Prof. Akiko Iwasaki sur Twitter :
“Are you confused about the role of type I #interferons (IFN) in #SARS_CoV_2 infection? Here is my speculation on what makes IFN-I helpful vs. harmful in #COVID19 patients - it comes down to timing and dose. A short thread. All figures made by BioRender & @annsea_park (1/n)” / Twitter
▻https://twitter.com/VirusesImmunity/status/1311414807581487104
Prof. Akiko Iwasaki sur Twitter : “In the best case scenario, a rapid and robust induction of IFN-I should result in viral control and mild disease. This may happen in young people, or with low viral exposure settings. For a discussion we wrote, please read this. (2/n)” / Twitter
▻https://twitter.com/VirusesImmunity/status/1311414813914886145
Prof. Akiko Iwasaki sur Twitter : “In older adults or after high dose viral exposure, impaired IFN response early during infection results in enhanced viral replication, and prolonged levels of IFN-I and IFN-III responses that could result in pathological consequences and severe disease. (3/n) ▻https://t.co/wRCSgRluyp” / Twitter
▻https://twitter.com/VirusesImmunity/status/1311414821330452481
Prof. Akiko Iwasaki sur Twitter :
“Not all studies show this pattern. Here is a study that showed lower IFN-I levels in more severe COVID patients. It would be interesting to understand this difference. (5/n) ▻https://t.co/0pFi0VebYd” / Twitter
▻https://twitter.com/VirusesImmunity/status/1311414825348595712
Prof. Akiko Iwasaki sur Twitter : “In the setting of host genetic mutations in viral sensors, signaling molecules, adaptors, transcription factors; or in older people with neutralizing antibodies to IFN-I, little to no IFN-I is available. Uncontrolled virus replication can lead to very severe COVID-19. (6/n)” / Twitter
▻https://twitter.com/VirusesImmunity/status/1311414830348165120
Prof. Akiko Iwasaki sur Twitter : "Papers supporting this scenario can be found here. (7/n)
▻https://science.sciencemag.org/content/early/2020/09/23/science.abd4585…
▻https://science.sciencemag.org/content/early/2020/09/29/science.abd4570…
►https://jamanetwork.com/journals/jama/fullarticle/2768926…
▻https://twitter.com/VirusesImmunity/status/1311414833414168576
Prof. Akiko Iwasaki sur Twitter : “Finally, recombinant IFN therapy, especially given early during infection, can shut down viral replication and promote recovery. Further, prophylactic treatment with rIFN might be useful in high risk groups. (8/n)” / Twitter
▻https://twitter.com/VirusesImmunity/status/1311414838426439682
Prof. Akiko Iwasaki sur Twitter : "A number of clinical trials are under way to test whether IFN therapy can help #COVID-19 patients recover quickly from infection and disease ▻https://www.clinicaltrials.gov/ct2/results?cond=COVID-19&term=interferon&cntry=&state=&city=&dist=&Sear. Thank you for reading! (End) / Twitter
▻https://twitter.com/VirusesImmunity/status/1311414841144270848