Groupe sanguin et coronavirus, un hasard génétique
▻https://www.franceinter.fr/sciences/groupe-sanguin-et-coronavirus-un-hasard-genetique
D’après une étude chinoise, les personnes de groupe sanguin O sont mieux immunisées contre le coronavirus que les autres groupes. Elles ont un risque d’infection 33% moindre. A contrario, les personnes de groupe A ont 20% de risque supplémentaire d’être infectées. Cette inégalité s’explique par l’action des anticorps.
L’étude originale (16/03/20202)
#not_peer-reviewed
Relationship between the ABO Blood Group and the COVID-19 Susceptibility | medRxiv
▻https://www.medrxiv.org/content/10.1101/2020.03.11.20031096v1
OBJECTIVE To investigate the relationship between the ABO blood group and the COVID-19 susceptibility.
DESIGN The study was conducted by comparing the blood group distribution in 2,173 patients with COVID-19 confirmed by SARS-CoV-2 test from three hospitals in Wuhan and Shenzhen, China with that in normal people from the corresponding regions. Data were analyzed using one-way ANOVA and 2-tailed χ2 and a meta-analysis was performed by random effects models.
SETTING Three tertiary hospitals in Wuhan and Shenzhen, China.
PARTICIPANTS A total of 1,775 patients with COVID-19, including 206 dead cases, from Wuhan Jinyintan Hospital, Wuhan, China were recruited. Another 113 and 285 patients with COVID-19 were respectively recruited from Renmin Hospital of Wuhan University, Wuhan and Shenzhen Third People’s Hospital, Shenzhen, China.
MAIN OUTCOME MEASURES Detection of ABO blood groups, infection occurrence of SARS-CoV-2, and patient death RESULTS The ABO group in 3694 normal people in Wuhan showed a distribution of 32.16%, 24.90%, 9.10% and 33.84% for A, B, AB and O, respectively, versus the distribution of 37.75%, 26.42%, 10.03% and 25.80% for A, B, AB and O, respectively, in 1775 COVID-19 patients from Wuhan Jinyintan Hospital. The proportion of blood group A and O in COVID-19 patients were significantly higher and lower, respectively, than that in normal people (both P < 0.001). Similar ABO distribution pattern was observed in 398 patients from another two hospitals in Wuhan and Shenzhen. Meta-analyses on the pooled data showed that blood group A had a significantly higher risk for COVID-19 (odds ratio-OR, 1.20; 95% confidence interval-CI 1.02~1.43, P = 0.02) compared with non-A blood groups, whereas blood group O had a significantly lower risk for the infectious disease (OR, 0.67; 95% CI 0.60~0.75, P < 0.001) compared with non-O blood groups.In addition, the influence of age and gender on the ABO blood group distribution in patients with COVID-19 from two Wuhan hospitals (1,888 patients) were analyzed and found that age and gender do not have much effect on the distribution.
CONCLUSION People with blood group A have a significantly higher risk for acquiring COVID-19 compared with non-A blood groups, whereas blood group O has a significantly lower risk for the infection compared with non-O blood groups.
Le pdf est accessible, le seul graphique représente les rapports de cote (#odds_ratios)
▻https://www.medrxiv.org/content/10.1101/2020.03.11.20031096v1.full.pdf
note : on a, comme il se doit puisque ce sont des rapports, une échelle logarithmique en abscisses
En fait, c’est un avantage sélectif pour toutes les infections. Ceci explique peut-être le fait que les O sont le groupe le + nombreux…
