Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients

/s41467-020-17907-w

  • Un autre essai sur des animaux, publié le 26 août : aucun résultat avec HCQ ; Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients | Nature Communications
    https://www.nature.com/articles/s41467-020-17907-w

    In simple Vero cell assays, CQ and HCQ appear to demonstrate anti-viral properties. However, these in vitro effects are not seen in more complex and life-like models of infection such as organ-on-chips, which use human respiratory cells. In addition, no significant therapeutic benefit derived from HCQ was observed in SARS-CoV-2 infection model studies in hamsters and non-human primates. These consistent findings have been observed in four independent laboratories.

    In summary, these data do not support the broad use of HCQ to treat or prevent SARS-CoV-2 disease.