JCI - #BCG #vaccination history associates with decreased #SARS-CoV-2 #seroprevalence across a diverse cohort of healthcare workers
▻https://www.jci.org/articles/view/145157/pdf
Étude observationnelle,
COVID-19 : Oui le BCG protège aussi | santé log
▻https://www.santelog.com/actualites/covid-19-oui-le-bcg-protege-aussi
De vastes essais cliniques randomisés sont en cours pour confirmer si la vaccination par le BCG peut induire un effet protecteur contre l’infection par le SRAS-CoV2.
Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial - The Lancet
▻https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32466-1/abstract
Participants were eligible if they did not have severe or uncontrolled medical comorbidities or a high frailty score (if aged ≥65 years).
[...]
ChAdOx1 nCoV-19 appears to be better tolerated in older adults than in younger adults and has similar immunogenicity across all age groups after a boost dose. Further assessment of the efficacy of this vaccine is warranted in all age groups and individuals with comorbidities.
Coronavirus : le vaccin d’AstraZeneca montre des résultats encourageants chez les plus âgés
▻https://www.futura-sciences.com/sante/actualites/coronavirus-coronavirus-vaccin-astrazeneca-montre-resultats-encoura
On ne sait pas encore, « future sciences » ne le dit pas, si ces anticorps sont protecteurs.
Thread by nataliexdean on Thread Reader App – Thread Reader App
▻https://threadreaderapp.com/thread/1325820512946302977.html
It may be time to reset expectations on when we’ll get a #Covid-19 vaccine
▻https://www.statnews.com/2020/10/29/it-may-be-time-to-reset-expectations-on-when-well-get-a-covid-19-vaccine
Anna Durbin, a vaccine researcher at Johns Hopkins Bloomberg School of Public Health, said the public needs to understand that Covid vaccines may be a bit further off than people have been led to believe.
“We may see efficacy in one or more trials by the end of 2020, but that doesn’t mean we’re going to have a vaccine available at the end of 2020,” she said.
“I think what people can take from this is that the process is not being rushed…. That’s a good thing,” Durbin said. “And certainly, I think the other message that has to be heard loud and clear is that even when an [emergency use authorization] is issued, we’re not going to have enough vaccine for everybody [immediately].”
The Challenges We Face Once a Coronavirus Vaccine Is Found - DER SPIEGEL
▻https://www.spiegel.de/international/zeitgeist/the-challenges-we-face-once-a-coronavirus-vaccine-is-found-a-3f076abd-6b3b-4
La déclaration de Great Barrington : la politique capitaliste mondiale de l’#immunité collective - World Socialist Web Site
▻https://www.wsws.org/fr/articles/2020/10/15/bari-o15.html
▻https://www.wsws.org/asset/de181613-158c-48f8-afec-48ef75cdf12f?rendition=image1280
« L’immunité collective est un concept utilisé pour la #vaccination, dans lequel une population peut être protégée contre un certain virus lorsqu’un seuil de vaccination est atteint. On atteint l’immunité collective en protégeant les personnes contre un #virus et non en les exposant à celui-ci. Jamais dans l’histoire de la santé publique, on n’a utilisé l’immunité collective comme stratégie pour répondre à une épidémie, et encore moins à une #pandémie. Laisser libre cours à un virus dangereux dont nous ne comprenons pas tout est tout simplement contraire à l’éthique. Ce n’est pas une option ». – Le Directeur général Tedros Adhanom Ghebreyesus, communiqué de presse de l’Organisation mondiale de la santé, 12 octobre 2020.
Les remarques préliminaires du directeur général font suite à l’annonce la semaine dernière de la Déclaration de « Great Barrington », une proposition internationale rédigée et signée le 4 octobre à l’Institut américain de recherche économique (American Institute for Economic Research – AIER) à Great Barrington, dans le Massachusetts.
La déclaration préconise une approche de l’immunité collective [en anglais : l’immunité de troupeau] appelée « protection ciblée », où on donne prétendument refuge aux plus vulnérables. Dans le même temps, les plus jeunes sont encouragés à s’infecter afin d’établir une immunité à grande échelle dans la population.
L’AIER, un groupe de réflexion libertaire qui se fixe comme objectif « une société fondée sur les droits de propriété et l’ouverture des marchés », est engagé dans une entreprise hautement réactionnaire, anti-classe ouvrière et anti-socialiste. Le milliardaire de droite Charles Koch a financé la déclaration en partie. Il a organisé une soirée privée de scientifiques, d’économistes et de journalistes pour conférer à la déclaration homicide un minimum de respectabilité et a formulé l’immunité collective comme une #politique mondiale nécessaire en réponse à la pandémie.
« L’AIER, un groupe de réflexion libertaire » #WTF ! Dommage, il peuvent parfois faire preuve de plus de justesse ("déclaration homicide", par ex.).
#Great_Barrington_Declaration #immunité_collective #immunité_de_troupeau
C’est une localisation : il faut comprendre libéral , bien sûr (tendance ultra).
Scott Morrison casts gloom on Australia’s prospects for quarantine-free travel with Europe and US | Australia news | The Guardian
▻https://www.theguardian.com/australia-news/2020/oct/11/scott-morrison-casts-gloom-on-australias-prospects-for-quarantine-free-
▻https://i.guim.co.uk/img/media/8fcbd5b5e68cacdbdf651a0f9fe5ca501c60e8ca/0_94_6773_4066/master/6773.jpg?width=1200&height=630&quality=85&auto=format&fit=crop&overlay-ali
Scott Morrison has confirmed Australia will move “very cautiously” to reopen quarantine-free travel with a “handful” of countries, raising the prospect Europe and the United States will be excluded until 2022 unless a Covid vaccine is available.Morrison made the comments at a doorstop in Redbank, campaigning with Queensland’s Liberal National party leader, Deb Frecklington, and targeting the Labor premier Annastacia Palaszczuk over the state’s reluctance to remove its state border travel ban. On Sunday the federal tourism minister, Simon Birmingham, said that moves to establish quarantine-free travel with low-risk countries such as New Zealand “can’t be done at the expense of our health and economic strength at home”.
“The prospects of opening up widespread travel with higher risk countries will remain very reliant on effective vaccination or other major breakthroughs in the management of Covid,” he told the Sun Herald.
Australia needs to find its heart, brain and courage to recover from the Covid nightmare. The comments were widely interpreted to mean travel to and from Europe and the United States will continue to be subject to the compulsory two-week quarantine period, which makes travel uneconomical except for longer stays such as international students.
Morrison told reporters New Zealand would be the “first step” and very soon New Zealanders “will be able to come to New South Wales, the ACT, and the Northern Territory”.
#Covid-19#migrant#migration#australie#nouvellezelande#ue#etatsunis#frontiere#sante#vaccination#etudiant#trourisme#economie#payssur
How India can contain coronavirus - Asia Times
▻https://asiatimes.com/2020/09/how-india-can-contain-covid-19
India should focus on controlling the spread of Covid-19 by imposing focused lockdowns in hotspots that threaten to negate the country’s containment successes, Dr Shiv Pillai, director of the Harvard Immunology Graduate Program at Harvard Medical School, told Asia Times in a telephone interview. Over a longer time frame, India’s best hope of controlling the runaway spread of the deadly virus would be injecting a significant number of citizens with the vaccines currently being tested in various countries. Dr Pillai expects approvals for vaccines to come before the end of the year.
“It will be a silver bullet compared with what we have now,’’ he said from Cambridge, Massachusetts. “India is a great country to make vaccines. We have the two best vaccine-making companies in the world – Bharat Biotech and Serum Institute. They are also cost-effective.’’
India has numerous pockets of high density across its 1.38 billion population, which makes it tough to contain Covid-19. Widespread lockdown fatigue and a lack of discipline regarding wearing masks, hand hygiene and social distancing is negating the tireless efforts of health workers and administrators in several parts of the country.“India is not Sweden, where you can tell people to stay apart. People have to go out, people have to work. Vaccination is the only answer,” said Pillai. “Fortunately, the deaths are not as dramatically high as elsewhere. Many [0f] the sick are recovering, including older people.’’Countrywide lockdowns had a severe impact on the economy, with the June quarter reporting a 23.9% contraction in gross domestic product. More than a hundred million lost their jobs and many workers had no option but to head back to their villages, inadvertently spreading the virus across the hinterland.
India, which has 5.6 million cases, the second-highest number after the United States (7 million), has a fatality rate of around 89,000, much lower than than the US’s 204,000. Brazil and Mexico have recorded 137,000 and 73,700 fatalities from 4.56 million and 700,000 cases, respectively.
#Covid-19#migrant#migration#inde#sante#confinement#travailleurmigrant#migrationinterne#vaccination
Thread by PeterHotez on Thread Reader App – Thread Reader App
▻https://threadreaderapp.com/thread/1301275248248139778.html
Especially given the vaccines we’re talking about are likely mRNA vaccines with a new technology that has never before been licensed. We have no history or experience on such vaccines. Even more reason for a full/comprehensive review
[...]
10. Not to mention, that we’ve seen how in 2020 the White House has abused the EUA mechanism - remember the EUA for hydroxychloroquine that was revoked? Neither does the White House or Dept. HHS.
#vaccination #vaccins #sars-cov2 #covid-19 #irresponsable #états-unis
Moderna and Pfizer’s #COVID-19 vaccine candidates require ultra-low temperatures, raising questions about storage, distribution - MarketWatch
▻https://www.marketwatch.com/story/moderna-and-pfizers-covid-19-vaccine-candidates-require-ultra-low-tempe
Moderna’s coronavirus vaccine candidate [...] requires a storage temperature of negative 4 degrees Fahrenheit. BioNTech and Pfizer’s candidates, BN1162b2 and BNT162b2, need to be stored in negative 94 degrees Fahrenheit.
[...]
The vaccines being developed by Moderna, BioNTech, and Pfizer are mRNA vaccines; however, other types of vaccines require less intense rules around storage. Concern about the difficulties of storing and shipping mMRNA COVID-19 vaccines to hundreds of millions of people could put the makers of these candidates at a competitive disadvantage, analysts say. It may also separate Moderna’s vaccine from the ones being developed by BioNTech and Pfizer.
#COVID-19 : des chercheurs disent avoir découvert un premier cas de #réinfection | JDM
▻https://www.journaldemontreal.com/2020/08/24/covid-19-des-chercheurs-disent-avoir-decouvert-un-premier-cas-de-
« Ce n’est pas un motif pour s’alarmer : cela illustre à merveille la façon dont l’#immunité devrait fonctionner », a quant à elle souligné sur Twitter la Dre Akiko Iwasaki, spécialiste de l’immunité à l’université Yale.
« La seconde infection était asymptomatique. Si l’immunité n’a pas été suffisante pour empêcher la réinfection, elle a protégé cette personne contre la maladie », a-t-elle développé.
« Puisqu’une réinfection peut se produire, il est improbable que l’immunité collective acquise par les infections naturelles suffise à éliminer le SARS-CoV-2 . La seule manière d’aboutir à une immunité collective est la #vaccination », a-t-elle conclu.
Sjors Provoost sur Twitter : “DrPieterPeach @apoorva_nyc
Also that an increase in low symptomatic folks, depending on how contagious they are, makes containment more challenging.” / Twitter
▻https://twitter.com/provoost/status/1297945772131078147
Coronavirus. Des cas de réinfection signalés en Belgique et aux Pays-Bas
▻https://www.ouest-france.fr/sante/virus/coronavirus/coronavirus-des-cas-de-reinfection-signales-en-belgique-et-aux-pays-bas
Pour confirmer qu’il s’agit d’une véritable recontamination, des tests génétiques sont nécessaires pour déterminer si la première et la seconde infection ont éventuellement été provoquées par des souches différentes du virus. Que des cas de réinfection émergent, cela ne m’inquiète pas, a souligné Marion Koopmans. Nous devons voir si cela arrive souvent, a-t-elle ajouté.
Aucun commentaire n’a pu être obtenu dans l’immédiat auprès du ministère néerlandais de la Santé.
« Ce n’est pas une bonne nouvelle »
En ce qui concerne le patient belge, le virologue Marc Van Ranst a précisé à la télévision publique belge VRT qu’il s’agissait d’une femme ayant été contaminée une première fois en mars, puis une seconde fois en juin.
Je pense que dans les prochains jours nous verrons d’autres histoires comparables […] Il pourrait s’agir d’exceptions, mais ces cas existent et il n’y en a pas qu’un, a-t-il dit en jugeant que ce n’est pas une bonne nouvelle.
Marc Van Ranst a expliqué que, dans le cas de la patiente belge, qui présentait des symptômes légers de Covid-19, les anticorps développés après l’infection initiale pourraient être insuffisants pour prévenir une nouvelle contamination par une souche légèrement différente du virus mais pourraient malgré tout contribuer à limiter la sévérité des symptômes.
Covid-19 News: Live Updates - The New York Times
A Nevada lab confirmed the first coronavirus reinfection in the U.S., a case that included severe symptoms.
▻https://www.nytimes.com/2020/08/28/world/covid-19-coronavirus.html
A public health laboratory in Nevada has reported the first confirmed coronavirus reinfection in the United States, and the first in the world known to have brought on severe symptoms.
The first three confirmed reinfections in the world were reported this week, one in Hong Kong and two in Europe, all mild.
Reinfection does not surprise researchers, given the millions of cases around the world, but it is not yet clear if such cases — particularly severe ones — are anomalies or will prove common.
The patient is a 25-year-old man in Reno who apparently experienced a second bout of infection just 48 days after his first, according to health officials in Nevada.
Experts have said that even low levels of antibodies and T cells in response to infection should last for a few months and provide some protection against the virus, which appears to have been borne out in the other confirmed reinfections.
The patient in Nevada had a sore throat, cough, nausea and diarrhea starting on March 25. He tested positive on April 18, recovered by April 27, and tested negative twice. He began to feel unwell again on May 28, and three days later sought help for a similar set of symptoms.
He was hospitalized on June 5 for shortness of breath and needed oxygen; an X-ray showed the “ground-glass opacities” typical of Covid-19.
Researchers genetically sequenced the viruses from each bout, and found they were too different to be accounted for by an extended first illness. The findings have been submitted for consideration to the Lancet Infectious Diseases journal.
Mark Pandori, the director of Nevada’s state lab, said it wasn’t clear why the second bout was more severe. “There may be a biological reason for that, but we can’t sure at this time,” he said.
The researchers did not test the man for antibodies after the first illness, but found that he had them after the second.
Some experts said the severe symptoms could mean that the patient had not developed antibodies after the first infection, or that his immune response was overpowered by a massive dose of virus the second time. It is also possible that he suffered antibody-dependent enhancement, in which the immune response may worsen symptoms on a second encounter.
The findings highlight the need for widespread testing and viral sequencing, said Angela Rasmussen, a virologist at Columbia University in New York who was not involved in the work. “You really are going to need to look at a lot of these cases to try to start to narrow down which hypothesis is probably right,” she said.
Several have been reinfected with Covid-19. Here’s what that means
▻https://www.statnews.com/2020/08/28/covid-19-reinfection-implications
It’s possible that these early cases of reinfection are outliers and have features that won’t apply to the tens of millions of other people who have already shaken off Covid-19.
[...]
“The most important question for reinfection, with the most serious implications for controlling the pandemic, is whether reinfected people can transmit the virus to others,” Columbia University virologist Angela Rasmussen wrote in Slate this week.
Unfortunately, neither the Hong Kong nor the Reno studies looked at this question. But if most people who get reinfected don’t spread the virus, that’s obviously good news.
[...]
A crucial question for which there is not an answer yet is whether what happened to the man in Reno, where the second case was more severe than the first, remains a rare occurrence, as researchers expect and hope. As the Nevada researchers wrote, “the generalizability of this finding is unknown.”
Covid-19 : un cas de réinfection aux Etats-Unis, le 5e dans le monde - France 24
▻https://seenthis.net/messages/880716
Explainer : What’s needed for immunity from #Covid-19 – and do Indians stand a better chance ?
►https://scroll.in/article/968550/explainer-whats-needed-for-immunity-from-covid-19-and-do-indians-stand-a-bett
L’extrême rapidité de la mise en place des vaccins contre le #sars-cov2 n’a pas pour seule (grosse) inconnue l’intensité des effets secondaires qui en découleront, mais aussi la durée d’efficacité de ces vaccins, cette dernière conditionnant le nombre de personnes qui pourront être vaccinées.
If the vaccine protective response is going to one year or less, then how are we going to cover the susceptible population every year? [...] It’s impossible. And we are not going to know if the vaccine protective response is going to last five years because we desperately need the vaccine and there will be short cuts implemented. The reason why vaccines take 10-12 years to develop is because you need to check if in a few years the vaccine is still protective to the recipient.
Coronavirus’s Genetics Not Changing Much, And That Bodes Well For A Vaccine : Shots - Health News : NPR
▻https://www.npr.org/sections/health-shots/2020/06/26/883477681/this-coronavirus-doesnt-change-quickly-and-thats-good-news-for-vaccine-makers
“There’s nothing alarming about the way the #coronavirus is mutating or the speed at which it’s mutating,” says Emma Hodcroft, a molecular epidemiologist at the University of Basel in Switzerland. “We don’t think this will be a problem [for vaccines] in the short term.”
“To date, there have been very few mutations observed,” says Peter Thielen, a senior scientist at Johns Hopkins Applied Physics Laboratory. “And any #mutations that we do see are likely not having an effect on the function of the virus itself.”
That’s good news for scientists working to produce an effective vaccine by the end of the year.
Decades-Old Soviet Studies Hint at #Coronavirus Strategy - The New York Times
▻https://www.nytimes.com/2020/06/24/world/europe/vaccine-repurposing-polio-coronavirus.html
https://static01.nyt.com/images/2020/06/21/world/21russia-vaccine/21russia-vaccine-facebookJumbo.jpg La #vaccination orale contre la #poliomyélite va être testée dans certains pays comme protection contre la #covid-19 en se basant sur les constations anciennes de virologues soviétiques (consistant en une protection élargie conférée par ce vaccin).
Something Dr. [Marina] Voroshilova noticed decades ago has renewed interest in the oral vaccine.
A typical healthy child is host to a dozen or so respiratory viruses that cause little or no illness. But Dr. Voroshilova could not find any of them in children soon after they were immunized against polio.
A huge study in the Soviet Union of 320,000 people, from 1968 to 1975, overseen by Dr. Voroshilova, found reduced mortality from flu in people immunized with other vaccines, including the oral polio vaccine.
She won recognition in the Soviet Union for demonstrating a link between vaccinations and broad protection against viral diseases, likely by stimulating the immune system.
L’#OMS veut engager une discussion sur la possibilité d’inoculer le #sars-cov2 à des adultes jeunes volontaires dans le but d’évaluer beaucoup plus rapidement des #vaccins,
Feasibility, potential value and limitations of establishing a closely monitored challenge model of experimental #COVID-19 infection and illness in healthy young adult volunteers
▻https://www.who.int/who-documents-detail-redirect/feasibility-potential-value-and-limitations-of-establishing-a-closely-monitored
PDF
▻https://www.who.int/docs/default-source/coronaviruse/blueprint-feasiblitiy-potential-value-limitations-draft-.pdf?sfvrsn=3381c98b_1&
Voir page 13
Recognizing the helpful role that experimental challenge studies in healthy adult volunteers have played (and are still playing) in the development of other vaccines,6-21 some have advocated a role for such studies with virulent SARS-CoV-2.22-25 However, several factors collectively warrant that special caution must be taken in working with SARS-Cov-2. These factors include:
[..,]
Précédemment le Lancet avait mis 12 ans pour retirer un article reposant sur des données frauduleuses (publié en 1998, retiré en 2010)
Affaire Wakefield : 12 ans d’errance car aucun lien entre autisme et #vaccination ROR n’a été montré - EM|consulte
▻https://www.em-consulte.com/en/article/749283
Non, Emmanuel Macron n’a pas interdit l’entrée en Europe aux Africains non vaccinés
►https://www.lemonde.fr/les-decodeurs/article/2020/06/09/non-emmanuel-macron-n-a-pas-interdit-l-entree-en-europe-aux-africains-non-va
Non, Emmanuel Macron n’a pas interdit l’entrée en Europe aux Africains non vaccinés
►https://www.lemonde.fr/les-decodeurs/article/2020/06/09/non-emmanuel-macron-n-a-pas-interdit-l-entree-en-europe-aux-africains-non-va
Trump’s Vaccine Chief Has Vast Ties to Drug Industry, Posing Possible Conflicts - The New York Times
▻https://www.nytimes.com/2020/05/20/health/coronavirus-vaccine-czar.html
Moncef Slaoui, a former pharmaceutical executive, is now overseeing the U.S. initiative to develop #coronavirus treatments and vaccines. His financial interests and corporate roles have come under scrutiny.
#conflit_d’intérêt #vaccins #vaccin #vaccination #pharma #porte_tournante
Les USA lancent un plan massif de test des #vaccins expérimentaux contre le #coronavirus - sources | Article [AMP] | Reuters
▻https://www.reuters.com/article/sante-coronavirus-usa-vaccin-idUSP6N2BW01O
L’idée est de ramener à une durée de quelques mois seulement un processus qui prend généralement dix ans, illustration de l’urgence de la crise sanitaire qui a paralysé des pans entiers de l’économie mondiale.
Pour y parvenir, indiquent ces chercheurs, les laboratoires ont accepté de partager leurs données et d’ouvrir leurs réseaux d’essais cliniques à leurs concurrents si leur propre « candidat vaccin » échoue.
Afin d’obtenir une réponse plus rapidement, ces vaccins seront en outre testés parmi des professionnels du secteur de la santé et des membres de communautés où le virus se répand toujours afin de voir si les injections réduisent l’apparition de nouveaux cas.
Exclusive: U.S. plans massive coronavirus vaccine testing effort to meet year-end deadline | Article [AMP] | Reuters
▻https://www.reuters.com/article/health-coronavirus-usa-vaccine-exclusive-idINKBN22Z07F
Trials will need to assess if the vaccines cause disease enhancement - a potentially dangerous side effect in which the vaccine makes the disease worse in some individuals instead of preventing it. Disease enhancement has been seen in animal studies of vaccines developed to fight a close cousin of the virus that causes COVID-19.
“If there is enhancement, that’s a big stop sign for everything,” said Dr. Anthony Fauci, director of the National Institutes of Allergy and Infectious Diseases at NIH.
“If all the cards fall into the right place and all the stars are aligned, you definitely could get a vaccine by December or January,” Fauci said.
COVID-19 Vaccine Won’t Be a Slam Dunk
▻https://www.medscape.com/viewarticle/930986
Une préoccupation de sécurité clé à surveiller dans les mois à venir est de savoir si un vaccin candidat est capable de contourner le problème du “#antibody-dependent_enhancement” (#facilitation_de_l'infection_par_des_anticorps ▻https://fr.wikipedia.org/wiki/Facilitation_de_l%27infection_par_des_anticorps), par lequel une infection antérieure par un coronavirus non SRAS, comme ceux qui causent le rhume, pourrait entraîner la création d’anticorps anti coronavirus peu neutralisants en réponse à la vaccination. Il est à craindre que ces anticorps non neutralisants puissent faciliter l’entrée du virus dans les monocytes et autres cellules dépourvues du récepteur ACE2, sa porte d’entrée habituelle. En réaction, cela pourrait déclencher une réplication virale étendue, une réponse hyperinflammatoire et une propagation virale vers des sites au-delà des poumons, comme le cœur ou les reins.
Illustré ci-dessous,
▻https://www.nature.com/scitable/content/model-of-antibody-dependent-enhancement-of-dengue-22403433
Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed…
▻https://seenthis.net/messages/853439#message853693
Les résultats de cette étude sont rassurants quant au phénomène de la #facilitation_de_l'infection_par_des_anticorps
The other good news is that this team looked for the signs of an #antibody-dependent-enhancement response, which would be bad news, and did not find evidence of it in the recovering patients (I didn’t go into these details, but wanted to mention that finding, which is quite reassuring).
SARS-CoV2 vaccines : Slow is fast | Science Advances
▻https://seenthis.net/messages/855077
Many advocate “fast-tracking” these trials, and some wish to rely soley on evidence of induction of neutralizing responses. However, this could be catastrophic. In 1966, a large trial of a vaccine for Respiratory Syncytial Virus (RSV) found that the immunized cohort actually faired significantly worse upon infection. There is some reason to worry that the same may occur with some SARS-CoV2 vaccines.
Vaccins Covid-19, rêve ou réalité ?
▻https://seenthis.net/messages/856424
Anthony Fauci on Covid-19 reopenings, vaccines, and ’warp speed’
▻https://www.statnews.com/2020/06/01/anthony-fauci-on-covid-19-reopenings-vaccines-and-moving-at-warp-speed
There’s a lot of interest in developing vaccine as quickly as possible, but there’s also a lot of concern about the speed at which this is being undertaken. Should there be major adverse events associated with use of these vaccines, it could really damage trust in vaccination in general. Is that something you are worrying about?
Yes, I am.
#SARS-CoV2 vaccines : Slow is fast | Science Advances
▻https://advances.sciencemag.org/content/early/2020/05/22/Sciadv.abc7428.full
Clinical trials proceed in three phases. In Phase I and II the vaccine is tested on a small cohort of individuals to determine if the vaccine is safe in the short term and elicits immune responses. A Phase III trial follows, which tests the vaccine in a large cohort for actual efficacy against infection and potential adverse effects. Phase III trials are necessarily time-consuming and require that infection among the control group is sufficiently high to draw a conclusion.
Many advocate “fast-tracking” these trials, and some wish to rely soley on evidence of induction of neutralizing responses. However, this could be catastrophic. In 1966, a large trial of a vaccine for Respiratory Syncytial Virus (RSV) found that the immunized cohort actually faired significantly worse upon infection. There is some reason to worry that the same may occur with some SARS-CoV2 vaccines.
Polio and Measles Could Surge After Disruption of Vaccine Programs - The New York Times
▻https://www.nytimes.com/2020/05/22/health/coronavirus-polio-measles-immunizations.html
Many public health experts say they are worried that deaths from diseases including cholera, rotavirus and diphtheria could far outstrip those from #Covid-19 itself.
Vaccinations : les #enfants ne doivent pas être les victimes collatérales du Covid-19 (OMS) | ONU Info
▻https://news.un.org/fr/story/2020/04/1067812
En dehors du cas de la #vaccination, l’#immunité de groupe est atteignable dans certaines conditions sans qu’il est besoin d’avoir 60% de la population contaminée du fait que le virus atteint d’abord les personnes les plus exposées donc les plus propagatrices ; ce n’est cependant pas pour demain la veille conclue l’auteur.
Thread by mlipsitch : Two preprints recently make an important point : for any infection, including COVID-19, it is possible that herd immunity can be accomplished…
▻https://threadreaderapp.com/thread/1258827506930667523.html
Thread by caesoma: As a coauthor in this study I’m going to start by saying what its conclusions are NOT: (i) it does NOT conclude that lockdowns/social distan…
▻https://threadreaderapp.com/thread/1257762721317224448.html
Thread by nataliexdean: Seeing papers make the rounds that the herd immunity threshold may be much lower than the rough approximation 1-1/R0. Maybe, but let’s slow…
▻https://threadreaderapp.com/thread/1259248274625761282.html
‘Finally, a virus got me.’ Scientist who fought Ebola and HIV reflects on facing death from #COVID-19 | Science | AAAS
►https://www.sciencemag.org/news/2020/05/finally-virus-got-me-scientist-who-fought-ebola-and-hiv-reflects-facing-
Le virologue Peter Piot raconte sa propre (et très éprouvante) expérience de la COVID-19 et appelle à prendre très au sérieux cette maladie,
Let’s be clear: Without a coronavirus vaccine, we will never be able to live normally again. The only real exit strategy from this crisis is a vaccine that can be rolled out worldwide. That means producing billions of doses of it, which, in itself, is a huge challenge in terms of manufacturing logistics. And despite the efforts, it is still not even certain that developing a COVID-19 vaccine is possible.
Today there’s also the paradox that some people who owe their lives to vaccines no longer want their children to be vaccinated. That could become a problem if we want to roll out a vaccine against the coronavirus, because if too many people refuse to join, we will never get the pandemic under control.
La #vaccination infantile en chute libre aux #États-Unis
▻https://www.lapresse.ca/international/etats-unis/202005/09/01-5272867-la-vaccination-infantile-en-chute-libre-aux-etats-unis.php
La vaccination infantile s’est effondrée aux États-Unis avec la #COVID-19. Depuis la mi-mars, le nombre de bébés qui reçoivent le vaccin de la #rougeole est deux fois moins important que la normale, et la chute est dix fois plus importante chez les enfants de 2 ans et plus. Une situation « terriblement inquiétante », dénonce l’Académie américaine de pédiatrie.
