #climat #changement_climatique
    ping @odilon

  • Scientists Are Teaching the Body to Accept New Organs - The New York Times
    https://www.nytimes.com/2019/01/22/health/organ-transplants-immune-system.html

    #Greffe d’organes sans recours aux (ou arrêt à terme des) #immunosuppresseurs.

    The idea is to isolate regulatory T cells from a patient about to have a liver or kidney transplant. Then scientists attempt to grow them in the lab along with cells from the donor.

    Then the T cells are infused back to the patient. The process, scientists hope, will teach the immune system to accept the donated organ as part of the patient’s body.

    “The new T cells signal the rest of the immune system to leave the organ alone,” said Angus Thomson, director of transplant immunology at the University of Pittsburgh Medical Center.

    Dr. Markmann, working with liver transplant patients, and Dr. Leventhal, working with kidney transplant patients, are starting studies using regulatory T cells.

    At Pittsburgh, the plan is to modify a different immune system cell, called regulatory dendritic cells. Like regulatory T cells, they are rare and enable the rest of the immune system to distinguish self from non-self.

    One advantage of regulatory dendritic cells is that researchers do not have to isolate them and grow them in sufficient quantities. Instead, scientists can prod a more abundant type of cell — immature white blood cells — to turn into dendritic cells in petri dishes.

    “It takes one week to generate dendritic cells,” Dr. Thomson said. In contrast, it can take weeks to grow enough regulatory T cells.

    The regulatory T cells also have to remain in the bloodstream to control the immune response, while dendritic cells need not stay around long — they control the immune system during a brief journey through the circulation.

    “Each of us is taking advantage of a different approach,” Dr. Markmann said. “It is not clear yet which is best. But the field is at a fascinating point.”

  • 23andMe Is Making Its First Foray into At-Home Research, to Study Pain - MIT Technology Review
    https://www.technologyreview.com/s/607928/23andme-is-making-its-first-foray-into-at-home-research-to-study-p
    https://d267cvn3rvuq91.cloudfront.net/i/images/ice.jpg?cx=0&cy=0&cw=1500&ch=843&sw=1200

    Une expérience médicale menée at home par les usagers de 23andMe. Une certaine conception de la médecine, dont l’entreprise est familière.

    “It was uncomfortable and slightly painful, but nothing like wearing wet gloves and shoveling snow for an hour at 10 below zero,” says Pardy, who lives in northwest Vermont. Most people can stand to keep their hands in near-freezing water for at least 100 seconds, according to 23andMe.

    The experiment Pardy did is known as a cold pressor test, and it’s one of many used to gauge a person’s tolerance to pain. It’s part of a new study 23andMe announced earlier this month to study the genetic links of pain tolerance, and it represents the company’s first foray into at-home research.

    23andMe has previously launched studies on medical conditions like depression, fertility problems, and irritable bowel disease, using surveys to ask participants about things like their health history, lifestyle, and diet (see “23andMe Pulls Off Massive Crowdsourced Depression Study”). The new study also includes two surveys about pain tolerance and pain history, but this is the first time the company has asked people to do an experiment on their own and report the results.

    Carrie Northover, director of research services for 23andMe, says the goal of the study is to “understand genetic factors associated with experiencing pain and response to medications that help alleviate pain.” Previous research has suggested that multiple genetic factors are at play in chronic pain, and that certain groups of people report pain more often than others.

    Ajay Wasan, vice chair for pain medicine at the University of Pittsburgh Medical Center, says the cold pressor test is only one way to measure pain. There are a range of other tests, including ones that measure a person’s tolerance to heat, pin pricks, and pressure.

    “The problem is no one single experimental pain test maps really well to overall pain sensitivity and doesn’t have high correlation to someone’s clinical chronic pain or their response to treatment,” he says.

    #médecine #génétique #23andMe #génomique

  • #CRISPR Eliminates #HIV in Live Animals | GEN
    http://www.genengnews.com/gen-news-highlights/crispr-eliminates-hiv-in-live-animals/81254287

    Due to their innate nature to hide away and remain latent for extended periods of time, HIV infections have proven notoriously difficult to eliminate. Yet now, new data released from a research team led by investigators at the Lewis Katz School of Medicine at Temple University (LKSOM) and the University of Pittsburgh shows that HIV DNA can be excised from the genomes of living animals to eliminate further infection. Additionally, the researchers are the first to perform this feat in three different animal models, including a “humanized” model in which mice were transplanted with human immune cells and infected with the virus. Findings from the new study were published recently in Molecular Therapy in an article entitled “In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models.”

  • Which World Cities Have the Best Universities ? - CityLab
    http://www.citylab.com/work/2017/01/mapping-the-worlds-knowledge-hubs/505748

    The global economy is increasingly powered by innovation and knowledge, and great universities are a key source of those, functioning as catalysts of the knowledge economy. Leading-edge universities form the axis of tech hubs like the Bay Area (Stanford, UC Berkeley, and the University of California at San Francisco), the Cambridge-Boston region (MIT and Harvard), and a regenerating Pittsburgh (Carnegie Mellon and the University of Pittsburgh).

    But what are the world’s leading centers for university knowledge?

    #savoir #université #connaissance #cartographie #classement #rating - tentative de nouveau mot clé dans lequel on pourrait bien intégrer le minable #decodex

  • Killing a Patient to Save His Life - NYTimes.com
    http://www.nytimes.com/2014/06/10/health/a-chilling-medical-trial.html

    Patients are routinely cooled before surgical procedures that involve stopping the heart. But so-called therapeutic hypothermia has never been tried in patients when the injury has already occurred, and until now doctors have never tried to replace a patient’s blood entirely with cold saltwater.

    In their trial, funded by the Department of Defense, doctors at the University of Pittsburgh Medical Center will be performing the procedure only on patients who arrive at the E.R. with “catastrophic penetrating trauma” and who have lost so much blood that they have gone into cardiac arrest.

    At normal body temperatures, surgeons typically have less than five minutes to restore blood flow before brain damage occurs.

    “In these situations, less than one in 10 survive,” said Dr. Samuel A. Tisherman, the lead researcher of the study. “We want to give people better odds.”

    Dr. Tisherman and his team will insert a tube called a cannula into the patient’s aorta, flushing the circulatory system with a cold saline solution until body temperature falls to 50 degrees Fahrenheit. As the patient enters a sort of suspended animation, without vital signs, the surgeons will have perhaps one hour to repair the injuries before brain damage occurs.

    After the operation, the team will use a heart-lung bypass machine with a heat exchanger to return blood to the patient. The blood will warm the body gradually, which should circumvent injuries that can happen when tissue is suddenly subjected to oxygen after a period of deprivation.

    If the procedure works, the patient’s heart should resume beating when body temperature reaches 85 to 90 degrees. But regaining consciousness may take several hours or several days.

    Dr. Tisherman and his colleagues plan to try the technique on 10 subjects, then review the data, consider changes in their approach, and enroll another 10. For every patient who has the operation, there will be a control subject for comparison.

    The experiment officially began in April and the surgeons predict they will see about one qualifying patient a month.

    It may take a couple of years to complete the study. Citing the preliminary nature of the research, Dr. Tisherman declined to say whether he and his colleagues had already operated on a patient.

    #hypothermie_thérapeutique

  • Biodefence since 9/11: The price of protection | Nature News
    http://www.nature.com/news/2011/110907/full/477150a.html

    Between 2001 and the end of this year, the federal government will have spent $60 billion on biodefence efforts, according to analyses from the Center for Biosecurity of the University of Pittsburgh Medical Center in Baltimore, Maryland. The money has helped to modernize the nation’s crumbling public-health system, and BioShield has invested in a stockpile of 20 million doses of smallpox vaccine, 28.75 million doses of #anthrax vaccine and 1.98 million doses of four medicines to treat complications of smallpox, anthrax and botulism. But few researchers or policy-makers seem happy with an arsenal of six drugs that address only three of the potential threats — even if they are among the most serious. “The pipeline we rely on to provide those critical countermeasures — diagnostics, vaccines, antivirals, antibiotics — is full of leaks, choke points and dead ends,” said Kathleen Sebelius, US Secretary of Health and Human Services, in a statement last year.

    Critics say that the effort has been hobbled by a lack of strategic thinking, focus and coordination between the federal agencies involved, and by unrealistic expectations of what the money could buy. “There was no evidence that they looked at what our top priorities are and asked, ’What’s needed on the basic-science side?’, ’What’s needed on the development side?’, and ’What’s needed in the stockpile?’,” says Andrew Pavia, an infectious-diseases doctor at the University of Utah in Salt Lake City. Until earlier this year, Pavia served on the National Biodefense Science Board, which advises the US Department of Health and Human Services (DHHS) and in March last year released a report, Where Are The Countermeasures?, that was critical of the federal biodefence effort.

    #armes #biologiques #etats-unis