person:sean parker

  • Can Mark Zuckerberg Fix Facebook Before It Breaks Democracy? | The New Yorker
    https://www.newyorker.com/magazine/2018/09/17/can-mark-zuckerberg-fix-facebook-before-it-breaks-democracy

    Since 2011, Zuckerberg has lived in a century-old white clapboard Craftsman in the Crescent Park neighborhood, an enclave of giant oaks and historic homes not far from Stanford University. The house, which cost seven million dollars, affords him a sense of sanctuary. It’s set back from the road, shielded by hedges, a wall, and mature trees. Guests enter through an arched wooden gate and follow a long gravel path to a front lawn with a saltwater pool in the center. The year after Zuckerberg bought the house, he and his longtime girlfriend, Priscilla Chan, held their wedding in the back yard, which encompasses gardens, a pond, and a shaded pavilion. Since then, they have had two children, and acquired a seven-hundred-acre estate in Hawaii, a ski retreat in Montana, and a four-story town house on Liberty Hill, in San Francisco. But the family’s full-time residence is here, a ten-minute drive from Facebook’s headquarters.

    Occasionally, Zuckerberg records a Facebook video from the back yard or the dinner table, as is expected of a man who built his fortune exhorting employees to keep “pushing the world in the direction of making it a more open and transparent place.” But his appetite for personal openness is limited. Although Zuckerberg is the most famous entrepreneur of his generation, he remains elusive to everyone but a small circle of family and friends, and his efforts to protect his privacy inevitably attract attention. The local press has chronicled his feud with a developer who announced plans to build a mansion that would look into Zuckerberg’s master bedroom. After a legal fight, the developer gave up, and Zuckerberg spent forty-four million dollars to buy the houses surrounding his. Over the years, he has come to believe that he will always be the subject of criticism. “We’re not—pick your noncontroversial business—selling dog food, although I think that people who do that probably say there is controversy in that, too, but this is an inherently cultural thing,” he told me, of his business. “It’s at the intersection of technology and psychology, and it’s very personal.”

    At the same time, former Facebook executives, echoing a growing body of research, began to voice misgivings about the company’s role in exacerbating isolation, outrage, and addictive behaviors. One of the largest studies, published last year in the American Journal of Epidemiology, followed the Facebook use of more than five thousand people over three years and found that higher use correlated with self-reported declines in physical health, mental health, and life satisfaction. At an event in November, 2017, Sean Parker, Facebook’s first president, called himself a “conscientious objector” to social media, saying, “God only knows what it’s doing to our children’s brains.” A few days later, Chamath Palihapitiya, the former vice-president of user growth, told an audience at Stanford, “The short-term, dopamine-driven feedback loops that we have created are destroying how society works—no civil discourse, no coöperation, misinformation, mistruth.” Palihapitiya, a prominent Silicon Valley figure who worked at Facebook from 2007 to 2011, said, “I feel tremendous guilt. I think we all knew in the back of our minds.” Of his children, he added, “They’re not allowed to use this shit.” (Facebook replied to the remarks in a statement, noting that Palihapitiya had left six years earlier, and adding, “Facebook was a very different company back then.”)

    In March, Facebook was confronted with an even larger scandal: the Times and the British newspaper the Observer reported that a researcher had gained access to the personal information of Facebook users and sold it to Cambridge Analytica, a consultancy hired by Trump and other Republicans which advertised using “psychographic” techniques to manipulate voter behavior. In all, the personal data of eighty-seven million people had been harvested. Moreover, Facebook had known of the problem since December of 2015 but had said nothing to users or regulators. The company acknowledged the breach only after the press discovered it.

    We spoke at his home, at his office, and by phone. I also interviewed four dozen people inside and outside the company about its culture, his performance, and his decision-making. I found Zuckerberg straining, not always coherently, to grasp problems for which he was plainly unprepared. These are not technical puzzles to be cracked in the middle of the night but some of the subtlest aspects of human affairs, including the meaning of truth, the limits of free speech, and the origins of violence.

    Zuckerberg is now at the center of a full-fledged debate about the moral character of Silicon Valley and the conscience of its leaders. Leslie Berlin, a historian of technology at Stanford, told me, “For a long time, Silicon Valley enjoyed an unencumbered embrace in America. And now everyone says, Is this a trick? And the question Mark Zuckerberg is dealing with is: Should my company be the arbiter of truth and decency for two billion people? Nobody in the history of technology has dealt with that.”

    In 2002, Zuckerberg went to Harvard, where he embraced the hacker mystique, which celebrates brilliance in pursuit of disruption. “The ‘fuck you’ to those in power was very strong,” the longtime friend said. In 2004, as a sophomore, he embarked on the project whose origin story is now well known: the founding of Thefacebook.com with four fellow-students (“the” was dropped the following year); the legal battles over ownership, including a suit filed by twin brothers, Cameron and Tyler Winklevoss, accusing Zuckerberg of stealing their idea; the disclosure of embarrassing messages in which Zuckerberg mocked users for giving him so much data (“they ‘trust me.’ dumb fucks,” he wrote); his regrets about those remarks, and his efforts, in the years afterward, to convince the world that he has left that mind-set behind.

    New hires learned that a crucial measure of the company’s performance was how many people had logged in to Facebook on six of the previous seven days, a measurement known as L6/7. “You could say it’s how many people love this service so much they use it six out of seven days,” Parakilas, who left the company in 2012, said. “But, if your job is to get that number up, at some point you run out of good, purely positive ways. You start thinking about ‘Well, what are the dark patterns that I can use to get people to log back in?’ ”

    Facebook engineers became a new breed of behaviorists, tweaking levers of vanity and passion and susceptibility. The real-world effects were striking. In 2012, when Chan was in medical school, she and Zuckerberg discussed a critical shortage of organs for transplant, inspiring Zuckerberg to add a small, powerful nudge on Facebook: if people indicated that they were organ donors, it triggered a notification to friends, and, in turn, a cascade of social pressure. Researchers later found that, on the first day the feature appeared, it increased official organ-donor enrollment more than twentyfold nationwide.

    Sean Parker later described the company’s expertise as “exploiting a vulnerability in human psychology.” The goal: “How do we consume as much of your time and conscious attention as possible?” Facebook engineers discovered that people find it nearly impossible not to log in after receiving an e-mail saying that someone has uploaded a picture of them. Facebook also discovered its power to affect people’s political behavior. Researchers found that, during the 2010 midterm elections, Facebook was able to prod users to vote simply by feeding them pictures of friends who had already voted, and by giving them the option to click on an “I Voted” button. The technique boosted turnout by three hundred and forty thousand people—more than four times the number of votes separating Trump and Clinton in key states in the 2016 race. It became a running joke among employees that Facebook could tilt an election just by choosing where to deploy its “I Voted” button.

    These powers of social engineering could be put to dubious purposes. In 2012, Facebook data scientists used nearly seven hundred thousand people as guinea pigs, feeding them happy or sad posts to test whether emotion is contagious on social media. (They concluded that it is.) When the findings were published, in the Proceedings of the National Academy of Sciences, they caused an uproar among users, many of whom were horrified that their emotions may have been surreptitiously manipulated. In an apology, one of the scientists wrote, “In hindsight, the research benefits of the paper may not have justified all of this anxiety.”

    Facebook was, in the words of Tristan Harris, a former design ethicist at Google, becoming a pioneer in “ persuasive technology.

    Facebook had adopted a buccaneering motto, “Move fast and break things,” which celebrated the idea that it was better to be flawed and first than careful and perfect. Andrew Bosworth, a former Harvard teaching assistant who is now one of Zuckerberg’s longest-serving lieutenants and a member of his inner circle, explained, “A failure can be a form of success. It’s not the form you want, but it can be a useful thing to how you learn.” In Zuckerberg’s view, skeptics were often just fogies and scolds. “There’s always someone who wants to slow you down,” he said in a commencement address at Harvard last year. “In our society, we often don’t do big things because we’re so afraid of making mistakes that we ignore all the things wrong today if we do nothing. The reality is, anything we do will have issues in the future. But that can’t keep us from starting.”

    In contrast to a traditional foundation, an L.L.C. can lobby and give money to politicians, without as strict a legal requirement to disclose activities. In other words, rather than trying to win over politicians and citizens in places like Newark, Zuckerberg and Chan could help elect politicians who agree with them, and rally the public directly by running ads and supporting advocacy groups. (A spokesperson for C.Z.I. said that it has given no money to candidates; it has supported ballot initiatives through a 501(c)(4) social-welfare organization.) “The whole point of the L.L.C. structure is to allow a coördinated attack,” Rob Reich, a co-director of Stanford’s Center on Philanthropy and Civil Society, told me. The structure has gained popularity in Silicon Valley but has been criticized for allowing wealthy individuals to orchestrate large-scale social agendas behind closed doors. Reich said, “There should be much greater transparency, so that it’s not dark. That’s not a criticism of Mark Zuckerberg. It’s a criticism of the law.”

    La question des langues est fondamentale quand il s’agit de réseaux sociaux

    Beginning in 2013, a series of experts on Myanmar met with Facebook officials to warn them that it was fuelling attacks on the Rohingya. David Madden, an entrepreneur based in Myanmar, delivered a presentation to officials at the Menlo Park headquarters, pointing out that the company was playing a role akin to that of the radio broadcasts that spread hatred during the Rwandan genocide. In 2016, C4ADS, a Washington-based nonprofit, published a detailed analysis of Facebook usage in Myanmar, and described a “campaign of hate speech that actively dehumanizes Muslims.” Facebook officials said that they were hiring more Burmese-language reviewers to take down dangerous content, but the company repeatedly declined to say how many had actually been hired. By last March, the situation had become dire: almost a million Rohingya had fled the country, and more than a hundred thousand were confined to internal camps. The United Nations investigator in charge of examining the crisis, which the U.N. has deemed a genocide, said, “I’m afraid that Facebook has now turned into a beast, and not what it was originally intended.” Afterward, when pressed, Zuckerberg repeated the claim that Facebook was “hiring dozens” of additional Burmese-language content reviewers.

    More than three months later, I asked Jes Kaliebe Petersen, the C.E.O. of Phandeeyar, a tech hub in Myanmar, if there had been any progress. “We haven’t seen any tangible change from Facebook,” he told me. “We don’t know how much content is being reported. We don’t know how many people at Facebook speak Burmese. The situation is getting worse and worse here.”

    I saw Zuckerberg the following morning, and asked him what was taking so long. He replied, “I think, fundamentally, we’ve been slow at the same thing in a number of areas, because it’s actually the same problem. But, yeah, I think the situation in Myanmar is terrible.” It was a frustrating and evasive reply. I asked him to specify the problem. He said, “Across the board, the solution to this is we need to move from what is fundamentally a reactive model to a model where we are using technical systems to flag things to a much larger number of people who speak all the native languages around the world and who can just capture much more of the content.”

    Lecture des journaux ou des aggrégateurs ?

    once asked Zuckerberg what he reads to get the news. “I probably mostly read aggregators,” he said. “I definitely follow Techmeme”—a roundup of headlines about his industry—“and the media and political equivalents of that, just for awareness.” He went on, “There’s really no newspaper that I pick up and read front to back. Well, that might be true of most people these days—most people don’t read the physical paper—but there aren’t many news Web sites where I go to browse.”

    A couple of days later, he called me and asked to revisit the subject. “I felt like my answers were kind of vague, because I didn’t necessarily feel like it was appropriate for me to get into which specific organizations or reporters I read and follow,” he said. “I guess what I tried to convey, although I’m not sure if this came across clearly, is that the job of uncovering new facts and doing it in a trusted way is just an absolutely critical function for society.”

    Zuckerberg and Sandberg have attributed their mistakes to excessive optimism, a blindness to the darker applications of their service. But that explanation ignores their fixation on growth, and their unwillingness to heed warnings. Zuckerberg resisted calls to reorganize the company around a new understanding of privacy, or to reconsider the depth of data it collects for advertisers.

    Antitrust

    In barely two years, the mood in Washington had shifted. Internet companies and entrepreneurs, formerly valorized as the vanguard of American ingenuity and the astronauts of our time, were being compared to Standard Oil and other monopolists of the Gilded Age. This spring, the Wall Street Journal published an article that began, “Imagine a not-too-distant future in which trustbusters force Facebook to sell off Instagram and WhatsApp.” It was accompanied by a sepia-toned illustration in which portraits of Zuckerberg, Tim Cook, and other tech C.E.O.s had been grafted onto overstuffed torsos meant to evoke the robber barons. In 1915, Louis Brandeis, the reformer and future Supreme Court Justice, testified before a congressional committee about the dangers of corporations large enough that they could achieve a level of near-sovereignty “so powerful that the ordinary social and industrial forces existing are insufficient to cope with it.” He called this the “curse of bigness.” Tim Wu, a Columbia law-school professor and the author of a forthcoming book inspired by Brandeis’s phrase, told me, “Today, no sector exemplifies more clearly the threat of bigness to democracy than Big Tech.” He added, “When a concentrated private power has such control over what we see and hear, it has a power that rivals or exceeds that of elected government.”

    When I asked Zuckerberg whether policymakers might try to break up Facebook, he replied, adamantly, that such a move would be a mistake. The field is “extremely competitive,” he told me. “I think sometimes people get into this mode of ‘Well, there’s not, like, an exact replacement for Facebook.’ Well, actually, that makes it more competitive, because what we really are is a system of different things: we compete with Twitter as a broadcast medium; we compete with Snapchat as a broadcast medium; we do messaging, and iMessage is default-installed on every iPhone.” He acknowledged the deeper concern. “There’s this other question, which is just, laws aside, how do we feel about these tech companies being big?” he said. But he argued that efforts to “curtail” the growth of Facebook or other Silicon Valley heavyweights would cede the field to China. “I think that anything that we’re doing to constrain them will, first, have an impact on how successful we can be in other places,” he said. “I wouldn’t worry in the near term about Chinese companies or anyone else winning in the U.S., for the most part. But there are all these places where there are day-to-day more competitive situations—in Southeast Asia, across Europe, Latin America, lots of different places.”

    The rough consensus in Washington is that regulators are unlikely to try to break up Facebook. The F.T.C. will almost certainly fine the company for violations, and may consider blocking it from buying big potential competitors, but, as a former F.T.C. commissioner told me, “in the United States you’re allowed to have a monopoly position, as long as you achieve it and maintain it without doing illegal things.”

    Facebook is encountering tougher treatment in Europe, where antitrust laws are stronger and the history of fascism makes people especially wary of intrusions on privacy. One of the most formidable critics of Silicon Valley is the European Union’s top antitrust regulator, Margrethe Vestager.

    In Vestager’s view, a healthy market should produce competitors to Facebook that position themselves as ethical alternatives, collecting less data and seeking a smaller share of user attention. “We need social media that will allow us to have a nonaddictive, advertising-free space,” she said. “You’re more than welcome to be successful and to dramatically outgrow your competitors if customers like your product. But, if you grow to be dominant, you have a special responsibility not to misuse your dominant position to make it very difficult for others to compete against you and to attract potential customers. Of course, we keep an eye on it. If we get worried, we will start looking.”

    Modération

    As hard as it is to curb election propaganda, Zuckerberg’s most intractable problem may lie elsewhere—in the struggle over which opinions can appear on Facebook, which cannot, and who gets to decide. As an engineer, Zuckerberg never wanted to wade into the realm of content. Initially, Facebook tried blocking certain kinds of material, such as posts featuring nudity, but it was forced to create long lists of exceptions, including images of breast-feeding, “acts of protest,” and works of art. Once Facebook became a venue for political debate, the problem exploded. In April, in a call with investment analysts, Zuckerberg said glumly that it was proving “easier to build an A.I. system to detect a nipple than what is hate speech.”

    The cult of growth leads to the curse of bigness: every day, a billion things were being posted to Facebook. At any given moment, a Facebook “content moderator” was deciding whether a post in, say, Sri Lanka met the standard of hate speech or whether a dispute over Korean politics had crossed the line into bullying. Zuckerberg sought to avoid banning users, preferring to be a “platform for all ideas.” But he needed to prevent Facebook from becoming a swamp of hoaxes and abuse. His solution was to ban “hate speech” and impose lesser punishments for “misinformation,” a broad category that ranged from crude deceptions to simple mistakes. Facebook tried to develop rules about how the punishments would be applied, but each idiosyncratic scenario prompted more rules, and over time they became byzantine. According to Facebook training slides published by the Guardian last year, moderators were told that it was permissible to say “You are such a Jew” but not permissible to say “Irish are the best, but really French sucks,” because the latter was defining another people as “inferiors.” Users could not write “Migrants are scum,” because it is dehumanizing, but they could write “Keep the horny migrant teen-agers away from our daughters.” The distinctions were explained to trainees in arcane formulas such as “Not Protected + Quasi protected = not protected.”

    It will hardly be the last quandary of this sort. Facebook’s free-speech dilemmas have no simple answers—you don’t have to be a fan of Alex Jones to be unnerved by the company’s extraordinary power to silence a voice when it chooses, or, for that matter, to amplify others, to pull the levers of what we see, hear, and experience. Zuckerberg is hoping to erect a scalable system, an orderly decision tree that accounts for every eventuality and exception, but the boundaries of speech are a bedevilling problem that defies mechanistic fixes. The Supreme Court, defining obscenity, landed on “I know it when I see it.” For now, Facebook is making do with a Rube Goldberg machine of policies and improvisations, and opportunists are relishing it. Senator Ted Cruz, Republican of Texas, seized on the ban of Jones as a fascist assault on conservatives. In a moment that was rich even by Cruz’s standards, he quoted Martin Niemöller’s famous lines about the Holocaust, saying, “As the poem goes, you know, ‘First they came for Alex Jones.’ ”

    #Facebook #Histoire_numérique

  • #tech, A.I & #kids : A Dangerous Mix ?
    https://hackernoon.com/tech-a-i-kids-a-dangerous-mix-78af371b7f6a?source=rss----3a8144eabfe3---

    Algorithms are now at the center of an online realm that’s changing the way the experts think about human developmentA few months ago, Facebook early investor Sean Parker dubbed himself a ‘conscientious objector’ on technology, arguing that “God only knows what it’s doing to our children’s brains”. Despite the hypocrisy of his statement, this is indeed a rarely touched-upon matter: how does modern tech affect kids in the long term? How do the two interact? Is it healthy? Science will have to wait decades to receive the beginning of definitive answers, but in the meantime, some insights are possible. But first, a little game: it’s 7 P.M. Do you know what apps your children are using?Is it Youtube? If so, read on.Because Youtube is the ultimate 21st century nanny, many creators on the platform (...)

    #parenting #ai-and-kids #tech-ai-and-kids

  • Facebook : un grave danger pour le cerveau des enfants selon l’un des créateurs
    https://www.crashdebug.fr/informatik/93-securite/14180-facebook-un-grave-danger-pour-le-cerveau-des-enfants-selon-l-un-des

    Facebook pourrait représenter un grave danger pour le cerveau des enfants selon l’un de ses tout premiers investisseurs, Sean Parker. Selon lui, le réseau social a été volontairement créé de manière à être le plus addictif possible, et les conséquences sur la psychologie des plus jeunes pourraient être potentiellement désastreuses. Hélas, il est trop tard pour faire marche arrière…

    Fawkes

    Avec 2 milliards d’utilisateurs Facebook est l’un des réseaux sociaux les plus populaires du monde.

    Malgré l’interdiction officielle du réseau social aux moins de 13 ans, on compte beaucoup d’enfants parmi ces nombreux usagers. Dans le cadre d’une conférence organisée par Axios à Philadelphie, l’un des premiers investisseurs de l’entreprise, le milliardaire Sean Parker, vient de faire part de son inquiétude concernant les (...)

    #En_vedette #Sécurité #Actualités_Informatiques

  • Ex-Facebook president Sean Parker: site made to exploit human ’vulnerability’ | Technology | The Guardian
    https://www.theguardian.com/technology/2017/nov/09/facebook-sean-parker-vulnerability-brain-psychology

    He explained that when Facebook was being developed the objective was: “How do we consume as much of your time and conscious attention as possible?” It was this mindset that led to the creation of features such as the “like” button that would give users “a little dopamine hit” to encourage them to upload more content.

    “It’s a social-validation feedback loop … exactly the kind of thing that a hacker like myself would come up with, because you’re exploiting a vulnerability in human psychology.”

    #Facebook #social_media

  • How #Facebook and #Google threaten public health – and democracy | Roger McNamee | Opinion | The Guardian
    https://www.theguardian.com/commentisfree/2017/nov/11/facebook-google-public-health-democracy

    In an interview this week with Axios, Facebook’s original president, Sean Parker, admitted that the company intentionally sought to addict users and expressed regret at the damage being inflicted on children.

    This admission, by one of the architects of Facebook, comes on the heels of last week’s hearings by Congressional committees about Russian interference in the 2016 election, where the general counsels of Facebook, Alphabet (parent of Google and #YouTube), and #Twitter attempted to deflect responsibility for #manipulation of their platforms.

    The term “#addiction” is no exaggeration. The average consumer checks his or her #smartphone 150 times a day, making more than 2,000 swipes and touches. The #applications they use most frequently are owned by Facebook and Alphabet, and the usage of those products is still increasing.

    #silicon_valley #santé #profits

  • Génétique : le mirage du bébé parfait

    http://www.lemonde.fr/series-d-ete/article/2016/08/22/le-mirage-du-bebe-parfait_4986291_3451060.html

    J’étais terrorisée, mais je suis rentrée dans cette pièce où Hitler se trouvait. Il avait un visage de cochon. (…) Il a dit : “Je veux comprendre les utilisations et les implications de cette formidable technologie.” Je me suis réveillée, couverte d’une sueur froide. » Jennifer Doudna a raconté, en novembre 2015, ce cauchemar au New Yorker, qui enquêtait sur Crispr-Cas9, un puissant outil d’édition du génome que la chercheuse à l’université Berkeley a contribué à mettre au point. Un dictateur pourrait-il aujourd’hui ressusciter les délires eugénistes des nazis, produire des lignées de « bébés parfaits » grâce à ces nouveaux outils ? Le « meilleur des mondes » est-il à notre porte ?

    Cette perspective est suffisamment inquiétante pour que Jennifer Doudna et ses pairs, mais aussi de nombreuses sociétés savantes – et même la CIA –, se soient emparés du brûlant sujet Crispr-Cas9, sur son versant éthique. Jamais l’humanité n’a semblé aussi proche de modifier sa propre lignée, son génome et celui des générations à venir.
    Il ne s’agirait plus de science-fiction, d’un scénario dystopique, mais d’une possibilité qui a émergé avec force en avril 2015 : une équipe chinoise publie alors les résultats d’une expérience sur des embryons humains visant à modifier le gène responsable de la bêta-thalassémie, une forme d’anémie d’origine génétique. L’étude fait grand bruit. Certains jugent qu’une barrière éthique a été transgressée. Les chercheurs chinois pensent avoir pris les précautions idoines : ils n’ont utilisé que des cellules dites triploïdes, incapables de se développer pour donner un être viable – ils ont stoppé leurs observations lorsque les embryons ne comptaient que huit cellules.

    De plus, leur étude suggère que Crispr-Cas9 n’est pas l’outil à la précision chirurgicale tant vantée : seul un faible nombre d’embryons ­modifiés porte les mutations souhaitées, et des modifications « hors cibles » ont été mises en évidence. Même constat un an plus tard, lors de la parution d’une nouvelle étude chinoise où Crispr-Cas9 est cette fois utilisé pour offrir une protection contre le VIH : le succès n’a été que partiel, avec de nombreuses mutations non voulues et des ratés dans l’édition des ­embryons, détruits après quelques divisions cellulaires. Les chercheurs chinois voulaient voir si l’on pourrait créer des humains naturellement immunisés contre le sida. Ils ont prouvé qu’on était loin du compte. Le bébé « sur mesure » n’est finalement pas pour demain.

    « Evaluer les aspects éthiques »

    Dans l’intervalle, une équipe de l’Institut Francis-Crick, à Londres, a reçu l’autorisation de procéder, elle aussi, à des manipulations sur des embryons humains. Il s’agit de désactiver de façon sélective certains gènes considérés comme cruciaux dans la différenciation des premières cellules en divers tissus. A Stockholm aussi, une équipe pourra procéder à de tels essais. Comme en Chine, pas question d’implanter ces embryons dans un utérus. Le but est de mieux comprendre certaines formes d’infertilité.

    Ces expérimentations sur l’embryon sont conformes au consensus qui a émergé au fil des réunions internationales et des réflexions conduites par les sociétés savantes nationales, de l’usage sur l’homme des nouvelles techniques d’édition du génome. « Crispr fonctionne si bien et rencontre un tel succès qu’il serait important d’évaluer les aspects éthiques de son utilisation », avait prévenu, dès juin 2014, la Française Emmanuelle Charpentier, co-inventrice de l’outil.

    Au printemps 2015, Nature et Science publient des mises en garde contre la modification des cellules germinales (sexuelles) qui passerait d’une génération à l’autre. Une de ces tribunes est cosignée par le Nobel de chimie, en 1980, Paul Berg. Ce dernier avait organisé, en 1975, la conférence d’Asilomar (Californie), qui avait abouti à la mise en place de protections contre les fuites dans l’environnement des premières bactéries génétiquement modifiées.

    Mais, cette fois, il s’agit de changer le patrimoine héréditaire de la lignée humaine elle-même. Jusqu’où peut-on aller ? Une réunion internationale est organisée, début décembre 2015, à Washington. Après des débats ­enflammés, la déclaration finale juge que la ­recherche fondamentale et préclinique sur l’édition des gènes est nécessaire et doit être poursuivie, ainsi que sur les bénéfices et risques potentiels de leur usage clinique. Mais, « si, dans ce processus de recherche, des ­embryons humains et des cellules germinales subissent des éditions de gènes, les cellules ­modifiées ne devront pas être utilisées pour lancer une grossesse », préviennent les organisateurs. L’usage clinique de ces techniques sur les cellules somatiques (non transmises d’une génération à l’autre) doit s’inscrire dans les dispositifs « existants et évolutifs » qui encadrent les thérapies géniques.

    Convention d’Oviedo

    Cette position est rejointe peu ou prou par diverses sociétés savantes et organismes de recherche, avec des nuances selon les législations nationales. La France, comme la plupart des pays d’Europe, est signataire de la convention d’Oviedo (1997), dont l’article 13 stipule qu’« une intervention ayant pour objet de ­modifier le génome humain ne peut être entreprise que pour des raisons préventives, diagnostiques ou thérapeutiques, et seulement si elle n’a pas pour but d’introduire une modification dans le génome de la descendance ». Une interprétation maximaliste du texte pourrait interdire toute utilisation de Crispr sur les cellules germinales.

    Si les tycoons de la Silicon Valley et l’empire du Milieu s’en mêlent, qui sait jusqu’où ira Crispr ?

    Mais le neurobiologiste Hervé Chneiweiss, président du comité d’éthique de l’Inserm, n’en fait pas la même lecture : « Il faut établir une distinction entre la recherche fondamentale autorisée et le transfert vers les applications humaines. » Au-delà, quand la technologie sera éprouvée, s’interroge-t-il, « en quoi cela serait-il une atteinte à l’humanité d’éradiquer des maladies d’une particulière gravité, comme celle de Huntington, en modifiant les embryons ? »
    George Church (Harvard) ne se satisfait pas du consensus actuel. Pour lui, la focalisation sur l’embryon a fait passer au second plan l’édition des cellules sexuelles masculines : « En partant de cellules souches, vous pouvez les modifier ex vivo, en faire des clones, et vérifier celles qui ont les bonnes modifications. On peut s’assurer qu’elles sont parfaites. » Et les utiliser pour éviter d’éliminer des embryons.

    Pour Alain Fischer (Imagine-Necker), « père » des bébés-bulles soignés par thérapie génique, cette vision relève de la « science-fiction délirante ». Crispr constitue un outil de recherche « incontournable » et prometteur pour les cellules somatiques (adultes), mais modifier les cellules germinales revient in fine « à toucher au patrimoine de l’humanité, ce qui n’est pas raisonnable et doit rester interdit ». Le biologiste de la reproduction Pierre Jouannet, qui a corédigé plusieurs rapports de sociétés savantes françaises sur Crispr, estime que George Church a raison d’insister sur le ­potentiel des cellules germinales, même s’« il ne faut pas être naïf » et que les défis à relever sont immenses.

    Obstacles parfois sous-estimés

    Ils le sont aussi pour les thérapies géniques imaginées sur les cellules adultes, moins problématiques d’un point de vue éthique. Là ­encore, la « magie Crispr » se heurte à des obstacles parfois sous-estimés, comme les mutations hors cibles. Keith Joung, du Massachusetts General Hospital, a mis les pieds dans le plat, début juillet, devant la Société américaine d’hématologie, en projetant une diapositive montrant un individu la tête dans le sable. Comme le raconte la revue en ligne Stat, il a souligné les carences des logiciels utilisés pour déterminer les zones du génome susceptibles d’être modifiées par inadvertance par Crispr – ce qui a douché l’enthousiasme général.
    L’autre grand défi, c’est la faculté de faire s’exprimer les cellules mutées par Crispr dans les bons tissus.

    La société Editas cible par exemple des maladies de l’œil, un organe qui se prête à l’injection de virus vecteurs de Crispr. Crispr Therapeutics mise sur une stratégie assez ­similaire. Intellia Therapeutics parie sur des nanoparticules lipidiques pour transporter Crispr jusqu’au foie, où il permettrait de lutter contre diverses maladies comme l’hémophilie. D’autres, comme David Bikard à l’Institut Pasteur, espèrent retourner Crispr contre les bactéries qui l’ont inventé, pour lutter contre les souches résistantes aux antibiotiques – là encore la question du vecteur sera essentielle.
    La pédiatre Marina Cavazzana (Imagine - Necker), qui a vécu les hauts et les bas de la thérapie génique des bébés-bulles, est très enthousiaste sur le potentiel de Crispr. « Je suis amenée à relire les résultats précliniques d’autres groupes dans le monde, encore non ­publiés, qui sont très impressionnants », dit-elle. Mais, de l’animal à l’homme, les embûches peuvent être nombreuses, prévient-elle : « Les chercheurs ne perçoivent pas toujours que l’application clinique est un très long chemin. »

    Conflit d’intérêts

    Les start-up pionnières, basées à Boston, ­espéraient être les premières à passer à ces ­essais cliniques. Elles viennent de se faire ­dépasser par une équipe de l’université de Pennsylvanie, qui a reçu, fin juin, un feu vert des Instituts nationaux de la santé (NIH) américains pour tester une thérapie ex vivo qui ­viserait simultanément trois gènes. L’idée ­reprend avec Crispr la stratégie dite des cellules CAR-T déjà mise en œuvre avec succès avec des outils plus anciens d’édition des gènes. L’un d’eux, développé par la société française Cellectis, a permis de sauver une petite Londonienne d’une leucémie, fin 2015. Cette thérapie consistera à prélever des lymphocytes T, des cellules immunitaires, et de les modifier pour qu’elles s’attaquent à des cellules tumorales une fois réinjectées à des patients souffrant de mélanome, sarcome ou myélome résistants aux traitements classiques.

    Certains se sont émus que la Penn State se ­retrouve aux avant-postes. En 1999, Jesse Gelsinger, un jeune homme de 18 ans, était mort lors d’un essai clinique de thérapie génique conduit dans cette université. On avait ensuite découvert que le directeur de l’étude, James Wilson, possédait des parts dans Genovo, une compagnie qui avait un intérêt direct à hâter sa réussite. Et que le patient, qui n’avait pas été correctement informé des risques, avait reçu des doses plus fortes que prévu. Carl June, le conseiller scientifique de la nouvelle étude, possède des brevets sur la technologie testée, mais il assure que des mesures seront prises pour surmonter ce conflit d’intérêts.

    « Hacker le cancer »

    L’essai sera financé par un institut créé, en avril, par le milliardaire Sean Parker, cofondateur de Napster et associé de Facebook, qui a injecté 250 millions de dollars (223 millions d’euros) dans un vaste programme d’immunothérapie. Cet ancien petit génie de l’informatique, âgé de 36 ans, s’est mis en tête de « hacker le cancer ».
    Mais, encore une fois, la Chine double tout le monde : le 6 juillet, une équipe de l’université du Sichuan a reçu l’autorisation de procéder à un essai clinique du même type, ciblant le cancer du poumon. Il pourrait débuter dès ce mois d’août.

    Si les tycoons de la Silicon Valley et l’empire du Milieu s’en mêlent, qui sait jusqu’où ira Crispr ? Inventé par les bactéries il y a des milliards d’années pour se défendre contre des ­virus, transformé en outil révolutionnaire d’édition des gènes par des chercheurs venus d’horizons aussi divers que l’étude du yaourt, de la peste ou des structures cellulaires, souvent mus par la pure curiosité, mais prêts à en découdre sur les brevets et le Nobel, il est aussi un formidable révélateur : son histoire est celle de la science d’aujourd’hui.

    • un peu de #censure sur #facebook
      un #trader #philanthrope
      et de la #disruption

      [Sean Parker] s’installe à New York et devient célèbre pour ses fêtes extravagantes.
      En 2006, il rejoint le Founders Fund, le fonds d’investissement de #Peter_Thiel, cofondateur de Paypal et de Facebook, et a carte blanche pour miser sur de nouvelles start-up. Il investit dans Spotify, un site de musique en ligne considéré comme l’héritier naturel de #Napster, et des start-up moins connues comme Airtime, une plateforme de chat vidéo. Ses admirateurs comme ses détracteurs reconnaissent qu’il a plus qu’une touche de génie. Thiel a déclaré à Vanity Fair : “J’ai dit à Sean qu’il devait être le petit-fils du célèbre magnat Howard Hughes – c’est un entrepreneur génial qui est en train de transformer les Etats-Unis mais que la société ne comprend pas.”