Alzheimer’s disease reversed in mice, offering hope for humans, new research shows - ABC News
▻http://abcnews.go.com/Health/alzheimers-disease-reversed-mice-offering-hope-humans-research/story?id=53114260
By using #BACE1 inhibitors to gradually lower the enzyme’s levels, researchers saw reduced neuron loss and better brain function in the mice, offering hope for human subjects down the line, according to the study.
Merck BACE1 drug fails in prodromal Alzheimer’s phase 3 | FierceBiotech
▻https://www.fiercebiotech.com/biotech/merck-bace1-drug-fails-prodromal-alzheimer-s-phase-3
Merck has stopped a phase 3 trial of BACE1 inhibitor verubecestat in prodromal Alzheimer’s patients following an interim review. News of the setback comes 12 months after Merck pulled the plug on a trial in patients with more advanced forms of the disease after seeing similarly lackluster data.